Inhibition of NF-κB expression and allergen-induced airway inflammation in a mouse allergic asthma model by andrographolide

Cellular and Molecular Immunology

Volumn 6, Issue 5, 2009, Pages 381-385

  Li, Jing ^a   Luo, Li ^a   Wang, Xiaoyun ^a   Liao, Bin ^a   Li, Guoping ^a  

^a THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

Airway inflammation; Andrographolide; Asthma; NF B

Indexed keywords

ANDROGRAPHOLIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OVALBUMIN; ALLERGEN; ANDROGRAPHOSIDE; ANTIINFLAMMATORY AGENT; DITERPENE; HERBACEOUS AGENT;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CELL NUCLEUS; CHINESE MEDICINE; CONTROLLED STUDY; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; INFLAMMATORY CELL; LUNG FUNCTION TEST; LUNG INFILTRATE; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROVOCATION TEST; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; DRUG MECHANISM; INHIBITION KINETICS; ANIMAL; ASTHMA; BRONCHIOLE; BRONCHUS HYPERREACTIVITY; DOWN REGULATION; DRUG EFFECT; EPITHELIUM; IMMUNOLOGY; LUNG ALVEOLUS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; ULTRASTRUCTURE;

MUS;

ALLERGENS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHIOLES; CELL NUCLEUS; DITERPENES; DOWN-REGULATION; DRUGS, CHINESE HERBAL; EPITHELIUM; MICE; NF-KAPPA B; OVALBUMIN; PULMONARY ALVEOLI;

EID: 70350786933     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2009.49     Document Type: Article

References (11)

1. Edwards MR, Bartlett NW, Clarke D, Birrell M, Belvisi M, Johnston SL. Targeting the NF-KB pathway in asthma and chronic obstructive pulmonary disease. Pharmacol Ther. 2009; 1211-1213.
2. Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory dieases. 2009; 30;373:1905-1917.
3. Abu-Ghefreh AA, Canatan EI, Ezeamuzie CL. In vitro and in vivo anti-inflammatory effects of Andrographolide. Int Immuno-pharmacol. 2009;9:313-318.
4. Xia YF, Ye BQ, Li YD, et al. Andrographolide attenuates inflammation by inhibition of NF-KB activation through covalent modification of reduced cysteine 62 of p50. J Immunol. 2004;173:4207-4217.
5. Li GP, Liu ZG, Qiu J, Ran PX, Zhong NS. DNA vaccine encoding Der p 2 allergen generates immunologic protection in recombinant Derp2 allergen-induced allergic airway inflammation mice model. Chin Med J. 2005; 5; 118:534-540.
6. Qiu J, Li GP, Liu ZG, Ran PX, Zhong NS. DNA vaccine encoding Der p2 allergen down-regulates STAT6 expression in mouse model of allergen-induced allergic airway inflammation. Chin Med J. 2006; 119:185-190.
7. Ala'a A, Abu-Ghefreh, Halit Canatan, Charles I Ezeamuzie. Anti-inflammatory effects of Andrographolide: inhibition of the release of cytokines relevant to asthma. Ala'a A. Abu-Ghefreh, Halit Canatan, and Charles I Ezeamuzie. FASEB J. 2009;23: 755-760.
8. Bao Z, Guan S, Cheng C, et al. A novel antiinflammatory role for Andrographolide in asthma via inhibition of the nuclear factor-KB pathway. Am J Respir Crit Care Med. 2009; 179:657-665.
9. Wang YJ, Wang JT, Fan QX, Geng JG. Andrographolide inhibits NF-KB activation and attenuates neointimal hyperplasia in arterial restenosis. Cell Res. 2007;17:933-941.
10. Poynter ME, Cloots R, van Woerkom T, et al. NF-KB activation in airways modulates allergic inflammation but not hyperresponsiveness. J Immunol. 2004;l;173:7003-7009.
11. Li G, Liu Z, Zhong N, Liao B, Xiong Y. Therapeutic effects of DNA vaccine on allergen-induced allergic airway inflammation in mouse model. Cell Mol Immunol. 2006;3:379-384.