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Volumn 31, Issue 6, 2017, Pages 2183-2205

Antifibrinolytic Agents in Cardiac and Noncardiac Surgery: A Comprehensive Overview and Update

Author keywords

aminocaproic acid; antifibrinolytic; antifibrinolytic agents; aprotinin; blood transfusion; cardiac surgical procedures; cardiopulmonary bypass; coagulation; multiple trauma; postoperative hemorrhage; serine proteinase inhibitors; surgical bleeding; tranexamic acid

Indexed keywords

AMINOCAPROIC ACID; APROTININ; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

EID: 85018325532     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2017.02.029     Document Type: Review
Times cited : (50)

References (230)
  • 1
    • 79951972309 scopus 로고    scopus 로고
    • 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines
    • Society of Thoracic Surgeons Blood Conservation Guideline Task Force, Ferraris, V.A., Brown, J.R., et al. 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg 91 (2011), 944–982.
    • (2011) Ann Thorac Surg , vol.91 , pp. 944-982
    • Ferraris, V.A.1    Brown, J.R.2
  • 2
    • 84921451901 scopus 로고    scopus 로고
    • Tranexamic acid—an old drug still going strong and making a revival
    • Tengborn, L., Blomback, M., Berntorp, E., Tranexamic acid—an old drug still going strong and making a revival. Thromb Res 135 (2015), 231–242.
    • (2015) Thromb Res , vol.135 , pp. 231-242
    • Tengborn, L.1    Blomback, M.2    Berntorp, E.3
  • 3
    • 85036562906 scopus 로고    scopus 로고
    • WHO model list of essential medicines. Available at: Accessed November 5.
    • World Health Organization. WHO model list of essential medicines. Available at: http://www.who.int/medicines/publications/essentialmedicines/en/. Accessed November 5, 2016.
    • (2016)
  • 4
    • 84979197675 scopus 로고    scopus 로고
    • Applying results from clinical trials: Tranexamic acid in trauma patients
    • Roberts, I., Prieto-Merino, D., Applying results from clinical trials: Tranexamic acid in trauma patients. J Intensive Care, 2, 2014, 56.
    • (2014) J Intensive Care , vol.2 , pp. 56
    • Roberts, I.1    Prieto-Merino, D.2
  • 5
    • 84925283438 scopus 로고    scopus 로고
    • Tranexamic acid use in severely injured civilian patients and the effects on outcomes: A prospective cohort study
    • Cole, E., Davenport, R., Willett, K., et al. Tranexamic acid use in severely injured civilian patients and the effects on outcomes: A prospective cohort study. Ann Surg 261 (2015), 390–394.
    • (2015) Ann Surg , vol.261 , pp. 390-394
    • Cole, E.1    Davenport, R.2    Willett, K.3
  • 6
    • 85036575651 scopus 로고    scopus 로고
    • WHO recommendations for the prevention and treatment of postpartum haemorrhage. Available at: Accessed January 14.
    • World Health Organization. WHO recommendations for the prevention and treatment of postpartum haemorrhage. Available at: http://apps.who.int/iris/bitstream/10665/75411/1/9789241548502_eng.pdf. Accessed January 14, 2017.
    • (2017)
  • 8
    • 0033917175 scopus 로고    scopus 로고
    • Tranexamic acid reduces red cell transfusion better than epsilon-aminocaproic acid or placebo in liver transplantation
    • Dalmau, A., Sabate, A., Acosta, F., et al. Tranexamic acid reduces red cell transfusion better than epsilon-aminocaproic acid or placebo in liver transplantation. Anesth Analg 91 (2000), 29–34.
    • (2000) Anesth Analg , vol.91 , pp. 29-34
    • Dalmau, A.1    Sabate, A.2    Acosta, F.3
  • 9
    • 0034655629 scopus 로고    scopus 로고
    • Aprotinin and transfusion requirements in orthotopic liver transplantation: A multicentre randomised double-blind study
    • Porte, R.J., Molenaar, I.Q., Begliomini, B., et al. Aprotinin and transfusion requirements in orthotopic liver transplantation: A multicentre randomised double-blind study. EMSALT Study Group. Lancet 355 (2000), 1303–1309.
    • (2000) EMSALT Study Group. Lancet , vol.355 , pp. 1303-1309
    • Porte, R.J.1    Molenaar, I.Q.2    Begliomini, B.3
  • 10
    • 84964446392 scopus 로고    scopus 로고
    • Tranexamic acid in total joint arthroplasty: Efficacy and safety
    • Rasouli, M.R., Parvizi, J., Tranexamic acid in total joint arthroplasty: Efficacy and safety. Arch Bone Jt Surg 3 (2015), 1–2.
    • (2015) Arch Bone Jt Surg , vol.3 , pp. 1-2
    • Rasouli, M.R.1    Parvizi, J.2
  • 11
    • 84917683344 scopus 로고    scopus 로고
    • Tranexamic acid for traumatic brain injury: A systematic review and meta-analysis
    • Zehtabchi, S., Abdel Baki, S.G., Falzon, L., et al. Tranexamic acid for traumatic brain injury: A systematic review and meta-analysis. Am J Emerg Med 32 (2014), 1503–1509.
    • (2014) Am J Emerg Med , vol.32 , pp. 1503-1509
    • Zehtabchi, S.1    Abdel Baki, S.G.2    Falzon, L.3
  • 12
    • 85020478932 scopus 로고    scopus 로고
    • Use of intravenous tranexamic acid during myomectomy: A randomized double-blind placebo controlled trial
    • Opoku-Anane, J., Vargas, M.V., Moawad, G., et al. Use of intravenous tranexamic acid during myomectomy: A randomized double-blind placebo controlled trial. J Minim Invasive Gynecol, 22, 2015, S197.
    • (2015) J Minim Invasive Gynecol , vol.22 , pp. S197
    • Opoku-Anane, J.1    Vargas, M.V.2    Moawad, G.3
  • 13
    • 84859002467 scopus 로고    scopus 로고
    • Intraoperative use of tranexamic acid to reduce transfusion rate in patients undergoing radical retropubic prostatectomy: Double blind, randomised, placebo controlled trial
    • Crescenti, A., Borghi, G., Bignami, E., et al. Intraoperative use of tranexamic acid to reduce transfusion rate in patients undergoing radical retropubic prostatectomy: Double blind, randomised, placebo controlled trial. BMJ, 343, 2011, d5701.
    • (2011) BMJ , vol.343 , pp. d5701
    • Crescenti, A.1    Borghi, G.2    Bignami, E.3
  • 14
    • 85020727123 scopus 로고    scopus 로고
    • Management of bleeding in vascular surgery
    • Chee, Y.E., Liu, S.E., Irwin, M.G., Management of bleeding in vascular surgery. Br J Anaesth 117:Suppl 2 (2016), ii85–ii94.
    • (2016) Br J Anaesth , vol.117 , pp. ii85-ii94
    • Chee, Y.E.1    Liu, S.E.2    Irwin, M.G.3
  • 15
    • 84988938085 scopus 로고    scopus 로고
    • Safety and efficacy of tranexamic acid in bleeding paediatric trauma patients: A systematic review protocol
    • Urban, D., Dehaeck, R., Lorenzetti, D., et al. Safety and efficacy of tranexamic acid in bleeding paediatric trauma patients: A systematic review protocol. BMJ Open, 6, 2016, e012947.
    • (2016) BMJ Open , vol.6 , pp. e012947
    • Urban, D.1    Dehaeck, R.2    Lorenzetti, D.3
  • 16
    • 0002919970 scopus 로고
    • Antifibrinolytic activity and metabolism of 6-aminocaproic acid in man
    • Nilsson, I.M., Sjoerdsma, A., Waldenstrom, J., Antifibrinolytic activity and metabolism of 6-aminocaproic acid in man. Lancet 1 (1960), 1322–1326.
    • (1960) Lancet , vol.1 , pp. 1322-1326
    • Nilsson, I.M.1    Sjoerdsma, A.2    Waldenstrom, J.3
  • 17
    • 40749137612 scopus 로고
    • Mechanism of action of epsilon aminocaproic acid in the control of hemorrhage
    • Deysine, M., Cliffton, E.E., Mechanism of action of epsilon aminocaproic acid in the control of hemorrhage. Ann N Y Acad Sci 115 (1964), 291–297.
    • (1964) Ann N Y Acad Sci , vol.115 , pp. 291-297
    • Deysine, M.1    Cliffton, E.E.2
  • 18
    • 73849154036 scopus 로고
    • Reduction of postprostatectomy bleeding by episilon-aminocaproic acid
    • Sack, E., Spaet, T.H., Gentile, R.L., et al. Reduction of postprostatectomy bleeding by episilon-aminocaproic acid. N Engl J Med 266 (1962), 541–543.
    • (1962) N Engl J Med , vol.266 , pp. 541-543
    • Sack, E.1    Spaet, T.H.2    Gentile, R.L.3
  • 19
    • 84907972088 scopus 로고    scopus 로고
    • Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders
    • Al-Horani, R.A., Desai, U.R., Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders. Med Res Rev 34 (2014), 1168–1216.
    • (2014) Med Res Rev , vol.34 , pp. 1168-1216
    • Al-Horani, R.A.1    Desai, U.R.2
  • 20
    • 85036527095 scopus 로고    scopus 로고
    • RxList. Amicar (Aminocaproic Acid Dug Information): Clinical Pharmacology. Available at: Accessed March 8.
    • RxList. Amicar (Aminocaproic Acid Dug Information): Clinical Pharmacology. Available at: http://www.rxlist.com/amicar-drug/clinical-pharmacology.htm. Accessed March 8, 2017.
    • (2017)
  • 21
    • 0015539254 scopus 로고
    • The use of antifibrinolytic drugs to prevent early recurrent aneurysmal subarachnoid haemorrhage
    • Tovi, D., The use of antifibrinolytic drugs to prevent early recurrent aneurysmal subarachnoid haemorrhage. Acta Neurol Scand 49 (1973), 163–175.
    • (1973) Acta Neurol Scand , vol.49 , pp. 163-175
    • Tovi, D.1
  • 22
    • 0019583645 scopus 로고
    • Pharmacokinetics of epsilon-aminocaproic acid during peritoneal dialysis
    • Fish, S.S., Pancorbo, S., Berkseth, R., Pharmacokinetics of epsilon-aminocaproic acid during peritoneal dialysis. J Neurosurg 54 (1981), 736–739.
    • (1981) J Neurosurg , vol.54 , pp. 736-739
    • Fish, S.S.1    Pancorbo, S.2    Berkseth, R.3
  • 23
    • 84876538344 scopus 로고    scopus 로고
    • Population pharmacokinetics of epsilon-aminocaproic acid in infants undergoing craniofacial reconstruction surgery
    • Stricker, P.A., Zuppa, A.F., Fiadjoe, J.E., et al. Population pharmacokinetics of epsilon-aminocaproic acid in infants undergoing craniofacial reconstruction surgery. Br J Anaesth 110 (2013), 788–799.
    • (2013) Br J Anaesth , vol.110 , pp. 788-799
    • Stricker, P.A.1    Zuppa, A.F.2    Fiadjoe, J.E.3
  • 24
    • 84937568857 scopus 로고    scopus 로고
    • Pharmacokinetics of epsilon-aminocaproic acid in neonates undergoing cardiac surgery with cardiopulmonary bypass
    • Eaton, M.P., Alfieris, G.M., Sweeney, D.M., et al. Pharmacokinetics of epsilon-aminocaproic acid in neonates undergoing cardiac surgery with cardiopulmonary bypass. Anesthesiology 122 (2015), 1002–1009.
    • (2015) Anesthesiology , vol.122 , pp. 1002-1009
    • Eaton, M.P.1    Alfieris, G.M.2    Sweeney, D.M.3
  • 25
    • 31344467254 scopus 로고    scopus 로고
    • The risk associated with aprotinin in cardiac surgery
    • Mangano, D.T., Tudor, I.C., Dietzel, C., et al. The risk associated with aprotinin in cardiac surgery. N Engl J Med 354 (2006), 353–365.
    • (2006) N Engl J Med , vol.354 , pp. 353-365
    • Mangano, D.T.1    Tudor, I.C.2    Dietzel, C.3
  • 26
    • 0024409547 scopus 로고
    • Prophylactic treatment of postperfusion bleeding using EACA
    • DelRossi, A.J., Cernaianu, A.C., Botros, S., et al. Prophylactic treatment of postperfusion bleeding using EACA. Chest 96 (1989), 27–30.
    • (1989) Chest , vol.96 , pp. 27-30
    • DelRossi, A.J.1    Cernaianu, A.C.2    Botros, S.3
  • 27
    • 34249913425 scopus 로고    scopus 로고
    • Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery
    • Brown, J.R., Birkmeyer, N.J., O'Connor, G.T., Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation 115 (2007), 2801–2813.
    • (2007) Circulation , vol.115 , pp. 2801-2813
    • Brown, J.R.1    Birkmeyer, N.J.2    O'Connor, G.T.3
  • 28
    • 44349089188 scopus 로고    scopus 로고
    • A comparison of aprotinin and lysine analogues in high-risk cardiac surgery
    • Fergusson, D.A., Hebert, P.C., Mazer, C.D., et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med 358 (2008), 2319–2331.
    • (2008) N Engl J Med , vol.358 , pp. 2319-2331
    • Fergusson, D.A.1    Hebert, P.C.2    Mazer, C.D.3
  • 29
    • 79251551708 scopus 로고    scopus 로고
    • epsilon-Aminocaproic acid and clinical value in cardiac anesthesia
    • Raghunathan, K., Connelly, N.R., Kanter, G.J., epsilon-Aminocaproic acid and clinical value in cardiac anesthesia. J Cardiothorac Vasc Anesth 25 (2011), 16–19.
    • (2011) J Cardiothorac Vasc Anesth , vol.25 , pp. 16-19
    • Raghunathan, K.1    Connelly, N.R.2    Kanter, G.J.3
  • 30
    • 79952270874 scopus 로고    scopus 로고
    • Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion
    • Henry, D.A., Carless, P.A., Moxey, A.J., et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev, 2011, CD:001886.
