Septin 9 promoter region methylation in free circulating DNA - Potential role in noninvasive diagnosis of lung cancer: Preliminary report

Medical Oncology

Volumn 31, Issue 4, 2014, Pages

  Powrózek, Tomasz ^a   Krawczyk, Paweł ^a   Kucharczyk, Tomasz ^a,b   Milanowski, Janusz ^a,c  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

DNA methylation; Free circulating DNA; Lung cancer; Septin 9

Indexed keywords

SEPTIN; SEPTIN 9; UNCLASSIFIED DRUG; DNA; SEPT9 PROTEIN, HUMAN; TUMOR MARKER;

AGED; ARTICLE; CANCER DIAGNOSIS; CANCER STAGING; CONTROLLED STUDY; DNA ISOLATION; DNA METHYLATION; DNA PURIFICATION; FEMALE; GENE AMPLIFICATION; HUMAN; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; BLOOD; DNA SEQUENCE; EARLY DIAGNOSIS; GENETIC EPIGENESIS; GENETICS; LUNG TUMOR; MIDDLE AGED; PREDICTIVE VALUE; REPRODUCIBILITY;

AGED; DNA; DNA METHYLATION; EARLY DETECTION OF CANCER; EPIGENESIS, GENETIC; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROMOTER REGIONS, GENETIC; REPRODUCIBILITY OF RESULTS; SEPTINS; SEQUENCE ANALYSIS, DNA; TUMOR MARKERS, BIOLOGICAL;

EID: 84898816773     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-014-0917-4     Document Type: Article

References (9)

1. Infante MV, Pedersen JH. Screening for lung cancer: are we there yet? Curr Opin Pulm Med. 2010;16:301-6.
2. Boiselle PM. Computed tomography screening for lung cancer. JAMA. 2013;309:1163-70.
3. Dela Cruz CS, Tanoue LT, Matthay RA. Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med. 2011;32:605-44.
4. Das PM, Singal R. DNA methylation and cancer. J Clin Oncol. 2004;22:4632-42.
5. Scott M, Hyland P, McGregor G, Hillan KJ, Russell H, Hall PA. Multimodality expression profiling shows SEPT9 to be overexpressed in a wide range of human tumours. Oncogene. 2005;24:4688-700.
6. Warren JD, Xiong W, Bunker AM, Vaughn CP, Furtado LV, Roberts WL, Fang JC, Samowitz WS, Heichman KA. Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer. BMC Med. 2011;9:133.
7. Grützmann R, Molnar B, Pilarsky C, Habermann JK, Schlag PM, Saeger HD, Miehlke S, Stolz T, Model F, Roblick UJ, Bruch HP, Koch R, Liebenberg V, deVos T, Song X, Day RH, Sledziewski AZ, Lofton-Day C. Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay. PLoS One. 2008;3:e3759.
8. deVos T, Tetzner R, Model F, Weiss G, Schuster M, Distler J, Steiger KV, Grutzmann R, Pilarsky C, Habermann JK, Fleshner PR, Oubre BM, Lofton-Day R. Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin Chem. 2009;55:1337-46.
9. Tóth K, Sipos F, Kalmár A, Patai A, Wichmann B, Stoehr R, Golcher H, Schellerer V, Tulassay Z, Molnar B. Detection of methylated SEPT9 in plasma is a reliable screening method for both left- and right-sided colon cancers. PLoS One. 2012;7:e46000.