메뉴 건너뛰기




Volumn 14, Issue 6, 2017, Pages 333-342

Molecular subtypes in cancers of the gastrointestinal tract

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTOME;

EID: 85017434208     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2017.33     Document Type: Review
Times cited : (102)

References (106)
  • 1
    • 84903266278 scopus 로고    scopus 로고
    • Stem cell dynamics in homeostasis and cancer of the intestine
    • Vermeulen, L. & Snippert, H. J. Stem cell dynamics in homeostasis and cancer of the intestine. Nat. Rev. 14, 468-480 (2014).
    • (2014) Nat. Rev. , vol.14 , pp. 468-480
    • Vermeulen, L.1    Snippert, H.J.2
  • 2
    • 84902147062 scopus 로고    scopus 로고
    • Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the United States
    • Rahib, L. et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74, 2913-2921 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 2913-2921
    • Rahib, L.1
  • 4
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
    • (2012) Nature , vol.487 , pp. 330-337
  • 5
    • 84960194345 scopus 로고    scopus 로고
    • Genomic analyses identify molecular subtypes of pancreatic cancer
    • Bailey, P. et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 531, 47-52 (2016).
    • (2016) Nature , vol.531 , pp. 47-52
    • Bailey, P.1
  • 6
    • 84907270779 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of gastric adenocarcinoma
    • Cancer Genome Atlas Research Network.
    • Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 513, 202-209 (2014).
    • (2014) Nature , vol.513 , pp. 202-209
  • 7
    • 85010756263 scopus 로고    scopus 로고
    • Fusobacterium nucleatum and T cells in colorectal carcinoma
    • Mima, K. et al. Fusobacterium nucleatum and T cells in colorectal carcinoma. JAMA Oncol. 1, 653-661 (2015).
    • (2015) JAMA Oncol. , vol.1 , pp. 653-661
    • Mima, K.1
  • 8
    • 84896527392 scopus 로고    scopus 로고
    • Fusobacterium in colonic flora and molecular features of colorectal carcinoma
    • Tahara, T. et al. Fusobacterium in colonic flora and molecular features of colorectal carcinoma. Cancer Res. 74, 1311-1318 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 1311-1318
    • Tahara, T.1
  • 9
    • 84964344891 scopus 로고    scopus 로고
    • Expert consensus document: Cholangiocarcinoma: Current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
    • Banales, J. M. et al. Expert consensus document: cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA). Nat. Rev. Gastroenterol. Hepatol. 13, 261-280 (2016).
    • (2016) Nat. Rev. Gastroenterol. Hepatol. , vol.13 , pp. 261-280
    • Banales, J.M.1
  • 10
    • 84943232150 scopus 로고    scopus 로고
    • Genetic landscape and biomarkers of hepatocellular carcinoma
    • Zucman-Rossi, J., Villanueva, A., Nault, J. C. & Llovet, J. M. Genetic landscape and biomarkers of hepatocellular carcinoma. Gastroenterology 149, 1226-1239.e4 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 1226-1226e4
    • Zucman-Rossi, J.1    Villanueva, A.2    Nault, J.C.3    Llovet, J.M.4
  • 11
    • 79751489596 scopus 로고    scopus 로고
    • Molecular genetics of colorectal cancer
    • Fearon, E. R. Molecular genetics of colorectal cancer. Annu. Rev. Pathol. 6, 479-507 (2011).
    • (2011) Annu. Rev. Pathol. , vol.6 , pp. 479-507
    • Fearon, E.R.1
  • 12
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E. R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell, 61, 759-767 (1990)
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 13
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood, L. D. et al. The genomic landscapes of human breast and colorectal cancers. Science 318, 1108-1113 (2007).
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1
  • 14
    • 85001736115 scopus 로고    scopus 로고
    • From tumour heterogeneity to advances in precision treatment of colorectal cancer
    • Punt, C. J., Koopman, M. & Vermeulen, L. From tumour heterogeneity to advances in precision treatment of colorectal cancer. Nat. Rev. Clin. Oncol. http://dx.doi.org/10.1038/nrclinonc.2016.171 (2016).
