Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 123, Issue 11, 2016, Pages 1745-1752

  Ker, K ^a   Shakur, H ^a   Roberts, I ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Postpartum haemorrhage; systematic review; tranexamic acid

Indexed keywords

PLACEBO; TRANEXAMIC ACID;

BLOOD TRANSFUSION; CESAREAN SECTION; CHILDBIRTH; DEEP VEIN THROMBOSIS; DRUG EFFICACY; EVIDENCE BASED MEDICINE; HUMAN; MATERNAL DEATH; OUTCOME ASSESSMENT; POSTPARTUM HEMORRHAGE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SAMPLE SIZE; SYSTEMATIC REVIEW; THROMBOEMBOLISM; VAGINAL DELIVERY; WELLBEING;

EID: 84988442245     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/1471-0528.14267     Document Type: Review

References (46)

1. Calvert C, Thomas SL, Ronsmans C, Wagner KS, Adler AJ, Filippi V. Identifying regional variation in the prevalence of postpartum haemorrhage: a systematic review and meta-analysis. PLoS ONE 2012;7:e41114.
2. Kassebaum NJ, Bertozzi-Villa A, Coggeshall MS, Shackelford KA, Steiner C, Heuton KR, et al. Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014;384:980–1004.
3. Geller SE, Adams MG, Kelly PJ, Kodkany BS, Derman RJ. Postpartum hemorrhage in resource-poor settings. Int J Gynaecol Obstet 2006;92:202–11.
4. Shakur H, Elbourne D, Gulmezoglu M, Alfirevic Z, Ronsmans C, Allen E, et al. The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial. Trials 2010;11:40.
5. Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, et al. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: a systematic analysis of population-representative data. Lancet Glob Health 2013;1:e16–25.
6. Jansen AJ, Essink-Bot ML, Duvekot JJ, van Rhenen DJ. Psychometric evaluation of health-related quality of life measures in women after different types of delivery. J Psychosom Res 2007;63:275–81.
7. Kruithof EK, Tran-Thang C, Gudinchet A, Hauert J, Nicoloso G, Genton C, et al. Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors. Blood 1987;69:460–6.
8. Higgins JPT, Altman DG, Sterne JAC (eds) Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. The Cochrane Collaboration. [www.cochrane-handbook.org. 2011].
9. Ker K, Prieto-Merino D, Roberts I. Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss. Br J Surg 2013;100:1271–9.
10. Abdel-Aleem H, Alhusaini TK, Abdel-Aleem MA, Menoufy M, Gulmezoglu AM. Effectiveness of tranexamic acid on blood loss in patients undergoing elective cesarean section: randomized clinical trial. J Matern Fetal Neonatal Med 2013;26:1705–9.
11. Deka N. Efficacy of tranexamic acid in decreasing blood loss during and after cesarean section: a randomized case controlled prospective study. Karnataka, Bangalore: Department of Obstetrics & Gynaecology, Rajiv Gandhi University of Health Sciences, 2012.
12. Gai MY, Wu LF, Su QF, Tatsumoto K. Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial. Eur J Obstet Gynecol Reprod Biol 2004;112:154–7.
13. Gobbur VR, Reddy SV, Bijapur UJ. Efficacy of tranexamic acid in reducing blood loss during lower segment caesarean section. 54th All India Congress of Obstet Gynaecol; 2011 January 5–9. Hyderabad, Andhra Pradesh, India. 2011: 92.
14. Gobbur VR, Shiragur SS, Jhanwar UR, Tehalia MJ. Efficacy of tranexamic acid in reducing blood loss during lower segment caesarean section. Int J Reprod Contracep Obstet Gynecol 2014;3:414–17.
15. Gohel M, Patel P, Gupta A, Desai P. Efficacy of tranexamic acid in decreasing blood loss during and after cesarean section: a randomized case controlled prospective study. J Obstet Gynaecol India 2007;57:228–30.
16. Goswami U, Sarangi S, Gupta S, Babbar S. Comparative evaluation of two doses of tranexamic acid used prophylactically in anemic parturients for lower segment cesarean section: a double-blind randomized case control prospective trial. Saudi J Anaesth 2013;7:427–31.
17. Gungorduk K, Asicioglu O, Yildirim G, Ark C, Tekirdag AI, Besimoglu B. Can intravenous injection of tranexamic acid be used in routine practice with active management of the third stage of labor in vaginal delivery? A randomized controlled study. Am J Perinatol 2013;30:407–13.
18. Gungorduk K, Yildirim G, Asicioglu O, Gungorduk OC, Sudolmus S, Ark C. Efficacy of Intravenous tranexamic acid in reducing blood loss after elective cesarean section: a prospective, randomized, double-blind, placebo-controlled study. Am J Perinatol 2011;28:233–40.
19. Halder S, Samanta B, Sardar R, Chattopadhyay S. Tranexamic acid used before caesarean section reduces blood loss based on pre- and postoperative haemoglobin level: a case-control study. J Indian Med Assoc 2013;111:184–6.
20. Jhanwar UR. Efficacy of Tranexamic Acid in Reducing Blood Loss during and after the Lower Segment Cesarean Section. Karnataka, Bangalore: Department of Obstetrics & Gynaecology, Rajiv Gandhi University of Health Sciences, 2010.
