-
1
-
-
84928062583
-
Immune checkpoint blockade: A common denominator approach to cancer therapy
-
Topalian, SL, Drake, CG and Pardoll, DM (2015). Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27: 450-461.
-
(2015)
Cancer Cell
, vol.27
, pp. 450-461
-
-
Topalian, S.L.1
Drake, C.G.2
Pardoll, D.M.3
-
2
-
-
0035186913
-
A phage display selected fab fragment with MHC class I-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes
-
Willemsen, RA, Debets, R, Hart, E, Hoogenboom, HR, Bolhuis, RL and Chames, P (2001). A phage display selected fab fragment with MHC class I-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes. Gene Ther 8: 1601-1608.
-
(2001)
Gene Ther
, vol.8
, pp. 1601-1608
-
-
Willemsen, R.A.1
Debets, R.2
Hart, E.3
Hoogenboom, H.R.4
Bolhuis, R.L.5
Chames, P.6
-
3
-
-
84969253943
-
Chimeric antigen receptor T cell therapy: 25 years in the making
-
Epub ahead of print
-
Gill, S, Maus, MV and Porter, DL (2015). Chimeric antigen receptor T cell therapy: 25 years in the making. Blood Rev (Epub ahead of print).
-
(2015)
Blood Rev
-
-
Gill, S.1
Maus, M.V.2
Porter, D.L.3
-
4
-
-
84942899415
-
The evolution of T-cell therapies for solid malignancies
-
Fousek, K and Ahmed, N (2015). The evolution of T-cell therapies for solid malignancies. Clin Cancer Res 21: 3384-3392.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 3384-3392
-
-
Fousek, K.1
Ahmed, N.2
-
5
-
-
82955207691
-
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
-
Louis, CU, Savoldo, B, Dotti, G, Pule, M, Yvon, E, Myers, GD et al. (2011). Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood 118: 6050-6056.
-
(2011)
Blood
, vol.118
, pp. 6050-6056
-
-
Louis, C.U.1
Savoldo, B.2
Dotti, G.3
Pule, M.4
Yvon, E.5
Myers, G.D.6
-
6
-
-
84933513655
-
Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor-modified T cells for the immunotherapy of HER2-positive sarcoma
-
Ahmed, N, Brawley, VS, Hegde, M, Robertson, C, Ghazi, A, Gerken, C et al. (2015). Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor-modified T cells for the immunotherapy of HER2-positive sarcoma. J Clin Oncol 33: 1688-1696.
-
(2015)
J Clin Oncol
, vol.33
, pp. 1688-1696
-
-
Ahmed, N.1
Brawley, V.S.2
Hegde, M.3
Robertson, C.4
Ghazi, A.5
Gerken, C.6
-
7
-
-
84858758766
-
Adoptive immunotherapy for cancer: Harnessing the T cell response
-
Restifo, NP, Dudley, ME and Rosenberg, SA (2012). Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 12: 269-281.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 269-281
-
-
Restifo, N.P.1
Dudley, M.E.2
Rosenberg, S.A.3
-
8
-
-
84923078274
-
Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma
-
Johnson, LA, Scholler, J, Ohkuri, T, Kosaka, A, Patel, PR, McGettigan, SE et al. (2015). Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma. Sci Transl Med 7: 275ra22.
-
(2015)
Sci Transl Med
, vol.7
, pp. 275ra22
-
-
Johnson, L.A.1
Scholler, J.2
Ohkuri, T.3
Kosaka, A.4
Patel, P.R.5
McGettigan, S.E.6
-
9
-
-
84875198775
-
Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma
-
Morgan, RA, Johnson, LA, Davis, JL, Zheng, Z, Woolard, KD, Reap, EA et al. (2012). Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma. Hum Gene Ther 23: 1043-1053.
-
(2012)
Hum Gene Ther
, vol.23
, pp. 1043-1053
-
-
Morgan, R.A.1
Johnson, L.A.2
Davis, J.L.3
Zheng, Z.4
Woolard, K.D.5
Reap, E.A.6
-
10
-
-
44449162630
-
Retargeting of human T cells to tumor-associated MUC1: The evolution of a chimeric antigen receptor
-
Wilkie, S, Picco, G, Foster, J, Davies, DM, Julien, S, Cooper, L et al. (2008). Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor. J Immunol 180: 4901-4909.