    • (2016) Nat. Rev. Clin. Oncol.
    • Punt, C.J.1    Koopman, M.2    Vermeulen, L.3
  • 15
    • 84954163383 scopus 로고    scopus 로고
    • Analysis of KRAS/NRAS mutations in a phase III study of panitumumab with FOLFIRI compared with FOLFIRI alone as second-line treatment for metastatic colorectal cancer
    • Peeters, M. et al. Analysis of KRAS/NRAS mutations in a phase III study of panitumumab with FOLFIRI compared with FOLFIRI alone as second-line treatment for metastatic colorectal cancer. Clin. Cancer Res. 21, 5469-5479 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 5469-5479
    • Peeters, M.1
  • 16
    • 84925324704 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer
    • Van Cutsem, E. et al. Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer. J. Clin. Oncol. 33, 692-700 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 692-700
    • Van Cutsem, E.1
  • 17
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty, K. T. et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N. Engl. J. Med. 363, 809-819 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 809-819
    • Flaherty, K.T.1
  • 18
    • 77954748953 scopus 로고    scopus 로고
    • Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracilbased adjuvant therapy in colon cancer
    • Sargent, D. J. et al. Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracilbased adjuvant therapy in colon cancer. J. Clin. Oncol. 28, 3219-3226 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3219-3226
    • Sargent, D.J.1
  • 19
    • 79960987047 scopus 로고    scopus 로고
    • Challenges in the management of stage II colon cancer
    • Dotan, E. & Cohen, S. J. Challenges in the management of stage II colon cancer. Semin. Oncol. 38, 511-520 (2011).
    • (2011) Semin. Oncol. , vol.38 , pp. 511-520
    • Dotan, E.1    Cohen, S.J.2
  • 21
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960-1964 (2006).
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1
  • 22
    • 84960466507 scopus 로고    scopus 로고
    • Integrative analyses of colorectal cancer show immunoscore is a stronger predictor of patient survival than microsatellite instability
    • Mlecnik, B. et al. Integrative analyses of colorectal cancer show immunoscore is a stronger predictor of patient survival than microsatellite instability. Immunity 44, 698-711 (2016).
    • (2016) Immunity , vol.44 , pp. 698-711
    • Mlecnik, B.1
  • 23
    • 84855225492 scopus 로고    scopus 로고
    • The immune score as a new possible approach for the classification of cancer
    • Galon, J. et al. The immune score as a new possible approach for the classification of cancer. J. Transl Med. 10, 1 (2012).
    • (2012) J. Transl Med. , vol.10 , pp. 1
    • Galon, J.1
  • 24
    • 73349088103 scopus 로고    scopus 로고
    • Metastasis-associated gene expression changes predict poor outcomes in patients with Dukes stage B and C colorectal cancer
    • Jorissen, R. N. et al. Metastasis-associated gene expression changes predict poor outcomes in patients with Dukes stage B and C colorectal cancer. Clin. Cancer Res. 15, 7642-7651 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7642-7651
    • Jorissen, R.N.1
  • 25
    • 84930932197 scopus 로고    scopus 로고
    • Oncotype DX colon cancer assay for prediction of recurrence risk in patients with stage II and III colon cancer: A review of the evidence
    • You, Y. N., Rustin, R. B. & Sullivan, J. D. Oncotype DX colon cancer assay for prediction of recurrence risk in patients with stage II and III colon cancer: a review of the evidence. Surg. Oncol. 24, 61-66 (2015).
    • (2015) Surg. Oncol. , vol.24 , pp. 61-66
    • You, Y.N.1    Rustin, R.B.2    Sullivan, J.D.3
  • 26
    • 79952438796 scopus 로고    scopus 로고
    • Genetics: An 18-gene signature (ColoPrint) for colon cancer prognosis
    • Tan, I. B. & Tan, P. Genetics: an 18-gene signature (ColoPrint) for colon cancer prognosis. Nat. Rev. Clin. Oncol. 8, 131-133 (2011).
