High-titer n-butanol production by clostridium acetobutylicum JB200 in fed-batch fermentation with intermittent gas stripping

Biotechnology and Bioengineering

Volumn 109, Issue 11, 2012, Pages 2746-2756

  Xue, Chuang ^a,b   Zhao, Jingbo ^b   Lu, Congcong ^b   Yang, Shang Tian ^b   Bai, Fengwu ^a   Tang, I Ching ^c  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b Ohio State University   (United States)

^c Bioprocessing Innovative Company   (United States)

Author keywords

Acetone butanol ethanol fermentation; Butanol; Clostridium acetobutylicum; Fed batch fermentation; Gas stripping

Indexed keywords

ABE FERMENTATIONS; ACETONE-BUTANOL-ETHANOL FERMENTATION; ACIDOGENESIS; BATCH FERMENTATION; BUTANOL INHIBITION; CLOSTRIDIUM ACETOBUTYLICUM; DE-MIXING; FED-BATCH FERMENTATION; FERMENTATION BROTHS; GAS STRIPPING; LIQUID-LIQUIDS; N-BUTANOL; WATER USAGE;

ACETONE; BUTENES; ENERGY UTILIZATION; ETHANOL; FERMENTATION; GAS CONDENSATES; GASES; GLUCOSE; PHASE SEPARATION; PRODUCTIVITY;

ALCOHOLS;

ACETONE; ALCOHOL; BUTANOL; GLUCOSE;

ACIDITY; ALCOHOL PRODUCTION; ARTICLE; BACTERIAL METABOLISM; BACTERIUM CULTURE; BIOACCUMULATION; CLOSTRIDIUM ACETOBUTYLICUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FED BATCH CULTURE; FED BATCH FERMENTATION; FED BATCH REACTOR; GAS STRIPPING; GLUCOSE METABOLISM; ISOLATION PROCEDURE; NONHUMAN;

1-BUTANOL; ACETONE; CLOSTRIDIUM ACETOBUTYLICUM; CULTURE MEDIA; ETHANOL; FERMENTATION; GASES; GLUCOSE; TIME FACTORS;

CLOSTRIDIUM ACETOBUTYLICUM;

EID: 84866744421     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24563     Document Type: Article

References (48)