-
(2008)
J Immunol
, vol.180
, pp. 4901-4909
-
-
Wilkie, S.1
Picco, G.2
Foster, J.3
Davies, D.M.4
Julien, S.5
Cooper, L.6
-
11
-
-
77954712252
-
Successful eradication of established peritoneal ovarian tumors in SCID-Beige mice following adoptive transfer of T cells genetically targeted to the MUC16 antigen
-
Chekmasova, AA, Rao, TD, Nikhamin, Y, Park, KJ, Levine, DA, Spriggs, DR et al. (2010). Successful eradication of established peritoneal ovarian tumors in SCID-Beige mice following adoptive transfer of T cells genetically targeted to the MUC16 antigen. Clin Cancer Res 16: 3594-3606.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3594-3606
-
-
Chekmasova, A.A.1
Rao, T.D.2
Nikhamin, Y.3
Park, K.J.4
Levine, D.A.5
Spriggs, D.R.6
-
12
-
-
84866653054
-
T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice
-
Chmielewski, M, Hahn, O, Rappl, G, Nowak, M, Schmidt-Wolf, IH, Hombach, AA et al. (2012). T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice. Gastroenterology 143: 1095-107.e2.
-
(2012)
Gastroenterology
, vol.143
, pp. 1095e2-1107e2
-
-
Chmielewski, M.1
Hahn, O.2
Rappl, G.3
Nowak, M.4
Schmidt-Wolf, I.H.5
Hombach, A.A.6
-
13
-
-
79952187823
-
T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis
-
Parkhurst, MR, Yang, JC, Langan, RC, Dudley, ME, Nathan, DA, Feldman, SA et al. (2011). T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis. Mol Ther 19: 620-626.
-
(2011)
Mol Ther
, vol.19
, pp. 620-626
-
-
Parkhurst, M.R.1
Yang, J.C.2
Langan, R.C.3
Dudley, M.E.4
Nathan, D.A.5
Feldman, S.A.6
-
14
-
-
70350772293
-
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia
-
Kenter, GG, Welters, MJ, Valentijn, AR, Lowik, MJ, Berends-van der Meer, DM, Vloon, AP et al. (2009). Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N Engl J Med 361: 1838-1847.
-
(2009)
N Engl J Med
, vol.361
, pp. 1838-1847
-
-
Kenter, G.G.1
Welters, M.J.2
Valentijn, A.R.3
Lowik, M.J.4
Der Berends-Van Meer, D.M.5
Vloon, A.P.6
-
15
-
-
84957059458
-
Mesothelin-targeted CARs driving T cells to solid tumors
-
Morello, A, Sadelain, M and Adusumilli, PS (2016). Mesothelin-targeted CARs: driving T cells to solid tumors. Cancer Discov 6: 133-146.
-
(2016)
Cancer Discov
, vol.6
, pp. 133-146
-
-
Morello, A.1
Sadelain, M.2
Adusumilli, P.S.3
-
16
-
-
84902124061
-
Discovery of mesothelin and exploiting it as a target for immunotherapy
-
Pastan, I and Hassan, R (2014). Discovery of mesothelin and exploiting it as a target for immunotherapy. Cancer Res 74: 2907-2912.
-
(2014)
Cancer Res
, vol.74
, pp. 2907-2912
-
-
Pastan, I.1
Hassan, R.2
-
17
-
-
0031931487
-
Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity
-
Chowdhury, PS, Viner, JL, Beers, R and Pastan, I (1998). Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity. Proc Natl Acad Sci USA 95: 669-674.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 669-674
-
-
Chowdhury, P.S.1
Viner, J.L.2
Beers, R.3
Pastan, I.4
-
18
-
-
84857794017
-
Redirected antitumor activity of primary human lymphocytes transduced with a fully human anti-mesothelin chimeric receptor
-
Lanitis, E, Poussin, M, Hagemann, IS, Coukos, G, Sandaltzopoulos, R, Scholler, N et al. (2012). Redirected antitumor activity of primary human lymphocytes transduced with a fully human anti-mesothelin chimeric receptor. Mol Ther 20: 633-643.
-
(2012)
Mol Ther
, vol.20
, pp. 633-643
-
-
Lanitis, E.1
Poussin, M.2
Hagemann, I.S.3
Coukos, G.4
Sandaltzopoulos, R.5
Scholler, N.6
-
19
-
-
84908891854
-
Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
-
Adusumilli, PS, Cherkassky, L, Villena-Vargas, J, Colovos, C, Servais, E, Plotkin, J et al. (2014). Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity. Sci Transl Med 6: 261ra151.