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 131-133
    • Tan, I.B.1    Tan, P.2
  • 28
    • 84946571753 scopus 로고    scopus 로고
    • The consensus molecular subtypes of colorectal cancer
    • Guinney, J. et al. The consensus molecular subtypes of colorectal cancer. Nat. Med. 21, 1350-1356 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 1350-1356
    • Guinney, J.1
  • 29
    • 84920944831 scopus 로고    scopus 로고
    • Colorectal cancer heterogeneity and targeted therapy: A case for molecular disease subtypes
    • Linnekamp, J. F., Wang, X., Medema, J. P. & Vermeulen, L. Colorectal cancer heterogeneity and targeted therapy: a case for molecular disease subtypes. Cancer Res. 75, 245-249 (2015).
    • (2015) Cancer Res. , vol.75 , pp. 245-249
    • Linnekamp, J.F.1    Wang, X.2    Medema, J.P.3    Vermeulen, L.4
  • 30
    • 84885184379 scopus 로고    scopus 로고
    • Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer
    • Budinska, E. et al. Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer. J. Pathol. 231, 63-76 (2013).
    • (2013) J. Pathol. , vol.231 , pp. 63-76
    • Budinska, E.1
  • 31
    • 84877600884 scopus 로고    scopus 로고
    • Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
    • De Sousa, E. M. F. et al. Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nat. Med. 19, 614-618 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 614-618
    • De Sousa, E.M.F.1
  • 32
    • 84878302099 scopus 로고    scopus 로고
    • Gene expression classification of colon cancer into molecular subtypes: Characterization, validation, and prognostic value
    • Marisa, L. et al. Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value. PLoS Med. 10, e1001453 (2013).
    • (2013) PLoS Med. , vol.10 , pp. e1001453
    • Marisa, L.1
  • 33
    • 84877619075 scopus 로고    scopus 로고
    • A colorectal cancer classification system that associates cellular phenotype and responses to therapy
    • Sadanandam, A. et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nat. Med. 19, 619-625 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 619-625
    • Sadanandam, A.1
  • 34
    • 84871676568 scopus 로고    scopus 로고
    • Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines
    • Schlicker, A. et al. Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines. BMC Med. Genomics 5, 66 (2012).
    • (2012) BMC Med. Genomics , vol.5 , pp. 66
    • Schlicker, A.1
  • 35
    • 84977616813 scopus 로고    scopus 로고
    • TGFbeta signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype
    • Fessler, E. et al. TGFbeta signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO Mol. Med. 8, 745-760 (2016).
    • (2016) EMBO Mol. Med. , vol.8 , pp. 745-760
    • Fessler, E.1
  • 36
    • 84907269780 scopus 로고    scopus 로고
    • Proteogenomic characterization of human colon and rectal cancer
    • Zhang, B. et al. Proteogenomic characterization of human colon and rectal cancer. Nature 513, 382-387 (2014).
    • (2014) Nature , vol.513 , pp. 382-387
    • Zhang, B.1
  • 37
    • 34547160717 scopus 로고    scopus 로고
    • Biology and management of pancreatic cancer
    • Ghaneh, P., Costello, E. & Neoptolemos, J. P. Biology and management of pancreatic cancer. Gut 56, 1134-1152 (2007).
    • (2007) Gut , vol.56 , pp. 1134-1152
    • Ghaneh, P.1    Costello, E.2    Neoptolemos, J.P.3
  • 38
    • 34248335374 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma: Update on the surgical pathology of carcinomas of ductal origin and PanINs
    • Hruban, R. H. & Fukushima, N. Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs. Mod. Pathol. 20 (Suppl. 1), S61-S70 (2007).
    • (2007) Mod. Pathol. , vol.20 , pp. S61-S70
    • Hruban, R.H.1    Fukushima, N.2
  • 39
    • 84955254641 scopus 로고    scopus 로고
    • Regulation of cellular identity in cancer
    • Roy, N. & Hebrok, M. Regulation of cellular identity in cancer. Dev. Cell 35, 674-684 (2015).
