The importance of early treatment with tranexamic acid in bleeding trauma patients: An exploratory analysis of the CRASH-2 randomised controlled trial

The Lancet

Volumn 377, Issue 9771, 2011, Pages

  Olldashi, Fatos ^a,je   Kerçi, Mihal ^a   Zhurda, Tefik ^a   Ruçi, Klotilda ^a   Banushi, Arben ^b   Traverso, Mario Sardón ^c   Jiménez, Juan ^c   Balbi, Jorge ^d   Dellera, Christian ^e   Svampa, Silvana ^f   Quintana, Gustavo ^g   Piñero, Gustavo ^e   Teves, Jorge ^e   Seppelt, Ian ^h   Mountain, David ⁱ   Balogh, Zsolt ^j   Zaman, Maniruz ^k   Druwé, Patrick ^l   Rutsaert, Robert ^l   Mazairac, Guy ^m   Pascal, Fogang ^n,t   Yvette, Zognou ⁿ   Chancellin, Djeuchon ⁿ   Okwen, Patrick ^o   Djokam Liapoe, Jules ^p   Jangwa, Ernest ^q   Mbuagbaw, Lawrence ^r   Fointama, Ninying ^s   Baillie, Frank ^u   Jiang, Ji Yao ^v   Gao, Guo Yi ^v   Bao, Yin Hui ^v   Morales, Carlos ^w   Sierra, Juan ^w   Naranjo, Santiago ^w   Correa, Camilo ^w   Gómez, Carolina ^w   Herrera, Jorge ^x   Caicedo, Liliana ^x   Rojas, Alexei ^x   Pastas, Henry ^x   Miranda, Hugo ^x   Constaín, Alfredo ^y   Perdomo, Mayla ^y   Muñoz, Diego ^y   Duarte, Álvaro ^y   Vásquez, Edwin ^y   Ortiz, Camilo ^z   Ayala, Bernardo ^z   Delgado, Hernán ^z,aj   Benavides, Gloria ^z   Rosero, Lorena ^z   Mejía Mantilla, Jorge ^aa   Varela, Ana ^aa   Calle, Maríaisabel ^aa   Castillo, José ^aa   García, Alberto ^aa   Ciro, Juan ^ab   Villa, Clara ^ab   Panesso, Roberto ^ab   Flórez, Luz ^ac   Gallego, Argemiro ^ac   Puentes Manosalva, Fabián ^ad   Medina, Leonor ^ad   Márquez, Kelly ^ad   Romero, Adalgiza Reyes ^ae   Hernández, Ricardo ^ae   Martínez, Julio ^ae   Gualteros, Wilson ^af   Urbina, Zulma ^ag   Velandia, Julio ^ag   Benítez, Federico ^ah   Trochez, Adolfo ^ah   Villarreal, Andrés ^ai   Pabón, Pamela ^ai   López, Héctor ^ak   Quintero, Laureano ^al   Rubiano, Andrés ^am   Tamayo, Juan ^an   Piñera, Marjoris ^ao   Martínez, Daimi ^ap   Martínez, Heriberto ^ap   Casola, Eugenio ^aq   Domínguez, Mario ^ar   Herrera, Carlos ^ar   Iraola, Marcos ^as   Rojas, Omar ^as   Pastrana, Irene ^at   Rodríguez, Daniel ^at   De La Campa, Sergio Álvarez ^at   Fortún, Thorvald ^au   Larrea, Martha ^av   Aragón, Lensky ^aw   Madrazo, Aida ^ax   Svoboda, Petr ^ay   Izurieta, Mario ^az   Daccach, Alberto ^az   Altamirano, Mónica ^az   Ortega, Antonio ^az   Cárdenas, Bolívar ^az   González, Luis ^az   Ochoa, Marcelo ^ba   Ortega, Fernando ^ba   Quichimbo, Fausto ^ba   Guiñanzaca, Jenny ^ba   Zavala, Ines ^e   Segura, Sayra ^e   Jerez, Johnny ^bb   Acosta, Daniel ^bc   Yánez, Fabián ^e   Camacho, Rubén ^bd   Khamis, Hussein ^be   Shafei, Hossam ^be   Kheidr, Ali ^be   Nasr, Hani ^be   Mosaad, Moetaz ^be   Rizk, Safwat ^be   El Sayed, Hesham ^bf   Moati, Taha ^bf   Hokkam, Emad ^bf   Amin, Mamdouh ^bg   Lowis, Hany ^bg   Fawzy, Medhat ^bg   Bedir, Nabil ^bg   Aldars, Mohamed ^bg   Rodríguez, Virginia ^bh   Tobar, Juan ^bh   Alvarenga, Jorge ^bh   Shalamberidze, Budu ^bi   Demuria, Elza ^bi   Rtveliashvili, Nikoloz ^bi   Chutkerashvili, Gocha ^bi   Dotiashvili, David ^bi   Gogichaishvili, Tamar ^bj   Ingorokva, George ^bj   Kazaishvili, David ^bj   Melikidze, Besik ^bj   Iashvili, Natia ^bj   Tomadze, Gia ^bk   Chkhikvadze, Manana ^bk   Khurtsidze, Leri ^bk   Lomidze, Zviad ^bk   Dzagania, Diana ^bk   Kvachadze, Nikoloz ^bl   Gotsadze, Giorgi ^bl   Kaloiani, Vakhtang ^bl   Kajaia, Nino ^bm   Dakubo, Jonathan ^bn   Naaeder, Simon ^bn   Sowah, Priscilla ^bn   Yusuf, Adamu ^bo   Ishak, Alhaji ^bo   Selasi Sefenu, Paul ^bp   Sibiri, Ballu ^bq   Sarpong Peprah, Sampson ^br   Boro, Theodore ^bs   Bopaiah, Kanjithanda ^bt   Shetty, Kishore ^bt   Subbiah, Raja ^bt   Mulla, Lukman ^bt   Doshi, Anand ^bt   Dewan, Yashbir ^bu   Grewal, Sarvpreet ^bu   Tripathy, Pradipta ^bu   Mathew, Jacob ^bu   Gupta, Bharat ^bu   Lal, Anil ^bv,cg,da   Choudhury, Majulie ^bv   Gupta, Sanjay ^bw,cm   Gupta, Smita ^bw   Chug, Arun ^bw   Pamidimukkala, Venkataramana ^bx   Jagannath, Palaniappan ^bx   Maharaj, Mohan ^bx   Vommi, Ramaraju ^bx   Gudipati, Naresh ^bx   Chhang, W H ^by   Patel, Pankaj ^bz   Suthar, Nilay ^bz   Banker, Deepa ^bz   Patel, Jyotish ^bz   Dharap, Satish ^ca   Kamble, Ranjeet ^ca   Patkar, Shraddha ^ca   Lohiya, Sushil ^ca   Saraf, Rakesh ^cb   Kumar, Dinesh ^cb   Parihar, Satish ^cb   Gupta, Rahul ^cb   Mangual, Rasananda ^cc   Alagumuthu, ^cc   Kooper, Don ^cc   Mohapatra, Chinmaya ^cc   David, Suresh ^cd   Rajaleelan, Wesley ^cd   Appas, ^cd   Pangi, Ashok ^ce   Saraf, Vivek ^ce   Chikareddy, Santhosh ^ce   Mankar, Sushil ^cf   Golhar, Anil ^cf   Sakhare, Rahul ^cf   Wagh, Nilesh ^cf   Hazarika, Dhiman ^cg   Chaudhuri, Pratyush ^ch   Ketan, Prakash ^ci   Purohit, Govindbhai ^cj   Purohit, Yogesh ^cj   Pandya, Mandakini ^cj   Gupta, Rakesh ^ck   Kiran, Shashi ^ck   Walia, Saurab ^ck   Goyal, Sonam ^cl   Goyal, Sidhant ^cl   Goyal, Satish ^cl   Attri, Ashok ^cm   Sharma, Rajeev ^cm   Oberai, Ashok ^cn   Oberai, Mahesh ^cn   Oberoi, Supriya ^cn   Tripathi, Gajendra Kant ^co   Peettakkandy, Vijayan ^cp   Karuthillath, Premkumar ^cp   Vadakammuriyil, Pavithran ^cp   Pol, Jalindar ^cq   Pol, Sunita ^cq   Saste, Manisha ^cq   Raul, Subrat ^cr   Tiwari, Shashi ^cr   Nelly, Neileino ^cr   Chidambaram, M ^cs   Kollengode, Viswanathan ^ct   Thampan, Sam ^ct   Rajan, Sunder ^cu   Rajan, Sushrut ^cu   Raju, Subodh ^cv   Sharma, Renuka ^cv   Babu, Subbiah Venkatesh ^cw   Sumathi, Chellappa ^cw   Chatterjee, Protyush ^cx   Agarwal, Alok ^cx   Magar, Hemant ^cy   Magar, Meera ^cy   Singh, Manmohan ^cz   Gupta, Deepak ^cz   Haloi, Kamal ^da   Sagdeo, Varsha ^db   Giri, Pramod ^db   Verma, Nimesh ^dc   Jariwala, Ravi ^dc   Goti, Ashish ^dc   Prabhu Gaonkar, Aman ^dd   Utagi, Sagar ^dd   Joshi, Mahesh ^de   Agrawal, Ruchit ^de   Sharma, Gopal ^df   Saini, Gurvinder ^df   Tewari, Vinod ^dg   Yadav, Yad ^dh   Parihar, Vijay ^dh   Venkataramana, Neelam ^di   Rao, Shailesh ^di   Reddy, Narayana ^dj   Hathila, Virsing ^dk   Das, Vithal ^dl   Agaja, Kantibhai ^dm   Purohit, Aniruddh ^dn   Lahari, Akilesh ^do   Bhagchandani, Rajesh ^dp   Vidyasagar, Bala ^e   Sachan, P K ^dq   Das, Tanmoy ^dr   Vyas, Sharad ^ds   Bhattacharjee, Sujoy ^dt   Sancheti, Parag ^du   Manoj, T ^dv   Moideen, Mubarak ^dw   Pansey, Kailash ^dx   Chandrasekaran, V P ^dy   Saikia, Kabul ^dz   Tata, Hoshedar ^ea   Vhora, Sanjay ^e   Shah, Aniket ^eb,et   Rangad, Gordon ^ec   Rajasekaran, S ^ed   Shankarlal, S T ^ee   Devadoss, Sathish ^ef   Saleem, M ^eg   Pillay, Haroon ^eh   Hazarika, Zulfiquer ^ei   Deshmukh, Parikshit ^ej   Murugappan, S P ^ek   Jaiswal, Amit ^el   Vangani, Deepak ^em   Modha, Prakash ^en   Chonzik, Chawngrolien ^eo   Praveen, Megha ^ep   Sethurayar, Vijaya ^eq   Ipe, Sojan ^er   Shetty, Naresh ^es   Gupta, R P ^eu   Jain, Vinod ^ev   Shah, Ketan ^ew   Dwikoryanto, Moch ^ex   Golden, Nyoman ^ey   Atmadjaya, Kuning ^ey   Wiargitha, Ketut ^ey   Sudiasa, Ketut ^ey   Suwedagatha, Gede ^ey   Bal'Afif, Farhad ^ez   Budipramana, Vicky ^fa   Tabrani, ^fa   Lemuel, Agung ^fa   Chandra, Susilo ^fb   Ama, Faisol ^fc   Sherafatkazemzadeh, Ehsan ^fd   Moradi, Ehsan ^fd   Sheikhi, Alireza ^fd   Ziaee, Ali ^fe   Fanaei, Ahmad ^fe   Hajinasrollah, Esmaeil ^ff   Heidari, Kamran ^fg   Mohammad, Bassim ^fh   Hadi, Najah ^fh   Perone, Giovanna ^fi   De Peri, Elena ^fi   Volpi, Annalisa ^fj   Johnson, Jean ^fk   Abe, Masayoshi ^fl   Mutiso, Vincent ^fm   Okanga, Benjamin ^fm   Ojuka, Daniel ^fn   Abdullah, Baharudin ^fo   Rahman, Hishamuddin ^fo   Noh, Yazid ^fo   Jamaluddin, Sabariah ^fp   Dawal, Hasnah ^fp   Roslani, April ^fq   Law, Chee Wei ^fq   Devashanti, P ^fq   Wahab, Yusof ^fr   Velaiutham, Shanta ^fr   Dato, Ridzuan ^fs   Loría, Jorge ^ft   Montes, Erandy ^ft   Gómez, Eduardo ^ft   Cazales, Víctor ^ft   Bautista, Paúl ^ft   Bautista, Raúl ^fu   Ahumada, David ^fu   Hernández, Edwin ^fu   Velásquez, Germahin ^fu   Ortega, Patricia ^e   Lira, Gabriel ^e   Estrada, Francisco ^e   Martínez, Jorge ^fv   Martínez, Juan ^fw   Casasola, Julio ^e   Olaomi, Oluwole ^fx   Abubakar, Yari ^fx   Apollo, Kanati ^fx   Badejo, Olawale ^fx   Ihekire, Ogemdi ^fx   Iribhogbe, Pius ^fy   Oludiran, Olugbenga ^fy   Obeta, Emmanuel ^fy   Okojie, Collins ^fy   Udefiagbon, Ernest ^fy   Komolafe, Edward ^fz   Olaleye, Patrick ^fz   Uzochukwu, Tochukwu ^fz   Onakpoya, Uvie ^fz   Dongo, Andrew ^ga   Thanni, Lateef ^gb   Afolabi, Adefemi ^gc   Akinola, Titilade ^gc   Ademola, Adeyinka ^gc   Akute, Olusola ^gc   Khalid, Lawal ^gd   Abubakar, Lawal ^gd   Aminu, Muhammad ^gd   Ogirima, Mike ^gd   Attansey, Ambrose ^ge   Michael, Durodola ^ge   Aremu, Olaniran ^ge   Olugbenga, Odebode ^gf   Ukpong, Udoffa ^gf   Salman, Yusuf ^gf   Obianyo, Nene ^gg   Ani, Chinenye ^gg   Ezeadawi, Roderick ^gg   Kehinde, Oluwadiya ^gh   Olaide, Agodirin ^gh   Jogo, Andrea ^gi   Bitto, Terna ^gi   Anyanwu, Stanley ^gj   Mbonu, Okechukwu ^gj   Oludara, Mobolaji ^gk   Somoye, Michael ^gk   Shehu, Bello ^gl   Ismail, Nasir ^gl   Katchy, Amechi ^gm   Ndoma Egba, Rowland ^gn   Grace Inah, Ngim ^gn   Songden, Zumnan ^go   Abdulraheem, Abdulrahman ^go   Otu, Akpan ^gp   Nottidge, Timothy ^gp   Inyang, Domingo ^gq   Idiapho, David ^gq   Giebel, Herb ^gr   Hassan, Ramatu ^gs   Adisa, Adeyinka ^gt   Akinkuolie, Akinbolaji ^gu   Okam, Kalu ^gq   Musa, Abubakar ^gv   Falope, Ignatius ^gw   Eze, John ^gx   Caballero, José ^gy   Azabache, Wenceslao ^gy   Salirrosas, Oscar ^gy   Soto, Alonso ^gz   Torres, Elfi ^gz   Ramírez, Gloria ^gz   Pérez, Mónica ^gz   Malca, Cesar ^ha   Velez, Juan ^hb   Yepez, Raul ^hc   Yupanqui, Hernan ^hd   Lagos, Pedro ^he   Rodriguez, Diana ^hf   Flores, Jorge ^hg   Moya, Anselmo ^hh   Barrionuevo, Alejandro ^hi   Gonzales Portillo, Marco ^hj   Núñez, Edgar ^hk   Eldawlatly, Abdelazeem ^hl   Al Naami, Mohammed ^hl   Delvi, Bilal ^hl   Alyafi, Walid ^hm   Djurovic, Branko ^hn   Ng, Ivan ^ho   Yaghi, Aktham ^hp   Laincz, Anton ^hq   Trenkler, Stefan ^hr   Valky, Jozef ^hs   Modiba, Mphako ^ht   Legodi, Peter ^ht   Rangaka, Thomas ^ht   Wallis, Lee ^hu   Muñoz, Ángeles ^hv   Serrano, Ana ^hw   Marcos, Pilar ^hx   Rubi, Martin ^hy   De La Torre, Victoria ^hz   Ellawala, Ranjith ^ia   Wijeratna, Samitha ^ia   Gunaratna, Lukshrini ^ia   Wijayanayaka, Crishantha ^ia   Nungu, Kitugi ^ib   Haonga, Billy ^ib   Mtapa, Grenda ^ib   Yutthakasemsunt, Surakrant ^ic   Kittiwattanagul, Warawut ^ic   Piyavechvirat, Parnumas ^ic   Impool, Tawatcahi ^ic   Thummaraj, Santipong ^ic   Salaeh, Rusta ^id   Tangchitvittaya, Sakchai ^ie   Wattanakrai, Kamol ^if   Jiravongbunrod, Teerasak ^if   Soonthornthum, Chatchai ^if   Meephant, Surasak ^ig   Subsompon, Pusit ^ih   Pensuwan, Phaiboon ⁱⁱ   Chamnongwit, Wicheanrat ^ij   Jerbi, Zouheir ^ik   Cherif, Abderraouef ^ik   Nash, Mark ^il   Harris, Tim ^im   Banerjee, Jay ⁱⁿ   Freij, Ramzi ^io   Kendall, Jason ^ip   Moore, Stephen ^iq   Townend, William ^ir   Cottingham, Rowland ^is   Becker, Dan ^it   Lloyd, Stuart ^iu   Burdett Smith, Peter ^iv   Mirza, Kazim ^iw   Webster, Andrew ^ix   Brady, Suzanne ^iy   Grocutt, Amanda ^iy   Thurston, John ^iz   Lecky, Fiona ^ja   Goodacre, Steve ^jb   Mulla, Yakub ^jc   Sakala, Dennis ^jc   Chengo, Charles ^jd   more..