-
(2014)
Sci Transl Med
, vol.6
, pp. 261ra151
-
-
Adusumilli, P.S.1
Cherkassky, L.2
Villena-Vargas, J.3
Colovos, C.4
Servais, E.5
Plotkin, J.6
-
20
-
-
84866740895
-
Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling
-
Wilkie, S, van Schalkwyk, MC, Hobbs, S, Davies, DM, van der Stegen, SJ, Pereira, AC et al. (2012). Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling. J Clin Immunol 32: 1059-1070.
-
(2012)
J Clin Immunol
, vol.32
, pp. 1059-1070
-
-
Wilkie, S.1
Van Schalkwyk, M.C.2
Hobbs, S.3
Davies, D.M.4
Van Der Stegen, S.J.5
Pereira, A.C.6
-
21
-
-
84996565577
-
Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity
-
Wang, LC, Lo, A, Scholler, J, Sun, J, Majumdar, RS, Kapoor, V et al. (2014). Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. Cancer Immunol Res 2: 154-166.
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 154-166
-
-
Wang, L.C.1
Lo, A.2
Scholler, J.3
Sun, J.4
Majumdar, R.S.5
Kapoor, V.6
-
22
-
-
84878588973
-
Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice
-
Chinnasamy, D, Tran, E, Yu, Z, Morgan, RA, Restifo, NP and Rosenberg, SA (2013). Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice. Cancer Res 73: 3371-3380.
-
(2013)
Cancer Res
, vol.73
, pp. 3371-3380
-
-
Chinnasamy, D.1
Tran, E.2
Yu, Z.3
Morgan, R.A.4
Restifo, N.P.5
Rosenberg, S.A.6
-
23
-
-
66149156276
-
Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment
-
Harlin, H, Meng, Y, Peterson, AC, Zha, Y, Tretiakova, M, Slingluff, C et al. (2009). Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Cancer Res 69: 3077-3085.
-
(2009)
Cancer Res
, vol.69
, pp. 3077-3085
-
-
Harlin, H.1
Meng, Y.2
Peterson, A.C.3
Zha, Y.4
Tretiakova, M.5
Slingluff, C.6
-
24
-
-
79960403269
-
Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor
-
Moon, EK, Carpenito, C, Sun, J, Wang, LC, Kapoor, V, Predina, J et al. (2011). Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor. Clin Cancer Res 17: 4719-4730.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4719-4730
-
-
Moon, E.K.1
Carpenito, C.2
Sun, J.3
Wang, L.C.4
Kapoor, V.5
Predina, J.6
-
25
-
-
77958063691
-
Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b
-
Craddock, JA, Lu, A, Bear, A, Pule, M, Brenner, MK, Rooney, CM et al. (2010). Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b. J Immunother 33: 780-788.
-
(2010)
J Immunother
, vol.33
, pp. 780-788
-
-
Craddock, J.A.1
Lu, A.2
Bear, A.3
Pule, M.4
Brenner, M.K.5
Rooney, C.M.6
-
26
-
-
84976552978
-
Augmentation of CAR T cell trafficking and antitumor efficact by blocking protein kinase A (PKA) localization
-
In press
-
Newick, K, O'Brien, S, Sun, J, Kapoor, V, Maceyko, S, Lo, A et al. (2016). Augmentation of CAR T cell trafficking and antitumor efficact by blocking protein kinase A (PKA) localization. Cancer Immunol Res. In press.
-
(2016)
Cancer Immunol Res.
-
-
Newick, K.1
O'Brien, S.2
Sun, J.3
Kapoor, V.4
Maceyko, S.5
Lo, A.6
-
27
-
-
84907546628
-
Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors
-
Nishio, N, Diaconu, I, Liu, H, Cerullo, V, Caruana, I, Hoyos, V et al. (2014). Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors. Cancer Res 74: 5195-5205.
-
(2014)
Cancer Res
, vol.74
, pp. 5195-5205
-
-
Nishio, N.1
Diaconu, I.2
Liu, H.3
Cerullo, V.4
Caruana, I.5
Hoyos, V.6
-
28
-
-
84943579933
-
T cells engineered with chimeric antigen receptors targeting NKG2D ligands display lethal toxicity in mice
-
VanSeggelen, H, Hammill, JA, Dvorkin-Gheva, A, Tantalo, DG, Kwiecien, JM, Denisova, GF et al. (2015). T cells engineered with chimeric antigen receptors targeting NKG2D ligands display lethal toxicity in mice. Mol Ther 23: 1600-1610.
