-
1
-
-
84855170001
-
Pancreatic endocrine tumours: Mutational and immunohistochemical survey of protein kinases reveals alterations in targetable kinases in cancer cell lines and rare primaries
-
1:STN:280:DC%2BC38%2FptVaitw%3D%3D 3276319 21447618 10.1093/annonc/mdr048
-
Corbo, V., et al. (2012). Pancreatic endocrine tumours: mutational and immunohistochemical survey of protein kinases reveals alterations in targetable kinases in cancer cell lines and rare primaries. Annals of Oncology, 23, 127-134.
-
(2012)
Annals of Oncology
, vol.23
, pp. 127-134
-
-
Corbo, V.1
-
2
-
-
77956354202
-
MEN1 in pancreatic endocrine tumors: Analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases
-
1:CAS:528:DC%2BC3cXht1KqsLbM 20566584 10.1677/ERC-10-0028
-
Corbo, V., et al. (2010). MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases. Endocrine-Related Cancer, 17, 771-783.
-
(2010)
Endocrine-Related Cancer
, vol.17
, pp. 771-783
-
-
Corbo, V.1
-
3
-
-
79952279828
-
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
-
1:CAS:528:DC%2BC3MXislOku70%3D 3144496 21252315 10.1126/science.1200609
-
Jiao, Y., et al. (2011). DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science, 331, 1199-1203.
-
(2011)
Science
, vol.331
, pp. 1199-1203
-
-
Jiao, Y.1
-
4
-
-
74949122343
-
Pancreatic endocrine tumors: Expression profiling evidences a role for AKT-mTOR pathway
-
1:CAS:528:DC%2BC3cXjtVSqt7c%3D 19917848 10.1200/JCO.2008.21.5988
-
Missiaglia, E., et al. (2010). Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. Journal of Clinical Oncology, 28, 245-255.
-
(2010)
Journal of Clinical Oncology
, vol.28
, pp. 245-255
-
-
Missiaglia, E.1
-
5
-
-
78649353727
-
Novel anticancer agents in clinical trials for well-differentiated neuroendocrine tumors
-
1:CAS:528:DC%2BC3cXhsVGrsb7I 21095547 10.1016/j.ecl.2010.09.006
-
Faivre, S., Sablin, M. P., Dreyer, C., & Raymond, E. (2010). Novel anticancer agents in clinical trials for well-differentiated neuroendocrine tumors. Endocrinology and Metabolism Clinics of North America, 39, 811-826.
-
(2010)
Endocrinology and Metabolism Clinics of North America
, vol.39
, pp. 811-826
-
-
Faivre, S.1
Sablin, M.P.2
Dreyer, C.3
Raymond, E.4
-
6
-
-
19944434272
-
Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: Negative correlation of microvascular density and VEGF expression with tumour progression
-
1:CAS:528:DC%2BD2MXhtFSjsr4%3D 2361752 15558070 10.1038/sj.bjc.6602245
-
Couvelard, A., et al. (2005). Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression. British Journal of Cancer, 92, 94-101.
-
(2005)
British Journal of Cancer
, vol.92
, pp. 94-101
-
-
Couvelard, A.1
-
7
-
-
70350442637
-
Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID Study Group
-
1:CAS:528:DC%2BD1MXhtlGgtbnJ 19704057 10.1200/JCO.2009.22.8510
-
Rinke, A., et al. (2009). Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. Journal of Clinical Oncology, 27, 4656-4663.
-
(2009)
Journal of Clinical Oncology
, vol.27
, pp. 4656-4663
-
-
Rinke, A.1
-
8
-
-
79851482955
-
Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
-
1:CAS:528:DC%2BC3MXhvVyisrY%3D 21306237 10.1056/NEJMoa1003825
-
Raymond, E., et al. (2011). Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. The New England Journal of Medicine, 364, 501-513.
-
(2011)
The New England Journal of Medicine
, vol.364
, pp. 501-513
-
-
Raymond, E.1
-
9
-
-
79851500081
-
Everolimus for advanced pancreatic neuroendocrine tumors
-
1:CAS:528:DC%2BC3MXhvVyiu7s%3D 21306238 10.1056/NEJMoa1009290
-
Yao, J. C., et al. (2011). Everolimus for advanced pancreatic neuroendocrine tumors. The New England Journal of Medicine, 364, 514-523.
