Influenza A virus virulence depends on two amino acids in the N-terminal domain of its NS1 protein to facilitate inhibition of the RNA-dependent protein kinase PKR

Journal of Virology

Volumn 91, Issue 10, 2017, Pages

  Schierhorn, Kristina L ^a,e   Jolmes, Fabian ^b   Bespalowa, Julia ^c   Saenger, Sandra ^a   Peteranderl, Christin ^c   Dzieciolowski, Julia ^d   Mielke, Maja ^b   Budt, Matthias ^a   Pleschka, Stephan ^d   Herrmann, Andreas ^b   Herold, Susanne ^c   Wolff, Thorsten ^a  

^a ROBERT KOCH INSTITUTE   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e GUY S HOSPITAL   (United Kingdom)

Author keywords

Influenza; Innate immunity; PKR; Virulence regulation

Indexed keywords

NONSTRUCTURAL PROTEIN 1; PROTEIN KINASE; PROTEIN KINASE R; AMINO ACID; INS1 PROTEIN, INFLUENZA VIRUS; VIRAL PROTEIN;

ANISOTROPY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INFLAMMATION; INFLUENZA A VIRUS; PHENOTYPE; PRIORITY JOURNAL; SIMULATION; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; ENZYME ACTIVATION; GENETICS; HOST PATHOGEN INTERACTION; INNATE IMMUNITY; LUNG; METABOLISM; MOUSE; MUTATION; PATHOGENICITY; VIROLOGY; VIRULENCE;

AMINO ACIDS; ANIMALS; CELL LINE; EIF-2 KINASE; ENZYME ACTIVATION; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INFLUENZA A VIRUS; LUNG; MICE; MUTATION; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

EID: 85018279836     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00198-17     Document Type: Article

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