21. Mirghafourvand M, Mohammad-Alizadeh S, Abbasalizadeh F, Shirdel M. The effect of prophylactic intravenous tranexamic acid on blood loss after vaginal delivery in women at low risk of postpartum haemorrhage: a double-blind randomised controlled trial. Aust N Z J Obstet Gynaecol 2015;55:53–8.
22. Movafegh A, Eslamian L, Dorabadi A. Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery. Int J Gynaecol Obstet 2011;115:224–6.
23. Poonia M, Bansal A, Bhardwaj N, Anita, Kumari S. Role of tranexamic acid in reducing blood loss after caesarean section: a randomized case control prospective study. J Med Sci Res 2012;3:44–6.
24. Ramani B, Nayak L. Intravenous 1 gram tranexamic acid for prevention of blood loss and blood transfusion during caesarean section: a randomized case control study. Int J Reprod Contracept Obstet Gynecol 2014;3:366–9.
25. Ramesh AC, Rajni S, Deka N. Efficacy of tranexamic acid in decreasing blood loss during and after cesarean section: a randomized case controlled prospective study. Indian J Public Health Res Dev 2015;6:12–15.
26. Rashmi PS, Sudha TR, Prema P, Rajashri P, Vijayanath V. Role of tranexamic acid in reducing blood loss during and after cesarean section. A randomized case control prospective study. J Med Res Pract 2012;1:40–3.
27. Safdarian L, Najafian A, Moshfeghi S, Alavi A, Shoar MM, Qanbarnezhad A. The effect of tranexamic acid in decreasing blood loss during and after cesarean section. GMP Rev 2015;17:158–61.
28. Samimi M, Moravveji SA, Heidari-Shirazi F. The effect of tranexamic acid on pregnancy outcome and vaginal post-parturition hemodynamics. Feyz J Kashan Univ Med Sci 2013;17:114–22.
29. Sekhavat L, Tabatabaii A, Dalili M, Farajkhoda T, Tafti AD. Efficacy of tranexamic acid in reducing blood loss after cesarean section. J Matern Fetal Neonatal Med 2009;22:72–5.
30. Senturk MB, Cakmak Y, Yildiz G, Yildiz P. Tranexamic acid for cesarean section: a double-blind, placebo-controlled, randomized clinical trial. Arch Gynecol Obstet 2013;287:641–5.
31. Shahid A, Khan A. Tranexamic acid in decreasing blood loss during and after caesarean section. J Coll Physicians Surg Pak 2013;23:459–62.
32. Sharma R, Najan R, Misra MK. Efficacy of tranexamic acid in decreasing blood loss during and after cesarean section. Biomed Pharmacol 2011;4:231–5.
33. Taj N, Firdous A, Akhtar N, Chaudhary MH, Sarah Bajwa Z, et al. Efficacy of tranexamic acid in reducing blood loss during and after cesarean section. Rawal Med J 2014;39:311–13.
34. Tarabrin O, Galich S, Tkachenko R, Gulyaev A, Shcherbakov S, Gavrychenko D. Reduced blood loss during Caesarean section under the action of tranexamic acid. Eur J Anaesthesiol 2012;29:97.
35. Tarabrin O, Kaminskiy V, Galich S, Tkachenko R, Gulyaev S, Shcherbakov S, et al. Efficacy of tranexamic acid in decreasing blood loss in cesarean section. Crit Care 2012;16(suppl 1):S157.
36. Xu J, Gao W, Ju Y. Tranexamic acid for the prevention of postpartum hemorrhage after cesarean section: a double-blind randomization trial. Arch Gynecol Obstet 2013;287:463–8.
37. Yang H, Zheng S, Shi C. Clinical study on the efficacy of tranexamic acid in reducing postpartum blood lose: a randomized, comparative, multicenter trial. Zhonghua Fu Chan Ke Za Zhi 2001;36:590–2.
38. Yehia AH, Koleib MH, Abdelazim IA, Atik A. Tranexamic acid reduces blood loss during and after cesarean section: a double blinded, randomized, controlled trial. Asian Pacific J Reprod 2014;3:53–6.
39. Zheng SR, Chi GZ. Effects of tranexamic acid on decreasing blood loss within two hours after delivery. A multicenter randomized comparative study. Blood 2000;96:846a.
40. Zizi A, Aris S, Suharjono HN. To study the role of tranexamic acid in reducing blood loss during and after caesarean section in Sarawak General Hospital. J Surg Acad 2013;3:50.
41. Clark L, Fairhurst C, Cook E, Torgerson DJ. Important outcome predictors showed greater baseline heterogeneity than age in two systematic reviews. J Clin Epidemiol 2015;68:175–81.
42. CRASH-2 trial collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010;376:23–32.
43. Ker K, Edwards P, Perel P, Shakur H, Roberts I. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012;344:e3054.
44. Heesen M, Bohmer J, Klohr S, Rossaint R, van de Velde M, Dudenhausen JW, et al. Prophylactic tranexamic acid in parturients at low risk for post-partum haemorrhage: systematic review and meta-analysis. Acta Anaesthesiol Scand 2014;58:1075–85.
45. Novikova N, Hofmeyr GJ, Cluver C. Tranexamic acid for preventing postpartum haemorrhage. Cochrane Database Syst Rev 2015;6:CD007872.
46. Sentilhes L, Lasocki S, Ducloy-Bouthors AS, Deruelle P, Dreyfus M, Perrotin F, et al. Tranexamic acid for the prevention and treatment of postpartum haemorrhage. Br J Anaesth 2015;114:576–87.