-
(2015)
Mol Ther
, vol.23
, pp. 1600-1610
-
-
VanSeggelen, H.1
Hammill, J.A.2
Dvorkin-Gheva, A.3
Tantalo, D.G.4
Kwiecien, J.M.5
Denisova, G.F.6
-
29
-
-
84937758074
-
Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
-
Caruana, I, Savoldo, B, Hoyos, V, Weber, G, Liu, H, Kim, ES et al. (2015). Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes. Nat Med 21: 524-529.
-
(2015)
Nat Med
, vol.21
, pp. 524-529
-
-
Caruana, I.1
Savoldo, B.2
Hoyos, V.3
Weber, G.4
Liu, H.5
Kim, E.S.6
-
30
-
-
44449165597
-
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways
-
Jacobs, SR, Herman, CE, Maciver, NJ, Wofford, JA, Wieman, HL, Hammen, JJ et al. (2008). Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol 180: 4476-4486.
-
(2008)
J Immunol
, vol.180
, pp. 4476-4486
-
-
Jacobs, S.R.1
Herman, C.E.2
Maciver, N.J.3
Wofford, J.A.4
Wieman, H.L.5
Hammen, J.J.6
-
31
-
-
34247352844
-
Inhibitory effect of tumor cell-derived lactic acid on human T cells
-
Fischer, K, Hoffmann, P, Voelkl, S, Meidenbauer, N, Ammer, J, Edinger, M et al. (2007). Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109: 3812-3819.
-
(2007)
Blood
, vol.109
, pp. 3812-3819
-
-
Fischer, K.1
Hoffmann, P.2
Voelkl, S.3
Meidenbauer, N.4
Ammer, J.5
Edinger, M.6
-
32
-
-
84919390016
-
Nutrient sensing via mTOR in T cells maintains a tolerogenic microenvironment
-
Howie, D, Waldmann, H and Cobbold, S (2014). Nutrient sensing via mTOR in T cells maintains a tolerogenic microenvironment. Front Immunol 5: 409.
-
(2014)
Front Immunol
, vol.5
, pp. 409
-
-
Howie, D.1
Waldmann, H.2
Cobbold, S.3
-
33
-
-
84935012050
-
Tumor indoleamine 2, 3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs
-
Ninomiya, S, Narala, N, Huye, L, Yagyu, S, Savoldo, B, Dotti, G et al. (2015). Tumor indoleamine 2, 3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs. Blood 125: 3905-3916.
-
(2015)
Blood
, vol.125
, pp. 3905-3916
-
-
Ninomiya, S.1
Narala, N.2
Huye, L.3
Yagyu, S.4
Savoldo, B.5
Dotti, G.6
-
34
-
-
84942626492
-
Genetic regulation of fate decisions in therapeutic T cells to enhance tumor protection and memory formation
-
Veliça, P, Zech, M, Henson, S, Holler, A, Manzo, T, Pike, R et al. (2015). Genetic regulation of fate decisions in therapeutic T cells to enhance tumor protection and memory formation. Cancer Res 75: 2641-2652.
-
(2015)
Cancer Res
, vol.75
, pp. 2641-2652
-
-
Veliça, P.1
Zech, M.2
Henson, S.3
Holler, A.4
Manzo, T.5
Pike, R.6
-
35
-
-
84885055994
-
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
-
Sukumar, M, Liu, J, Ji, Y, Subramanian, M, Crompton, JG, Yu, Z et al. (2013). Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J Clin Invest 123: 4479-4488.
-
(2013)
J Clin Invest
, vol.123
, pp. 4479-4488
-
-
Sukumar, M.1
Liu, J.2
Ji, Y.3
Subramanian, M.4
Crompton, J.G.5
Yu, Z.6
-
36
-
-
0017658218
-
Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell
-
Goodwin, JS, Bankhurst, AD and Messner, RP (1977). Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell. J Exp Med 146: 1719-1734.
-
(1977)
J Exp Med
, vol.146
, pp. 1719-1734
-
-
Goodwin, J.S.1
Bankhurst, A.D.2
Messner, R.P.3
-
37
-
-
50649108394
-
Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression
-
Su, Y, Huang, X, Raskovalova, T, Zacharia, L, Lokshin, A, Jackson, E et al. (2008). Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression. Cancer Immunol Immunother 57: 1611-1623.
