메뉴 건너뛰기




Volumn 123, Issue 1, 2015, Pages 214-221

Antifibrinolytic Therapy for Cardiac Surgery: An Update

Author keywords

[No Author keywords available]

Indexed keywords

AMINOCAPROIC ACID; ANTIFIBRINOLYTIC AGENT; APROTININ; ECALLANTIDE; LYSINE; MDCO 2010; SERINE PROTEINASE INHIBITOR; TRANEXAMIC ACID; UNCLASSIFIED DRUG;

EID: 84937393992     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000688     Document Type: Review
Times cited : (84)

References (41)
  • 3
    • 31344467254 scopus 로고    scopus 로고
    • The risk associated with aprotinin in cardiac surgery
    • Multicenter Study of Perioperative Ischemia Research Group; Ischemia Research and Education Foundation
    • Mangano DT, Tudor IC, Dietzel C; Multicenter Study of Perioperative Ischemia Research Group; Ischemia Research and Education Foundation: The risk associated with aprotinin in cardiac surgery. N Engl J Med 2006; 354:353-65
    • (2006) N Engl J Med , vol.354 , pp. 353-365
    • Mangano, D.T.1    Tudor, I.C.2    Dietzel, C.3
  • 4
    • 39549100109 scopus 로고    scopus 로고
    • Aprotinin during coronary-artery bypass grafting and risk of death
    • Schneeweiss S, Seeger JD, Landon J, Walker AM: Aprotinin during coronary-artery bypass grafting and risk of death. N Engl J Med 2008; 358:771-83
    • (2008) N Engl J Med , vol.358 , pp. 771-783
    • Schneeweiss, S.1    Seeger, J.D.2    Landon, J.3    Walker, A.M.4
  • 7
    • 84884596241 scopus 로고    scopus 로고
    • Increased perioperative mortality following aprotinin withdrawal: A real-world analysis of blood management strategies in adult cardiac surgery
    • Walkden GJ, Verheyden V, Goudie R, Murphy GJ: Increased perioperative mortality following aprotinin withdrawal: A real-world analysis of blood management strategies in adult cardiac surgery. Intensive Care Med 2013; 39:1808-17
    • (2013) Intensive Care Med , vol.39 , pp. 1808-1817
    • Walkden, G.J.1    Verheyden, V.2    Goudie, R.3    Murphy, G.J.4
  • 10
    • 84874594832 scopus 로고    scopus 로고
    • Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and-aminocaproic acid: A meta-analysis of randomised and observational trials of over 30, 000 patients
    • Meybohm P, Herrmann E, Nierhoff J, Zacharowski K: Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and-aminocaproic acid: A meta-analysis of randomised and observational trials of over 30, 000 patients. PLoS One 2013; 8:e58009
    • (2013) PLoS One , vol.8 , pp. e58009
    • Meybohm, P.1    Herrmann, E.2    Nierhoff, J.3    Zacharowski, K.4
  • 11
    • 84867281693 scopus 로고    scopus 로고
    • Risks of harms using antifibrinolytics in cardiac surgery: Systematic review and network meta-analysis of randomised and observational studies
    • Hutton B, Joseph L, Fergusson D, Mazer CD, Shapiro S, Tinmouth A: Risks of harms using antifibrinolytics in cardiac surgery: Systematic review and network meta-analysis of randomised and observational studies. BMJ 2012; 345:e5798
    • (2012) BMJ , vol.345 , pp. e5798
    • Hutton, B.1    Joseph, L.2    Fergusson, D.3    Mazer, C.D.4    Shapiro, S.5    Tinmouth, A.6
  • 12
    • 84856971781 scopus 로고    scopus 로고
    • A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial)
    • Bokesch PM, Szabo G, Wojdyga R, Grocott HP, Smith PK, Mazer CD, Vetticaden S, Wheeler A, Levy JH: A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial). J Thorac Cardiovasc Surg 2012; 143:1022-9
    • (2012) J Thorac Cardiovasc Surg , vol.143 , pp. 1022-1029
    • Bokesch, P.M.1    Szabo, G.2    Wojdyga, R.3    Grocott, H.P.4    Smith, P.K.5    Mazer, C.D.6    Vetticaden, S.7    Wheeler, A.8    Levy, J.H.9
  • 14
    • 84903303775 scopus 로고    scopus 로고