    • (2011) Cochrane Database Syst Rev , pp. CD001886
    • Henry, D.A.1    Carless, P.A.2    Moxey, A.J.3
  • 31
    • 84888297898 scopus 로고    scopus 로고
    • Comparison of epsilon aminocaproic acid and tranexamic acid in thoracic aortic surgery: Clinical efficacy and safety
    • Makhija, N., Sarupria, A., Kumar Choudhary, S., et al. Comparison of epsilon aminocaproic acid and tranexamic acid in thoracic aortic surgery: Clinical efficacy and safety. J Cardiothorac Vasc Anesth 27 (2013), 1201–1207.
    • (2013) J Cardiothorac Vasc Anesth , vol.27 , pp. 1201-1207
    • Makhija, N.1    Sarupria, A.2    Kumar Choudhary, S.3
  • 32
    • 84921467554 scopus 로고    scopus 로고
    • Efficacy and safety of tranexamic acid versus aminocaproic acid in cardiovascular surgery
    • Falana, O., Patel, G., Efficacy and safety of tranexamic acid versus aminocaproic acid in cardiovascular surgery. Ann Pharmacother 48 (2014), 1563–1569.
    • (2014) Ann Pharmacother , vol.48 , pp. 1563-1569
    • Falana, O.1    Patel, G.2
  • 33
    • 84925348610 scopus 로고    scopus 로고
    • Practice guidelines for perioperative blood management: An updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management
    • American Society of Anesthesiologists Task Force on Perioperative Blood Management. Practice guidelines for perioperative blood management: An updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management. Anesthesiology 122 (2015), 241–275.
    • (2015) Anesthesiology , vol.122 , pp. 241-275
  • 34
    • 0043124368 scopus 로고    scopus 로고
    • Biological effects of off-pump vs. on-pump coronary artery surgery: Focus on inflammation, hemostasis and oxidative stress
    • Biglioli, P., Cannata, A., Alamanni, F., et al. Biological effects of off-pump vs. on-pump coronary artery surgery: Focus on inflammation, hemostasis and oxidative stress. Eur J Cardiothorac Surg 24 (2003), 260–269.
    • (2003) Eur J Cardiothorac Surg , vol.24 , pp. 260-269
    • Biglioli, P.1    Cannata, A.2    Alamanni, F.3
  • 35
    • 63249134363 scopus 로고    scopus 로고
    • Quantitative and temporal differences in coagulation, fibrinolysis and platelet activation after on-pump and off-pump coronary artery bypass surgery
    • Vallely, M.P., Bannon, P.G., Bayfield, M.S., et al. Quantitative and temporal differences in coagulation, fibrinolysis and platelet activation after on-pump and off-pump coronary artery bypass surgery. Heart Lung Circ 18 (2009), 123–130.
    • (2009) Heart Lung Circ , vol.18 , pp. 123-130
    • Vallely, M.P.1    Bannon, P.G.2    Bayfield, M.S.3
  • 36
    • 0034767115 scopus 로고    scopus 로고
    • Activation of coagulation and fibrinolysis during coronary surgery: On-pump versus off-pump techniques
    • Casati, V., Gerli, C., Franco, A., et al. Activation of coagulation and fibrinolysis during coronary surgery: On-pump versus off-pump techniques. Anesthesiology 95 (2001), 1103–1109.
    • (2001) Anesthesiology , vol.95 , pp. 1103-1109
    • Casati, V.1    Gerli, C.2    Franco, A.3
  • 37
    • 11444268290 scopus 로고    scopus 로고
    • Does off-pump coronary artery bypass reduce mortality, morbidity, and resource utilization when compared with conventional coronary artery bypass? A meta-analysis of randomized trials
    • Cheng, D.C., Bainbridge, D., Martin, J.E., et al. Does off-pump coronary artery bypass reduce mortality, morbidity, and resource utilization when compared with conventional coronary artery bypass? A meta-analysis of randomized trials. Anesthesiology 102 (2005), 188–203.
    • (2005) Anesthesiology , vol.102 , pp. 188-203
    • Cheng, D.C.1    Bainbridge, D.2    Martin, J.E.3
  • 38
    • 84864409894 scopus 로고    scopus 로고
    • Tranexamic acid for routine use in off-pump coronary artery bypass surgery: Evidence base “fait accompli” or more research needed?
    • Martin, J., Cheng, D., Tranexamic acid for routine use in off-pump coronary artery bypass surgery: Evidence base “fait accompli” or more research needed?. Anesth Analg 115 (2012), 227–230.
    • (2012) Anesth Analg , vol.115 , pp. 227-230
    • Martin, J.1    Cheng, D.2
  • 39
    • 85036509825 scopus 로고    scopus 로고
    • Comparing epsilon-aminocaproic acid and tranexamic acid in reducing postoperative transfusions in total knee arthroplasty
    • [E-pub ahead of print]
    • Churchill, J.L., Puca, K.E., Meyer, E., et al. Comparing epsilon-aminocaproic acid and tranexamic acid in reducing postoperative transfusions in total knee arthroplasty. J Knee Surg, 2016 Oct 3 [E-pub ahead of print].
    • (2016) J Knee Surg
    • Churchill, J.L.1    Puca, K.E.2    Meyer, E.3
  • 40
    • 84948983868 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of the use of antifibrinolytic agents in total hip arthroplasty
    • Huang, F., Wu, Y., Yin, Z., et al. A systematic review and meta-analysis of the use of antifibrinolytic agents in total hip arthroplasty. Hip Int 25 (2015), 502–509.
    • (2015) Hip Int , vol.25 , pp. 502-509
    • Huang, F.1    Wu, Y.2    Yin, Z.3
  • 41
    • 33645892258 scopus 로고    scopus 로고
    • Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: A randomized clinical trial
    • Camarasa, M.A., Olle, G., Serra-Prat, M., et al. Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: A randomized clinical trial. Br J Anaesth 96 (2006), 576–582.
    • (2006) Br J Anaesth , vol.96 , pp. 576-582
    • Camarasa, M.A.1    Olle, G.2    Serra-Prat, M.3
  • 42
    • 85027014810 scopus 로고    scopus 로고
    • Using aminocaproic acid to reduce blood loss after primary unilateral total knee arthroplasty
    • Churchill, J.L., Toney, V.A., Truchan, S., et al. Using aminocaproic acid to reduce blood loss after primary unilateral total knee arthroplasty. Am J Orthop 45 (2016), E245–E248.
    • (2016) Am J Orthop , vol.45 , pp. E245-E248
    • Churchill, J.L.1    Toney, V.A.2    Truchan, S.3
  • 43
    • 60449090703 scopus 로고    scopus 로고
    • Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: A systematic review of randomized trials
    • Kagoma, Y.K., Crowther, M.A., Douketis, J., et al. Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: A systematic review of randomized trials. Thrombosis Research 123 (2009), 687–696.
    • (2009) Thrombosis Research , vol.123 , pp. 687-696
    • Kagoma, Y.K.1    Crowther, M.A.2    Douketis, J.3
  • 44
    • 25144450153 scopus 로고    scopus 로고
    • Aprotinin and epsilon aminocaproic acid are effective in reducing blood loss after primary total hip arthroplasty—a prospective randomized double-blind placebo-controlled study
    • Ray, M., Hatcher, S., Whitehouse, S.L., et al. Aprotinin and epsilon aminocaproic acid are effective in reducing blood loss after primary total hip arthroplasty—a prospective randomized double-blind placebo-controlled study. J Thromb Haemost 3 (2005), 1421–1427.
    • (2005) J Thromb Haemost , vol.3 , pp. 1421-1427
    • Ray, M.1    Hatcher, S.2    Whitehouse, S.L.3
  • 45
    • 84958178049 scopus 로고    scopus 로고
    • Antifibrinolytics reduce blood loss in adult spinal deformity surgery: A prospective, randomized controlled trial
    • Peters, A., Verma, K., Slobodyanyuk, K., et al. Antifibrinolytics reduce blood loss in adult spinal deformity surgery: A prospective, randomized controlled trial. Spine 40 (2015), E443–E449.
    • (2015) Spine , vol.40 , pp. E443-E449
    • Peters, A.1    Verma, K.2    Slobodyanyuk, K.3
  • 46
    • 77951766184 scopus 로고    scopus 로고
    • Blood loss in major spine surgery: Are there effective measures to decrease massive hemorrhage in major spine fusion surgery?
    • Elgafy, H., Bransford, R.J., McGuire, R.A., et al. Blood loss in major spine surgery: Are there effective measures to decrease massive hemorrhage in major spine fusion surgery?. Spine 35 (2010), S47–S56.
    • (2010) Spine , vol.35 , pp. S47-S56
    • Elgafy, H.1    Bransford, R.J.2    McGuire, R.A.3
  • 47
    • 84991508684 scopus 로고    scopus 로고
    • Spine surgery and blood loss: Systematic review of Clinical evidence
    • Willner, D., Spennati, V., Stohl, S., et al. Spine surgery and blood loss: Systematic review of Clinical evidence. Anesth Analg 123 (2016), 1307–1315.
    • (2016) Anesth Analg , vol.123 , pp. 1307-1315
    • Willner, D.1    Spennati, V.2    Stohl, S.3
  • 48
    • 84991328205 scopus 로고    scopus 로고
    • Efficacy of antifibrinolytic agents on surgical bleeding and transfusion requirements in spine surgery: A meta-analysis
    • Li, G., Sun, T.W., Luo, G., et al. Efficacy of antifibrinolytic agents on surgical bleeding and transfusion requirements in spine surgery: A meta-analysis. Eur Spine J 26 (2017), 140–154.
    • (2017) Eur Spine J , vol.26 , pp. 140-154
    • Li, G.1    Sun, T.W.2    Luo, G.3
  • 49
    • 84976439841 scopus 로고    scopus 로고
    • Effect of antifibrinolytic therapy on complications, thromboembolic events, blood product utilization, and fusion in adult spinal deformity surgery
    • Soroceanu, A., Oren, J.H., Smith, J.S., et al. Effect of antifibrinolytic therapy on complications, thromboembolic events, blood product utilization, and fusion in adult spinal deformity surgery. Spine 41 (2016), E879–E886.
    • (2016) Spine , vol.41 , pp. E879-E886
    • Soroceanu, A.1    Oren, J.H.2    Smith, J.S.3
  • 50
    • 84946550812 scopus 로고    scopus 로고
    • Efficacy and safety of antifibrinolytic agents in reducing perioperative blood loss and transfusion requirements in scoliosis surgery: A systematic review and meta-analysis
    • Wang, M., Zheng, X.F., Jiang, L.S., Efficacy and safety of antifibrinolytic agents in reducing perioperative blood loss and transfusion requirements in scoliosis surgery: A systematic review and meta-analysis. PLoS One, 10, 2015, e0137886.
    • (2015) PLoS One , vol.10 , pp. e0137886
    • Wang, M.1    Zheng, X.F.2    Jiang, L.S.3
  • 51
    • 84877984570 scopus 로고    scopus 로고
    • Ultra-early tranexamic acid after subarachnoid hemorrhage (ULTRA): Study protocol for a randomized controlled trial
    • Germans, M.R., Post, R., Coert, B.A., et al. Ultra-early tranexamic acid after subarachnoid hemorrhage (ULTRA): Study protocol for a randomized controlled trial. Trials, 14, 2013, 143.
    • (2013) Trials , vol.14 , pp. 143
    • Germans, M.R.1    Post, R.2    Coert, B.A.3
  • 52
    • 0042418462 scopus 로고    scopus 로고
    • Antifibrinolytic therapy for aneurysmal subarachnoid hemorrhage: A major update of a Cochrane review
    • Roos, Y., Rinkel, G., Vermeulen, M., et al. Antifibrinolytic therapy for aneurysmal subarachnoid hemorrhage: A major update of a Cochrane review. Stroke 34 (2003), 2308–2309.
    • (2003) Stroke , vol.34 , pp. 2308-2309
    • Roos, Y.1    Rinkel, G.2    Vermeulen, M.3
  • 53
  • 54
    • 84861595790 scopus 로고    scopus 로고
    • Guidelines for the management of aneurysmal subarachnoid hemorrhage: A guideline for healthcare professionals from the American Heart Association/American Stroke Association
    • Connolly, E.S. Jr, Rabinstein, A.A., Carhuapoma, J.R., et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 43 (2012), 1711–1737.
    • (2012) Stroke , vol.43 , pp. 1711-1737
    • Connolly, E.S.1    Rabinstein, A.A.2    Carhuapoma, J.R.3
  • 55
    • 80053131240 scopus 로고    scopus 로고
    • Critical care management of patients following aneurysmal subarachnoid hemorrhage: Recommendations from the Neurocritical Care Society's Multidisciplinary Consensus Conference
    • Diringer, M.N., Bleck, T.P., Claude Hemphill, J. 3rd, et al. Critical care management of patients following aneurysmal subarachnoid hemorrhage: Recommendations from the Neurocritical Care Society's Multidisciplinary Consensus Conference. Neurocrit Care 15 (2011), 211–240.
    • (2011) Neurocrit Care , vol.15 , pp. 211-240
    • Diringer, M.N.1    Bleck, T.P.2    Claude Hemphill, J.3
  • 56
    • 85036544305 scopus 로고    scopus 로고
    • Ultra-early tranexamic acid after subarachnoid hemorrhage. Available at: Accessed January 8.
    • Netherlands Trial Register. Ultra-early tranexamic acid after subarachnoid hemorrhage. Available at: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3272. Accessed January 8, 2017.
    • (2017)
  • 57
    • 33845651348 scopus 로고    scopus 로고
    • Efficacy and safety of antifibrinolytic drugs in liver transplantation: A systematic review and meta-analysis
    • Molenaar, I.Q., Warnaar, N., Groen, H., et al. Efficacy and safety of antifibrinolytic drugs in liver transplantation: A systematic review and meta-analysis. Am J Transplant 7 (2007), 185–194.
