Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

Cell Metabolism

Volumn 25, Issue 6, 2017, Pages 1282-1293.e7

  Angelin, Alessia ^a   Gil de Gómez, Luis ^b   Dahiya, Satinder ^a   Jiao, Jing ^a   Guo, Lili ^b   Levine, Matthew H ^a   Wang, Zhonglin ^a   Quinn, William J ^c   Kopinski, Piotr K ^a,b   Wang, Liqing ^a   Akimova, Tatiana ^a   Liu, Yujie ^a   Bhatti, Tricia R ^a   Han, Rongxiang ^a   Laskin, Benjamin L ^a   Baur, Joseph A ^c   Blair, Ian A ^b   Wallace, Douglas C ^a,c   Hancock, Wayne W ^a   Beier, Ulf H ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

immune regulation; immunometabolism; T cell metabolism

Indexed keywords

CD8 ANTIGEN; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LACTATE DEHYDROGENASE; LACTIC ACID; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRUVATE DEHYDROGENASE; PYRUVIC ACID; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; MYC PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; GLYCOLYSIS; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; LEUKOCYTE METABOLISM; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; OXIDATION; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL; TUMOR MICROENVIRONMENT; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE;

ANIMALS; CELL LINE; CELLULAR MICROENVIRONMENT; CELLULAR REPROGRAMMING; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; GLYCOLYSIS; HUMANS; LACTIC ACID; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OXIDATIVE PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MYC; T-LYMPHOCYTES, REGULATORY;

EID: 85017467396     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.12.018     Document Type: Article

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