    • A novel blood-sparing agent in cardiac surgery First in-patient experience with the synthetic serine protease inhibitor MDCO-2010: A phase II, randomized, double-blind, placebo-controlled study in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass
    • Englberger L, Dietrich W, Eberle B, Erdoes G, Keller D, Carrel T: A novel blood-sparing agent in cardiac surgery First in-patient experience with the synthetic serine protease inhibitor MDCO-2010: A phase II, randomized, double-blind, placebo-controlled study in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. Anesth Analg 2014; 119:16-25
    • (2014) Anesth Analg , vol.119 , pp. 16-25
    • Englberger, L.1    Dietrich, W.2    Eberle, B.3    Erdoes, G.4    Keller, D.5    Carrel, T.6
  • 16
    • 84885020989 scopus 로고    scopus 로고
    • The effective concentration of tranexamic acid for inhibition of fibrinolysis in neonatal plasma in vitro
    • Yee BE, Wissler RN, Zanghi CN, Feng C, Eaton MP: The effective concentration of tranexamic acid for inhibition of fibrinolysis in neonatal plasma in vitro. Anesth Analg 2013; 117:767-72
    • (2013) Anesth Analg , vol.117 , pp. 767-772
    • Yee, B.E.1    Wissler, R.N.2    Zanghi, C.N.3    Feng, C.4    Eaton, M.P.5
  • 17
    • 84856082921 scopus 로고    scopus 로고
    • Therapeutic monitoring of tranexamic acid concentration: High-throughput analysis with solidphase microextraction
    • Bojko B, Vuckovic D, Mirnaghi F, Cudjoe E, Wasowicz M, Jerath A, Pawliszyn J: Therapeutic monitoring of tranexamic acid concentration: High-throughput analysis with solidphase microextraction. Ther Drug Monit 2012; 34:31-7
    • (2012) Ther Drug Monit , vol.34 , pp. 31-37
    • Bojko, B.1    Vuckovic, D.2    Mirnaghi, F.3    Cudjoe, E.4    Wasowicz, M.5    Jerath, A.6    Pawliszyn, J.7
  • 18
    • 84887935146 scopus 로고    scopus 로고
    • Population pharmacokinetics of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass
    • Grassin-Delyle S, Tremey B, Abe E, Fischler M, Alvarez JC, Devillier P, Urien S: Population pharmacokinetics of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass. Br J Anaesth 2013; 111:916-24
    • (2013) Br J Anaesth , vol.111 , pp. 916-924
    • Grassin-Delyle, S.1    Tremey, B.2    Abe, E.3    Fischler, M.4    Alvarez, J.C.5    Devillier, P.6    Urien, S.7
  • 19
    • 84875901879 scopus 로고    scopus 로고
    • A practical tranexamic acid dosing scheme based on population pharmacokinetics in children undergoing cardiac surgery
    • Grassin-Delyle S, Couturier R, Abe E, Alvarez JC, Devillier P, Urien S: A practical tranexamic acid dosing scheme based on population pharmacokinetics in children undergoing cardiac surgery. Anesthesiology 2013; 118:853-62
    • (2013) Anesthesiology , vol.118 , pp. 853-862
    • Grassin-Delyle, S.1    Couturier, R.2    Abe, E.3    Alvarez, J.C.4    Devillier, P.5    Urien, S.6
  • 20
    • 84927923934 scopus 로고    scopus 로고
    • Effect of two doses of tranexamic acid on fibrinolysis evaluated by thromboelastography during cardiac surgery: A pilot, prospective, randomised, controlled study
    • Faraoni D, Cacheux C, Van Aelbrouck C, Ickx BE, Barvais L, Levy JH: Effect of two doses of tranexamic acid on fibrinolysis evaluated by thromboelastography during cardiac surgery: A pilot, prospective, randomised, controlled study. Eur J Anaesthesiol 2014; 34:491-8
    • (2014) Eur J Anaesthesiol , vol.34 , pp. 491-498
    • Faraoni, D.1    Cacheux, C.2    Van Aelbrouck, C.3    Ickx, B.E.4    Barvais, L.5    Levy, J.H.6
  • 21
    • 84873120368 scopus 로고    scopus 로고
    • Efficacy of tranexamic acid in paediatric cardiac surgery: A systematic review and meta-analysis
    • Faraoni D, Willems A, Melot C, De Hert S, Van der Linden P: Efficacy of tranexamic acid in paediatric cardiac surgery: A systematic review and meta-analysis. Eur J Cardiothorac Surg 2012; 42:781-6
    • (2012) Eur J Cardiothorac Surg , vol.42 , pp. 781-786