    • (2007) Am J Transplant , vol.7 , pp. 185-194
    • Molenaar, I.Q.1    Warnaar, N.2    Groen, H.3
  • 58
    • 84902437853 scopus 로고    scopus 로고
    • Aminocaproic Acid (amicar) as an alternative to aprotinin (trasylol) in liver transplantation
    • Mangus, R.S., Kinsella, S.B., Fridell, J.A., et al. Aminocaproic Acid (amicar) as an alternative to aprotinin (trasylol) in liver transplantation. Transplant Proc 46 (2014), 1393–1399.
    • (2014) Transplant Proc , vol.46 , pp. 1393-1399
    • Mangus, R.S.1    Kinsella, S.B.2    Fridell, J.A.3
  • 59
    • 84977156832 scopus 로고    scopus 로고
    • Epsilon-aminocaproic acid has no association with thromboembolic complications, renal failure, or nortality after liver transplantation
    • Nicolau-Raducu, R., Ku, T.C., Ganier, D.R., et al. Epsilon-aminocaproic acid has no association with thromboembolic complications, renal failure, or nortality after liver transplantation. J Cardiothorac Vasc Anesth 30 (2016), 917–923.
    • (2016) J Cardiothorac Vasc Anesth , vol.30 , pp. 917-923
    • Nicolau-Raducu, R.1    Ku, T.C.2    Ganier, D.R.3
  • 60
    • 84941915384 scopus 로고    scopus 로고
    • Antifibrinolytic drugs for acute traumatic injury
    • CD:004896
    • Ker, K., Roberts, I., Shakur, H., et al. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Re, 2015 CD:004896.
    • (2015) Cochrane Database Syst Re
    • Ker, K.1    Roberts, I.2    Shakur, H.3
  • 61
    • 84962859139 scopus 로고    scopus 로고
    • The European guideline on management of major bleeding and coagulopathy following trauma: Fourth edition
    • Rossaint, R., Bouillon, B., Cerny, V., et al. The European guideline on management of major bleeding and coagulopathy following trauma: Fourth edition. Crit Care, 20, 2016, 100.
    • (2016) Crit Care , vol.20 , pp. 100
    • Rossaint, R.1    Bouillon, B.2    Cerny, V.3
  • 62
    • 84953393595 scopus 로고    scopus 로고
    • Peri-operative blood-loss after total hip arthroplasty can be significantly reduced with topical application of epsilon-aminocaproic acid
    • Sucher, M.G., Giordani, M., Figoni, A., et al. Peri-operative blood-loss after total hip arthroplasty can be significantly reduced with topical application of epsilon-aminocaproic acid. Int Orthop 40 (2016), 2019–2023.
    • (2016) Int Orthop , vol.40 , pp. 2019-2023
    • Sucher, M.G.1    Giordani, M.2    Figoni, A.3
  • 63
    • 84906059858 scopus 로고    scopus 로고
    • A randomized trial of the topical effect of antifibrinolytic epsilon aminocaproic acid on coronary artery bypass surgery without cardiopulmonary bypass
    • Gurian, D.B., Meneghini, A., Abreu, L.C., et al. A randomized trial of the topical effect of antifibrinolytic epsilon aminocaproic acid on coronary artery bypass surgery without cardiopulmonary bypass. Clin Appl Thromb Hemost 20 (2014), 615–620.
    • (2014) Clin Appl Thromb Hemost , vol.20 , pp. 615-620
    • Gurian, D.B.1    Meneghini, A.2    Abreu, L.C.3
  • 64
    • 0030609812 scopus 로고    scopus 로고
    • epsilon-Aminocaproic acid plasma levels during cardiopulmonary bypass
    • Bennett-Guerrero, E., Sorohan, J.G., Canada, A.T., et al. epsilon-Aminocaproic acid plasma levels during cardiopulmonary bypass. Anesth Analg 85 (1997), 248–251.
    • (1997) Anesth Analg , vol.85 , pp. 248-251
    • Bennett-Guerrero, E.1    Sorohan, J.G.2    Canada, A.T.3
  • 65
    • 0034997755 scopus 로고    scopus 로고
    • Gender does not influence epsilon-aminocaproic acid concentrations in adults undergoing cardiopulmonary bypass
    • Butterworth, J., James, R.L., Lin, Y.A., et al. Gender does not influence epsilon-aminocaproic acid concentrations in adults undergoing cardiopulmonary bypass. Anesth Analg 92 (2001), 1384–1390.
    • (2001) Anesth Analg , vol.92 , pp. 1384-1390
    • Butterworth, J.1    James, R.L.2    Lin, Y.A.3
  • 66
    • 85081391978 scopus 로고    scopus 로고
    • Evidence-based EACA dosing?
    • author reply 1673
    • Lundell, J.C., Evidence-based EACA dosing?. Anesth Analg, 94, 2002, 1673 author reply 1673.
    • (2002) Anesth Analg , vol.94 , pp. 1673
    • Lundell, J.C.1
  • 67
    • 0345356441 scopus 로고    scopus 로고
    • Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: A randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin
    • Greilich, P.E., Brouse, C.F., Whitten, C.W., et al. Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: A randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin. J Thorac Cardiovasc Surg 126 (2003), 1498–1503.
    • (2003) J Thorac Cardiovasc Surg , vol.126 , pp. 1498-1503
    • Greilich, P.E.1    Brouse, C.F.2    Whitten, C.W.3
  • 68
    • 84940668791 scopus 로고    scopus 로고
    • What dose of tranexamic acid is most effective and safe for adult patients undergoing cardiac surgery?
    • Hodgson, S., Larvin, J.T., Dearman, C., What dose of tranexamic acid is most effective and safe for adult patients undergoing cardiac surgery?. Interact Cardiov Th 21 (2015), 384–388.
    • (2015) Interact Cardiov Th , vol.21 , pp. 384-388
    • Hodgson, S.1    Larvin, J.T.2    Dearman, C.3
  • 69
    • 84867193761 scopus 로고    scopus 로고
    • Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass
    • Sharma, V., Fan, J., Jerath, A., et al. Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass. Anaesthesia 67 (2012), 1242–1250.
    • (2012) Anaesthesia , vol.67 , pp. 1242-1250
    • Sharma, V.1    Fan, J.2    Jerath, A.3
  • 70
    • 84935516631 scopus 로고    scopus 로고
    • Pharmacokinetic modeling of tranexamic acid for patients undergoing cardiac surgery with normal renal function and model simulations for patients with renal impairment
    • Yang, Q.J., Jerath, A., Bies, R.R., et al. Pharmacokinetic modeling of tranexamic acid for patients undergoing cardiac surgery with normal renal function and model simulations for patients with renal impairment. Biopharm Drug Dispos 36 (2015), 294–307.
    • (2015) Biopharm Drug Dispos , vol.36 , pp. 294-307
    • Yang, Q.J.1    Jerath, A.2    Bies, R.R.3
  • 71
    • 0036138408 scopus 로고    scopus 로고
    • The pharmacokinetics of epsilon-aminocaproic acid in children undergoing surgical repair of congenital heart defects
    • Ririe, D.G., James, R.L., O'Brien, J.J., et al. The pharmacokinetics of epsilon-aminocaproic acid in children undergoing surgical repair of congenital heart defects. Anesth Analg 94 (2002), 44–49.
    • (2002) Anesth Analg , vol.94 , pp. 44-49
    • Ririe, D.G.1    James, R.L.2    O'Brien, J.J.3
  • 72
    • 84872138094 scopus 로고    scopus 로고
    • Comparison of different doses of epsilon-aminocaproic acid in children for tetralogy of Fallot surgery: Clinical efficacy and safety
    • Sarupria, A., Makhija, N., Lakshmy, R., et al. Comparison of different doses of epsilon-aminocaproic acid in children for tetralogy of Fallot surgery: Clinical efficacy and safety. J Cardiothorac Vasc Anesth 27 (2013), 23–29.
    • (2013) J Cardiothorac Vasc Anesth , vol.27 , pp. 23-29
    • Sarupria, A.1    Makhija, N.2    Lakshmy, R.3
  • 73
    • 84875901879 scopus 로고    scopus 로고
    • A practical tranexamic acid dosing scheme based on population pharmacokinetics in children undergoing cardiac surgery
    • Grassin-Delyle, S., Couturier, R., Abe, E., et al. A practical tranexamic acid dosing scheme based on population pharmacokinetics in children undergoing cardiac surgery. Anesthesiology 118 (2013), 853–862.
    • (2013) Anesthesiology , vol.118 , pp. 853-862
    • Grassin-Delyle, S.1    Couturier, R.2    Abe, E.3
  • 74
    • 84926659181 scopus 로고    scopus 로고
    • Population pharmacokinetics of ε-aminocaproic acid in adolescents undergoing posterior spinal fusion surgery
    • Stricker, P.A., Gastonguay, M.R., Singh, D., et al. Population pharmacokinetics of ε-aminocaproic acid in adolescents undergoing posterior spinal fusion surgery. Br J Anaesth 114 (2015), 689–699.
    • (2015) Br J Anaesth , vol.114 , pp. 689-699
    • Stricker, P.A.1    Gastonguay, M.R.2    Singh, D.3
  • 75
    • 84936992027 scopus 로고    scopus 로고
    • The effectiveness and safety of tranexamic acid in total hip or knee arthroplasty: A meta-analysis of 2720 cases
    • Wei, Z., Liu, M., The effectiveness and safety of tranexamic acid in total hip or knee arthroplasty: A meta-analysis of 2720 cases. Transfus Med 25 (2015), 151–162.
    • (2015) Transfus Med , vol.25 , pp. 151-162
    • Wei, Z.1    Liu, M.2
  • 76
    • 85020014076 scopus 로고    scopus 로고
    • Effect of short-term epsilon-aminocaproic acid treatment on patients undergoing endovascular coil embolization following aneurysmal subarachnoid hemorrhage
    • [Epub ahead of print]
    • Malekpour, M., Kulwin, C., Bohnstedt, B.N., et al. Effect of short-term epsilon-aminocaproic acid treatment on patients undergoing endovascular coil embolization following aneurysmal subarachnoid hemorrhage. J Neurosurg, 2016 June 17 [Epub ahead of print].
    • (2016) J Neurosurg
    • Malekpour, M.1    Kulwin, C.2    Bohnstedt, B.N.3
  • 77
    • 77954717667 scopus 로고    scopus 로고
    • Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial
    • CRASH-2 Trial Collaborators, Shakur, H., Roberts, I., et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial. Lancet 376 (2010), 23–32.
    • (2010) Lancet , vol.376 , pp. 23-32
    • Shakur, H.1    Roberts, I.2
  • 78
    • 84857430357 scopus 로고    scopus 로고
    • Military application of tranexamic acid in Trauma Emergency Resuscitation (MATTERs) Study
    • Morrison, J.J., Dubose, J.J., Rasmussen, T.E., et al. Military application of tranexamic acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg 147 (2012), 113–119.
    • (2012) Arch Surg , vol.147 , pp. 113-119
    • Morrison, J.J.1    Dubose, J.J.2    Rasmussen, T.E.3
  • 79
    • 84875457479 scopus 로고    scopus 로고
    • Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: Findings from the MATTERs II Study
    • Morrison, J.J., Ross, J.D., Dubose, J.J., et al. Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: Findings from the MATTERs II Study. JAMA Surg 148 (2013), 218–225.
    • (2013) JAMA Surg , vol.148 , pp. 218-225
    • Morrison, J.J.1    Ross, J.D.2    Dubose, J.J.3
  • 80
    • 84917684193 scopus 로고    scopus 로고
    • Tranexamic acid administration to pediatric trauma patients in a combat setting: The pediatric trauma and tranexamic acid study (PED-TRAX)
    • Eckert, M.J., Wertin, T.M., Tyner, S.D., et al. Tranexamic acid administration to pediatric trauma patients in a combat setting: The pediatric trauma and tranexamic acid study (PED-TRAX). J Trauma Acute Care Surg 77 (2014), 852–858.
    • (2014) J Trauma Acute Care Surg , vol.77 , pp. 852-858
    • Eckert, M.J.1    Wertin, T.M.2    Tyner, S.D.3
  • 81
    • 84988442245 scopus 로고    scopus 로고
    • Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials
    • Ker, K., Shakur, H., Roberts, I., Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials. BJOG 123 (2016), 1745–1752.
    • (2016) BJOG , vol.123 , pp. 1745-1752
    • Ker, K.1    Shakur, H.2    Roberts, I.3
  • 82
    • 79953220798 scopus 로고    scopus 로고
    • Efficacy of tranexamic acid in pediatric craniosynostosis surgery: A double-blind, placebo-controlled trial
    • Goobie, S.M., Meier, P.M., Pereira, L.M., et al. Efficacy of tranexamic acid in pediatric craniosynostosis surgery: A double-blind, placebo-controlled trial. Anesthesiology 114 (2011), 862–871.
    • (2011) Anesthesiology , vol.114 , pp. 862-871
    • Goobie, S.M.1    Meier, P.M.2    Pereira, L.M.3
  • 83
    • 0345714943 scopus 로고    scopus 로고
    • Epsilon-aminocaproic acid in coronary artery bypass graft surgery: Preincision or postheparin?
    • Kluger, R., Olive, D.J., Stewart, A.B., et al. Epsilon-aminocaproic acid in coronary artery bypass graft surgery: Preincision or postheparin?. Anesthesiology 99 (2003), 1263–1269.
    • (2003) Anesthesiology , vol.99 , pp. 1263-1269
    • Kluger, R.1    Olive, D.J.2    Stewart, A.B.3
  • 84
    • 84858778521 scopus 로고    scopus 로고
    • Tranexamic acid: A review of its use in the treatment of hyperfibrinolysis
    • McCormack, P.L., Tranexamic acid: A review of its use in the treatment of hyperfibrinolysis. Drugs 72 (2012), 585–617.
    • (2012) Drugs , vol.72 , pp. 585-617
    • McCormack, P.L.1
  • 85
    • 0031030981 scopus 로고    scopus 로고
    • Prevalence of anaphylactic reactions to aprotinin: Analysis of two hundred forty-eight reexposures to aprotinin in heart operations
    • Dietrich, W., Spath, P., Ebell, A., et al. Prevalence of anaphylactic reactions to aprotinin: Analysis of two hundred forty-eight reexposures to aprotinin in heart operations. J Thorac Cardiov Sur 113 (1997), 194–201.
