Increased thrombogenesity in patients with cyanotic congenital heart disease

Circulation Journal

Volumn 71, Issue 6, 2007, Pages 948-953

  Kajimoto, Hidemi ^a   Nakazawa, Makoto ^a   Murasaki, Kagari ^a   Mori, Yoshiki ^a   Tanoue, Kenjiro ^a   Kasanuki, Hiroshi ^a   Nakanishi, Toshio ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Endothelium; Hypoxia; Thromboembolism

Indexed keywords

ANTITHROMBIN III; PADGEM PROTEIN; PROTEIN C; THROMBIN ANTITHROMBIN COMPLEX; THROMBOMODULIN;

ADOLESCENT; ADULT; ANTICOAGULATION; ARTICLE; CARDIAC PATIENT; CHILD; CLINICAL ARTICLE; CONGENITAL HEART DISEASE; ENDOTHELIUM; FEMALE; FLUORESCENCE; HUMAN; MALE; PROTEIN BLOOD LEVEL; THROMBOCYTE ACTIVATION; THROMBOEMBOLISM; THROMBOGENESIS;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; CHILD, PRESCHOOL; FEMALE; HEART DEFECTS, CONGENITAL; HUMANS; INFANT; MALE; P-SELECTIN; PLATELET ACTIVATION; PROTEIN C; THROMBIN; THROMBOEMBOLISM; THROMBOMODULIN;

EID: 34249750010     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.71.948     Document Type: Article

References (40)