    • (2015) Dev. Cell , vol.35 , pp. 674-684
    • Roy, N.1    Hebrok, M.2
  • 40
    • 84869091997 scopus 로고    scopus 로고
    • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
    • Biankin, A. V. et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 491, 399-405 (2012).
    • (2012) Nature , vol.491 , pp. 399-405
    • Biankin, A.V.1
  • 41
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321, 1801-1806 (2008).
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1
  • 42
    • 0023735997 scopus 로고
    • KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas
    • Smit, V. T. et al. KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acids Res. 16, 7773-7782 (1988).
    • (1988) Nucleic Acids Res. , vol.16 , pp. 7773-7782
    • Smit, V.T.1
  • 43
    • 84924056345 scopus 로고    scopus 로고
    • Whole genomes redefine the mutational landscape of pancreatic cancer
    • Waddell, N. et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 518, 495-501 (2015).
    • (2015) Nature , vol.518 , pp. 495-501
    • Waddell, N.1
  • 44
    • 84863012865 scopus 로고    scopus 로고
    • Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
    • Collins, M. A. et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J. Clin. Invest. 122, 639-653 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 639-653
    • Collins, M.A.1
  • 45
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani, S. R. et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7, 469-483 (2005).
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1
  • 46
    • 84869236330 scopus 로고    scopus 로고
    • Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors
    • Yachida, S. et al. Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors. Clin. Cancer Res. 18, 6339-6347 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 6339-6347
    • Yachida, S.1
  • 47
    • 84863278019 scopus 로고    scopus 로고
    • Integrative survival-based molecular profiling of human pancreatic cancer
    • Donahue, T. R. et al. Integrative survival-based molecular profiling of human pancreatic cancer. Clin. Cancer Res. 18, 1352-1363 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1352-1363
    • Donahue, T.R.1
  • 48
    • 84927916016 scopus 로고    scopus 로고
    • A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma
    • Haider, S. et al. A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma. Genome Med. 6, 105 (2014).
    • (2014) Genome Med. , vol.6 , pp. 105
    • Haider, S.1
  • 49
    • 84992740842 scopus 로고    scopus 로고
    • RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4
    • Kirby, M. K. et al. RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4. Mol. Oncol. 10, 1169-1182 (2016).
    • (2016) Mol. Oncol. , vol.10 , pp. 1169-1182
    • Kirby, M.K.1
  • 50
    • 77955048480 scopus 로고    scopus 로고
    • A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma
    • Stratford, J. K. et al. A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma. PLoS Med. 7, e1000307 (2010).
    • (2010) PLoS Med. , vol.7 , pp. e1000307
    • Stratford, J.K.1
  • 51
    • 79953756460 scopus 로고    scopus 로고
    • Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
    • Collisson, E. A. et al. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat. Med. 17, 500-503 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 500-503
    • Collisson, E.A.1
  • 52
    • 84942885357 scopus 로고    scopus 로고
    • Virtual microdissection identifies distinct tumor-and stroma-specific subtypes of pancreatic ductal adenocarcinoma
    • Moffitt, R. A. et al. Virtual microdissection identifies distinct tumor-and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat. Genet. 47, 1168-1178 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 1168-1178
    • Moffitt, R.A.1
  • 53
    • 84988373844 scopus 로고    scopus 로고
    • Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma
    • Janky, R. et al. Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma. BMC Cancer 16, 632 (2016).
    • (2016) BMC Cancer , vol.16 , pp. 632
    • Janky, R.1
  • 54
    • 84965188725 scopus 로고    scopus 로고
    • Identifying molecular subtypes related to clinicopathologic factors in pancreatic cancer
    • Kim, S. et al. Identifying molecular subtypes related to clinicopathologic factors in pancreatic cancer. Biomed. Eng. Online 13 (Suppl. 2), S5 (2014).