    • (1997) J Thorac Cardiov Sur , vol.113 , pp. 194-201
    • Dietrich, W.1    Spath, P.2    Ebell, A.3
  • 86
    • 84942612381 scopus 로고    scopus 로고
    • Aprotinin: Is it time to reconsider?
    • European Society of Anaesthesiology Task Force Reports on Place of Aprotinin in Clinical Anesthesia. Aprotinin: Is it time to reconsider?. Eur J Anaesthesiol 32 (2015), 591–595.
    • (2015) Eur J Anaesthesiol , vol.32 , pp. 591-595
  • 87
    • 79251598195 scopus 로고    scopus 로고
    • Tranexamic acid is associated with less blood transfusion in off-pump coronary artery bypass graft surgery: A systematic review and meta-analysis
    • Ma, S.C.A., Brindle, W., Burton, G., et al. Tranexamic acid is associated with less blood transfusion in off-pump coronary artery bypass graft surgery: A systematic review and meta-analysis. J Cardiothor Vasc Anesth 25 (2011), 26–35.
    • (2011) J Cardiothor Vasc Anesth , vol.25 , pp. 26-35
    • Ma, S.C.A.1    Brindle, W.2    Burton, G.3
  • 88
    • 78651396685 scopus 로고    scopus 로고
    • Recurrent pulmonary embolism associated with a hemostatic drug: Tranexamic acid
    • Krivokuca, I., Lammers, J.W., Recurrent pulmonary embolism associated with a hemostatic drug: Tranexamic acid. Clin Appl Thromb Hemost 17 (2011), 106–107.
    • (2011) Clin Appl Thromb Hemost , vol.17 , pp. 106-107
    • Krivokuca, I.1    Lammers, J.W.2
  • 89
    • 77953638979 scopus 로고    scopus 로고
    • Risk factors for venous thromboembolism
    • Goldhaber, S.Z., Risk factors for venous thromboembolism. J Am Coll Cardiol 56 (2010), 1–7.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1-7
    • Goldhaber, S.Z.1
  • 90
    • 0019267976 scopus 로고
    • Clinical pharmacology of aminocaproic and tranexamic acids
    • Nilsson, I.M., Clinical pharmacology of aminocaproic and tranexamic acids. J Clin Pathol Suppl 14 (1980), 41–47.
    • (1980) J Clin Pathol Suppl , vol.14 , pp. 41-47
    • Nilsson, I.M.1
  • 91
    • 84874681395 scopus 로고    scopus 로고
    • The great deception: Tranexamic acid and extensive pulmonary emboli
    • Salam, A., King, C., Orhan, O., et al. The great deception: Tranexamic acid and extensive pulmonary emboli. BMJ Case Rep, 2013, 2013.
    • (2013) BMJ Case Rep , vol.2013
    • Salam, A.1    King, C.2    Orhan, O.3
  • 92
    • 84880576447 scopus 로고    scopus 로고
    • Cerebrovascular infarction following bilateral total knee arthroplasty and tranexamic acid administration
    • Bruce-Brand, R., Dragomir, R., Baker, J., et al. Cerebrovascular infarction following bilateral total knee arthroplasty and tranexamic acid administration. Acta Orthop Belg 79 (2013), 351–354.
    • (2013) Acta Orthop Belg , vol.79 , pp. 351-354
    • Bruce-Brand, R.1    Dragomir, R.2    Baker, J.3
  • 94
    • 0023884829 scopus 로고
    • Retinal artery occlusion associated with tranexamic acid therapy
    • Parsons, M.R., Merritt, D.R., Ramsay, R.C., Retinal artery occlusion associated with tranexamic acid therapy. Am J Ophthalmol 105 (1988), 688–689.
    • (1988) Am J Ophthalmol , vol.105 , pp. 688-689
    • Parsons, M.R.1    Merritt, D.R.2    Ramsay, R.C.3
  • 95
    • 84950127227 scopus 로고    scopus 로고
    • Left ventricle thrombus after tranexamic acid for spine surgery in an HIV-positive patient
    • Gerstein, N.S., Brierley, J.K., Culling, M.D., Left ventricle thrombus after tranexamic acid for spine surgery in an HIV-positive patient. Spine J 16 (2016), e77–e82.
    • (2016) Spine J , vol.16 , pp. e77-e82
    • Gerstein, N.S.1    Brierley, J.K.2    Culling, M.D.3
  • 96
    • 0031960064 scopus 로고    scopus 로고
    • Aprotinin versus lysine analogues: The debate continues
    • discussion S27–8
    • Royston, D., Aprotinin versus lysine analogues: The debate continues. Ann Thorac Surg 65 (1998), S9–19 discussion S27–8.
    • (1998) Ann Thorac Surg , vol.65 , pp. S9-19
    • Royston, D.1
  • 97
    • 0032955950 scopus 로고    scopus 로고
    • Acute hyperkalemia associated with intravenous epsilon-aminocaproic acid therapy
    • Perazella, M.A., Biswas, P., Acute hyperkalemia associated with intravenous epsilon-aminocaproic acid therapy. Am J Kidney Dis 33 (1999), 782–785.
    • (1999) Am J Kidney Dis , vol.33 , pp. 782-785
    • Perazella, M.A.1    Biswas, P.2
  • 98
    • 80455174493 scopus 로고    scopus 로고
    • Acute hyperkalemia as a complication of intravenous therapy with epsilon-aminocaproic acid
    • Banerjee, A., Stoica, C., Walia, A., Acute hyperkalemia as a complication of intravenous therapy with epsilon-aminocaproic acid. J Clin Anesth 23 (2011), 565–568.
    • (2011) J Clin Anesth , vol.23 , pp. 565-568
    • Banerjee, A.1    Stoica, C.2    Walia, A.3
  • 99
    • 0031032742 scopus 로고    scopus 로고
    • Rhabdomyolysis induced by epsilon-aminocaproic acid
    • Seymour, B.D., Rubinger, M., Rhabdomyolysis induced by epsilon-aminocaproic acid. Ann Pharmacother 31 (1997), 56–58.
    • (1997) Ann Pharmacother , vol.31 , pp. 56-58
    • Seymour, B.D.1    Rubinger, M.2
  • 100
    • 77951068216 scopus 로고    scopus 로고
    • Incidence and risk factors for deep venous thrombosis after moderate and severe brain injury
    • Ekeh, A.P., Dominguez, K.M., Markert, R.J., et al. Incidence and risk factors for deep venous thrombosis after moderate and severe brain injury. J Trauma 68 (2010), 912–915.
    • (2010) J Trauma , vol.68 , pp. 912-915
    • Ekeh, A.P.1    Dominguez, K.M.2    Markert, R.J.3
  • 101
    • 51449117262 scopus 로고    scopus 로고
    • Antifibrinolytic therapy to prevent early rebleeding after subarachnoid hemorrhage
    • Chwajol, M., Starke, R.M., Kim, G.H., et al. Antifibrinolytic therapy to prevent early rebleeding after subarachnoid hemorrhage. Neurocrit Care 8 (2008), 418–426.
    • (2008) Neurocrit Care , vol.8 , pp. 418-426
    • Chwajol, M.1    Starke, R.M.2    Kim, G.H.3
  • 102
    • 85009274687 scopus 로고    scopus 로고
    • Tranexamic acid in patients undergoing coronary-artery surgery
    • Myles, P.S., Smith, J.A., Forbes, A., et al. Tranexamic acid in patients undergoing coronary-artery surgery. N Engl J Med 376 (2017), 136–148.
    • (2017) N Engl J Med , vol.376 , pp. 136-148
    • Myles, P.S.1    Smith, J.A.2    Forbes, A.3
  • 103
    • 84960171946 scopus 로고    scopus 로고
    • Tranexamic acid-associated seizures: A meta-analysis
    • Lin, Z., Xiaoyi, Z., Tranexamic acid-associated seizures: A meta-analysis. Seizure 36 (2016), 70–73.
    • (2016) Seizure , vol.36 , pp. 70-73
    • Lin, Z.1    Xiaoyi, Z.2
  • 104
    • 12344279132 scopus 로고    scopus 로고
    • Antifibrinolytics in orthotopic liver transplantation: Current status and controversies
    • Xia, V.W., Steadman, R.H., Antifibrinolytics in orthotopic liver transplantation: Current status and controversies. Liver Transpl 11 (2005), 10–18.
    • (2005) Liver Transpl , vol.11 , pp. 10-18
    • Xia, V.W.1    Steadman, R.H.2
  • 105
    • 85036558141 scopus 로고    scopus 로고
    • Drugs.com. Aminocaproic acid pregnancy and breastfeeding warnings. Available at: Accessed Novemeber 5.
    • Drugs.com. Aminocaproic acid pregnancy and breastfeeding warnings. Available at: https://www.drugs.com/pregnancy/aminocaproic-acid.html. Accessed Novemeber 5, 2016.
    • (2016)
  • 106
    • 33751347061 scopus 로고    scopus 로고
    • Antifibrinolytic therapy use to mitigate blood loss during staged complex major spine surgery: Postoperative visual color changes after tranexamic acid administration
    • Cravens, G.T., Brown, M.J., Brown, D.R., et al. Antifibrinolytic therapy use to mitigate blood loss during staged complex major spine surgery: Postoperative visual color changes after tranexamic acid administration. Anesthesiology 105 (2006), 1274–1276.
    • (2006) Anesthesiology , vol.105 , pp. 1274-1276
    • Cravens, G.T.1    Brown, M.J.2    Brown, D.R.3
  • 107
    • 0035208696 scopus 로고    scopus 로고
    • Two cases of fatal thrombosis after aminocaproic acid therapy and deep hypothermic circulatory arrest
    • Fanashawe, M.P., Shore-Lesserson, L., Reich, D.L., Two cases of fatal thrombosis after aminocaproic acid therapy and deep hypothermic circulatory arrest. Anesthesiology 95 (2001), 1525–1527.
    • (2001) Anesthesiology , vol.95 , pp. 1525-1527
    • Fanashawe, M.P.1    Shore-Lesserson, L.2    Reich, D.L.3
  • 108
    • 0029051038 scopus 로고
    • The intraoperative use of Amicar to reduce bleeding associated with open heart surgery
    • Aprile, A.E., Palmer, T.J., The intraoperative use of Amicar to reduce bleeding associated with open heart surgery. AANA J 63 (1995), 325–331.
    • (1995) AANA J , vol.63 , pp. 325-331
    • Aprile, A.E.1    Palmer, T.J.2
  • 109
    • 0025363010 scopus 로고
    • Cerebral sinus thrombosis as a potential hazard of antifibrinolytic treatment in menorrhagia
    • Achiron, A., Gornish, M., Melamed, E., Cerebral sinus thrombosis as a potential hazard of antifibrinolytic treatment in menorrhagia. Stroke 21 (1990), 817–819.
    • (1990) Stroke , vol.21 , pp. 817-819
    • Achiron, A.1    Gornish, M.2    Melamed, E.3
  • 110
    • 85036512199 scopus 로고    scopus 로고
    • Aminocaproic acid is associated with decreased cognition early after cardiac surgery compared to tranexamic acid. Abstract #JS03. Presented at 2016 American Society of Annual Meeting, Chicago, IL.
    • Low YMC, Terrando N, Berger M, et al. Aminocaproic acid is associated with decreased cognition early after cardiac surgery compared to tranexamic acid. Abstract #JS03. Presented at 2016 American Society of Annual Meeting, Chicago, IL.
    • Low, Y.M.C.1    Terrando, N.2    Berger, M.3
  • 111
    • 58249136318 scopus 로고    scopus 로고
    • Thrombotic microangiopathy and renal failure exacerbated by epsilon-aminocaproic acid
    • Mutter, W.P., Stillman, I.E., Dahl, N.K., Thrombotic microangiopathy and renal failure exacerbated by epsilon-aminocaproic acid. Am J Kidney Dis 53 (2009), 346–350.
    • (2009) Am J Kidney Dis , vol.53 , pp. 346-350
    • Mutter, W.P.1    Stillman, I.E.2    Dahl, N.K.3
  • 112
    • 0036019819 scopus 로고    scopus 로고
    • Epsilon-aminocaproic acid and renal complications: Case report and review of the literature
    • Manjunath, G., Fozailoff, A., Mitcheson, D., et al. Epsilon-aminocaproic acid and renal complications: Case report and review of the literature. Clin Nephrol 58 (2002), 63–67.
    • (2002) Clin Nephrol , vol.58 , pp. 63-67
    • Manjunath, G.1    Fozailoff, A.2    Mitcheson, D.3
  • 113
    • 84867281693 scopus 로고    scopus 로고
    • Risks of harms using antifibrinolytics in cardiac surgery: Systematic review and network meta-analysis of randomised and observational studies
    • Hutton, B., Joseph, L., Fergusson, D., et al. Risks of harms using antifibrinolytics in cardiac surgery: Systematic review and network meta-analysis of randomised and observational studies. Brit Med J, 345, 2012, e5798.
    • (2012) Brit Med J , vol.345 , pp. e5798
    • Hutton, B.1    Joseph, L.2    Fergusson, D.3
  • 114
    • 0020567032 scopus 로고
    • Epsilon-aminocaproic acid-induced myopathy. A case report
    • Morris, C.D., Jacobs, P., Berman, P.A., et al. Epsilon-aminocaproic acid-induced myopathy. A case report. S Afr Med J 64 (1983), 363–366.
    • (1983) S Afr Med J , vol.64 , pp. 363-366
    • Morris, C.D.1    Jacobs, P.2    Berman, P.A.3
  • 115
    • 0021012921 scopus 로고
    • Why may epsilon-aminocaproic acid (EACA) induce myopathy in man? Report of a case and literature review
    • Galassi, G., Gibertoni, M., Corradini, L., et al. Why may epsilon-aminocaproic acid (EACA) induce myopathy in man? Report of a case and literature review. Ital J Neurol Sci 4 (1983), 489–492.