    • Faraoni, D.1    Willems, A.2    Melot, C.3    De Hert, S.4    Van Der Linden, P.5
  • 23
    • 84893909232 scopus 로고    scopus 로고
    • Prospective clinical trial on dosage optimizing of tranexamic acid in non-emergency cardiac surgery procedures
    • Waldow T, Szlapka M, Haferkorn M, Bürger L, Plötze K, Matschke K: Prospective clinical trial on dosage optimizing of tranexamic acid in non-emergency cardiac surgery procedures. Clin Hemorheol Microcirc 2013; 55:457-68
    • (2013) Clin Hemorheol Microcirc , vol.55 , pp. 457-468
    • Waldow, T.1    Szlapka, M.2    Haferkorn, M.3    Bürger, L.4    Plötze, K.5    Matschke, K.6
  • 25
    • 76249100902 scopus 로고    scopus 로고
    • High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients
    • Murkin JM, Falter F, Granton J, Young B, Burt C, Chu M: High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg 2010; 110:350-3
    • (2010) Anesth Analg , vol.110 , pp. 350-353
    • Murkin, J.M.1    Falter, F.2    Granton, J.3    Young, B.4    Burt, C.5    Chu, M.6
  • 26
    • 77955117750 scopus 로고    scopus 로고
    • Mortality associated with administration of highdose tranexamic acid and aprotinin in primary open-heart procedures: A retrospective analysis
    • Sander M, Spies CD, Martiny V, Rosenthal C, Wernecke KD, von Heymann C: Mortality associated with administration of highdose tranexamic acid and aprotinin in primary open-heart procedures: A retrospective analysis. Crit Care 2010; 14:R148
    • (2010) Crit Care , vol.14 , pp. R148
    • Sander, M.1    Spies, C.D.2    Martiny, V.3    Rosenthal, C.4    Wernecke, K.D.5    Von Heymann, C.6
  • 27
    • 84871199216 scopus 로고    scopus 로고
    • Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: Incidence and clinical outcome
    • Koster A, Börgermann J, Zittermann A, Lueth JU, Gillis-Januszewski T, Schirmer U: Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: Incidence and clinical outcome. Br J Anaesth 2013; 110:34-40
    • (2013) Br J Anaesth , vol.110 , pp. 34-40
    • Koster, A.1    Börgermann, J.2    Zittermann, A.3    Lueth, J.U.4    Gillis-Januszewski, T.5    Schirmer, U.6
  • 28
    • 84888297898 scopus 로고    scopus 로고
    • Comparison of-aminocaproic acid and tranexamic acid in thoracic aortic surgery: Clinical efficacy and safety
    • Makhija N, Sarupria A, Kumar Choudhary S, Das S, Lakshmy R, Kiran U: Comparison of-aminocaproic acid and tranexamic acid in thoracic aortic surgery: Clinical efficacy and safety. J Cardiothorac Vasc Anesth 2013; 27:1201-7
    • (2013) J Cardiothorac Vasc Anesth , vol.27 , pp. 1201-1207
    • Makhija, N.1    Sarupria, A.2    Kumar Choudhary, S.3    Das, S.4    Lakshmy, R.5    Kiran, U.6
  • 31
    • 84895486195 scopus 로고    scopus 로고
    • Tranexamic acid impairs-aminobutyric acid receptor type A-mediated synaptic transmission in the murine amygdala: A potential mechanism for drug-induced seizures
    • Kratzer S, Irl H, Mattusch C, Bürge M, Kurz J, Kochs E, Eder M, Rammes G, Haseneder R: Tranexamic acid impairs-aminobutyric acid receptor type A-mediated synaptic transmission in the murine amygdala: A potential mechanism for drug-induced seizures? Anesthesiology 2014; 120:639-49
    • (2014) Anesthesiology , vol.120 , pp. 639-649
    • Kratzer, S.1    Irl, H.2    Mattusch, C.3    Bürge, M.4    Kurz, J.5    Kochs, E.6    Eder, M.7    Rammes, G.8    Haseneder, R.9
  • 33
    • 84892804137 scopus 로고    scopus 로고
    • The association between tranexamic acid and convulsive seizures after cardiac surgery: A multivariate analysis in 11, 529 patients
    • Sharma V, Katznelson R, Jerath A, Garrido-Olivares L, Carroll J, Rao V, Wasowicz M, Djaiani G: The association between tranexamic acid and convulsive seizures after cardiac surgery: A multivariate analysis in 11, 529 patients. Anaesthesia 2014; 69:124-30
