Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass

Anaesthesia

Volumn 67, Issue 11, 2012, Pages 1242-1250

  Sharma, V ^a   Fan, J ^a   Jerath, A ^a   Pang, K S ^b   Bojko, B ^c   Pawliszyn, J ^c   Karski, J M ^a   Yau, T ^a   McCluskey, S ^a   Wasowicz M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR; TRANEXAMIC ACID;

ADULT; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG MEGADOSE; FEMALE; GLOMERULUS FILTRATION RATE; HEART SURGERY; HUMAN; INTRAOPERATIVE PERIOD; KIDNEY FUNCTION; MALE; PLASMA PROTEIN BINDING; POSTOPERATIVE PERIOD; SEIZURE;

AGED; ALGORITHMS; ANESTHESIA; ANTIFIBRINOLYTIC AGENTS; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; LINEAR MODELS; MALE; MIDDLE AGED; TISSUE DISTRIBUTION; TRANEXAMIC ACID;

EID: 84867193761     PISSN: 00032409     EISSN: 13652044     Source Type: Journal    
DOI: 10.1111/j.1365-2044.2012.07266.x     Document Type: Article

References (25)

1. Jimenez JJ, Iribarren JL, Lorente L, et al., Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial. Critical Care 2007; 11: R117.
2. Karski JM, Teasdale SJ, Norman PH, Carroll JA, Weisel RD, Glynn MF,. Prevention of postbypass bleeding with tranexamic acid and epsilon-aminocaproic acid. Journal of Cardiothoracic and Vascular Anesthesia 1993; 7: 431-5.
3. Karski JM, Teasdale SJ, Norman P, et al., Prevention of bleeding after cardiopulmonary bypass with high-dose tranexamic acid. Double-blind, randomized clinical trial. Journal of Thoracic and Cardiovascular Surgery 1995; 110: 835-42.
4. Laupacis A, Fergusson D,. Drugs to minimize perioperative blood loss in cardiac surgery: meta-analyses using perioperative blood transfusion as the outcome. The International Study of Peri-operative Transfusion (ISPOT) Investigators. Anesthesia and Analgesia 1997; 85: 1258-67.
5. Fergusson DA, Hébert PC, Mazer CD, et al., A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. New England Journal of Medicine 2008; 358: 2319-31.
6. Nilsson IM,. Clinical pharmacology of aminocaproic acid and tranexamic acids. Journal of Clinical Pathology 1980; 33: 41-7.
7. Martin K, Wiesner G, Breuer T, Lange R, Tassani P,. The risks of aprotinin and tranexamic acid in cardiac surgery: a one-year follow-up of 1188 consecutive patients. Anesthesia and Analgesia 2008; 107: 1783-90.
8. Murkin JM, Falter F, Granton J, Young B, Burt C, Chu M,. High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesthesia and Analgesia 2010; 110: 350-3.
9. Keyl C, Uhl R, Beyersdorf F, et al., High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement. European Journal of Cardiothoracic Surgery 2011; 39: 114-21.
10. Berman M, Cardone D, Sharples L, et al., Safety and efficacy of aprotinin and tranexamic acid in pulmonary endarterectomy surgery with hypothermia: review of 200 patients. Annals of Thoracic Surgery 2010; 90: 1432-6.
11. Manji RA, Grocott HP, Leake J, et al., Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. Canadian Journal of Anesthesia 2012; 59: 6-13.
12. Dowd NP, Karski JM, Cheng DC, et al., Pharmacokinetics of tranexamic acid during cardiopulmonary bypass. Anesthesiology 2002; 97: 390-99.
13. Horrow JC, Van Riper DF, Strong MD, Grunewald KE, Parmet JL,. The dose-response relationship of tranexamic acid. Anesthesiology 1995; 82: 383-92.
14. Fiechtner BK, Nuttall GA, Johnson ME, et al., Plasma tranexamic acid concentrations during cardiopulmonary bypass. Anesthesia and Analgesia 2001; 92: 1131-6.
15. Nuttall GA, Gutierrez MC, Dewey JD, et al., A preliminary study of a new tranexamic acid dosing schedule for cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia 2008; 22: 230-5.
16. WÄsowicz M, Jerath A, Bojko B, Sharma V, Pawliszyn J, McCluskey S,. Use of a novel technique, solid phase microextraction, to measure tranexamic acid in patients undergoing cardiac surgery. Canadian Journal of Anesthesia 2012; 59: 14-20.
17. Bojko B, Vuckovic D, Cudjoe E, et al., Determination of tranexamic acid concentration by solid phase microextraction and liquid chromatography-tandem mass spectrometry: first step to in vivo analysis. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2011; 879: 3781-7.
18. Andersson L, Eriksson O, Hedlund PO, Kjellman H, Lindqvist B,. Special considerations with regard to the dosage of tranexamic acid in patients with chronic renal diseases. Urological Research 1978; 6: 83-8.
19. Musteata FM, Pawliszyn J,. In vivo sampling with solid phase microextraction. Journal of Biochemical and Biophysical Methods 2007; 70: 181-93.
20. Vuckovic D, Zhang X, Cudjoe E, Pawliszyn J,. Solid-phase microextraction in bioanalysis: new devices and directions. Journal of Chromatography A 2010; 1217: 4041-60.
21. Lord HL, Zhang X, Musteata FM, Vuckovic D, Pawliszyn J,. In vivo solid-phase microextraction for monitoring intravenous concentrations of drugs and metabolites. Nature Protocols 2011; 6: 896-924.
22. Pilbrant A, Schannong M, Vessman J,. Pharmacokinetics and bioavailability of tranexamic acid. European Journal of Clinical Pharmacology 1981; 20: 65-72.
23. Health Canada. Trasylol (aprotinin)-Advisories, Warnings and Recalls for hospitals, 2011. http://www.hc-sc.gc.ca/dhp-mps/alt-formats/medeff/advisories- avis/prof/2011/trasylol-3-nth-aah-eng.pdf (accessed 02/01/2012).
24. Karkouti K, Wijeysundera DN, Yau TM, et al., Acute kidney injury after cardiac surgery: focus on modifiable risk factors. Circulation 2009; 119: 495-502.
25. Gibaldi M, Perrier D,. Pharmacokinetics, 2nd edn. New York: Marcel Dekker, 1982.