    • (1983) Ital J Neurol Sci , vol.4 , pp. 489-492
    • Galassi, G.1    Gibertoni, M.2    Corradini, L.3
  • 116
    • 0019989396 scopus 로고
    • Epsilon-aminocaproic acid myopathy. Report of a case and literature review
    • Vanneste, J.A., van Wijngaarden, G.K., Epsilon-aminocaproic acid myopathy. Report of a case and literature review. Eur Neurol 21 (1982), 242–248.
    • (1982) Eur Neurol , vol.21 , pp. 242-248
    • Vanneste, J.A.1    van Wijngaarden, G.K.2
  • 117
    • 84941911803 scopus 로고    scopus 로고
    • Antifibrinolytic therapy in aneurysmal subarachnoid hemorrhage increases the risk for deep venous thrombosis: A case-control study
    • Foreman, P.M., Chua, M., Harrigan, M.R., et al. Antifibrinolytic therapy in aneurysmal subarachnoid hemorrhage increases the risk for deep venous thrombosis: A case-control study. Clin Neurol Neurosurg 139 (2015), 66–69.
    • (2015) Clin Neurol Neurosurg , vol.139 , pp. 66-69
    • Foreman, P.M.1    Chua, M.2    Harrigan, M.R.3
  • 118
    • 33745380789 scopus 로고    scopus 로고
    • Successful use of recombinant activated FVII and aminocaproic acid in four neonates with life-threatening hemorrhage
    • Grizelj, R., Vukovic, J., Filipovic-Grcic, B., et al. Successful use of recombinant activated FVII and aminocaproic acid in four neonates with life-threatening hemorrhage. Blood Coagul Fibrinolysis 17 (2006), 413–415.
    • (2006) Blood Coagul Fibrinolysis , vol.17 , pp. 413-415
    • Grizelj, R.1    Vukovic, J.2    Filipovic-Grcic, B.3
  • 119
    • 85036514443 scopus 로고    scopus 로고
    • High dose, prolonged epsilon aminocaproic acid infusion, and recombinant factor VII for massive postoperative retroperitoneal hemorrhage following splenectomy. Case Rep Anesthesiol
    • Lee AT, Barnes CR, Jain S, et al. High dose, prolonged epsilon aminocaproic acid infusion, and recombinant factor VII for massive postoperative retroperitoneal hemorrhage following splenectomy. Case Rep Anesthesiol 2016;2016:1630385.
    • (2016) , vol.2016 , pp. 1630385
    • Lee, A.T.1    Barnes, C.R.2    Jain, S.3
  • 120
    • 85036559478 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. Neonatals death associated with use of benzyl alcohol—United States. Available at: Accessed January 5.
    • Centers for Disease Control and Prevention. Neonatals death associated with use of benzyl alcohol—United States. Available at: https://www.cdc.gov/mmwr/preview/mmwrhtml/00001109.htm. Accessed January 5, 2017.
    • (2017)
  • 121
    • 0000518408 scopus 로고
    • An active stereo-isomer (trans-form) of Amcha and its antifibrinolytic (antiplasminic) action in vitro and in vivo
    • Okamoto, S., Sato, S., Takada, Y., et al. An active stereo-isomer (trans-form) of Amcha and its antifibrinolytic (antiplasminic) action in vitro and in vivo. Keio J Med 13 (1964), 177–185.
    • (1964) Keio J Med , vol.13 , pp. 177-185
    • Okamoto, S.1    Sato, S.2    Takada, Y.3
  • 122
    • 84964378160 scopus 로고    scopus 로고
    • CRASH-2 study of tranexamic acid to treat bleeding in trauma patients: A controversy fueled by science and social media
    • Binz, S., McCollester, J., Thomas, S., et al. CRASH-2 study of tranexamic acid to treat bleeding in trauma patients: A controversy fueled by science and social media. J Blood Transfus, 2015, 2015, 874920.
    • (2015) J Blood Transfus , vol.2015 , pp. 874920
    • Binz, S.1    McCollester, J.2    Thomas, S.3
  • 123
    • 0030867076 scopus 로고    scopus 로고
    • Tranexamic acid is effective in decreasing postoperative bleeding and transfusions in primary coronary artery bypass operations: A double-blind, randomized, placebo-controlled trial
    • Brown, R.S., Thwaites, B.K., Mongan, P.D., Tranexamic acid is effective in decreasing postoperative bleeding and transfusions in primary coronary artery bypass operations: A double-blind, randomized, placebo-controlled trial. Anesth Analg 85 (1997), 963–970.
    • (1997) Anesth Analg , vol.85 , pp. 963-970
    • Brown, R.S.1    Thwaites, B.K.2    Mongan, P.D.3
  • 124
    • 0025141363 scopus 로고
    • Prophylactic tranexamic acid decreases bleeding after cardiac operations
    • Horrow, J.C., Hlavacek, J., Strong, M.D., et al. Prophylactic tranexamic acid decreases bleeding after cardiac operations. J Thorac Cardiovasc Surg 99 (1990), 70–74.
    • (1990) J Thorac Cardiovasc Surg , vol.99 , pp. 70-74
    • Horrow, J.C.1    Hlavacek, J.2    Strong, M.D.3
  • 125
    • 18444386848 scopus 로고    scopus 로고
    • Molecular mechanisms of fibrinolysis
    • Cesarman-Maus, G., Hajjar, K.A., Molecular mechanisms of fibrinolysis. Br J Haematol 129 (2005), 307–321.
    • (2005) Br J Haematol , vol.129 , pp. 307-321
    • Cesarman-Maus, G.1    Hajjar, K.A.2
  • 126
    • 0019456044 scopus 로고
    • Studies on the mechanism of the antifibrinolytic action of tranexamic acid
    • Hoylaerts, M., Lijnen, H.R., Collen, D., Studies on the mechanism of the antifibrinolytic action of tranexamic acid. Biochim Biophys Acta 673 (1981), 75–85.
    • (1981) Biochim Biophys Acta , vol.673 , pp. 75-85
    • Hoylaerts, M.1    Lijnen, H.R.2    Collen, D.3
  • 127
    • 84988733918 scopus 로고    scopus 로고
    • Antifibrinolytic therapy for perioperative blood conservation in lower-extremity primary total joint arthroplasty
    • Nadeau, R.P., Howard, J.L., Naudie, D.D., Antifibrinolytic therapy for perioperative blood conservation in lower-extremity primary total joint arthroplasty. JBJS Rev, 2015, 3.
    • (2015) JBJS Rev , pp. 3
    • Nadeau, R.P.1    Howard, J.L.2    Naudie, D.D.3
  • 128
    • 0018100115 scopus 로고
    • Special considerations with regard to the dosage of tranexamic acid in patients with chronic renal diseases
    • Andersson, L., Eriksson, O., Hedlund, P.O., et al. Special considerations with regard to the dosage of tranexamic acid in patients with chronic renal diseases. Urol Res 6 (1978), 83–88.
    • (1978) Urol Res , vol.6 , pp. 83-88
    • Andersson, L.1    Eriksson, O.2    Hedlund, P.O.3
  • 129
    • 0028797713 scopus 로고
    • The dose-response relationship of tranexamic acid
    • Horrow, J.C., Van Riper, D.F., Strong, M.D., et al. The dose-response relationship of tranexamic acid. Anesthesiology 82 (1995), 383–392.
    • (1995) Anesthesiology , vol.82 , pp. 383-392
    • Horrow, J.C.1    Van Riper, D.F.2    Strong, M.D.3
  • 130
    • 0035033333 scopus 로고    scopus 로고
    • Plasma tranexamic acid concentrations during cardiopulmonary bypass
    • Fiechtner, B.K., Nuttall, G.A., Johnson, M.E., et al. Plasma tranexamic acid concentrations during cardiopulmonary bypass. Anesth Analg 92 (2001), 1131–1136.
    • (2001) Anesth Analg , vol.92 , pp. 1131-1136
    • Fiechtner, B.K.1    Nuttall, G.A.2    Johnson, M.E.3
  • 131
    • 41049108279 scopus 로고    scopus 로고
    • A preliminary study of a new tranexamic acid dosing schedule for cardiac surgery
    • Nuttall, G.A., Gutierrez, M.C., Dewey, J.D., et al. A preliminary study of a new tranexamic acid dosing schedule for cardiac surgery. J Cardiothorac Vasc Anesth 22 (2008), 230–235.
    • (2008) J Cardiothorac Vasc Anesth , vol.22 , pp. 230-235
    • Nuttall, G.A.1    Gutierrez, M.C.2    Dewey, J.D.3
  • 132
    • 84912130276 scopus 로고    scopus 로고
    • Outcome following tranexamic acid exposure during breastfeeding
    • Gilad, O., Merlob, P., Stahl, B., et al. Outcome following tranexamic acid exposure during breastfeeding. Breastfeed Med 9 (2014), 407–410.
    • (2014) Breastfeed Med , vol.9 , pp. 407-410
    • Gilad, O.1    Merlob, P.2    Stahl, B.3
  • 133
    • 0036321694 scopus 로고    scopus 로고
    • Pharmacokinetics of tranexamic acid during cardiopulmonary bypass
    • Dowd, N.P., Karski, J.M., Cheng, D.C., et al. Pharmacokinetics of tranexamic acid during cardiopulmonary bypass. Anesthesiology 97 (2002), 390–399.
    • (2002) Anesthesiology , vol.97 , pp. 390-399
    • Dowd, N.P.1    Karski, J.M.2    Cheng, D.C.3
  • 134
    • 84861503406 scopus 로고    scopus 로고
    • Effect of tranexamic acid on surgical bleeding: Systematic review and cumulative meta-analysis
    • Ker, K., Edwards, P., Perel, P., et al. Effect of tranexamic acid on surgical bleeding: Systematic review and cumulative meta-analysis. Brit Med J, 344, 2012, e3054.
    • (2012) Brit Med J , vol.344 , pp. e3054
    • Ker, K.1    Edwards, P.2    Perel, P.3
  • 135
    • 0034908049 scopus 로고    scopus 로고
    • Tranexamic acid in off-pump coronary surgery: A preliminary, randomized, double-blind, placebo-controlled study
    • Casati, V., Gerli, C., Franco, A., et al. Tranexamic acid in off-pump coronary surgery: A preliminary, randomized, double-blind, placebo-controlled study. Ann Thorac Surg 72 (2001), 470–475.
    • (2001) Ann Thorac Surg , vol.72 , pp. 470-475
    • Casati, V.1    Gerli, C.2    Franco, A.3
  • 136
    • 0038264388 scopus 로고    scopus 로고
    • Tranexamic acid reduces bleeding after off-pump coronary artery bypass grafting
    • Jares, M., Vanek, T., Straka, Z., et al. Tranexamic acid reduces bleeding after off-pump coronary artery bypass grafting. J Cardiovasc Surg 44 (2003), 205–208.
    • (2003) J Cardiovasc Surg , vol.44 , pp. 205-208
    • Jares, M.1    Vanek, T.2    Straka, Z.3
  • 137
    • 33645869564 scopus 로고    scopus 로고
    • Tranexamic acid reduces postoperative bleeding in off-pump coronary artery bypass grafting
    • Wei, M., Jian, K., Guo, Z., et al. Tranexamic acid reduces postoperative bleeding in off-pump coronary artery bypass grafting. Scand Cardiovasc J 40 (2006), 105–109.
    • (2006) Scand Cardiovasc J , vol.40 , pp. 105-109
    • Wei, M.1    Jian, K.2    Guo, Z.3
  • 138
    • 3042811398 scopus 로고    scopus 로고
    • Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: Comparison between on-pump and off-pump techniques
    • Casati, V., Della Valle, P., Benussi, S., et al. Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: Comparison between on-pump and off-pump techniques. J Thorac Cardiovasc Surg 128 (2004), 83–91.
    • (2004) J Thorac Cardiovasc Surg , vol.128 , pp. 83-91
    • Casati, V.1    Della Valle, P.2    Benussi, S.3
  • 139
    • 25144525008 scopus 로고    scopus 로고
    • Fibrinolytic inhibitors in off-pump coronary surgery: A prospective, randomized, double-blind TAP study (tranexamic acid, aprotinin, placebo)
    • Vanek, T., Jares, M., Fajt, R., et al. Fibrinolytic inhibitors in off-pump coronary surgery: A prospective, randomized, double-blind TAP study (tranexamic acid, aprotinin, placebo). Eur J Cardiothorac Surg 28 (2005), 563–568.
    • (2005) Eur J Cardiothorac Surg , vol.28 , pp. 563-568
    • Vanek, T.1    Jares, M.2    Fajt, R.3
  • 140
    • 67349151288 scopus 로고    scopus 로고
    • Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery
    • Taghaddomi, R.J., Mirzaee, A., Attar, A.S., et al. Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery. J Cardiothorac Vasc Anesth 23 (2009), 312–315.
    • (2009) J Cardiothorac Vasc Anesth , vol.23 , pp. 312-315
    • Taghaddomi, R.J.1    Mirzaee, A.2    Attar, A.S.3
  • 141
    • 84864414281 scopus 로고    scopus 로고
    • Tranexamic acid reduces blood loss after off-pump coronary surgery: A prospective, randomized, double-blind, placebo-controlled study
    • Wang, G., Xie, G., Jiang, T., et al. Tranexamic acid reduces blood loss after off-pump coronary surgery: A prospective, randomized, double-blind, placebo-controlled study. Anesth Analg 115 (2012), 239–243.
    • (2012) Anesth Analg , vol.115 , pp. 239-243
    • Wang, G.1    Xie, G.2    Jiang, T.3
  • 142
    • 84869776367 scopus 로고    scopus 로고
    • Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: A consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011
    • Menkis, A.H., Martin, J., Cheng, D.C., et al. Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: A consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011. Innovations 7 (2012), 229–241.