    • (2014) Biomed. Eng. Online , vol.13 , pp. S5
    • Kim, S.1
  • 55
    • 84971238315 scopus 로고    scopus 로고
    • Molecular subtypes of pancreatic cancer based on miRNA expression profiles have independent prognostic value
    • Namkung, J. et al. Molecular subtypes of pancreatic cancer based on miRNA expression profiles have independent prognostic value. J. Gastroenterol. Hepatol. 31, 1160-1167 (2015).
    • (2015) J. Gastroenterol. Hepatol. , vol.31 , pp. 1160-1167
    • Namkung, J.1
  • 56
    • 84964542736 scopus 로고    scopus 로고
    • Stratification of digestive cancers with different pathological features and survival outcomes by microRNA expression
    • Tang, S. et al. Stratification of digestive cancers with different pathological features and survival outcomes by microRNA expression. Sci. Rep. 6, 24466 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 24466
    • Tang, S.1
  • 57
    • 84980480250 scopus 로고    scopus 로고
    • Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling
    • Humphrey, E. S. et al. Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling. Mol. Cell. Proteomics 15, 2671-2685 (2016).
    • (2016) Mol. Cell. Proteomics , vol.15 , pp. 2671-2685
    • Humphrey, E.S.1
  • 58
    • 84938940583 scopus 로고    scopus 로고
    • Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
    • Daemen, A. et al. Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors. Proc. Natl Acad. Sci. USA 112, E4410-E4417 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. E4410-E4417
    • Daemen, A.1
  • 59
    • 84927144113 scopus 로고    scopus 로고
    • Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
    • Witkiewicz, A. K. et al. Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets. Nat. Commun. 6, 6744 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6744
    • Witkiewicz, A.K.1
  • 60
    • 77953152285 scopus 로고    scopus 로고
    • Epidemiology of gastrointestinal and liver tumors
    • Herszenyi, L. & Tulassay, Z. Epidemiology of gastrointestinal and liver tumors. Eur. Rev. Med. Pharmacol. Sci. 14, 249-258 (2010).
    • (2010) Eur. Rev. Med. Pharmacol. Sci. , vol.14 , pp. 249-258
    • Herszenyi, L.1    Tulassay, Z.2
  • 61
    • 84952898527 scopus 로고    scopus 로고
    • Recent advances from basic and clinical studies of esophageal squamous cell carcinoma
    • Ohashi, S. et al. Recent advances from basic and clinical studies of esophageal squamous cell carcinoma. Gastroenterology 149, 1700-1715 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 1700-1715
    • Ohashi, S.1
  • 62
    • 84943224482 scopus 로고    scopus 로고
    • Genetic insights in Barretts esophagus and esophageal adenocarcinoma
    • Reid, B. J., Paulson, T. G. & Li, X. Genetic insights in Barretts esophagus and esophageal adenocarcinoma. Gastroenterology 149, 1142-1152.e3 (2015).
    • (2015) Gastroenterology , vol.149 , pp. 1142-1142e3
    • Reid, B.J.1    Paulson, T.G.2    Li, X.3
  • 63
    • 84922068082 scopus 로고    scopus 로고
    • Genetic landscape of esophageal squamous cell carcinoma
    • Gao, Y. B. et al. Genetic landscape of esophageal squamous cell carcinoma. Nat. Genet. 46, 1097-1102 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 1097-1102
    • Gao, Y.B.1
  • 64
    • 84899628626 scopus 로고    scopus 로고
    • Genomic and molecular characterization of esophageal squamous cell carcinoma
    • Lin, D. C. et al. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat. Genet. 46, 467-473 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 467-473
    • Lin, D.C.1
  • 65
    • 84899747138 scopus 로고    scopus 로고
    • Identification of genomic alterations in oesophageal squamous cell cancer
    • Song, Y. et al. Identification of genomic alterations in oesophageal squamous cell cancer. Nature 509, 91-95 (2014).
