Efficacy of antifibrinolytic agents on surgical bleeding and transfusion requirements in spine surgery: a meta-analysis

European Spine Journal

Volumn 26, Issue 1, 2017, Pages 140-154

  Li, Guang ^a   Sun, Tian Wei ^b   Luo, Gan ^a   Zhang, Chao ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b TIANJIN PEOPLE'S HOSPITAL   (China)

Author keywords

Antifibrinolytic agents; Blood loss; Blood transfusion; Meta analysis; Spine surgery

Indexed keywords

AMINOCAPROIC ACID; ANTIFIBRINOLYTIC AGENT; APROTININ; TRANEXAMIC ACID;

BLOOD TRANSFUSION; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; HUMAN; HYPOTENSION; META ANALYSIS; MULTICENTER STUDY (TOPIC); OPERATIVE BLOOD LOSS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SPINE SURGERY; SYSTEMATIC REVIEW; THROMBOEMBOLISM; POSTOPERATIVE HEMORRHAGE; STATISTICS AND NUMERICAL DATA;

ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; HUMANS; POSTOPERATIVE HEMORRHAGE;

EID: 84991328205     PISSN: 09406719     EISSN: 14320932     Source Type: Journal    
DOI: 10.1007/s00586-016-4792-x     Document Type: Review

References (46)