    • (2012) Innovations , vol.7 , pp. 229-241
    • Menkis, A.H.1    Martin, J.2    Cheng, D.C.3
  • 143
    • 84857508828 scopus 로고    scopus 로고
    • Avoidable mortality from giving tranexamic acid to bleeding trauma patients: An estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial
    • Ker, K., Kiriya, J., Perel, P., et al. Avoidable mortality from giving tranexamic acid to bleeding trauma patients: An estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial. BMC Emerg Med, 12, 2012, 3.
    • (2012) BMC Emerg Med , vol.12 , pp. 3
    • Ker, K.1    Kiriya, J.2    Perel, P.3
  • 144
    • 84944454706 scopus 로고    scopus 로고
    • Safety and efficacy of tranexamic acid in total knee arthroplasty
    • Yu, X., Li, W., Xu, P., et al. Safety and efficacy of tranexamic acid in total knee arthroplasty. Med Sci Monit 21 (2015), 3095–3103.
    • (2015) Med Sci Monit , vol.21 , pp. 3095-3103
    • Yu, X.1    Li, W.2    Xu, P.3
  • 145
    • 84988311543 scopus 로고    scopus 로고
    • A systematic review of tranexamic acid in hip fracture surgery
    • Farrow, L.S., Smith, T.O., Ashcroft, G.P., et al. A systematic review of tranexamic acid in hip fracture surgery. Br J Clin Pharmacol 82 (2016), 1548–1570.
    • (2016) Br J Clin Pharmacol , vol.82 , pp. 1548-1570
    • Farrow, L.S.1    Smith, T.O.2    Ashcroft, G.P.3
  • 146
    • 84885326541 scopus 로고    scopus 로고
    • Is tranexamic acid effective and safe in spinal surgery? A meta-analysis of randomized controlled trials
    • Li, Z.J., Fu, X., Xing, D., et al. Is tranexamic acid effective and safe in spinal surgery? A meta-analysis of randomized controlled trials. Eur Spine J 22 (2013), 1950–1957.
    • (2013) Eur Spine J , vol.22 , pp. 1950-1957
    • Li, Z.J.1    Fu, X.2    Xing, D.3
  • 147
    • 84925381279 scopus 로고    scopus 로고
    • Efficacy of tranexamic acid on surgical bleeding in spine surgery: A meta-analysis
    • Cheriyan, T., Maier, S.P., Bianco, K., et al. Efficacy of tranexamic acid on surgical bleeding in spine surgery: A meta-analysis. Spine J 15 (2015), 752–761.
    • (2015) Spine J , vol.15 , pp. 752-761
    • Cheriyan, T.1    Maier, S.P.2    Bianco, K.3
  • 148
    • 77952605810 scopus 로고    scopus 로고
    • The WOMAN Trial (World Maternal Antifibrinolytic Trial): Tranexamic acid for the treatment of postpartum haemorrhage: An international randomised, double blind placebo controlled trial
    • Shakur, H., Elbourne, D., Gulmezoglu, M., et al. The WOMAN Trial (World Maternal Antifibrinolytic Trial): Tranexamic acid for the treatment of postpartum haemorrhage: An international randomised, double blind placebo controlled trial. Trials, 11, 2010, 40.
    • (2010) Trials , vol.11 , pp. 40
    • Shakur, H.1    Elbourne, D.2    Gulmezoglu, M.3
  • 149
    • 85036574869 scopus 로고    scopus 로고
    • London School of Hygiene and Tropical Medicine. Woman World Maternal Antifibrinolytic Trial. Available at: Accessed January 8.
    • London School of Hygiene and Tropical Medicine. Woman World Maternal Antifibrinolytic Trial. Available at: http://womantrial.lshtm.ac.uk/. Accessed January 8, 2017.
    • (2017)
  • 150
    • 84931010660 scopus 로고    scopus 로고
    • Topical and intravenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty: A multicenter, randomized, controlled trial
    • Aguilera, X., Martinez-Zapata, M., Hinarejos, P., et al. Topical and intravenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty: A multicenter, randomized, controlled trial. Arch Orthop Traum Surg 135 (2015), 1017–1025.
    • (2015) Arch Orthop Traum Surg , vol.135 , pp. 1017-1025
    • Aguilera, X.1    Martinez-Zapata, M.2    Hinarejos, P.3
  • 151
    • 84988441754 scopus 로고    scopus 로고
    • Comparison of efficacy and safety of topical versus intravenous tranexamic acid in total hip arthroplasty: A meta-analysis
    • Li, J., Zhang, Z.J., Chen, J., Comparison of efficacy and safety of topical versus intravenous tranexamic acid in total hip arthroplasty: A meta-analysis. Medicine (Baltimore), 95, 2016, e4689.
    • (2016) Medicine (Baltimore) , vol.95 , pp. e4689
    • Li, J.1    Zhang, Z.J.2    Chen, J.3
  • 152
    • 84950156045 scopus 로고    scopus 로고
    • Topical vs intravenous tranexamic acid in primary total hip arthroplasty: A double-blind, randomized controlled trial
    • North, W.T., Mehran, N., Davis, J.J., et al. Topical vs intravenous tranexamic acid in primary total hip arthroplasty: A double-blind, randomized controlled trial. J Arthroplasty 31 (2016), 1022–1026.
    • (2016) J Arthroplasty , vol.31 , pp. 1022-1026
    • North, W.T.1    Mehran, N.2    Davis, J.J.3
  • 153
    • 85010028277 scopus 로고    scopus 로고
    • The Michigan experience with safety and effectiveness of tranexamic acid use in hip and knee arthroplasty
    • Hallstrom, B., Singal, B., Cowen, M.E., et al. The Michigan experience with safety and effectiveness of tranexamic acid use in hip and knee arthroplasty. J Bone Joint Surg Am 98 (2016), 1646–1655.
    • (2016) J Bone Joint Surg Am , vol.98 , pp. 1646-1655
    • Hallstrom, B.1    Singal, B.2    Cowen, M.E.3
  • 154
    • 84862241763 scopus 로고    scopus 로고
    • High mortality associated with intracardiac and intrapulmonary thromboses after cardiopulmonary bypass
    • Ogawa, S., Richardson, J.E., Sakai, T., et al. High mortality associated with intracardiac and intrapulmonary thromboses after cardiopulmonary bypass. J Anesth 26 (2012), 9–19.
    • (2012) J Anesth , vol.26 , pp. 9-19
    • Ogawa, S.1    Richardson, J.E.2    Sakai, T.3
  • 155
    • 85021288497 scopus 로고    scopus 로고
    • Topical tranexamic acid in total knee arthroplasty patients with increased thromboembolic risk
    • [Epub ahead of print]
    • Spanyer, J., Patel, J., Emberton, E., et al. Topical tranexamic acid in total knee arthroplasty patients with increased thromboembolic risk. J Knee Surg, 2016 Oct 5 [Epub ahead of print].
    • (2016) J Knee Surg
    • Spanyer, J.1    Patel, J.2    Emberton, E.3
  • 156
    • 84856953707 scopus 로고    scopus 로고
    • Seizures following cardiac surgery: The impact of tranexamic acid and other risk factors
    • Manji, R.A., Grocott, H.P., Leake, J., et al. Seizures following cardiac surgery: The impact of tranexamic acid and other risk factors. Can J Anaesth 59 (2012), 6–13.
    • (2012) Can J Anaesth , vol.59 , pp. 6-13
    • Manji, R.A.1    Grocott, H.P.2    Leake, J.3
  • 157
    • 84956574965 scopus 로고    scopus 로고
    • Tranexamic acid-associated seizures: Causes and treatment
    • Lecker, I., Wang, D.S., Whissell, P.D., et al. Tranexamic acid-associated seizures: Causes and treatment. Ann Neurol 79 (2016), 18–26.
    • (2016) Ann Neurol , vol.79 , pp. 18-26
    • Lecker, I.1    Wang, D.S.2    Whissell, P.D.3
  • 158
    • 58149293358 scopus 로고    scopus 로고
    • The risks of aprotinin and tranexamic acid in cardiac surgery: A one-year follow-up of 1188 consecutive patients
    • Martin, K., Wiesner, G., Breuer, T., et al. The risks of aprotinin and tranexamic acid in cardiac surgery: A one-year follow-up of 1188 consecutive patients. Anesth Analg 107 (2008), 1783–1790.
    • (2008) Anesth Analg , vol.107 , pp. 1783-1790
    • Martin, K.1    Wiesner, G.2    Breuer, T.3
  • 159
    • 84925224772 scopus 로고    scopus 로고
    • The current place of tranexamic acid in the management of bleeding
    • e18
    • Hunt, B.J., The current place of tranexamic acid in the management of bleeding. Anaesthesia 70:Suppl 1 (2015), 50–53 e18.
    • (2015) Anaesthesia , vol.70 , pp. 50-53
    • Hunt, B.J.1
  • 160
    • 85006967973 scopus 로고    scopus 로고
    • Seizures following cardiopulmonary bypass
    • Brouwer, M.E., McMeniman, W.J., Seizures following cardiopulmonary bypass. J Extra Corpor Technol 48 (2016), 137–140.
    • (2016) J Extra Corpor Technol , vol.48 , pp. 137-140
    • Brouwer, M.E.1    McMeniman, W.J.2
  • 161
    • 84055192250 scopus 로고    scopus 로고
    • High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass
    • Kalavrouziotis, D., Voisine, P., Mohammadi, S., et al. High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass. Ann Thorac Surg 93 (2013), 148–155.
    • (2013) Ann Thorac Surg , vol.93 , pp. 148-155
    • Kalavrouziotis, D.1    Voisine, P.2    Mohammadi, S.3
  • 162
    • 84895441383 scopus 로고    scopus 로고
    • Comparison of two doses of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass
    • Sigaut, S., Tremey, B., Ouattara, A., et al. Comparison of two doses of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass. Anesthesiology 120 (2014), 590–600.
    • (2014) Anesthesiology , vol.120 , pp. 590-600
    • Sigaut, S.1    Tremey, B.2    Ouattara, A.3
  • 163
    • 4444322589 scopus 로고
    • Studies of trasylol. Evaluation of trasylol against the hypotensive effects of trypsin and kallikrein
    • Singh, L.M., Howard, J.M., Studies of trasylol. Evaluation of trasylol against the hypotensive effects of trypsin and kallikrein. Arch Surg 91 (1965), 635–639.
    • (1965) Arch Surg , vol.91 , pp. 635-639
    • Singh, L.M.1    Howard, J.M.2
  • 164
    • 85047677651 scopus 로고
    • Basis of antifibrinolytic therapy
    • Prentice, C.R., Basis of antifibrinolytic therapy. J Clin Pathol Suppl 14 (1980), 35–40.
    • (1980) J Clin Pathol Suppl , vol.14 , pp. 35-40
    • Prentice, C.R.1
  • 165
    • 0020678186 scopus 로고
    • Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs
    • Fritz, H., Wunderer, G., Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs. Arzneimittelforschung 33 (1983), 479–494.
    • (1983) Arzneimittelforschung , vol.33 , pp. 479-494
    • Fritz, H.1    Wunderer, G.2
  • 166
    • 0034655925 scopus 로고    scopus 로고
    • Aprotinin: Pharmacological reduction of perioperative bleeding
    • Segal, H., Hunt, B.J., Aprotinin: Pharmacological reduction of perioperative bleeding. Lancet 355 (2000), 1289–1290.
    • (2000) Lancet , vol.355 , pp. 1289-1290
    • Segal, H.1    Hunt, B.J.2
  • 167
    • 33645030859 scopus 로고    scopus 로고
    • Engineered protein inhibitors of proteases
    • Nixon, A.E., Wood, C.R., Engineered protein inhibitors of proteases. Curr Opin Drug Discov Devel 9 (2006), 261–268.
    • (2006) Curr Opin Drug Discov Devel , vol.9 , pp. 261-268
    • Nixon, A.E.1    Wood, C.R.2
  • 168
    • 40149098691 scopus 로고    scopus 로고
    • Aprotinin: Twenty-five years of claim and counterclaim
    • Westaby, S., Aprotinin: Twenty-five years of claim and counterclaim. J Thorac Cardiovasc Surg 135 (2008), 487–491.
    • (2008) J Thorac Cardiovasc Surg , vol.135 , pp. 487-491
    • Westaby, S.1
  • 169
    • 0023204701 scopus 로고
    • Effect of aprotinin on need for blood transfusion after repeat open-heart surgery
    • Royston, D., Bidstrup, B.P., Taylor, K.M., et al. Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet 2 (1987), 1289–1291.
    • (1987) Lancet , vol.2 , pp. 1289-1291
    • Royston, D.1    Bidstrup, B.P.2    Taylor, K.M.3
  • 170
    • 0031960143 scopus 로고    scopus 로고
    • Management of bleeding complications in redo cardiac operations
    • discussion S27–8
    • Smith, C.R., Management of bleeding complications in redo cardiac operations. Ann Thorac Surg 65 (1998), S2–S8 discussion S27–8.
    • (1998) Ann Thorac Surg , vol.65 , pp. S2-S8
    • Smith, C.R.1
  • 171
    • 0036072048 scopus 로고    scopus 로고
    • Aprotinin versus placebo in major orthopedic surgery: A randomized, double-blinded, dose-ranging study
    • Samama, C.M., Langeron, O., Rosencher, N., et al. Aprotinin versus placebo in major orthopedic surgery: A randomized, double-blinded, dose-ranging study. Anesth Analg 95 (2002), 287–293.
    • (2002) Anesth Analg , vol.95 , pp. 287-293
    • Samama, C.M.1    Langeron, O.2    Rosencher, N.3
  • 172
    • 21344435080 scopus 로고    scopus 로고
    • Randomized controlled trials of aprotinin in cardiac surgery: Could clinical equipoise have stopped the bleeding?
    • Fergusson, D., Glass, K.C., Hutton, B., et al. Randomized controlled trials of aprotinin in cardiac surgery: Could clinical equipoise have stopped the bleeding?. Clin Trials 2 (2005), 218–232.
    • (2005) Clin Trials , vol.2 , pp. 218-232
    • Fergusson, D.1    Glass, K.C.2    Hutton, B.3
  • 173
    • 33644680067 scopus 로고    scopus 로고
    • A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery
    • Karkouti, K., Beattie, W.S., Dattilo, K.M., et al. A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery. Transfusion 46 (2006), 327–338.