    • (2014) Nature , vol.509 , pp. 91-95
    • Song, Y.1
  • 66
    • 84878593111 scopus 로고    scopus 로고
    • Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
    • Dulak, A. M. et al. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat. Genet. 45, 478-486 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 478-486
    • Dulak, A.M.1
  • 67
    • 84905502758 scopus 로고    scopus 로고
    • Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis
    • Weaver, J. M. et al. Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis. Nat. Genet. 46, 837-843 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 837-843
    • Weaver, J.M.1
  • 68
    • 70350641014 scopus 로고    scopus 로고
    • SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
    • Bass, A. J. et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat. Genet. 41, 1238-1242 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1238-1242
    • Bass, A.J.1
  • 69
    • 79955495946 scopus 로고    scopus 로고
    • Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypes
    • Su, H. et al. Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypes. Clin. Cancer Res. 17, 2955-2966 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2955-2966
    • Su, H.1
  • 70
    • 84948981557 scopus 로고    scopus 로고
    • An integrative analysis to identify driver genes in esophageal squamous cell carcinoma
    • Sawada, G. et al. An integrative analysis to identify driver genes in esophageal squamous cell carcinoma. PLoS ONE 10, e0139808 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0139808
    • Sawada, G.1
  • 71
    • 84949256226 scopus 로고    scopus 로고
    • Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas
    • Bain, G. H. et al. Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas. Br. J. Cancer 113, 1641 (2015).
    • (2015) Br. J. Cancer , vol.113 , pp. 1641
    • Bain, G.H.1
  • 72
    • 84987629410 scopus 로고    scopus 로고
    • Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance
    • Secrier, M. et al. Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance. Nat. Genet. 48, 1131-1141 (2016).
    • (2016) Nat. Genet. , vol.48 , pp. 1131-1141
    • Secrier, M.1
  • 73
    • 85016278868 scopus 로고    scopus 로고
    • Integrated genomic characterization of oesophageal carcinoma
    • The Cancer Genome Atlas Research Network.
    • The Cancer Genome Atlas Research Network. Integrated genomic characterization of oesophageal carcinoma. Nature 541, 169-175 (2017).
    • Nature , vol.541 , Issue.169-175 , pp. 2017
  • 74
    • 0037195107 scopus 로고    scopus 로고
    • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
    • Higashi, H. et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc. Natl Acad. Sci. USA 99, 14428-14433 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 14428-14433
    • Higashi, H.1
  • 75
    • 12644292106 scopus 로고
    • The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification
    • Lauren, P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. an attempt at a histo-clinical classification. Acta Pathol. Microbiol. Scand. 64, 31-49 (1965).
    • (1965) Acta Pathol. Microbiol. Scand. , vol.64 , pp. 31-49
    • Lauren, P.1
  • 76
    • 84901677114 scopus 로고    scopus 로고
    • Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma
    • Kakiuchi, M. et al. Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma. Nat. Genet. 46, 583-587 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 583-587
    • Kakiuchi, M.1
  • 77
    • 82255183148 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
    • Wang, K. et al. Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat. Genet. 43, 1219-1223 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 1219-1223
    • Wang, K.1
  • 78
    • 84901680089 scopus 로고    scopus 로고
    • Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
    • Wang, K. et al. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nat. Genet. 46, 573-582 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 573-582
    • Wang, K.1
  • 79
    • 84860327480 scopus 로고    scopus 로고
    • Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
    • Zang, Z. J. et al. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nat. Genet. 44, 570-574 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 570-574
    • Zang, Z.J.1
  • 80
    • 84862777035 scopus 로고    scopus 로고
    • A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets
    • Deng, N. et al. A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. Gut 61, 673-684 (2012).
    • (2012) Gut , vol.61 , pp. 673-684
    • Deng, N.1
  • 81
    • 84982958036 scopus 로고    scopus 로고
    • High-level clonal FGFR amplification and response to FGFR inhibition in a translational clinical trial
    • Pearson, A. et al. High-level clonal FGFR amplification and response to FGFR inhibition in a translational clinical trial. Cancer Discov. 6, 838-851 (2016).