-
(2008)
Cancer Immunol Immunother
, vol.57
, pp. 1611-1623
-
-
Su, Y.1
Huang, X.2
Raskovalova, T.3
Zacharia, L.4
Lokshin, A.5
Jackson, E.6
-
38
-
-
84885457151
-
TGF-β: Guardian of T cell function
-
Oh, SA and Li, MO (2013). TGF-β: guardian of T cell function. J Immunol 191: 3973-3979.
-
(2013)
J Immunol
, vol.191
, pp. 3973-3979
-
-
Oh, S.A.1
Li, M.O.2
-
39
-
-
47549090432
-
TGFbeta in cancer
-
Massagué, J (2008). TGFbeta in Cancer. Cell 134: 215-230.
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massagué, J.1
-
40
-
-
52449122955
-
Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers
-
Wallace, A, Kapoor, V, Sun, J, Mrass, P, Weninger, W, Heitjan, DF et al. (2008). Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers. Clin Cancer Res 14: 3966-3974.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3966-3974
-
-
Wallace, A.1
Kapoor, V.2
Sun, J.3
Mrass, P.4
Weninger, W.5
Heitjan, D.F.6
-
41
-
-
0036566184
-
Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity
-
Bollard, CM, Rössig, C, Calonge, MJ, Huls, MH, Wagner, HJ, Massague, J et al. (2002). Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity. Blood 99: 3179-3187.
-
(2002)
Blood
, vol.99
, pp. 3179-3187
-
-
Bollard, C.M.1
Rössig, C.2
Calonge, M.J.3
Huls, M.H.4
Wagner, H.J.5
Massague, J.6
-
42
-
-
84902146901
-
Reversal of tumor immune inhibition using a chimeric cytokine receptor
-
Leen, AM, Sukumaran, S, Watanabe, N, Mohammed, S, Keirnan, J, Yanagisawa, R et al. (2014). Reversal of tumor immune inhibition using a chimeric cytokine receptor. Mol Ther 22: 1211-1220.
-
(2014)
Mol Ther
, vol.22
, pp. 1211-1220
-
-
Leen, A.M.1
Sukumaran, S.2
Watanabe, N.3
Mohammed, S.4
Keirnan, J.5
Yanagisawa, R.6
-
43
-
-
77955503406
-
Selective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4
-
Wilkie, S, Burbridge, SE, Chiapero-Stanke, L, Pereira, AC, Cleary, S, van der Stegen, SJ et al. (2010). Selective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4. J Biol Chem 285: 25538-25544.
-
(2010)
J Biol Chem
, vol.285
, pp. 25538-25544
-
-
Wilkie, S.1
Burbridge, S.E.2
Chiapero-Stanke, L.3
Pereira, A.C.4
Cleary, S.5
Van Der Stegen, S.J.6
-
44
-
-
84890179288
-
Of CARs and TRUCKs: Chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma
-
Chmielewski, M, Hombach, AA and Abken, H (2014). Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma. Immunol Rev 257: 83-90.
-
(2014)
Immunol Rev
, vol.257
, pp. 83-90
-
-
Chmielewski, M.1
Hombach, A.A.2
Abken, H.3
-
45
-
-
84929433571
-
Tumorinfiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma
-
Zhang, L, Morgan, RA, Beane, JD, Zheng, Z, Dudley, ME, Kassim, SH et al. (2015). Tumorinfiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma. Clin Cancer Res 21: 2278-2288.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 2278-2288
-
-
Zhang, L.1
Morgan, R.A.2
Beane, J.D.3
Zheng, Z.4
Dudley, M.E.5
Kassim, S.H.6
-
46
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
Gabrilovich, DI and Nagaraj, S (2009). Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9: 162-174.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 162-174
-
-
Gabrilovich, D.I.1
Nagaraj, S.2
-
47
-
-
84942884570
-
Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity
-
Mussai, F, Egan, S, Hunter, S, Webber, H, Fisher, J, Wheat, R et al. (2015). Neuroblastoma Arginase Activity Creates an Immunosuppressive Microenvironment That Impairs Autologous and Engineered Immunity. Cancer Res 75: 3043-3053.
-
(2015)
Cancer Res
, vol.75
, pp. 3043-3053
-
-
Mussai, F.1
Egan, S.2
Hunter, S.3
Webber, H.4
Fisher, J.5
Wheat, R.6
-
48
-
-
84933178008
-
Liver myeloidderived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T
-
Burga, RA, Thorn, M, Point, GR, Guha, P, Nguyen, CT, Licata, LA et al. (2015). Liver myeloidderived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T. Cancer Immunol Immunother 64: 817-829.