    • (2006) Transfusion , vol.46 , pp. 327-338
    • Karkouti, K.1    Beattie, W.S.2    Dattilo, K.M.3
  • 174
    • 34748882511 scopus 로고    scopus 로고
    • Aprotinin does not increase the risk of renal failure in cardiac surgery patients
    • Furnary, A.P., Wu, Y., Hiratzka, L.F., et al. Aprotinin does not increase the risk of renal failure in cardiac surgery patients. Circulation 116 (2007), I127–I133.
    • (2007) Circulation , vol.116 , pp. I127-I133
    • Furnary, A.P.1    Wu, Y.2    Hiratzka, L.F.3
  • 175
    • 33846885901 scopus 로고    scopus 로고
    • Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery
    • Mangano, D.T., Miao, Y., Vuylsteke, A., et al. Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA 297 (2007), 471–479.
    • (2007) JAMA , vol.297 , pp. 471-479
    • Mangano, D.T.1    Miao, Y.2    Vuylsteke, A.3
  • 176
    • 80052713194 scopus 로고    scopus 로고
    • Early postoperative outcomes and blood product utilization in adult cardiac surgery: The post-aprotinin era
    • DeSantis, S.M., Toole, J.M., Kratz, J.M., et al. Early postoperative outcomes and blood product utilization in adult cardiac surgery: The post-aprotinin era. Circulation 124 (2011), S62–S69.
    • (2011) Circulation , vol.124 , pp. S62-S69
    • DeSantis, S.M.1    Toole, J.M.2    Kratz, J.M.3
  • 178
    • 77951064217 scopus 로고    scopus 로고
    • Prohemostatic therapy: The rise and fall of aprotinin
    • Vande Vusse, L.K., Zacharski, L.R., Dumas, M.G., et al. Prohemostatic therapy: The rise and fall of aprotinin. Semin Thromb Hemost 36 (2010), 103–112.
    • (2010) Semin Thromb Hemost , vol.36 , pp. 103-112
    • Vande Vusse, L.K.1    Zacharski, L.R.2    Dumas, M.G.3
  • 179
    • 84876546995 scopus 로고    scopus 로고
    • III. Aprotinin and cardiac surgery: A sorry tale of evidence misused
    • McMullan, V., Alston, R.P., III. Aprotinin and cardiac surgery: A sorry tale of evidence misused. Br J Anaesth 110 (2013), 675–678.
    • (2013) Br J Anaesth , vol.110 , pp. 675-678
    • McMullan, V.1    Alston, R.P.2
  • 180
    • 85036541857 scopus 로고    scopus 로고
    • Health Canada. Final report-expert panel advisory on Trasylol (aprotinin). Available at: Accessed September 20.
    • Health Canada. Final report-expert panel advisory on Trasylol (aprotinin). Available at: http://hc-sc.gc.ca/dhp-mps/medeff/advise-consult/eap-gce_trasylol/final_rep-rap-eng.php. Accessed September 20, 2016.
    • (2016)
  • 181
    • 85036535918 scopus 로고    scopus 로고
    • Science Medicines Health. European Medicines Agency recommends lifting suspension on aprotinin. Available at: Accessed September 17.
    • European Medicines Agency, Science Medicines Health. European Medicines Agency recommends lifting suspension on aprotinin. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2012/02/WC500122914.pdf. Accessed September 17, 2016.
    • (2016)
    • Agency, E.M.1
  • 182
    • 85036547673 scopus 로고    scopus 로고
    • Government of Canada. Recalls and safety alerts: Trasylol (aprotinin) – important safety information – for the public. Available at: Accessed November 5.
    • Government of Canada. Recalls and safety alerts: Trasylol (aprotinin) – important safety information – for the public. Available at: http://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2011/14107a-eng.php. Accessed November 5, 2016.
    • (2016)
  • 183
    • 85036579147 scopus 로고    scopus 로고
    • Nordic Group. European Commission approved reinstatement of aprotinin/Trasylol marketing authorisations in European Union. Available at: Accessed November 5.
    • Nordic Group. European Commission approved reinstatement of aprotinin/Trasylol marketing authorisations in European Union. Available at: http://www.prnewswire.co.uk/news-releases/european-commission-approved-reinstatement-of-aprotinintrasylol-marketing-authorisations-in-european-union-227205591.html. Accessed November 5, 2016.
    • (2016)
  • 184
    • 84918815142 scopus 로고    scopus 로고
    • Regulatory decisions pertaining to aprotinin may be putting patients at risk
    • Hebert, P.C., Fergusson, D.A., Hutton, B., et al. Regulatory decisions pertaining to aprotinin may be putting patients at risk. CMAJ 186 (2014), 1379–1386.
    • (2014) CMAJ , vol.186 , pp. 1379-1386
    • Hebert, P.C.1    Fergusson, D.A.2    Hutton, B.3
  • 185
    • 74049141396 scopus 로고    scopus 로고
    • The risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery
    • Karkouti, K., Wijeysundera, D.N., Yau, T.M., et al. The risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery. Anesth Analg 110 (2010), 21–29.
    • (2010) Anesth Analg , vol.110 , pp. 21-29
    • Karkouti, K.1    Wijeysundera, D.N.2    Yau, T.M.3
  • 186
    • 77955117750 scopus 로고    scopus 로고
    • Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: A retrospective analysis
    • Sander, M., Spies, C.D., Martiny, V., et al. Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: A retrospective analysis. Crit Care, 14, 2010, R148.
    • (2010) Crit Care , vol.14 , pp. R148
    • Sander, M.1    Spies, C.D.2    Martiny, V.3
  • 187
    • 84962556318 scopus 로고    scopus 로고
    • Tranexamic acid use in United States children's hospitals
    • Nishijima, D.K., Monuteaux, M.C., Faraoni, D., et al. Tranexamic acid use in United States children's hospitals. J Emerg Med, 50(868–74), 2016, e1.
    • (2016) J Emerg Med , vol.50 , Issue.868-74 , pp. e1
    • Nishijima, D.K.1    Monuteaux, M.C.2    Faraoni, D.3
  • 188
    • 77953709413 scopus 로고    scopus 로고
    • Safety of aprotinin in congenital heart operations: Results from a large multicenter database
    • Pasquali, S.K., Hall, M., Li, J.S., et al. Safety of aprotinin in congenital heart operations: Results from a large multicenter database. Ann Thorac Surg 90 (2010), 14–21.
    • (2010) Ann Thorac Surg , vol.90 , pp. 14-21
    • Pasquali, S.K.1    Hall, M.2    Li, J.S.3
  • 189
    • 84862784609 scopus 로고    scopus 로고
    • Comparative analysis of antifibrinolytic medications in pediatric heart surgery
    • Pasquali, S.K., Li, J.S., He, X., et al. Comparative analysis of antifibrinolytic medications in pediatric heart surgery. J Thorac Cardiov Sur 143 (2012), 550–557.
    • (2012) J Thorac Cardiov Sur , vol.143 , pp. 550-557
    • Pasquali, S.K.1    Li, J.S.2    He, X.3
  • 190
    • 84859751812 scopus 로고    scopus 로고
    • Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery
    • Graham, E.M., Atz, A.M., Gillis, J., et al. Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery. J Thorac Cardiovasc Surg 143 (2012), 1069–1076.
    • (2012) J Thorac Cardiovasc Surg , vol.143 , pp. 1069-1076
    • Graham, E.M.1    Atz, A.M.2    Gillis, J.3
  • 191
    • 68649128707 scopus 로고    scopus 로고
    • The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: A meta-analysis
    • Schouten, E.S., van de Pol, A.C., Schouten, A.N., et al. The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: A meta-analysis. Pediatr Crit Care Med 10 (2009), 182–190.
    • (2009) Pediatr Crit Care Med , vol.10 , pp. 182-190
    • Schouten, E.S.1    van de Pol, A.C.2    Schouten, A.N.3
  • 192
    • 84901652434 scopus 로고    scopus 로고
    • Increased recombinant activated factor VII use and need for surgical reexploration following a switch from aprotinin to epsilon-aminocaproic acid in infant cardiac surgery
    • Scott, J.P., Costigan, D.J., Hoffman, G.M., et al. Increased recombinant activated factor VII use and need for surgical reexploration following a switch from aprotinin to epsilon-aminocaproic acid in infant cardiac surgery. J Clin Anesth 26 (2014), 204–211.
    • (2014) J Clin Anesth , vol.26 , pp. 204-211
    • Scott, J.P.1    Costigan, D.J.2    Hoffman, G.M.3
  • 193
    • 84255205031 scopus 로고    scopus 로고
    • Effect of tranexamic acid on blood loss in pediatric cardiac surgery: A randomized trial
    • Shimizu, K., Toda, Y., Iwasaki, T., et al. Effect of tranexamic acid on blood loss in pediatric cardiac surgery: A randomized trial. J Anesth 25 (2011), 823–830.
    • (2011) J Anesth , vol.25 , pp. 823-830
    • Shimizu, K.1    Toda, Y.2    Iwasaki, T.3
  • 194
    • 84866644223 scopus 로고    scopus 로고
    • Tranexamic acid therapy in pediatric cardiac surgery: A single-center study
    • Giordano, R., Palma, G., Poli, V., et al. Tranexamic acid therapy in pediatric cardiac surgery: A single-center study. Ann Thorac Surg 94 (2012), 1302–1306.
    • (2012) Ann Thorac Surg , vol.94 , pp. 1302-1306
    • Giordano, R.1    Palma, G.2    Poli, V.3
  • 195
    • 85012982875 scopus 로고    scopus 로고
    • Epsilon aminocaproic acid reduces blood transfusion and improves the coagulation test after pediatric open-heart surgery: A meta-analysis of 5 clinical trials
    • Lu, J., Meng, H., Meng, Z., et al. Epsilon aminocaproic acid reduces blood transfusion and improves the coagulation test after pediatric open-heart surgery: A meta-analysis of 5 clinical trials. Int J Clin Exp Pathol 8 (2015), 7978–7987.
    • (2015) Int J Clin Exp Pathol , vol.8 , pp. 7978-7987
    • Lu, J.1    Meng, H.2    Meng, Z.3
  • 196
    • 79955619126 scopus 로고    scopus 로고
    • Tranexamic acid versus varepsilon-aminocaproic acid: Efficacy and safety in paediatric cardiac surgery
    • Martin, K., Breuer, T., Gertler, R., et al. Tranexamic acid versus varepsilon-aminocaproic acid: Efficacy and safety in paediatric cardiac surgery. Eur J Cardiothorac Surg 39 (2011), 892–897.
    • (2011) Eur J Cardiothorac Surg , vol.39 , pp. 892-897
    • Martin, K.1    Breuer, T.2    Gertler, R.3
  • 197
    • 57549085150 scopus 로고    scopus 로고
    • The blood sparing effect and the safety of aprotinin compared to tranexamic acid in paediatric cardiac surgery
    • author reply 171
    • Breuer, T., Martin, K., Wilhelm, M., et al. The blood sparing effect and the safety of aprotinin compared to tranexamic acid in paediatric cardiac surgery. Eur J Cardiothorac Surg 35 (2009), 167–171 author reply 171.
    • (2009) Eur J Cardiothorac Surg , vol.35 , pp. 167-171
    • Breuer, T.1    Martin, K.2    Wilhelm, M.3
  • 198
    • 84941125370 scopus 로고    scopus 로고
    • Subclinical seizures identified by postoperative electroencephalographic monitoring are common after neonatal cardiac surgery
    • Naim, M.Y., Gaynor, J.W., Chen, J., et al. Subclinical seizures identified by postoperative electroencephalographic monitoring are common after neonatal cardiac surgery. J Thorac Cardiovasc Surg 150 (2015), 169–180.
    • (2015) J Thorac Cardiovasc Surg , vol.150 , pp. 169-180
    • Naim, M.Y.1    Gaynor, J.W.2    Chen, J.3
  • 199
    • 84879180045 scopus 로고    scopus 로고
    • Postoperative electroencephalographic seizures are associated with deficits in executive function and social behaviors at 4 years of age following cardiac surgery in infancy
    • Gaynor, J.W., Jarvik, G.P., Gerdes, M., et al. Postoperative electroencephalographic seizures are associated with deficits in executive function and social behaviors at 4 years of age following cardiac surgery in infancy. J Thorac Cardiovasc Surg 146 (2013), 132–137.
    • (2013) J Thorac Cardiovasc Surg , vol.146 , pp. 132-137
    • Gaynor, J.W.1    Jarvik, G.P.2    Gerdes, M.3
  • 200
    • 34249750010 scopus 로고    scopus 로고
    • Increased thrombogenesity in patients with cyanotic congenital heart disease
    • Kajimoto, H., Nakazawa, M., Murasaki, K., et al. Increased thrombogenesity in patients with cyanotic congenital heart disease. Circ J 71 (2007), 948–953.
    • (2007) Circ J , vol.71 , pp. 948-953
    • Kajimoto, H.1    Nakazawa, M.2    Murasaki, K.3
  • 201
    • 0034763053 scopus 로고    scopus 로고
    • Increased platelet reactivity and significant changes in coagulation markers after cavopulmonary connection
    • Ravn, H.B., Hjortdal, V.E., Stenbog, E.V., et al. Increased platelet reactivity and significant changes in coagulation markers after cavopulmonary connection. Heart 85 (2001), 61–65.
    • (2001) Heart , vol.85 , pp. 61-65
    • Ravn, H.B.1    Hjortdal, V.E.2    Stenbog, E.V.3
  • 202
    • 84878796538 scopus 로고    scopus 로고
    • The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience
    • Lykissas, M.G., Crawford, A.H., Chan, G., et al. The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience. J Child Orthop 7 (2013), 245–249.