    • (2016) Cancer Discov. , vol.6 , pp. 838-851
    • Pearson, A.1
  • 82
    • 84940585870 scopus 로고    scopus 로고
    • A randomized open-label phase II study of AZD4547 (AZD) versus Paclitaxel (P) in previously treated patients with advanced gastric cancer (AGC) with Fibroblast Growth Factor Receptor 2 (FGR2) polysomy or gene amplification (amp): SHINE study [abstract]
    • Bang, Y. J. et al. A randomized, open-label phase II study of AZD4547 (AZD) versus Paclitaxel (P) in previously treated patients with advanced gastric cancer (AGC) with Fibroblast Growth Factor Receptor 2 (FGR2) polysomy or gene amplification (amp): SHINE study [abstract]. J. Clin. Oncol 33 (Suppl.), a4014 (2015).
    • (2015) J. Clin. Oncol , vol.33 , pp. a4014
    • Bang, Y.J.1
  • 83
    • 0038576352 scopus 로고    scopus 로고
    • Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer
    • Boussioutas, A. et al. Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer. Cancer Res. 63, 2569-2577 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 2569-2577
    • Boussioutas, A.1
  • 84
    • 80051486834 scopus 로고    scopus 로고
    • Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy
    • Tan, I. B. et al. Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. Gastroenterology 141, 476-485.e11 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 476-476e11
    • Tan, I.B.1
  • 85
    • 84883185766 scopus 로고    scopus 로고
    • Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil
    • Lei, Z. et al. Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil. Gastroenterology 145, 554-565 (2013).
    • (2013) Gastroenterology , vol.145 , pp. 554-565
    • Lei, Z.1
  • 86
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov http://www.clinicaltrials.gov/ct2/show/NCT01100801 (2016).
    • (2016) ClinicalTrials.gov
  • 87
    • 84937765053 scopus 로고    scopus 로고
    • Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes
    • Cristescu, R. et al. Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes. Nat. Med. 21, 449-456 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 449-456
    • Cristescu, R.1
  • 88
    • 84880315917 scopus 로고    scopus 로고
    • Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer
    • Wu, Y. et al. Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer. Gut 62, 1100-1111 (2013).
    • (2013) Gut , vol.62 , pp. 1100-1111
    • Wu, Y.1
  • 89
    • 84947942506 scopus 로고    scopus 로고
    • Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas
    • Lin, S. J. et al. Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas. Gut 64, 1721-1731 (2015).
    • (2015) Gut , vol.64 , pp. 1721-1731
    • Lin, S.J.1
  • 90
    • 84866595521 scopus 로고    scopus 로고
    • Neuroendocrine gastro-entero-pancreatic tumors: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • Oberg, K., Knigge, U., Kwekkeboom, D. & Perren, A. Neuroendocrine gastro-entero-pancreatic tumors: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 23 (Suppl. 7), vii124-vii130 (2012).
    • (2012) Ann. Oncol. , vol.23 , pp. vii124-vii130
    • Oberg, K.1    Knigge, U.2    Kwekkeboom, D.3    Perren, A.4
  • 91
    • 79851482955 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
    • Raymond, E. et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N. Engl. J. Med. 364, 501-513 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 501-513
    • Raymond, E.1
  • 92
    • 79851500081 scopus 로고    scopus 로고
    • Everolimus for advanced pancreatic neuroendocrine tumors
    • Yao, J. C. et al. Everolimus for advanced pancreatic neuroendocrine tumors. N. Engl. J. Med. 364, 514-523 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 514-523
    • Yao, J.C.1
  • 93
    • 84944930338 scopus 로고    scopus 로고
    • Subgroup analysis of patients with G2 gastroenteropancreatic neuroendocrine tumors
    • Hauck, L., Bitzer, M., Malek, N. & Plentz, R. R. Subgroup analysis of patients with G2 gastroenteropancreatic neuroendocrine tumors. Scand. J. Gastroenterol. 51, 55-59 (2016).
    • (2016) Scand. J. Gastroenterol. , vol.51 , pp. 55-59
    • Hauck, L.1    Bitzer, M.2    Malek, N.3    Plentz, R.R.4
  • 94
    • 83255171192 scopus 로고    scopus 로고
    • Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)
    • Ramage, J. K. et al. Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs). Gut 61, 6-32 (2012).
