Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action

Biochemical Pharmacology

Volumn 139, Issue , 2017, Pages 71-81

  Tan, W S Daniel ^a   Liao, Wupeng ^a   Zhou, Shuo ^a   Wong, W S Fred ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Asthma; Autoimmune; Hepatitis; Neurodegeneration; NF B; Nrf2

Indexed keywords

12,13 DIHYDROANDROGRAPHOLIDE; 14 DEOXY 11,12 DIDEHYDROANDROGRAPHOLIDE; 14 DEOXY 14,15 DEHYDROANDROGRAPHOLIDE; 14 DEOXYANDROGRAPHOLIDE; 19 O ACETYLANHYDROANDROGRAPHOLIDE; 3,19 DIPALMITOYL 14 DEOXY 11,12 DIDEHYDROANDROGRAPHOLIDE; 3,19 O DIACETYLANHYDROANDROGRAPHOLIDE; 4 HYDROANDROGRAPHOLIDE; ANDROGRAPHISIDE; ANDROGRAPHOLIDE; ANDROGRAPHOLIDE LIPOIC ACID; ANDROGRAPHOLIDE SULFONATE; ANTIOXIDANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOANDROGRAPHOLIDE; NEOANDROGRAPHOLIDE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; DITERPENE; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NEW DRUG; NFE2L2 PROTEIN, HUMAN; NFKB1 PROTEIN, HUMAN; NONSTEROID ANTIINFLAMMATORY AGENT; PROTECTIVE AGENT;

ANTIINFLAMMATORY ACTIVITY; AUTOIMMUNE DISEASE; DEGENERATIVE DISEASE; DERMATITIS; DRUG MECHANISM; DRUG STRUCTURE; HEPATITIS; HUMAN; INFLAMMATORY DISEASE; LIVER CIRRHOSIS; PNEUMONIA; PRIORITY JOURNAL; REVIEW; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOIMMUNE DISEASES; BIOLOGICAL MODEL; CHEMICAL AND DRUG INDUCED LIVER INJURY; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AUTOIMMUNE DISEASES; CHEMICAL AND DRUG INDUCED LIVER INJURY; DERMATITIS; DITERPENES; DRUG DESIGN; DRUGS, INVESTIGATIONAL; HEPATITIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER CIRRHOSIS; MODELS, BIOLOGICAL; NEURODEGENERATIVE DISEASES; NF-E2-RELATED FACTOR 2; NF-KAPPA B P50 SUBUNIT; OXIDATIVE STRESS; PNEUMONIA; PROTECTIVE AGENTS; SIGNAL TRANSDUCTION;

EID: 85017178078     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2017.03.024     Document Type: Review

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