Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: Autoregulation of GSK-3β in vivo

Biochemical Journal

Volumn 466, Issue , 2015, Pages 415-430

  Tapia Rojas, Cheril ^a   Schüller, Andreas ^a,b   Lindsay, Carolina B ^a   Ureta, Roxana C ^a   Mejías Reyes, Cristóbal ^a   Hancke, Juan ^c   Melo, Francisco ^a   Inestrosa, Nibaldo C ^a,d,e  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b Pontificia Universidad Católica de Chile   (Chile)

^c UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e Centro de Excelencia en Biomedicina de Magallanes (CEBIMA)   (Chile)

Author keywords

Andrographolide; GSK 3 ; Universidad de magallanes; Wnt signalling; Wnt target genes; Wnt catenin

Indexed keywords

ANDROGRAPHOLIDE; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHOPROTEIN PHOSPHATASE 1; WNT PROTEIN; DITERPENE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; NOOTROPIC AGENT; PROTEIN KINASE INHIBITOR; SERINE;

ANDROGRAPHIS PANICULATA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOREGULATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE COMPLEX; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VIVO STUDY; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; WNT SIGNALING PATHWAY; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENZYME ACTIVE SITE; GENETICS; HIPPOCAMPUS; IN VITRO STUDY; METABOLISM; MOLECULAR DOCKING; NERVE CELL; PHOSPHORYLATION; PROTEIN PROCESSING;

ANDROGRAPHIS PANICULATA; ANIMALIA;

ANIMALS; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CELLS, CULTURED; DITERPENES; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; IN VITRO TECHNIQUES; MICE; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; NEURONS; NOOTROPIC AGENTS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; SERINE; WNT SIGNALING PATHWAY;

EID: 84923233767     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140207     Document Type: Article

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