-
(2015)
Cancer Immunol Immunother
, vol.64
, pp. 817-829
-
-
Burga, R.A.1
Thorn, M.2
Point, G.R.3
Guha, P.4
Nguyen, C.T.5
Licata, L.A.6
-
49
-
-
84862633912
-
Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-? and GM-CSF
-
Spear, P, Barber, A, Rynda-Apple, A and Sentman, CL (2012). Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-? and GM-CSF. J Immunol 188: 6389-6398.
-
(2012)
J Immunol
, vol.188
, pp. 6389-6398
-
-
Spear, P.1
Barber, A.2
Rynda-Apple, A.3
Sentman, C.L.4
-
50
-
-
77954141914
-
FOXP3+ regulatory T cells in the human immune system
-
Sakaguchi, S, Miyara, M, Costantino, CM and Hafler, DA (2010). FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 10: 490-500.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 490-500
-
-
Sakaguchi, S.1
Miyara, M.2
Costantino, C.M.3
Hafler, D.A.4
-
51
-
-
77957747417
-
Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia
-
Zhou, Q, Munger, ME, Highfill, SL, Tolar, J, Weigel, BJ, Riddle, M et al. (2010). Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood 116: 2484-2493.
-
(2010)
Blood
, vol.116
, pp. 2484-2493
-
-
Zhou, Q.1
Munger, M.E.2
Highfill, S.L.3
Tolar, J.4
Weigel, B.J.5
Riddle, M.6
-
52
-
-
84883767441
-
Inhibition of p300 impairs Foxp3? T regulatory cell function and promotes antitumor immunity
-
Liu, Y, Wang, L, Predina, J, Han, R, Beier, UH, Wang, LC et al. (2013). Inhibition of p300 impairs Foxp3? T regulatory cell function and promotes antitumor immunity. Nat Med 19: 1173-1177.
-
(2013)
Nat Med
, vol.19
, pp. 1173-1177
-
-
Liu, Y.1
Wang, L.2
Predina, J.3
Han, R.4
Beier, U.H.5
Wang, L.C.6
-
53
-
-
84892165951
-
Interleukin-7 mediates selective expansion of tumor-redirected cytotoxic T lymphocytes (CTLs) without enhancement of regulatory T-cell inhibition
-
Perna, SK, Pagliara, D, Mahendravada, A, Liu, H, Brenner, MK, Savoldo, B et al. (2014). Interleukin-7 mediates selective expansion of tumor-redirected cytotoxic T lymphocytes (CTLs) without enhancement of regulatory T-cell inhibition. Clin Cancer Res 20: 131-139.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 131-139
-
-
Perna, S.K.1
Pagliara, D.2
Mahendravada, A.3
Liu, H.4
Brenner, M.K.5
Savoldo, B.6
-
54
-
-
84862490985
-
Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer
-
Yao, X, Ahmadzadeh, M, Lu, YC, Liewehr, DJ, Dudley, ME, Liu, F et al. (2012). Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer. Blood 119: 5688-5696.
-
(2012)
Blood
, vol.119
, pp. 5688-5696
-
-
Yao, X.1
Ahmadzadeh, M.2
Lu, Y.C.3
Liewehr, D.J.4
Dudley, M.E.5
Liu, F.6
-
55
-
-
79953320804
-
CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory T cells which can be overcome by preventing Lck activation
-
Kofler, DM, Chmielewski, M, Rappl, G, Hombach, A, Riet, T, Schmidt, A et al. (2011). CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory T cells which can be overcome by preventing Lck activation. Mol Ther 19: 760-767.
-
(2011)
Mol Ther
, vol.19
, pp. 760-767
-
-
Kofler, D.M.1
Chmielewski, M.2
Rappl, G.3
Hombach, A.4
Riet, T.5
Schmidt, A.6
-
56
-
-
77951746241
-
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice
-
Markley, JC and Sadelain, M (2010). IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice. Blood 115: 3508-3519.
-
(2010)
Blood
, vol.115
, pp. 3508-3519
-
-
Markley, J.C.1
Sadelain, M.2
-
57
-
-
0347994955
-
Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
-
Finney, HM, Akbar, AN and Lawson, AD (2004). Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol 172: 104-113.