1. Barton WE, Daugulis AJ. 1992. Evaluation of solvents for extractive butanol fermentation with Clostridium acetobutylicum and the use of poly (propylene glycol) 1200. Appl Microbiol Biotechnol 36: 632-663.
2. Chen CK, Blaschek HP. 1999. Acetate enhances solvent production and prevents degeneration in Clostridium beijerinckii BA101. Appl Microbiol Biotechnol 52: 170-173.
3. Dürre P. 1998. New insights and novel developments in clostridial acetone/butanol/isopropanol fermentation. Appl Microbiol Biotechnol 49: 639-648.
4. Dürre P. 2007. Biobutanol: An attractive biofuel. Biotechnol J 2: 1525-1534.
5. Ennis B, Marshall CT, Maddox IS, Paterson AHJ. 1986. Continuous product recovery by in-situ gas stripping/condensation during solvent production from whey permeate using Clostridium acetobutylicum. Biotechnol Lett 8: 725-730.
6. Evans PJ, Wang HY. 1988. Enhancement of butanol formation by Clostridium acetobutylicum in the presence of decanol-oleyl alcohol mixed extractants. Appl Environ Microbiol 54: 1662-1667.
7. Ezeji TC, Qureshi N, Blaschek HP. 2003. Production of acetone, butanol and ethanol by Clostridium beijerinckii BA101 and in situ recovery by gas stripping. World J Microbiol Biotechnol 19: 595-603.
8. Ezeji TC, Qureshi N, Blaschek HP. 2004. Acetone-Butanol-Ethanol (ABE) production from concentrated substrate: Reduction in substrate inhibition by fed-batch technique and product inhibition by gas stripping. Appl Microbiol Biotechnol 63: 653-658.
9. Ezeji TC, Karcher PM, Qureshi N, Blaschek HP. 2005. Improving performance of a gas stripping-based recovery system to remove butanol from Clostridium beijerinckii fermentation. Bioprocess Biosyst Eng 27: 207-214.
10. Ezeji TC, Qureshi N, Blaschek HP. 2007a. Bioproduction of butanol from biomass: From genes to bioreactors. Curr Opin Biotechnol 18: 220-227.
11. Ezeji TC, Qureshi N, Blaschek HP. 2007b. Production of acetone butanol (AB) from liquefied corn starch, a commercial substrate, using Clostridium beijerinckii coupled with product recovery by gas stripping. J Ind Microbiol Biotechnol 34: 771-777.
12. Ezeji TC, Milne C, Price ND, Blaschek HP. 2010. Achievements and perspectives to overcome the poor solvent resistance in acetone and butanol-producing microorganisms. Appl Microbiol Biotechnol 85: 1697-1712.
13. Gapes JR, Nimcevic D, Friedl A. 1996. Long-term continuous cultivation of Clostridium beijerinckii in a two-stage chemostat with on-line solvent removal. Appl Environ Microbiol 62: 3210-3219.
14. Groot WJ, Lans RGJM, Luyben KChAM. 1989. Batch and continuous butanol fermentations with free cells: Integration with product recovery by gas-stripping. Appl Microbiol Biotechnol 32: 305-308.
15. Groot WJ, Lans RGJM, Luyben KChAM. 1992. Technologies for butanol recovery integrated with fermentations. Process Biochem 27: 61-75.
16. Huang WC, Ramey DE, Yang ST. 2004. Continuous production of butanol by Clostridium acetobutylicum immobilized in a fibrous bed bioreactor. Appl Biochem Biotechnol 113-116: 887-898.
17. Institute for Agriculture and Trade Policy, (IATP). 2006. Water use by ethanol plants potential challenges, Minneapolis, MN. www.agobservatory.org/library.cfm?refid=89449.
18. Jain MK, Beacom D, Datta R. 1993. Mutant strain of C. acetobutylicum and process for making butanol, US patent 5192673.
19. Jones DT, Keis S. 1995. Origins and relationships of industrial solvent producing clostridial strains. FEMS Microbiol Rev 17: 223-232.
20. Jones DT, Woods DR. 1986. Acetone-butanol fermentation revisited. Microbiol Rev 50: 484-524.
21. Kashket ER, Cao ZY. 1993. Isolation of a degeneration-resistant mutant of Clostridium acetobutylicum NCIMB 8052. Appl Environ Microbiol 59: 4198-4202.
22. Lee SY, Park JH, Jang SH, Nielsen LK, Kim J, Jung KS. 2008. Fermentative butanol production by Clostridia. Biotechnol Bioeng 101: 209-228.
23. Lu CC, Zhao JB, Yang ST, Wei D. 2012. Fed-batch fermentation for butanol production from cassava bagasse hydrolysate in a fibrous bed bioreactor with continuous gas stripping. Bioresour Technol 104: 380-387.
24. Maddox IS. 1988. The acetone-butanol-ethanol fermentation: Recent progress in technology. Biotechnol Genet Eng Rev 7: 189-220.