-
(2011)
The New England Journal of Medicine
, vol.364
, pp. 514-523
-
-
Yao, J.C.1
-
10
-
-
34249818466
-
Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors
-
1:CAS:528:DC%2BD2sXlt1Krtro%3D 17505000 10.1158/1078-0432.CCR-06-2053
-
Ekeblad, S., et al. (2007). Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors. Clinical Cancer Research, 13, 2986-2991.
-
(2007)
Clinical Cancer Research
, vol.13
, pp. 2986-2991
-
-
Ekeblad, S.1
-
11
-
-
58849093671
-
O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors
-
1:CAS:528:DC%2BD1MXhs1eqsQ%3D%3D 3100724 19118063 10.1158/1078-0432.CCR- 08-1476
-
Kulke, M. H., et al. (2009). O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors. Clinical Cancer Research, 15, 338-345.
-
(2009)
Clinical Cancer Research
, vol.15
, pp. 338-345
-
-
Kulke, M.H.1
-
12
-
-
78650993549
-
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas
-
1:CAS:528:DC%2BC3MXhs1yrsbk%3D 20824724 10.1002/cncr.25425
-
Strosberg, J. R., et al. (2011). First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer, 117, 268-275.
-
(2011)
Cancer
, vol.117
, pp. 268-275
-
-
Strosberg, J.R.1
-
13
-
-
84872270483
-
Resistance to targeted therapies in pancreatic neuroendocrine tumors (PNETs): Molecular basis, preclinical data, and counteracting strategies
-
22923165 10.1007/s11523-012-0229-6
-
Tijeras-Raballand, A., et al. (2012). Resistance to targeted therapies in pancreatic neuroendocrine tumors (PNETs): molecular basis, preclinical data, and counteracting strategies. Targeted Oncology, 7, 173-181.
-
(2012)
Targeted Oncology
, vol.7
, pp. 173-181
-
-
Tijeras-Raballand, A.1
-
14
-
-
51049109033
-
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
-
1:CAS:528:DC%2BD1cXoslCgtb4%3D 18606717 10.1158/1535-7163.MCT-08-0017
-
Maira, S. M., et al. (2008). Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Molecular Cancer Therapeutics, 7, 1851-1863.
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, pp. 1851-1863
-
-
Maira, S.M.1
-
15
-
-
84865726242
-
Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model
-
1:CAS:528:DC%2BC38Xht1ygsLjF 22753592 10.1158/1078-0432.CCR-11-2968
-
Fraedrich, K., et al. (2012). Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model. Clinical Cancer Research, 18, 4621-4632.
-
(2012)
Clinical Cancer Research
, vol.18
, pp. 4621-4632
-
-
Fraedrich, K.1
-
16
-
-
79951677739
-
Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors
-
21239987 10.1097/SLA.0b013e31820a5bbe
-
Fendrich, V., et al. (2011). Hedgehog inhibition with cyclopamine represses tumor growth and prolongs survival in a transgenic mouse model of islet cell tumors. Annals of Surgery, 253, 546-552.
-
(2011)
Annals of Surgery
, vol.253
, pp. 546-552
-
-
Fendrich, V.1
-
17
-
-
84856776511
-
Glucose- dependent insulinotropic polypeptide receptors in most gastroenteropancreatic and bronchial neuroendocrine tumors
-
1:CAS:528:DC%2BC38XisFOgtbs%3D 22112810 10.1210/jc.2011-2454
-
Waser, B., et al. (2012). Glucose- dependent insulinotropic polypeptide receptors in most gastroenteropancreatic and bronchial neuroendocrine tumors. Journal of Clinical Endocrinology and Metabolism, 97, 482-488.
-
(2012)
Journal of Clinical Endocrinology and Metabolism
, vol.97
, pp. 482-488
-
-
Waser, B.1
-
18
-
-
84899958446
-
Relief of bowel-related symptoms with telotristat etiprate in octreotide refractory carcinoid syndrome: Preliminary results of a double-blind, placebo-controlled multicenter study
-
abstr 4085
-
O'Dorisio, B., et al. (2012) Relief of bowel-related symptoms with telotristat etiprate in octreotide refractory carcinoid syndrome: Preliminary results of a double-blind, placebo-controlled multicenter study. Journal Clinical Oncology, 30, suppl; abstr 4085.