-
(2004)
J Immunol
, vol.172
, pp. 104-113
-
-
Finney, H.M.1
Akbar, A.N.2
Lawson, A.D.3
-
58
-
-
84905993539
-
Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptortransduced human T cells in solid tumors
-
Moon, EK, Wang, LC, Dolfi, DV, Wilson, CB, Ranganathan, R, Sun, J et al. (2014). Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptortransduced human T cells in solid tumors. Clin Cancer Res 20: 4262-4273.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 4262-4273
-
-
Moon, E.K.1
Wang, L.C.2
Dolfi, D.V.3
Wilson, C.B.4
Ranganathan, R.5
Sun, J.6
-
59
-
-
84886397930
-
Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by genemodified T cells
-
John, LB, Devaud, C, Duong, CP, Yong, CS, Beavis, PA, Haynes, NM et al. (2013). Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by genemodified T cells. Clin Cancer Res 19: 5636-5646.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 5636-5646
-
-
John, L.B.1
Devaud, C.2
Duong, C.P.3
Yong, C.S.4
Beavis, P.A.5
Haynes, N.M.6
-
60
-
-
84959036332
-
Blockade of programmed death 1 augments the ability of human T cells engineered to target NY-ESO-1 to control tumor growth after adoptive transfer
-
Moon, EK, Ranganathan, R, Eruslanov, E, Kim, S, Newick, K, O'Brien, S et al. (2016). Blockade of programmed death 1 augments the ability of human T cells engineered to target NY-ESO-1 to control tumor growth after adoptive transfer. Clin Cancer Res 22: 436-447.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 436-447
-
-
Moon, E.K.1
Ranganathan, R.2
Eruslanov, E.3
Kim, S.4
Newick, K.5
O'Brien, S.6
-
61
-
-
84939448088
-
Impact of a new fusion receptor on PD-1-mediated immunosuppression in adoptive T cell therapy
-
Kobold, S, Grassmann, S, Chaloupka, M, Lampert, C, Wenk, S, Kraus, F et al. (2015). Impact of a new fusion receptor on PD-1-mediated immunosuppression in adoptive T cell therapy. J Natl Cancer Inst 107:djv146 .
-
(2015)
J Natl Cancer Inst
, vol.107
, pp. djv146
-
-
Kobold, S.1
Grassmann, S.2
Chaloupka, M.3
Lampert, C.4
Wenk, S.5
Kraus, F.6
-
62
-
-
84922718852
-
Ctla-4 blockade plus adoptive T-cell transfer promotes optimal melanoma immunity in mice
-
Mahvi, DA, Meyers, JV, Tatar, AJ, Contreras, A, Suresh, M, Leverson, GE et al. (2015). Ctla-4 blockade plus adoptive T-cell transfer promotes optimal melanoma immunity in mice. J Immunother 38: 54-61.
-
(2015)
J Immunother
, vol.38
, pp. 54-61
-
-
Mahvi, D.A.1
Meyers, J.V.2
Tatar, A.J.3
Contreras, A.4
Suresh, M.5
Leverson, G.E.6
-
63
-
-
84892406353
-
Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road
-
Wang, LC, Riese, MJ, Moon, EK and Albelda, SM (2013). Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road. Oncoimmunology 2: e26492.
-
(2013)
Oncoimmunology
, vol.2
, pp. e26492
-
-
Wang, L.C.1
Riese, M.J.2
Moon, E.K.3
Albelda, S.M.4
-
64
-
-
84879097325
-
Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases
-
Riese, MJ, Wang, LC, Moon, EK, Joshi, RP, Ranganathan, A, June, CH et al. (2013). Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases. Cancer Res 73: 3566-3577.
-
(2013)
Cancer Res
, vol.73
, pp. 3566-3577
-
-
Riese, M.J.1
Wang, L.C.2
Moon, E.K.3
Joshi, R.P.4
Ranganathan, A.5
June, C.H.6
-
65
-
-
16444381331
-
Bcl-2 overexpression enhances tumor-specific T-cell survival
-
Charo, J, Finkelstein, SE, Grewal, N, Restifo, NP, Robbins, PF and Rosenberg, SA (2005). Bcl-2 overexpression enhances tumor-specific T-cell survival. Cancer Res 65: 2001-2008.
