Metabolomics-driven approach to solving a CoA imbalance for improved 1-butanol production in Escherichia coli

Metabolic Engineering

Volumn 41, Issue , 2017, Pages 135-143

  Ohtake, Toshiyuki ^a   Pontrelli, Sammy ^b   Laviña, Walter A ^a   Liao, James C ^b   Putri, Sastia P ^a   Fukusaki, Eiichiro ^a  

^a OSAKA UNIVERSITY   (Japan)

^b University of California   (United States)

Author keywords

1 Butanol; CoA balance; Escherichia coli; Metabolomics; Strain improvement

Indexed keywords

AMINO ACIDS; CARBON; ESCHERICHIA COLI; METABOLISM;

1-BUTANOL; ALCOHOL DEHYDROGENASE; ANAEROBIC CONDITIONS; ENGINEERING PRINCIPLES; METABOLOME ANALYSIS; METABOLOMICS; STRAIN IMPROVEMENT; TERMINAL ELECTRON ACCEPTORS;

METABOLIC ENGINEERING;

ALCOHOL DEHYDROGENASE; AMPICILLIN; BUTANOL; CHLORAMPHENICOL; COENZYME A; FORMATE DEHYDROGENASE; FUMARATE REDUCTASE; KANAMYCIN; LACTATE DEHYDROGENASE; PHOSPHATE ACETYLTRANSFERASE; PHOSPHOENOLPYRUVATE; PYRUVIC ACID; TETRACYCLINE; ADHE PROTEIN, E COLI; ALDEHYDE DEHYDROGENASE; CYSTEINE; ESCHERICHIA COLI PROTEIN;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CONTROLLED STUDY; ESCHERICHIA COLI; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; METABOLIC ENGINEERING; METABOLOMICS; MULTIPLE REACTION MONITORING; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; STOP CODON; STRAIN IMPROVEMENT; TRANSLATION INITIATION; GENETICS; METABOLISM; METABOLOME;

1-BUTANOL; ALCOHOL DEHYDROGENASE; ALDEHYDE OXIDOREDUCTASES; COENZYME A; CYSTEINE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; METABOLOME; METABOLOMICS;

EID: 85017430967     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2017.04.003     Document Type: Article

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