^a National Trauma Centre Hospital   (United Kingdom)

^b Spitali Civil Durres   (United Kingdom)

^c Hospital Ángel Cruz Padilla   (Argentina)

^d Hospital Regional Rio Grande   (Argentina)

^e Hospital 4 de Junio Dr Ramon Carrillo ^*  (Mexico)

^f Hospital Castro Rendon   (Argentina)

^g HOSPITAL SAN MARTÍN   (Argentina)

^h NEPEAN HOSPITAL   (Australia)

ⁱ SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^j JOHN HUNTER HOSPITAL   (Australia)

^k United Hospital Limited   (Bangladesh)

^l Nursing Institute Sint Vincentius   (Belgium)

^m Centre Hospitalier Regional de Namur   (Belgium)

ⁿ Tombel District Hospital   (Cameroon)

^o St Theresa's Catholic Medical Centre   (United Kingdom)

^p Bamenda Provincial Hospital   (Cameroon)

^q Bali District Hospital   (Indonesia)

^r Bafut District Hospital   (Cameroon)

^s Fundong District Hospital   (Cameroon)

^t St John of God Medical Centre   (Australia)

^u HAMILTON GENERAL HOSPITAL   (Canada)

^v SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^w UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^x Hospital Universitario San José   (Colombia)

^y HOSPITAL PABLO TOBÓN URIBE   (Colombia)

^z Hospital San Andrés de Tumaco   (Colombia)

^aa FUNDACIÓN VALLE DEL LILI   (Colombia)

^ab Clinica Las Americas   (United States)

^ac Hospital General de Medellin Luz Castro de Gutierrez ESE   (Colombia)

^ad Hospital San Felix ESE   (Colombia)

^ae Hospital Universitario del Caribe   (Colombia)

^af Hospital Universitario San Jorge   (Colombia)

^ag Hospital San Rafael   (Colombia)

^ah Clínica La Estancia SA   (Colombia)

^ai Fundacion Hospital San Jose de Buga   (Colombia)

^aj Hospital Civil de Ipiales   (Colombia)

^ak Hospital Universitário Departamental Nariño   (Colombia)

^al Hospital Universitario del Valle   (Colombia)

^am Hospital Universitario de Neiva   (Colombia)

^an Hospital Manuel Uribe Angel   (Colombia)

^ao Hospital Clínico Quirúrgico Docente Saturnino Lora   (Cuba)

^ap Hospital General Universitario Carlos Manuel de Cespedes   (Cuba)

^aq Hospital Provincial Docente Manuel Ascunce Domenech   (Cuba)

^ar Hospital Universitario Arnaldo Milián Castro   (Cuba)

^as Hospital Universitario Dr Gustavo Aldereguia Lima   (Cuba)

^at Hospital Abel Santamaria Cuadrado   (Cuba)

^au Hospital Miguel Enriquez   (Cuba)

^av HOSPITAL UNIVERSITARIO GENERAL CALIXTO GARCÍA   (Cuba)

^aw Hospital Antonio Luaces Iraola   (Cuba)

^ax Hospital Provincial Docente VI Lenin   (Cuba)

^ay Research Institute for Special Surgery and Trauma   (Czech Republic)

^az HOSPITAL LUIS VERNAZA   (Ecuador)

^ba Hospital Jose Carrasco Arteaga   (Ecuador)

^bb Hospital Naval Guayaquil   (Ecuador)

^bc Hospital Alcivar   (Ecuador)

^bd Clínica De Especialidades Medicas San Gregorio   (Ecuador)

^be Mataria Teaching Hospital   (Egypt)

^bf SUEZ CANAL UNIVERSITY   (Egypt)

^bg Aswan Chest Hospital   (Egypt)

^bh Hospital Nacional Rosales   (El Salvador)

^bi Tbilisi State University Clinical Hospital i Javakhishvili   (Georgia)

^bj Tbilisi First Hospital   (Georgia)

^bk Tbilisi City Hospital 1   (Georgia)

^bl TBILISI STATE MEDICAL UNIVERSITY   (Georgia)

^bm Institute of Critical Care Medicine   (Georgia)

^bn KORLE BU TEACHING HOSPITAL   (Ghana)

^bo Nyinahin Government Hospital   (Ghana)

^bp Sogakope District Hospital   (Ghana)

^bq Methodist Hospital Wenchi   (Ghana)