-
(2005)
Cancer Res
, vol.65
, pp. 2001-2008
-
-
Charo, J.1
Finkelstein, S.E.2
Grewal, N.3
Restifo, N.P.4
Robbins, P.F.5
Rosenberg, S.A.6
-
67
-
-
84904097189
-
Current concepts in the diagnosis and management of cytokine release syndrome
-
Lee, DW, Gardner, R, Porter, DL, Louis, CU, Ahmed, N, Jensen, M et al. (2014). Current concepts in the diagnosis and management of cytokine release syndrome. Blood 124: 188-195.
-
(2014)
Blood
, vol.124
, pp. 188-195
-
-
Lee, D.W.1
Gardner, R.2
Porter, D.L.3
Louis, C.U.4
Ahmed, N.5
Jensen, M.6
-
68
-
-
77950475517
-
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
-
Morgan, RA, Yang, JC, Kitano, M, Dudley, ME, Laurencot, CM and Rosenberg, SA (2010). Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther 18: 843-851.
-
(2010)
Mol Ther
, vol.18
, pp. 843-851
-
-
Morgan, R.A.1
Yang, J.C.2
Kitano, M.3
Dudley, M.E.4
Laurencot, C.M.5
Rosenberg, S.A.6
-
69
-
-
84890174110
-
Chimeric antigen receptor T cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo
-
Lanitis, E, Poussin, M, Klattenhoff, AW, Song, D, Sandaltzopoulos, R, June, CH et al. (2013). Chimeric antigen receptor T cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo. Cancer Immunol Res 1: 43-53.
-
(2013)
Cancer Immunol Res
, vol.1
, pp. 43-53
-
-
Lanitis, E.1
Poussin, M.2
Klattenhoff, A.W.3
Song, D.4
Sandaltzopoulos, R.5
June, C.H.6
-
70
-
-
84872196489
-
Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
-
Kloss, CC, Condomines, M, Cartellieri, M, Bachmann, M and Sadelain, M (2013). Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells. Nat Biotechnol 31: 71-75.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 71-75
-
-
Kloss, C.C.1
Condomines, M.2
Cartellieri, M.3
Bachmann, M.4
Sadelain, M.5
-
71
-
-
34447310075
-
Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation
-
Tey, SK, Dotti, G, Rooney, CM, Heslop, HE and Brenner, MK (2007). Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation. Biol Blood Marrow Transplant 13: 913-924.
-
(2007)
Biol Blood Marrow Transplant
, vol.13
, pp. 913-924
-
-
Tey, S.K.1
Dotti, G.2
Rooney, C.M.3
Heslop, H.E.4
Brenner, M.K.5
-
72
-
-
84996572349
-
Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce antitumor activity in solid malignancies
-
Beatty, GL, Haas, AR, Maus, MV, Torigian, DA, Soulen, MC, Plesa, G et al. (2014). Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce antitumor activity in solid malignancies. Cancer Immunol Res 2: 112-120.
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 112-120
-
-
Beatty, G.L.1
Haas, A.R.2
Maus, M.V.3
Torigian, D.A.4
Soulen, M.C.5
Plesa, G.6
-
73
-
-
84905996839
-
ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
-
Guedan, S, Chen, X, Madar, A, Carpenito, C, McGettigan, SE, Frigault, MJ et al. (2014). ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells. Blood 124: 1070-1080.
-
(2014)
Blood
, vol.124
, pp. 1070-1080
-
-
Guedan, S.1
Chen, X.2
Madar, A.3
Carpenito, C.4
McGettigan, S.E.5
Frigault, M.J.6
-
74
-
-
84856071702
-
CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo
-
Song, DG, Ye, Q, Poussin, M, Harms, GM, Figini, M and Powell, DJ Jr (2012). CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo. Blood 119: 696-706.
-
(2012)
Blood
, vol.119
, pp. 696-706
-
-
Song, D.G.1
Ye, Q.2
Poussin, M.3
Harms, G.M.4
Figini, M.5
Powell, D.J.6
-
75
-
-
84961997810
-
Generation of potent T-cell immunotherapy for cancer using DAP12-based, multichain, chimeric immunoreceptors
-
Wang, E, Wang, LC, Tsai, CY, Bhoj, V, Gershenson, Z, Moon, E et al. (2015). Generation of potent T-cell immunotherapy for cancer using DAP12-based, multichain, chimeric immunoreceptors. Cancer Immunol Res 3: 815-826
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 815-826
-
-
Wang, E.1
Wang, L.C.2
Tsai, C.Y.3
Bhoj, V.4
Gershenson, Z.5
Moon, E.6
|