1. Perloff JK. Neurologic disorders. In: Perloff JK, Child JS, editors. Congenital heart disease in adults. 2nd ed. Philadelphia, PA: W. B. Saunders; 1998; 237-246.
2. Candice KS, John TG, Eli K, Michelle AH. Pulmonary thrombosis in adults with Eisenmenger syndrome. J Am Coll Cardiol 2003; 42: 1982-1987.
3. Reuben SR. Compliance of the human pulmonary arterial system in disease. Circ Res 1971; 29: 40-50.
4. Levin E, Wu J, Devine DV, Alexander J, Reichart C, Sett S, et al. Hemostatic parameters and platelet activation marker expression in cyanotic and acyanotic pediatric patients undergoing cardiac surgery in the presence of tranexamic acid. Thromb Haemost 2000; 83: 54-59.
5. Adatia I, Barrow SE, Stratton P, Ritter JM, Haworth SG. Abnormalities in the biosynthesis of thromboxane A2 and prostacyclin in children with cyanotic congenital heart disease. Br Heart J 1993; 69: 179-182.
6. Lefer AM, Weyrich AS, Buerke M. Role of selectins, a new family of adhesion molecules, in ischemia-reperfusion injury. Cardiovasc Res 1994; 28: 289-294.
7. Shaun RC. Thrombin signaling and protease-activated receptors. Nature 2000; 407: 258-264.
8. Palabrica T, Lobb R, Furie BC, Aronovitz M, Benjamin C, Hsu YM, et al. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature 1992; 359: 848-851.
9. Stenberg PE, McEver RP, Shuman MA, Jacoques YV, Bainton DF. A platelet alpha-granule membrane after activation. J Cell Biol 1985; 101: 880-886.
10. McEver RP, Beckstead JH, Moore KL, Marshall-Carison L, Bainton DF. GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest 1989; 84: 92-99.
11. Hrachovinová I, Cambien B, Hafezi-Moghadam A, Kappelmayer J, Camphausen RT, Widom A, et al. Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Nat Med 2003; 9: 1020-1025.
12. Horigome H, Murakami T, Isobe T, Nagasawa T, Matsui A. Soluble P-selectin and thrombomodulin-protein C-Protein S pathway in cyanotic congenital heart disease with secondary erythrocytosis. Thromb Res 2003; 112: 223-227.
13. Olgun N, Uysal KM, Irken G, Unal N, Under B, Akkoc N, et al. Platelet activation in congenital heart diseases. Acta Paediatr Jpn 1997; 39: 566-569.
14. Walker FJ, Fay PJ. Regulation of blood coagulation by the protein C system. FASEB J 1992; 6: 2561-2567.
15. Kodama S, Uchijima E, Nagai M, Mikawatani K, Hayashi T, Suzuki K. One-step sandwich enzyme immunoassay for soluble human thrombomodulin using monoclonal antibodies. Clin Chim Acta 1990; 192: 191-199.
16. Seigneur M, Dufourcq P, Conri C, Constans J, Mercie P, Pruvost A, et al. Levels of plasma thrombomodulin are increased in atheromatous arterial disease. Thromb Res 1993; 71: 423-431.
17. Kumada T, Dittman WA, Majerus PW. A role for thrombomodulin in the pathogenesis of thrombin-induced thromboembolism in mice. Blood 1988; 71: 728-733.
18. Gomi K, Zushi M, Honda G, Kawahara S, Matsuzaki O, Kanabayashi T, et al. Antithrombotic effect of recombinant human thrombomodulin on thrombin-induced thromboembolism in mice. Blood 1990; 75: 1396-1399.
19. Healy AM, Hancock WW, Christie PD, Rayburn HB, Rosenberg RD. Intravascular coagulation activation in a murine model of thrombomodulin deficiency: Effects of lesion size, age, and hypoxia on fibrin deposition. Blood 1998; 92: 4188-4197.
20. Ikeda H, Takajo Y, Ichiki K, Ueno T, Maki S, Noda T, et al. Increased soluble form of P-selectin in patients with unstable angina. Circulation 1995; 92: 1693-1696.
21. Gerhard P, Magdalena BP, Karl HH, Carsten P, Doris Z, Gisbert G, et al. Platelet activation in embolic and preembolic status of patients with nonrheumatic atrial fibrillation. Chest 1997; 111: 929-933.
22. Koyama H, Maeno T, Fukumoto S, Shoji T, Yamane T, Yokoyama H, et al. Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans. Circulation 2003; 108: 524-529.
23. Sakamaki F, Kyotani S, Nagaya N, Sato N, Oya H, Satoh T, et al. Increased plasma P-selectin and decreased thrombomodulin in pulmonary arterial hypertension were improved by continuous prostacyclin therapy. Circulation 2000; 102: 2720-2725.
24. Minamino T, Kitakaze M, Sanada S, Asanuama H, Kurotobi T, Koretsune Y, et al. Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation: Role of nitric oxide. Circulation 1998; 98: 1721-1727.
25. Horigome H, Hiramatsu Y, Shigeta O, Nagasawa T, Matsui A. Overproduction of platlet microparticles in cyanotic congenital heart disease with polycythemia. J Am Coll Cardiol 2002; 39: 1072-1077.
26. Michelson AD, Barnard MR, Hechtman HB, MacGregor H, Connolly RJ, Loscalzo J, et al. In vivo tracking of platelets: Circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function. Proc Natl Acad Sci USA 1996; 93: 11877-11882.
27. Kario K, Matsuo T, Kobayashi H, Asada R, Matsuo M. 'Silent' cerebral infarction is associated with hypercoagulability, endothelial cell damage, and high Lp(a) levels in elderly Japanese. Arterioscler Thromb Vasc Biol 1996; 16: 734-741.
28. O'Connor CM, Gurbel PA, Serebruany VL. Usefulness of soluble and surface-bound P-selectin in detecting heightened platelet activity in patients with congestive heart failure. Am J Cardiol 1999; 83: 1345-1349.
29. Komai H, Haworth SG. Effect of cardiopulmonary bypass on the circulating bypass on the circulating level of soluble GMP-140. Ann Thorac Surg 1994; 58: 478-482.
30. Merten M, Chow T, Hellums JD, Thiagarajan P. A new role for Pselectin in shear-induced platelet aggregation. Circulation 2000; 102: 2045-2050.
31. Owen WG, Esmon CT. Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. J Biol Chem 1981; 256: 5532-5535.
32. Maruyama I, Salem HH, Majerus PW. Coagulation factor Va binds to human umbilical vein endothelial cells and accelerates protein C activation. J Clin Invest 1984; 74: 224-230.
33. Esmon CT. The roles of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem 1989; 264: 4743-4746.
34. Suzuki K, Kusumoto H, Deyashiki Y, Nishioka J, Maruyama I, Zushi M, et al. Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. EMBO J 1987; 6: 1991-1997.
35. Golino P, Ragni M, Cimmino G, Forte L. Role of tissue factor pathway inhibitor in the regulation of tissue factor-dependent blood coagulation. Cardiovasc Drug Rev 2002; 20: 67-80.
36. Cacoub P, Karmochkine M, Dorent R, Nataf P, Piette JC, Godeau P, et al. Plasma levels of thrombomodulin in pulmonary hypertension. Am J Med 1996; 101: 160-164.
37. Hassell KL. Altered hemostasis in pulmonary hypertension. Blood Coagul Fibrinolysis 1998; 9: 107-117.
38. Yamashita T, Sekiguchi A, Iwasaki YK, Sagara K, Hatano S, Iinuma H, et al. Thrombomodulin and tissue factor pathway inhibitor in endocardium of rapidly paced rat atria. Circulation 2003; 108: 2450-2452.
39. Ferreiro CR, Chagas AC, Carvalho MH, Dantas AP, Jatene MB, Bento De Souza LC, et al. Influence of hypoxia on nitric oxide synthase activity and gene expression in children with congenital heart disease: A novel pathophysiological adaptive mechanism. Circulation 2001; 103: 2272-2276.
40. Serebruany VL, Bahr RD, O'Connor CM, Lowry DR, Gurbel PA. Antecedent aspirin therapy inhibits baseline platelet activity in patients presenting with acute myocardial infarction. Cardiology 1998; 90: 37-42.