^br Effia Nkwanta Regional Hospital   (Ghana)

^bs Saint Theresa's Hospital   (India)

^bt Medical Trust Hospital Kochi   (Ghana)

^bu CHRISTIAN MEDICAL COLLEGE   (India)

^bv Aditya Neuroscience Centre   (India)

^bw Sri Sai Hospital   (India)

^bx CARE Hospital   (India)

^by North Bengal Neuro Research Centre   (India)

^bz Sheth VS General Hospital and NHL Municipal College   (India)

^ca LTM Medical College and General Hospital   (India)

^cb Government Medical College and Associated Hospitals Jammu   (India)

^cc MKCG Medical College   (India)

^cd CHRISTIAN MEDICAL COLLEGE   (India)

^ce KLE Hospital and Medical Research Centre   (India)

^cf NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital   (India)

^cg Sanjivani Diagnostics and Hospital   (India)

^ch Parkar Hospital   (India)

^ci Jeevan Jyoti Hospital and Research Centre   (India)

^cj Mansarovar Hospital   (India)

^ck Postgraduate Institute of Medical Science Rohtak   (India)

^cl Goyal Hospital Jalna   (India)

^cm GOVERNMENT MEDICAL COLLEGE AND HOSPITAL   (India)

^cn Oberai Hospital   (India)

^co Rajeev Gandhi Memorial Hospital and Research Centre   (India)

^cp GOVERNMENT MEDICAL COLLEGE   (India)

^cq Krishnamai Medical and Research Foundation's NIKOP Hospital   (India)

^cr St Stephen's Hospital   (India)

^cs Government Rajaji Hospital   (India)

^ct GOVERNMENT MEDICAL COLLEGE   (India)

^cu Sanjeevani Hospital   (India)

^cv KAMINENI HOSPITALS   (India)

^cw Sri Sakthi Hospital   (India)

^cx Bhattacharya Orthopaedic and Related Research Centre   (India)

^cy Sushrut Hospital   (India)

^cz GOVERNMENT OF INDIA   (India)

^da GM Hospital (P)   (India)

^db Government Medical College and Superspeciality Hospital Nagpur   (India)

^dc Government Medical College New Civil Hospital   (India)

^dd Chikitsa Hospital   (India)

^de Apollo Health City   (India)

^df Apex Neurotrauma and Superspeciality Hospital   (India)

^dg Neuro Center Gola Ghat   (India)

^dh NSCB MEDICAL COLLEGE   (India)

^di BGS Global Hospital   (India)

^dj CHETTINAD HOSPITAL AND RESEARCH INSTITUTE   (India)

^dk Sir Sayajirao General Hospital and Medical College Baroda   (India)

^dl Goyal Hospital   (India)

^dm Krishna Surgical Hospital and Trauma Care Centre   (India)

^dn NIZAM'S INSTITUTE OF MEDICAL SCIENCES   (India)

^do Niramay Hospital   (India)

^dp Apex Hospital   (India)

^dq HIMALAYAN INSTITUTE OF MEDICAL SCIENCES   (India)

^dr Department of Anesthesiology   (India)

^ds Civil Hospital Gandhinagar   (India)

^dt Sukhdev Raj Soin Hospital   (India)

^du Sancheti Institute for Orthopaedics and Rehabilitation   (India)

^dv ST JAMES S HOSPITAL   (Ireland)

^dw Al Shifa Hospital   (Kuwait)

^dx Anant Institute of Medical Sciences   (India)

^dy VINAYAKA MISSION S RESEARCH FOUNDATION DEEMED TO BE UNIVERSITY   (India)

^dz GAUHATI MEDICAL COLLEGE   (India)

^ea Krishna Hospital and Medical Research Centre   (India)

^eb Shreejee Hospital   (India)

^ec Nazareth Hospital   (India)

^ed GANGA HOSPITAL   (India)

^ee Vadamalayan Hospitals   (India)

^ef Devadoss Multispeciality Hospital   (India)

^eg KIOT Hospital   (India)

^eh Department of Medical Oncology Baby Memorial Hospital   (India)

^ei Bethany Hospital   (India)

^ej Suretech Hospital and Research Centre   (India)

^ek Surya Hospital   (India)

^el Apollo Clinic   (India)

^em FORTIS HOSPITAL   (India)

^en Gokul Hospital and Trauma Centre   (India)

^eo International Hospital Assam   (India)

^ep Lifeline Multispeciality Hospital   (India)

^eq MEENAKSHI MISSION HOSPITAL AND RESEARCH CENTRE   (India)

