Topical vs Intravenous Tranexamic Acid in Primary Total Hip Arthroplasty: A Double-Blind, Randomized Controlled Trial

Journal of Arthroplasty

Volumn 31, Issue 5, 2016, Pages 1022-1026

  North, Wayne T ^a   Mehran, Nima ^a   Davis, Jason J ^a   Silverton, Craig D ^a   Weir, Robb M ^a   Laker, Michael W ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

Cost reduction in primary hip arthroplasty; Perioperative blood conservation; Risk reduction in primary hip arthroplasty; Total hip arthroplasty; Tranexamic acid

Indexed keywords

PLACEBO; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ADULT; ARTICLE; BLOOD TRANSFUSION; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; FEMALE; HEALTH CARE COST; HEMOGLOBIN DETERMINATION; HIP ARTHROPLASTY; HUMAN; MAJOR CLINICAL STUDY; MALE; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; OPERATIVE BLOOD LOSS; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REIMBURSEMENT; TREATMENT INDICATION; AGED; BLOOD LOSS, SURGICAL; CLINICAL TRIAL; COMPARATIVE STUDY; HIP REPLACEMENT; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; MULTICENTER STUDY; POSTOPERATIVE HEMORRHAGE; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, TOPICAL; AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDIES; TRANEXAMIC ACID;

EID: 84950156045     PISSN: 08835403     EISSN: 15328406     Source Type: Journal    
DOI: 10.1016/j.arth.2015.11.003     Document Type: Article

References (29)

1. Mesko N.W., Bachmann K.R., Kovacevic D., et al. Thirty-day readmission following total hip and knee arthroplasty-a preliminary single institution predictive model. J Arthroplasty 2014, 29:1532.
2. Myers E., O'Grady P., Dolan A.M. The influence of preclinical anaemia on outcome following total hip replacement. Arch Orthop Trauma Surg 2004, 124(10):699.
3. Kaneko K., Kawai K., Tsuno N.H. Perioperative allogeneic blood transfusion is associated with surgical site infection after abdominoperineal resection-a space for the implementation of patient blood management strategies. Int Surg 2015, 100(5):797.
4. Blajchman M.A. Immunomodulatory effects of allogeneic blood transfusions: clinical manifestations and mechanisms. Vox Sang 1998, 74(Suppl 2):315.
5. Callaghan J.J., Spitzer A.I. Blood management and patient specific transfusion options in total joint replacement surgery. Iowa Orthop J 2000, 20:36.
6. Kirkley S.A., Cowles J., Pellegrini V.D., et al. Blood transfusion and total joint replacement surgery: T helper 2 (TH2) cytokine secretion and clinical outcome. Transfus Med 1998, 8(3):195.
7. MacFarlane B.J., Marx L., Anquist K., et al. Analysis of a protocol for an autologous blood transfusion program for total joint replacement surgery. Can J Surg 1988, 31(2):126.
8. De Bonis M., Cavaliere F., Alessandrini F., et al. Topical use of tranexamic acid in coronary artery bypass operations: a double-blind, prospective, randomized, placebo-controlled study. J Thor Cardiovasc Surg 2000, 119(3):575.
9. Kurtz S., Ong K., Lau E., Mowat F., Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am 2007, 89(4):780.
10. Georgiadis A.G., Muh S.J., Silverton C.D., et al. A prospective double-blind placebo controlled trial of topical tranexamic acid in total knee arthroplasty. J Arthroplasty 2013, 28(8 Suppl):78.
11. Alshryda S., Sarda P., Sukeik M., et al. Tranexamic acid in total knee replacement: a systematic review and meta-analysis. J Bone Joint Surg Br 2011, 93(12):1577.
12. Gilbody J., Dhotar H.S., Perruccio A.V., et al. Topical tranexamic acid reduces transfusion rates in total hip and knee arthroplasty. J Arthroplasty 2014, 29:681.
13. Konig G., Hamlin B.R., Waters J.H. Topical tranexamic acid reduces blood loss and transfusion rates in total hip and total knee arthroplasty. J Arthroplasty 2013, 28(9):1473.
14. Chang C.H., C Y., Chen D.W., et al. Topical tranexamic acid reduces blood loss and transfusion rates associated with primary total hip arthroplasty. Clin Orthop Relat Res 2014, 472(5):1552.
15. Hsu C.H., L P., Kuo F.C., et al. A regime of two intravenous injections of tranexamic acid reduces blood loss in minimally invasive total hip arthroplasty: a prospective randomised double-blind study. Bone Joint J 2015, 97-B(7):905.
16. Sukeik M., Alshryda S., Haddad F.S., et al. Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg Br 2011, 93(1):39.
17. Mont M.A., Jacobs J.J. AAOS clinical practice guideline: preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty. J Am Acad Orthop Surg 2011, 19(12):777.
18. Nadler S.B., Hidalgo J.H., Bloch T. Prediction of blood volume in normal human adults. Surgery 1962, 51(2):224.
19. Claeys M.A., Vermeersch N., Haentjens P. Reduction of blood loss with tranexamic acid in primary total hip replacement surgery. Acta Chirurgica Belgica 2007, 107(4):397.
20. Husted H., Blond L., Sonne-Holm S., et al. Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplasty: a prospective randomized double-blind study in 40 patients. Acta Orthop Scand 2003, 74(6):665.
21. Lemay E., Guay J., Cote C., et al. Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement. Can J Anaesth 2004, 51(1):31.
22. Yue C., K P., Yang P., et al. Topical application of tranexamic acid in primary total hip arthroplasty: a randomized double-blind controlled trial. J Arthroplasty 2014, 29(12):2452.
23. Jaszczyk M., Kozerawski D., Kolodziej L., et al. Effect of single preoperative dose of tranexamic acid on blood loss and transfusion in hip arthroplasty. Ortop Traumatol Rehabil 2015, 17(3):265.
24. Wind T.C., Barfield W.R., Moskal J.T. The effect of tranexamic acid on transfusion rate in primary total hip arthroplasty. J Arthroplasty 2014, 29:387.
25. Gillette B.P., DeSimone L.J., Trousdale R.T., et al. Low risk of thromboembolic complications with tranexamic acid after primary total hip and knee arthroplasty. Clin Orthop Relat Res 2013, 471(1):150.
26. Browne J.A., Adib F., Brown T.E., et al. Transfusion rates are increasing following total hip arthroplasty: risk factors and outcomes. J Arthroplasty 2013, 28(8 Suppl):34.
27. Harris R.N., Moskal J., Capps S.G. Does tranexamic acid reduce blood transfusion cost for primary total hip arthroplasty? A case-control study. J Arthroplasty 2015, 30(2):192.
28. Gillette B.P., Maradit Kremers H., Duncan C.M., et al. Economic impact of tranexamic acid in healthy patients undergoing primary total hip and knee arthroplasty. J Arthroplasty 2013, 28(8 Suppl):137.
29. Slover J., Bosco J. Cost analysis of use of tranexamic acid to prevent major bleeding complications in hip and knee arthroplasty surgery. Am J Orthop (Belle Mead NJ) 2014, 43(10):E217.