1. Verma K, Errico TJ, Vaz KM, Lonner BS (2010) A prospective, randomized, double-blinded single-site controlled study comparing blood loss prevention of tranexamic acid (TXA) to epsilon aminocaproic avid (EACA) for corrective spinal surgery. BMC Surg 10:13. doi:10.1186/1471-2482-10-13
2. Hassan N, Halanski M, Wincek J, Reischman D, Sanfilippo D et al (2011) Blood management in pediatric spinal deformity surgery: review of a 2-year experience. Transfusion 51:2133–2141. doi:10.1111/j.1537-2995,2011.03175.x
3. Neilipovitz DT, Murto K, Hall L, Barrowman NJ, Splinter WM (2001) A random trial of tranexamic acid to reduce blood transfusion for scoliosis. Anesth_Analg 93:82–87
4. Hu SS (2004) Blood loss in adult spinal surgery. Eur Spine J 13(Suppl 1):S3–S5
5. Mannucci PM, Levi M (2007) Prevention and treatment of major blood loss. N Engl J Med 3(56):2301–2311
6. Yonenobu K, Hosono N, Iwasaki M et al (1991) Neurologic complications of surgery for cervical compression myelopathy. Spine 16:1277–1282
7. Kebaish KM, Awad JN (2004) Spinal epidural hematoma causing acute cauda equina syndrome. Neurosurg Focus 16:e1
8. Sokolowski MJ, Garvey TA, Perl J II et al (2008) Prospective study of postoperative lumbar epidural hematoma: incidence and risk factors. Spine 33:108–113
9. Henry DA, Carless PA, Moxey AJ et al (2011) Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 1:CD001886
10. Yang B, Li H, Wang D et al (2013) Systematic review and meta-analysis of perioperative intravenous tranexamic acid use in spine surgery. PLoS One 8:e55436
11. Baldus CR, Bridwell KH, Lenke LG, Okubadejo GO (2010) Can we safely reduce blood loss during lumbar pedicle subtraction osteotomy procedures using tranexamic acid or aprotinin? A comparative study with controls. Spine (Phila Pa 1976) 35:235–239
12. Mannucci PM (1998) Hemostatic drugs. N Engl J Med 339:245–253
13. Schouten ES, van de Pol AC, Schouten AN, Turner NM, Jansen NJ, Bollen CW (2009) The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: a meta-analysis. Pediatric critical care medicine 10(2):182–190. doi:10.1097/PCC.0b013e3181956d61
14. Brown JR, Birkmeyer NJ, O’Connor GT (2007) Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation 115(22):2801–2813. doi:10.1161/CIRCULATIONAHA.106.671222
15. Alshryda S, Sukeik M, Sarda P, Blenkinsopp J, Haddad FS, Mason JM (2014) A systematic review and metaanalysis of the topical administration of tranexamic acid in total hip and knee replacement. The bone & joint journal. 96-B(8):1005–15. doi: 10.1302/0301-620X.96B8.33745
16. Higgins JP, Altman DG (2008) Assessing risk of bias in included studies, vol 2008. Wiley, pp 187–241. doi:10.1002/9780470712184.ch8
17. Lentschener C, Cottin P, Bouaziz H, Mercier FJ, Wolf M, Aljabi Y et al (1999) Reduction of blood loss and transfusion requirement by aprotinin in posterior lumbar spine fusion. Anesth Analg 89(3):590–597
18. Karapurkar AKA, Naik L (2002) Aprotinin, to reduced perioperative blood loss in scoliosis surgery Indian J Anaesth 46(5):378–80
19. Cole JW, Murray DJ, Snider RJ, Bassett GS, Bridwell KH, Lenke LG (2003) Aprotinin reduces blood loss during spinal surgery in children. Spine 28(21):2482–2485. doi:10.1097/01.BRS.0000090835.45437.7F
20. Khoshhal K, Mukhtar I, Clark P, Jarvis J, Letts M, Splinter W (2003) Efficacy of aprotinin in reducing blood loss in spinal fusion for idiopathic scoliosis. J Pediatr Orthop 23(5):661–664
21. Sethna NF, Zurakowski D, Brustowicz RM, Bacsik J, Sullivan LJ, Shapiro F (2005) Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery. Anesthesiology 102(4):727–732
22. Elwatidy S, Jamjoom Z, Elgamal E, Zakaria A, Turkistani A et al. (2008) Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study. Spine (Phila Pa 1976) 33:2577–2580
23. Wong J, El Beheiry H, Rampersaud YR, Lewis S, Ahn H et al (2008) Tranexamic Acid reduces perioperative blood loss in adult patients having spinal fusion surgery. Anesth Analg 107:1479–1486
24. Farrokhi MR, Kazemi AP, Eftekharian HR, Akbari K (2011) Efficacy of prophylactic low dose of tranexamic acid in spinal fixation surgery: a randomized clinical trial. J Neurosurg Anesthesiol 23:290–296
25. Tsutsumimoto T, Shimogata M, Ohta H, Yui M, Yoda I et al. (2011) Tranexamic acid reduces perioperative blood loss in cervical laminoplasty: a prospective randomized study. Spine (Phila Pa 1976) 36:1913–1918
26. Xu C, Wu A, Yue Y (2012) Which is more effective in adolescent idiopathic scoliosis surgery: batroxobin, tranexamic acid or a combination? Arch Orthop Trauma Surg 132(1):25–31. doi:10.1007/s00402-011-1390-6
27. Wang Q, Liu J, Fan R et al (2013) Tranexamic acid reduces postoperative blood loss of degenerative lumbar instability with stenosis in posterior approach lumbar surgery: a randomized controlled trial. Eur Spine J 22:2035–2038. doi:10.1007/s00586-013-2836-z
28. Raksakietisak M, Sathitkarnmanee B, Srisaen P et al (2015) Two Doses of tranexamic acid reduce blood transfusion in complex spine surgery: a prospective randomized study. Spine 40:E1257–E1263
29. Florentino-Pineda I, Thompson GH, Poe-Kochert C, Huang RP, Haber LL, Blakemore LC (2004) The effect of amicar on perioperative blood loss in idiopathic scoliosis: the results of a prospective, randomized double-blind study. Spine 29(3):233–238
30. Berenholtz SM, Pham JC, Garrett-Mayer E, Atchison CW, Kostuik JP et al. (2009) Effect of epsilon aminocaproic acid on red-cell transfusion requirements in major spinal surgery. Spine (Phila Pa 1976) 34: 2096–2103
31. Peters A, Verma K, Slobodyanyuk K et al (2015) Antifibrinolytics reduce blood loss in adult spinal deformity surgery: a prospective randomized controlled trial. Spine 40:E443–E449
32. Ortmann E, Besser MW, Klein AA (2013) Antifibrinolytic agents in current anaesthetic practice. Br J Anaesth 111(4):549–563. doi:10.1093/bja/aet154
33. K G, EGD T, JH M (2011) Normal haemostasis. In: Hoffbrand AV, Catovsky D, Tuddenham EGD (eds) Postgraduate haematology. Wiley-Blackwell, Oxford
34. U H, J H, V M, Colman RW, Hirsch J, Marder V, Clowes A, George J (2001) Hemostasis and thrombosis: basic principles and clinical practice. Lippincott Williams &Wilkins, Philadelphia
35. Dietrich W, Spath P, Zuhlsdorf M, et al. (2001) Anaphylactic reactions to aprotinin reexposure in cardiac surgery: relation to antiaprotinin immunoglobulin G and E antibodies. Anesthesiology 95:64–71 (discussion 5A–6A)
36. Eberle B, Mayer E, Hafner G et al (1998) High dose epsilon-aminocaproic acid versus aprotinin: antifibrinolytic therapy in first-time coronary operations. Ann Thorac Surg 65:667–673
37. Beierlein W, Scheule AM, Ziemer G (2000) Anaphylactic aprotinin reaction. Ann Thorac Surg 69:1298
38. Mangano DT, Tudor IC, Dietzel C, Ischemia Research G, Ischemia R, Education F (2006) The risk associated with aprotinin in cardiac surgery. New England J Med 354(4):353–365. doi:10.1056/NEJMoa051379
39. Mangano DT, Miao Y, Vuylsteke A, Tudor IC, Juneja R, Filipescu D, et al. (2007)Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA: the journal of the American Medical Association. 297(5):471–479. doi:10.1001/jama.297.5.471
40. Rao BH, Saxena N, Chauhan S et al (2000) Epsilon aminocaproic acid in paediatric cardiac surgery to reduce postoperative blood loss. Indian J Med Res 111:57–61
41. Vander Salm TJ, Kaur S, Lancey RA et al (1996) Reduction of bleeding after heart operations through the prophylactic use of epsilon-aminocaproic acid. J Thoracic Cardiovasc Surg 112:1098–1107
42. Williams GD, Bratton SL, Riley EC et al (1999) Efficacy of epsilon-aminocaproic acid in children undergoing cardiac surgery. J Cardiothorac Vasc Anesth 13:304–308
43. Yagi M, Hasegawa J, Nagoshi N, lizuka S, Kaneko S, et al. (2012) Does the intraoperative tranexamic Acid decrease operative blood loss during posterior spinal fusion for treatment of adolescent idiopathic scoliosis? Spine (Phila Pa 1976) 37:1336–1342
44. Thompson GH, Florentino-Pineda I, Poe-Kochert C, Armstrong DG, Son-Hing (2008) The role of amicar in same-day anterior and posterior spinal fusion for idiopathic scoliosis. Spine (Phila Pa 1976) 33:2237–2242
45. Dhawale AA, Shah SA, Sponseller PD, Bastrom T, Neiss G et al. (2012) Are antifibrinolytics helpful in decreasing blood loss and transfusions during spinal fusion surgery in children with cerebral palsy scoliosis? Spine (Phila Pa 1976) 37:549–555
46. Jain A, Karas DJ, Skolasky RL, Sponseller PD (2014) Thromboembolic complications in children after spinal fusion surgery. Spine 39(16):1325–1329. doi:10.1097/BRS.0000000000000402