^er MOSC Medical College Hospital   (India)

^es M S Ramaiah Memorial Hospital   (India)

^et Saykhedkar Hospital and Research Centre   (India)

^eu Shanti Mukand Hospital   (India)

^ev Shri KM Memorial Jain Heart and General Hospital   (India)

^ew Usha Hospital   (India)

^ex Soebandi Hospital Jember   (India)

^ey Sanglah General Hospital   (Indonesia)

^ez Saiful Anwar General Hospital   (Indonesia)

^fa Dr Soetomo General Hospital   (Indonesia)

^fb CIPTO MANGUNKUSUMO HOSPITAL   (Indonesia)

^fc Muhammadiyah Lamongan Hospital   (Indonesia)

^fd SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^fe Erfan Hospital   (Saudi Arabia)

^ff Loqman Medical Center   (United Kingdom)

^fg Imam Hosain Hospital   (Iran)

^fh UNIVERSITY OF AL QADISIYAH   (Iraq)

^fi SPEDALI CIVILI   (Italy)

^fj UNIVERSITY HOSPITAL OF PARMA   (Italy)

^fk UNIVERSITY HOSPITAL OF THE WEST INDIES   (Jamaica)

^fl FUKUOKA UNIVERSITY HOSPITAL   (Japan)

^fm KENYATTA NATIONAL HOSPITAL   (Kenya)

^fn Kapenguria District Hospital   (Kenya)

^fo HOSPITAL UNIVERSITI SAINS MALAYSIA   (Malaysia)

^fp Sungai Buloh Hospital   (Malaysia)

^fq UNIVERSITY MALAYA MEDICAL CENTRE   (Malaysia)

^fr Hospital Tengku Ampuan Rahimah   (Malaysia)

^fs Ampang Hospital   (Malaysia)

^ft Hospital General Regional 25   (Mexico)

^fu Hospital Gustavo Rovirosa   (Mexico)

^fv Hospital General Ecatepec Las Américas   (Mexico)

^fw Hospital General la Perla   (Mexico)

^fx NATIONAL HOSPITAL   (Nigeria)

^fy UNIVERSITY OF BENIN   (Nigeria)

^fz OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

^ga IRRUA SPECIALIST TEACHING HOSPITAL   (Nigeria)

^gb OLABISI ONABANJO UNIVERSITY   (Nigeria)

^gc UNIVERSITY OF IBADAN   (Nigeria)

^gd AHMADU BELLO UNIVERSITY   (Nigeria)

^ge Baptist Medical Centre   (Nigeria)

^gf UNIVERSITY OF ILORIN   (Nigeria)

^gg Enugu State University Teaching Hospital   (Nigeria)

^gh LAUTECH Teaching Hospital   (Nigeria)

^gi Federal Medical Centre Makurdi   (Nigeria)

^gj NNAMDI AZIKIWE UNIVERSITY   (Nigeria)

^gk LAGOS STATE UNIVERSITY TEACHING HOSPITAL   (Nigeria)

^gl USMANU DANFODIYO UNIVERSITY   (Nigeria)

^gm National Orthopaedic Hospital Enugu   (Nigeria)

^gn UNIVERSITY OF CALABAR   (Nigeria)

^go UNIVERSITY OF ABUJA   (Nigeria)

^gp UNIVERSITY OF UYO   (Nigeria)

^gq FEDERAL MEDICAL CENTER   (Nigeria)

^gr Seventh Day Adventist Hospital   (Nigeria)

^gs Federal Medical Centre Birnin Kebbi   (Nigeria)

^gt ABIA STATE UNIVERSITY   (Nigeria)

^gu Wesley Guild Hospital   (Nigeria)

^gv UNIVERSITY OF MAIDUGURI   (Nigeria)

^gw National Orthopaedic Hospital   (Nigeria)

^gx UNIVERSITY OF NIGERIA   (Nigeria)

^gy HOSPITAL REGIONAL DOCENTE DE TRUJILLO   (Peru)

^gz Hospital Nacional Hipólito Unanue   (Peru)

^ha Clinica Santa Ana   (Peru)

^hb Hospital la Caleta   (Peru)

^hc Hospital Nacional Sergio E Bernales   (Peru)

^hd Hospital de Apoyo de Sullana   (Peru)

^he Hospital IV Essalud Huancayo   (Peru)

^hf HOSPITAL NACIONAL ARZOBISPO LOAYZA   (Peru)

^hg Hospital Municipal Los Olivos   (Peru)

^hh Hospital ESSALUD José Cayetano Heredia   (Peru)