25. Maddox IS, Qureshi N, Roberts-Thomson K. 1995. Production of acetone-butanol-ethanol from concentrated substrates using Clostridium acetobutylicum in an integrated fermentation-product removal process. Process Biochem 30: 209-215.
26. Maddox IS, Steiner E, Hirsch S, Wessner S, Gutierrez NA, Gapes JR, Schuster KC. 2000. The cause of "acid crash" and "acidogenic fermentations" during the batch acetone-butanol-ethanol (ABE) fermentation process. J Mol Microbiol Biotechnol 2: 95-100.
27. Mariano AP, Qureshi N, Filho RM, Ezeji TC. 2011. Bioproduction of butanol in bioreactors: New insights from simultaneous in situ butanol recovery to eliminate product toxicity. Biotechnol Bioeng 108: 1757-1765.
28. Matsumura M, Kataoka H, Sueki M, Araki K. 1988. Energy saving effect of pervaporation using oleyl alcohol liquid membrane in butanol purification. Bioprocess Eng 3: 93-100.
29. Nicolaou SA, Gaida SM, Papoutsakis ET. 2010. A comparative view of metabolite and substrate stress and tolerance in microbial bioprocessing: From biofuels and chemicals, to biocatalysis and bioremediation. Metab Eng 12: 307-331.
30. Nielsen DR, Prather KJ. 2009. In situ product recovery of n-butanol using polymeric resins. Biotechnol Bioeng 102: 811-821.
31. Oudshoorn A, Van der Wielen LAM, Straathof AJJ. 2009. Assessment of options for selective 1-butanol recovery from aqueous solutions. Ind Eng Chem Res 48: 7325-7336.
32. Papoutsakis ET. 2008. Engineering solventogenic clostridia. Curr Opin Biotechnol 19: 420-429.
33. Park CH, Okos MR, Wankat PC. 1991. Acetone-butanol-ethanol (ABE) fermentation and simultaneous separation in a trickle bed reactor. Biotechnol Prog 7: 185-194.
34. Qureshi N, Blaschek HP. 1999. Butanol recovery from model solutions/fermentation broth by pervaporation: Evaluation of membrane performance. Biomass Bioenerg 17: 175-184.
35. Qureshi N, Blaschek HP. 2001. Recovery of butanol from fermentation broth by gas stripping. Renew Energy 22: 557-564.
36. Qureshi N, Maddox IS. 1991. Integration of continuous production and recovery of solvents from whey permeate: Use of immobilized cells of Clostridium acetobutylicum in a fluidized bed reactor coupled with gas stripping. Biopro Eng 6: 63-69.
37. Qureshi N, Maddox IS, Friedl A. 1992. Application of continuous substrate feeding to the ABE fermentation: Relief of product inhibition using extraction, perstraction, stripping, and pervaporation. Biotechnol Prog 8: 382-390.
38. Qureshi N, Hughes S, Maddox IS, Cotta MA. 2005. Energy-efficient recovery of butanol from model solutions and fermentation broth by adsorption. Bioprocess Biosyst Eng 27: 215-222.
39. Qureshi N, Saha BC, Hector RE, Hughes SR, Cotta MA. 2008. Butanol production from wheat straw by simultaneous saccharification and fermentation using Clostridium beijerinckii: Part I batch fermentation. Biomass Bioenergy 32: 168-175.
40. Roffler SR, Blanch HW, Wilke CR. 1987a. In-situ recovery of butanol during fermentation. Part 1: Batch extractive fermentation. Bioproc Eng 2: 1-12.
41. Roffler SR, Blanch HW, Wilke CR. 1987b. In-situ recovery of butanol during fermentation. Part 2: Fed-batch extractive fermentation. Bioproc Eng 2: 181-190.
42. Roffler SR, Blanch HW, Wilke CR. 1987c. Extractive fermentation of acetone and butanol: Process design and economic evaluation. Biotechnol Prog 3: 131-140.
43. Roffler SR, Blanch HW, Wilke CR. 1988. In situ extractive fermentation of acetone and butanol. Biotechnol Bioeng 31: 135-143.
44. Soni BK, Das K, Ghose TK. 1987. Inhibitory factors involved in acetone-butanol fermentation by Clostridium saccharoperbutylacetonicum. Curr Microbiol 16: 61-67.
45. Vane LM. 2008. Separation technologies for the recovery and dehydration of alcohols from fermentation broths. Biofuels Bioprod Biorefin 2: 553-588.
46. Woolley RC, Morris JG. 1990. Stability of solvent production by Clostridium acetobutylicum in continuous culture: Strain differences. J Appl Bacteriol 69: 718-728.
47. Yu MR, Zhang YL, Tang IC, Yang ST. 2011. Metabolic engineering of Clostridium tyrobutyricum for n-butanol production. Metab Eng 13: 373-382.
48. Zheng YN, Li LZ, Xian M, Ma YJ, Yang JM, Xu X, He DZ. 2009. Problems with the microbial production of butanol. J Ind Microbiol Biotechnol 36: 1127-1138.