-
(2012)
Journal Clinical Oncology
, vol.30
, Issue.SUPPL.
-
-
O'Dorisio, B.1
-
19
-
-
84863704553
-
Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors
-
1:CAS:528:DC%2BC38XktVGntbc%3D 3354652 22585997 10.1158/2159-8290.CD-11- 0240
-
Sennino, B., et al. (2012). Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discovery, 2, 270-287.
-
(2012)
Cancer Discovery
, vol.2
, pp. 270-287
-
-
Sennino, B.1
-
20
-
-
51449095342
-
Targeting the PI3K-AKT-mTOR pathway: Progress, pitfalls, and promises
-
1:CAS:528:DC%2BD1cXhtFCktL7E 18721898 10.1016/j.coph.2008.08.004
-
Yap, T. A., et al. (2008). Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Current Opinion in Pharmacology, 8, 393-412.
-
(2008)
Current Opinion in Pharmacology
, vol.8
, pp. 393-412
-
-
Yap, T.A.1
-
21
-
-
51849111524
-
NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
-
1:CAS:528:DC%2BD1cXhtF2msLrK 18829560 10.1158/0008-5472.CAN-08-1385
-
Serra, V., et al. (2008). NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Research, 68, 8022-8030.
-
(2008)
Cancer Research
, vol.68
, pp. 8022-8030
-
-
Serra, V.1
-
22
-
-
53049087363
-
Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: Implications for clinical imaging
-
1:CAS:528:DC%2BD1cXpslKnu7w%3D 18701483 10.1158/0008-5472.CAN-08-1044
-
Schnell, C. R., et al. (2008). Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging. Cancer Research, 68, 6598-6607.
-
(2008)
Cancer Research
, vol.68
, pp. 6598-6607
-
-
Schnell, C.R.1
-
23
-
-
84874111766
-
Translation of molecular pathways into clinical trials of neuroendocrine tumors
-
1:CAS:528:DC%2BC3sXis1Srtr4%3D 22508344 10.1159/000336089
-
Pavel, M. (2013). Translation of molecular pathways into clinical trials of neuroendocrine tumors. Neuroendocrinology, 97(1), 99-112.
-
(2013)
Neuroendocrinology
, vol.97
, Issue.1
, pp. 99-112
-
-
Pavel, M.1
-
24
-
-
79951864002
-
Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis
-
1:CAS:528:DC%2BC3cXhsVejt7zP 3041788 20823411 10.1200/JCO.2010.28.0198
-
Chiu, C. W., Nozawa, H., & Hanahan, D. (2010). Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis. Journal of Clinical Oncology, 28, 4425-4433.
-
(2010)
Journal of Clinical Oncology
, vol.28
, pp. 4425-4433
-
-
Chiu, C.W.1
Nozawa, H.2
Hanahan, D.3
-
25
-
-
84865165918
-
The price we pay for progress: A meta-analysis of harms of newly approved anticancer drugs
-
22802313 10.1200/JCO.2011.40.3824
-
Niraula, S., et al. (2012). The price we pay for progress: a meta-analysis of harms of newly approved anticancer drugs. Journal of Clinical Oncology, 30, 3012-3019.
-
(2012)
Journal of Clinical Oncology
, vol.30
, pp. 3012-3019
-
-
Niraula, S.1
-
26
-
-
84858848994
-
Meta-analysis of randomized controlled trials for the incidence and risk of treatment-related mortality in patients with cancer treated with vascular endothelial growth factor tyrosine kinase inhibitors
-
1:CAS:528:DC%2BC38XntV2lsbk%3D 22312105 10.1200/JCO.2011.37.1195
-
Schutz, F. A., Je, Y., Richards, C. J., & Choueiri, T. K. (2012). Meta-analysis of randomized controlled trials for the incidence and risk of treatment-related mortality in patients with cancer treated with vascular endothelial growth factor tyrosine kinase inhibitors. Journal of Clinical Oncology, 30, 871-877.
-
(2012)
Journal of Clinical Oncology
, vol.30
, pp. 871-877
-
-
Schutz, F.A.1
Je, Y.2
Richards, C.J.3
Choueiri, T.K.4
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