    • (2012) Gut , vol.61 , pp. 6-32
    • Ramage, J.K.1
  • 96
    • 84900298433 scopus 로고    scopus 로고
    • Neuroendocrine tumors of the pancreas: Current concepts and controversies
    • Reid, M. D., Balci, S., Saka, B. & Adsay, N. V. Neuroendocrine tumors of the pancreas: current concepts and controversies. Endocr. Pathol. 25, 65-79 (2014).
    • (2014) Endocr. Pathol. , vol.25 , pp. 65-79
    • Reid, M.D.1    Balci, S.2    Saka, B.3    Adsay, N.V.4
  • 97
    • 84899941260 scopus 로고    scopus 로고
    • Molecular biology of neuroendocrine tumors: From pathways to biomarkers and targets
    • Capdevila, J. et al. Molecular biology of neuroendocrine tumors: from pathways to biomarkers and targets. Cancer Metastasis Rev. 33, 345-351 (2014).
    • (2014) Cancer Metastasis Rev. , vol.33 , pp. 345-351
    • Capdevila, J.1
  • 98
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • Jiao, Y. et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science 331, 1199-1203 (2011).
    • (2011) Science , vol.331 , pp. 1199-1203
    • Jiao, Y.1
  • 99
    • 84888369188 scopus 로고    scopus 로고
    • Somatic mutation of CDKN1B in small intestine neuroendocrine tumors
    • Francis, J. M. et al. Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat. Genet. 45, 1483-1486 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1483-1486
    • Francis, J.M.1
  • 100
    • 84960109620 scopus 로고    scopus 로고
    • A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics
    • Sadanandam, A. et al. A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics. Cancer Discov. 5, 1296-1313 (2015).
    • (2015) Cancer Discov. , vol.5 , pp. 1296-1313
    • Sadanandam, A.1
  • 101
    • 84903214223 scopus 로고    scopus 로고
    • From cancer genomics to precision oncology-tissues still an issue
    • Cohen, R. L. & Settleman, J. From cancer genomics to precision oncology-tissues still an issue. Cell 157, 1509-1514 (2014).
    • (2014) Cell , vol.157 , pp. 1509-1514
    • Cohen, R.L.1    Settleman, J.2
  • 102
    • 84988971872 scopus 로고    scopus 로고
    • Molecular or metabolic reprograming: What triggers tumor subtypes?
    • Eason, K. & Sadanandam, A. Molecular or metabolic reprograming: what triggers tumor subtypes? Cancer Res. 76, 5195-5200 (2016).
    • (2016) Cancer Res. , vol.76 , pp. 5195-5200
    • Eason, K.1    Sadanandam, A.2
  • 103
    • 84887989710 scopus 로고    scopus 로고
    • Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition
    • Roepman, P. et al. Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition. Int. J. Cancer 134, 552-562 (2014).
    • (2014) Int. J. Cancer , vol.134 , pp. 552-562
    • Roepman, P.1
  • 104
    • 85011003019 scopus 로고    scopus 로고
    • Practical and robust identification of molecular subtypes in colorectal cancer by immunohistochemistry
    • Trinh, A. et al. Practical and robust identification of molecular subtypes in colorectal cancer by immunohistochemistry. Clin. Cancer Res. 23, 387-398 (2017).
    • (2017) Clin. Cancer Res. , vol.23 , pp. 387-398
    • Trinh, A.1
  • 105
    • 84957640649 scopus 로고    scopus 로고
    • CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma
    • Noll, E. M. et al. CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma. Nat. Med. 22, 278-287 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 278-287
    • Noll, E.M.1
  • 106
    • 84946568126 scopus 로고    scopus 로고
    • RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics
    • Best, M. G. et al. RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics. Cancer Cell 28, 666-676 (2015).
    • (2015) Cancer Cell , vol.28 , pp. 666-676
    • Best, M.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.