    • (2013) J Child Orthop , vol.7 , pp. 245-249
    • Lykissas, M.G.1    Crawford, A.H.2    Chan, G.3
  • 203
    • 84868632771 scopus 로고    scopus 로고
    • Antifibrinolytic agents reduce blood loss during pediatric vertebral column resection procedures
    • Newton, P.O., Bastrom, T.P., Emans, J.B., et al. Antifibrinolytic agents reduce blood loss during pediatric vertebral column resection procedures. Spine 37 (2012), E1459–E1463.
    • (2012) Spine , vol.37 , pp. E1459-E1463
    • Newton, P.O.1    Bastrom, T.P.2    Emans, J.B.3
  • 204
    • 84942119637 scopus 로고    scopus 로고
    • Antifibrinolytic use and blood transfusions in pediatric scoliosis surgeries performed at US children's hospitals
    • McLeod, L.M., French, B., Flynn, J.M., et al. Antifibrinolytic use and blood transfusions in pediatric scoliosis surgeries performed at US children's hospitals. J Spinal Disord Tech 28 (2015), E460–E466.
    • (2015) J Spinal Disord Tech , vol.28 , pp. E460-E466
    • McLeod, L.M.1    French, B.2    Flynn, J.M.3
  • 205
    • 84937567315 scopus 로고    scopus 로고
    • Predictors of clinically significant postoperative events after open craniosynostosis surgery
    • Goobie, S.M., Zurakowski, D., Proctor, M.R., et al. Predictors of clinically significant postoperative events after open craniosynostosis surgery. Anesthesiology 122 (2015), 1021–1032.
    • (2015) Anesthesiology , vol.122 , pp. 1021-1032
    • Goobie, S.M.1    Zurakowski, D.2    Proctor, M.R.3
  • 206
    • 84921438254 scopus 로고    scopus 로고
    • Evaluating the safety and efficacy of tranexamic acid administration in pediatric cranial vault reconstruction
    • Crantford, J.C., Wood, B.C., Claiborne, J.R., et al. Evaluating the safety and efficacy of tranexamic acid administration in pediatric cranial vault reconstruction. J Craniofac Surg 26 (2015), 104–107.
    • (2015) J Craniofac Surg , vol.26 , pp. 104-107
    • Crantford, J.C.1    Wood, B.C.2    Claiborne, J.R.3
  • 207
    • 84954078397 scopus 로고    scopus 로고
    • Aminocaproic acid administration is associated with reduced perioperative blood loss and transfusion in pediatric craniofacial surgery
    • Hsu, G., Taylor, J.A., Fiadjoe, J.E., et al. Aminocaproic acid administration is associated with reduced perioperative blood loss and transfusion in pediatric craniofacial surgery. Acta Anaesthesiol Scand 60 (2016), 158–165.
    • (2016) Acta Anaesthesiol Scand , vol.60 , pp. 158-165
    • Hsu, G.1    Taylor, J.A.2    Fiadjoe, J.E.3
  • 208
    • 84983365259 scopus 로고    scopus 로고
    • Implementation of a tranexamic acid protocol to reduce blood loss during cranial vault remodeling for craniosynostosis
    • Martin, D.T., Gries, H., Esmonde, N., et al. Implementation of a tranexamic acid protocol to reduce blood loss during cranial vault remodeling for craniosynostosis. J Craniofac Surg 27 (2016), 1527–1531.
    • (2016) J Craniofac Surg , vol.27 , pp. 1527-1531
    • Martin, D.T.1    Gries, H.2    Esmonde, N.3
  • 209
    • 84873281280 scopus 로고    scopus 로고
    • Tranexamic acid reducing blood transfusion in children undergoing craniosynostosis surgery
    • Song, G., Yang, P., Zhu, S., et al. Tranexamic acid reducing blood transfusion in children undergoing craniosynostosis surgery. J Craniofac Surg 24 (2013), 299–303.
    • (2013) J Craniofac Surg , vol.24 , pp. 299-303
    • Song, G.1    Yang, P.2    Zhu, S.3
  • 210
    • 84871422870 scopus 로고    scopus 로고
    • A systematic review of the use of antifibrinolytic agents in pediatric surgery and implications for craniofacial use
    • Basta, M.N., Stricker, P.A., Taylor, J.A., A systematic review of the use of antifibrinolytic agents in pediatric surgery and implications for craniofacial use. Pediatr Surg Int 28 (2012), 1059–1069.
    • (2012) Pediatr Surg Int , vol.28 , pp. 1059-1069
    • Basta, M.N.1    Stricker, P.A.2    Taylor, J.A.3
  • 211
    • 79953163189 scopus 로고    scopus 로고
    • The importance of early treatment with tranexamic acid in bleeding trauma patients: An exploratory analysis of the CRASH-2 randomised controlled trial
    • 1101.e1–2
    • CRASH-2 Collaborators, Roberts, I., Shakur, H., et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: An exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 377 (2011), 1096–1101 1101.e1–2.
    • (2011) Lancet , vol.377 , pp. 1096-1101
    • Roberts, I.1    Shakur, H.2
  • 212
    • 84958164092 scopus 로고    scopus 로고
    • Cost analysis of tranexamic acid in anemic total joint arthroplasty patients
    • Phan, D.L., Ani, F., Schwarzkopf, R., Cost analysis of tranexamic acid in anemic total joint arthroplasty patients. J Arthroplasty 31 (2016), 579–582.
    • (2016) J Arthroplasty , vol.31 , pp. 579-582
    • Phan, D.L.1    Ani, F.2    Schwarzkopf, R.3
  • 213
    • 84962602349 scopus 로고    scopus 로고
    • Safety, efficacy, and cost-effectiveness of tranexamic acid in orthopedic surgery
    • Lin, Z.L.X., Woolf, S.K., Safety, efficacy, and cost-effectiveness of tranexamic acid in orthopedic surgery. Orthopedics 39 (2016), 119–130.
    • (2016) Orthopedics , vol.39 , pp. 119-130
    • Lin, Z.L.X.1    Woolf, S.K.2
  • 214
    • 84964756596 scopus 로고    scopus 로고
    • Commentary: Clinical and financial benefits of intra-articular tranexamic acid in total knee arthroplasty
    • Yan, C.H., Commentary: Clinical and financial benefits of intra-articular tranexamic acid in total knee arthroplasty. J Orthop Surg (Hong Kong), 24, 2016, 2.
    • (2016) J Orthop Surg (Hong Kong) , vol.24 , pp. 2
    • Yan, C.H.1
  • 215
    • 84934286919 scopus 로고    scopus 로고
    • HALT-IT—tranexamic acid for the treatment of gastrointestinal bleeding: Study protocol for a randomised controlled trial
    • Roberts, I., Coats, T., Edwards, P., et al. HALT-IT—tranexamic acid for the treatment of gastrointestinal bleeding: Study protocol for a randomised controlled trial. Trials, 15, 2014, 450.
    • (2014) Trials , vol.15 , pp. 450
    • Roberts, I.1    Coats, T.2    Edwards, P.3
  • 216
    • 84862496057 scopus 로고    scopus 로고
    • CRASH-3—tranexamic acid for the treatment of significant traumatic brain injury: Study protocol for an international randomized, double-blind, placebo-controlled trial
    • Dewan, Y., Komolafe, E.O., Mejia-Mantilla, J.H., et al. CRASH-3—tranexamic acid for the treatment of significant traumatic brain injury: Study protocol for an international randomized, double-blind, placebo-controlled trial. Trials, 13, 2012, 87.
    • (2012) Trials , vol.13 , pp. 87
    • Dewan, Y.1    Komolafe, E.O.2    Mejia-Mantilla, J.H.3
  • 217
    • 84856971781 scopus 로고    scopus 로고
    • A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial)
    • Bokesch, P.M., Szabo, G., Wojdyga, R., et al. A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial). J Thorac Cardiovasc Surg 143 (2012), 1022–1029.
    • (2012) J Thorac Cardiovasc Surg , vol.143 , pp. 1022-1029
    • Bokesch, P.M.1    Szabo, G.2    Wojdyga, R.3
  • 218
    • 77953042258 scopus 로고    scopus 로고
    • Interstitial plasmin activity with epsilon aminocaproic acid: Temporal and regional heterogeneity
    • Reust, D.L., Reeves, S.T., Abernathy, J.H., et al. Interstitial plasmin activity with epsilon aminocaproic acid: Temporal and regional heterogeneity. Ann Thorac Surg 89 (2010), 1538–1545.
    • (2010) Ann Thorac Surg , vol.89 , pp. 1538-1545
    • Reust, D.L.1    Reeves, S.T.2    Abernathy, J.H.3
  • 219
    • 84903303775 scopus 로고    scopus 로고
    • A novel blood-sparing agent in cardiac surgery? First in-patient experience with the synthetic serine protease inhibitor MDCO-2010: A phase II, randomized, double-blind, placebo-controlled study in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass
    • Englberger, L., Dietrich, W., Eberle, B., et al. A novel blood-sparing agent in cardiac surgery? First in-patient experience with the synthetic serine protease inhibitor MDCO-2010: A phase II, randomized, double-blind, placebo-controlled study in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. Anesth Analg 119 (2014), 16–25.
    • (2014) Anesth Analg , vol.119 , pp. 16-25
    • Englberger, L.1    Dietrich, W.2    Eberle, B.3
  • 220
    • 84937393992 scopus 로고    scopus 로고
    • Antifibrinolytic therapy for cardiac surgery: An update
    • Koster, A., Faraoni, D., Levy, J.H., Antifibrinolytic therapy for cardiac surgery: An update. Anesthesiology 123 (2015), 214–221.
    • (2015) Anesthesiology , vol.123 , pp. 214-221
    • Koster, A.1    Faraoni, D.2    Levy, J.H.3
  • 221
    • 85041321205 scopus 로고    scopus 로고
    • Self-propelled particles that transport cargo through flowing blood and halt hemorrhage
    • Baylis, J.R., Yeon, J.H., Thomson, M.H., et al. Self-propelled particles that transport cargo through flowing blood and halt hemorrhage. Sci Adv, 1, 2015, e1500379.
    • (2015) Sci Adv , vol.1 , pp. e1500379
    • Baylis, J.R.1    Yeon, J.H.2    Thomson, M.H.3
  • 222
    • 84967188656 scopus 로고    scopus 로고
    • Adsorption of tranexamic acid on hydroxyapatite: Toward the development of biomaterials with local hemostatic activity
    • Sarda, S., Errassifi, F., Marsan, O., et al. Adsorption of tranexamic acid on hydroxyapatite: Toward the development of biomaterials with local hemostatic activity. Mater Sci Eng C Mater Biol Appl 66 (2016), 1–7.
    • (2016) Mater Sci Eng C Mater Biol Appl , vol.66 , pp. 1-7
    • Sarda, S.1    Errassifi, F.2    Marsan, O.3
  • 223
    • 85036579498 scopus 로고    scopus 로고
    • Available at: Accessed December 15.
    • U.S. Food and Drug Administration. Available at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm142720.htm. Accessed December 15, 2016.
    • (2016)
    • US Food and Drug Administration1
  • 224
    • 84896706060 scopus 로고    scopus 로고
    • Efficacy and safety of using antifibrinolytic agents in spine surgery: A meta-analysis
    • Yuan, C., Zhang, H., He, S., Efficacy and safety of using antifibrinolytic agents in spine surgery: A meta-analysis. PLoS One, 8, 2013, e82063.
    • (2013) PLoS One , vol.8 , pp. e82063
    • Yuan, C.1    Zhang, H.2    He, S.3
  • 225
    • 10444232098 scopus 로고    scopus 로고
    • Hemostatic agents
    • Levy, J.H., Hemostatic agents. Transfusion 44 (2004), 58S–62S.
    • (2004) Transfusion , vol.44 , pp. 58S-62S
    • Levy, J.H.1
  • 226
    • 84989927593 scopus 로고    scopus 로고
    • Meta-analysis of intravenous tranexamic acid in primary total hip arthroplasty
    • Moskal, J.T., Capps, S.G., Meta-analysis of intravenous tranexamic acid in primary total hip arthroplasty. Orthopedics 39 (2016), e883–e892.
    • (2016) Orthopedics , vol.39 , pp. e883-e892
    • Moskal, J.T.1    Capps, S.G.2
  • 227
    • 33750468330 scopus 로고    scopus 로고
    • Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery?
    • Zufferey, P., Merquiol, F., Laporte, S., et al. Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery?. Anesthesiology 105 (2006), 1034–1046.
    • (2006) Anesthesiology , vol.105 , pp. 1034-1046
    • Zufferey, P.1    Merquiol, F.2    Laporte, S.3
  • 228
    • 70349116975 scopus 로고    scopus 로고
    • Effect of epsilon aminocaproic acid on red-cell transfusion requirements in major spinal surgery
    • Berenholtz, S.M., Pham, J.C., Garrett-Mayer, E., et al. Effect of epsilon aminocaproic acid on red-cell transfusion requirements in major spinal surgery. Spine 34 (2009), 2096–2103.
    • (2009) Spine , vol.34 , pp. 2096-2103
    • Berenholtz, S.M.1    Pham, J.C.2    Garrett-Mayer, E.3
  • 229
    • 78049239997 scopus 로고    scopus 로고
    • Safety and efficacy of aprotinin and tranexamic acid in pulmonary endarterectomy surgery with hypothermia: Review of 200 patients
    • Berman, M., Cardone, D., Sharples, L., et al. Safety and efficacy of aprotinin and tranexamic acid in pulmonary endarterectomy surgery with hypothermia: Review of 200 patients. Ann Thorac Surg 90 (2010), 1432–1436.
    • (2010) Ann Thorac Surg , vol.90 , pp. 1432-1436
    • Berman, M.1    Cardone, D.2    Sharples, L.3
  • 230
    • 84868537856 scopus 로고    scopus 로고
    • Deep vein thrombosis, tranexamic acid, and a negative d-dimer
    • Mihalache, R.M., Ames, P.R., Deep vein thrombosis, tranexamic acid, and a negative d-dimer. Clin Appl Thromb Hemost 18 (2012), 666–667.
    • (2012) Clin Appl Thromb Hemost , vol.18 , pp. 666-667
    • Mihalache, R.M.1    Ames, P.R.2


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