    • (2014) Anaesthesia , vol.69 , pp. 124-130
    • Sharma, V.1    Katznelson, R.2    Jerath, A.3    Garrido-Olivares, L.4    Carroll, J.5    Rao, V.6    Wasowicz, M.7    Djaiani, G.8
  • 34
    • 84866065917 scopus 로고    scopus 로고
    • Tranexamic acid for the treatment of heavy menstrual bleeding: Efficacy and safety
    • Leminen H, Hurskainen R: Tranexamic acid for the treatment of heavy menstrual bleeding: Efficacy and safety. Int J Womens Health 2012; 4:413-21
    • (2012) Int J Womens Health , vol.4 , pp. 413-421
    • Leminen, H.1    Hurskainen, R.2
  • 36
    • 84911003585 scopus 로고    scopus 로고
    • A prospective observational study of seizures after cardiac surgery using continuous EEG monitoring
    • Gofton TE, Chu MW, Norton L, Fox SA, Chase L, Murkin JM, Young GB: A prospective observational study of seizures after cardiac surgery using continuous EEG monitoring. Neurocrit Care 2014; 21:220-7
    • (2014) Neurocrit Care , vol.21 , pp. 220-227
    • Gofton, T.E.1    Chu, M.W.2    Norton, L.3    Fox, S.A.4    Chase, L.5    Murkin, J.M.6    Young, G.B.7
  • 37
    • 30944448194 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of-aminocaproic acid for reducing blood loss in coronary artery bypass grafting surgery
    • quiz A44-5
    • Kikura M, Levy JH, Tanaka KA, Ramsay JG: A double-blind, placebo-controlled trial of-aminocaproic acid for reducing blood loss in coronary artery bypass grafting surgery. J Am Coll Surg 2006; 202:216-22; quiz A44-5
    • (2006) J Am Coll Surg , vol.202 , pp. 216-222
    • Kikura, M.1    Levy, J.H.2    Tanaka, K.A.3    Ramsay, J.G.4
  • 38
    • 67650687046 scopus 로고    scopus 로고
    • The effect of-aminocaproic acid and aprotinin on fibrinolysis and blood loss in patients undergoing primary, isolated coronary artery bypass surgery: A randomized, double-blind, placebo-controlled, noninferiority trial
    • Greilich PE, Jessen ME, Satyanarayana N, Whitten CW, Nuttall GA, Beckham JM, Wall MH, Butterworth JF: The effect of-aminocaproic acid and aprotinin on fibrinolysis and blood loss in patients undergoing primary, isolated coronary artery bypass surgery: A randomized, double-blind, placebo-controlled, noninferiority trial. Anesth Analg 2009; 109:15-24
    • (2009) Anesth Analg , vol.109 , pp. 15-24
    • Greilich, P.E.1    Jessen, M.E.2    Satyanarayana, N.3    Whitten, C.W.4    Nuttall, G.A.5    Beckham, J.M.6    Wall, M.H.7    Butterworth, J.F.8
  • 39
    • 84872138094 scopus 로고    scopus 로고
    • Comparison of different doses of-aminocaproic acid in children for tetralogy of Fallot surgery: Clinical efficacy and safety
    • Sarupria A, Makhija N, Lakshmy R, Kiran U: Comparison of different doses of-aminocaproic acid in children for tetralogy of Fallot surgery: Clinical efficacy and safety. J Cardiothorac Vasc Anesth 2013; 27:23-9
    • (2013) J Cardiothorac Vasc Anesth , vol.27 , pp. 23-29
    • Sarupria, A.1    Makhija, N.2    Lakshmy, R.3    Kiran, U.4
  • 41
    • 84901652434 scopus 로고    scopus 로고
    • Increased recombinant activated factor VII use and need for surgical reexploration following a switch from aprotinin to-aminocaproic acid in infant cardiac surgery
    • Scott JP, Costigan DJ, Hoffman GM, Simpson PM, Dasgupta M, Punzalan R, Berens RJ, Tweddell JS, Stuth EA: Increased recombinant activated factor VII use and need for surgical reexploration following a switch from aprotinin to-aminocaproic acid in infant cardiac surgery. J Clin Anesth 2014; 26:204-11
    • (2014) J Clin Anesth , vol.26 , pp. 204-211
    • Scott, J.P.1    Costigan, D.J.2    Hoffman, G.M.3    Simpson, P.M.4    Dasgupta, M.5    Punzalan, R.6    Berens, R.J.7    Tweddell, J.S.8    Stuth, E.A.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.