^hi Hospital Carlos Alberto Seguin Escobedo   (Peru)

^hj HOSPITAL NACIONAL DOS DE MAYO   (Peru)

^hk HOSPITAL NACIONAL CAYETANO HEREDIA   (Peru)

^hl KING KHALID UNIVERSITY HOSPITAL   (Saudi Arabia)

^hm KING KHALID NATIONAL GUARD HOSPITAL   (Saudi Arabia)

^hn CLINICAL CENTER OF SERBIA   (Serbia)

^ho NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^hp FNsP Ru inov   (Slovakia)

^hq NsP Poprad   (Slovakia)

^hr NsP JA Reiman Hospital   (Slovakia)

^hs Faculty Hospital F D Roosevelta   (Slovakia)

^ht Dr George Mukhari Hospital   (South Africa)

^hu Provincial Hospital   (South Africa)

^hv HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^hw HOSPITAL RAMÓN Y CAJAL   (Spain)

^hx HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^hy HOSPITAL TORRECÁRDENAS   (Spain)

^hz HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^ia NATIONAL HOSPITAL OF SRI LANKA   (Sri Lanka)

^ib Muhimbili Orthopaedic Institute   (Tanzania)

^ic KHON KAEN HOSPITAL   (Thailand)

^id Pattani Hospital   (Thailand)

^ie Suratthani Hospital   (Thailand)

^if BHUMIBOL ADULYADEJ HOSPITAL   (Thailand)

^ig LAMPANG HOSPITAL   (Thailand)

^ih Rayong Hospital   (Thailand)

ⁱⁱ Roi Et Hospital   (Thailand)

^ij Phrae Hospital   (Thailand)

^ik HABIB THAMEUR HOSPITAL   (Tunisia)

^il Department of Diabetes and Endocrinology   (United Kingdom)

^im ROYAL LONDON HOSPITAL   (United Kingdom)

ⁱⁿ LEICESTER ROYAL INFIRMARY   (United Kingdom)

^io NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^ip FRENCHAY HOSPITAL   (United Kingdom)

^iq Roi Et Hospital ^*  (United Kingdom)

^ir HULL ROYAL INFIRMARY   (United Kingdom)

^is ROYAL SUSSEX COUNTY HOSPITAL   (United Kingdom)

^it DERBY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^iu BEDFORD HOSPITAL NHS TRUST   (United Kingdom)

^iv ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^iw O and G   (United Kingdom)

^ix ROYAL LANCASTER INFIRMARY   (United Kingdom)

^iy WORTHING HOSPITAL   (United Kingdom)

^iz DARENT VALLEY HOSPITAL   (United Kingdom)

^ja HOPE HOSPITAL   (United Kingdom)

^jb Northern General Hospital   (United Kingdom)

^jc UNIVERSITY TEACHING HOSPITAL   (Zambia)

^jd Nchanga North General Hospital   (Zambia)

^je LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; TRANEXAMIC ACID;

ADULT; ARTICLE; BLEEDING; BLOOD TRANSFUSION; BLOOD VESSEL OCCLUSION; CONTROLLED STUDY; DEATH; DISEASE SEVERITY; GLASGOW COMA SCALE; HUMAN; INJURY; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; THERAPY EFFECT;

EID: 79953163189     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(11)60278-X     Document Type: Article

References (13)

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3. JH Levy Antifibrinolytic therapy: new data and new concepts Lancet 376 2010 3 4
4. MS Lauer, EH Blackstone, JB Young, EJ Topol Cause of death in clinical research: time for a reassessment? J Am Coll Cardiol 34 1999 618 620 (Pubitemid 29436163)
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8. K Brohi, MJ Cohen, MT Ganter Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis J Trauma 64 2008 1211 1217 (Pubitemid 351671214)
9. JR Hess, K Brohi, RP Dutton, CJ Hauser, JB Holcomb, Y Kluger The coagulopathy of trauma: a review of mechanisms J Trauma 65 2008 748 754
10. A Sawamura, M Hayakawa, S Gando Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortality Thromb Res 1214 2009 608 613
11. CR Prentice Basis of antifibrinolytic therapy J Clin Pathol 33 1980 35 40
12. I Roberts, H Shakur, K Ker, T Coats for the CRASH-2 Trial collaborators Antifibrinolytic drugs for acute traumatic injury Cochrane Database Syst Rev 1 2011 CD004896.
13. NIHR Health Technology Assessment Programme Development and validation of a risk score for trauma patients with haemorrhage http://www.hta.ac.uk/ protocols/200900220165.pdf August 2010 (accessed March 6, 2011).