메뉴 건너뛰기




Volumn , Issue , 2012, Pages 191-213

Protein drug delivery to retina and choroid

Author keywords

[No Author keywords available]

Indexed keywords


EID: 85017157560     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b12950     Document Type: Chapter
Times cited : (3)

References (140)
  • 1
    • 85055845174 scopus 로고    scopus 로고
    • The promise of ocular implants
    • Parkinson J. The promise of ocular implants. Retinal Physician. 2005; 2: 79-84.
    • (2005) Retinal Physician. , vol.2 , pp. 79-84
    • Parkinson, J.1
  • 2
    • 41949120596 scopus 로고    scopus 로고
    • Safety evaluation of ocular drug delivery formulations: Techniques and prac-tical considerations
    • Short BG. Safety evaluation of ocular drug delivery formulations: Techniques and prac-tical considerations. Toxicol Pathol. 2008; 36: 49-62.
    • (2008) Toxicol Pathol. , vol.36 , pp. 49-62
    • Short, B.G.1
  • 6
    • 0035980341 scopus 로고    scopus 로고
    • Biodegradable microspheres for vitreoretinal drug deliv-ery
    • Herrero-Vanrell R, Refojo MF. Biodegradable microspheres for vitreoretinal drug deliv-ery. Adv Drug Deliv Rev. 2001; 52: 5-16.
    • (2001) Adv Drug Deliv Rev. , vol.52 , pp. 5-16
    • Herrero-Vanrell, R.1    Refojo, M.F.2
  • 7
    • 0033635054 scopus 로고    scopus 로고
    • Protein instability in poly(lactic-co-glycolic acid) microparticles
    • van de Weert M, Hennink WE, Jiskoot W. Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharm Res. 2000; 17: 1159-1167.
    • (2000) Pharm Res. , vol.17 , pp. 1159-1167
    • van de Weert, M.1    Hennink, W.E.2    Jiskoot, W.3
  • 8
    • 52449094115 scopus 로고    scopus 로고
    • Chemical degradation of peptides and proteins in PLGA: A review of reactions and mechanisms
    • Houchin ML, Topp EM. Chemical degradation of peptides and proteins in PLGA: A review of reactions and mechanisms. J Pharm Sci. 2008; 97: 2395-2404.
    • (2008) J Pharm Sci. , vol.97 , pp. 2395-2404
    • Houchin, M.L.1    Topp, E.M.2
  • 9
    • 0031752709 scopus 로고    scopus 로고
    • Protein delivery from poly(lactic-co-glycolic acid) biodegrad-able microspheres: Release kinetics and stability issues
    • Crotts G, Park TG. Protein delivery from poly(lactic-co-glycolic acid) biodegrad-able microspheres: Release kinetics and stability issues. J Microencapsul 1998; 15: 699-713.
    • (1998) J Microencapsul , vol.15 , pp. 699-713
    • Crotts, G.1    Park, T.G.2
  • 10
    • 67650444052 scopus 로고    scopus 로고
    • Downregulation of endo-toxin-induced uveitis by intravitreal injection of polylactic-glycolic acid (PLGA) micro-spheres loaded with dexamethasone
    • Barcia E, Herrero-Vanrell R, Díez A, Alvarez-Santiago C. Downregulation of endo-toxin-induced uveitis by intravitreal injection of polylactic-glycolic acid (PLGA) micro-spheres loaded with dexamethasone. Exp Eye Res. 2009; 89: 238-245.
    • (2009) Exp Eye Res. , vol.89 , pp. 238-245
    • Barcia, E.1    Herrero-Vanrell, R.2    Díez, A.3    Alvarez-Santiago, C.4
  • 12
    • 0142231905 scopus 로고    scopus 로고
    • Periocular injection of microspheres containing PKC412 inhibits choroidal neovascularization in a porcine model
    • Saisbin Y, Silva RL, Saisbin Y, Callaban K, Schoch C, Ablbeim M, Lai H et al. Periocular injection of microspheres containing PKC412 inhibits choroidal neovascularization in a porcine model. Invest Ophthalmol Vis Sci 2003; 44: 4989-4993.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 4989-4993
    • Saisbin, Y.1    Silva, R.L.2    Saisbin, Y.3    Callaban, K.4    Schoch, C.5    Ablbeim, M.6    Lai, H.7
  • 14
  • 16
    • 0032699973 scopus 로고    scopus 로고
    • Intraocular pharmacokinetics and safety of a humanized monoclonal antibody in rab-bits after intravitreal administration of a solution or a PLGA microsphere formulation
    • Mordenti J, Thomsen K, Licko V, Berleau L, Kahn JW, Cuthbertson RA, Duenas ET et al. Intraocular pharmacokinetics and safety of a humanized monoclonal antibody in rab-bits after intravitreal administration of a solution or a PLGA microsphere formulation. Toxicol Sci 1999; 52: 101-106.
    • (1999) Toxicol Sci , vol.52 , pp. 101-106
    • Mordenti, J.1    Thomsen, K.2    Licko, V.3    Berleau, L.4    Kahn, J.W.5    Cuthbertson, R.A.6    Duenas, E.T.7
  • 17
    • 77953173751 scopus 로고    scopus 로고
    • New techniques for drug delivery to the posterior eye treatment
    • Eljarrat-Binstock E, Pe’er J, Domb AJ. New techniques for drug delivery to the posterior eye treatment. Pharm Res. 2010; 27: 530-543.
    • (2010) Pharm Res. , vol.27 , pp. 530-543
    • Eljarrat-Binstock, E.1    Pe’er, J.2    Domb, A.J.3
  • 18
    • 39149121847 scopus 로고    scopus 로고
    • Current and future ophthalmic drug delivery systems. A shift to the posterior segment
    • del Amo EM, Urtti A. Current and future ophthalmic drug delivery systems. A shift to the posterior segment. Drug Discov Today. 2008; 13: 135-143.
    • (2008) Drug Discov Today. , vol.13 , pp. 135-143
    • del Amo, E.M.1    Urtti, A.2
  • 19
    • 0021123496 scopus 로고
    • Controlled release of a luteinizing hormone-releasing hormone analogue from poly(d, l-lactide-co-gly-colide) microspheres
    • Sanders LM, Kent JS, McRae GI, Vickery BH, Tice TR, Lewis DH. Controlled release of a luteinizing hormone-releasing hormone analogue from poly(d, l-lactide-co-gly-colide) microspheres. J Pharm Sci. 1984; 73: 1294-1297.
    • (1984) J Pharm Sci. , vol.73 , pp. 1294-1297
    • Sanders, L.M.1    Kent, J.S.2    McRae, G.I.3    Vickery, B.H.4    Tice, T.R.5    Lewis, D.H.6
  • 20
    • 23144467114 scopus 로고    scopus 로고
    • Effects of additives on the release of model protein from PLGA micro-spheres
    • Kang F, Singh J. Effects of additives on the release of model protein from PLGA micro-spheres. AAPS PharmSciTech. 2001; 2:1-7.
    • (2001) AAPS PharmSciTech , vol.2 , pp. 1-7
    • Kang, F.1    Singh, J.2
  • 22
    • 0032555520 scopus 로고    scopus 로고
    • Sustained delivery of proteins for novel therapeutic products
    • Bartus RT, Tracey MA, Emerich DE, Zale SE. Sustained delivery of proteins for novel therapeutic products. Science. 1998; 281: 1161-1162.
    • (1998) Science. , vol.281 , pp. 1161-1162
    • Bartus, R.T.1    Tracey, M.A.2    Emerich, D.E.3    Zale, S.E.4
  • 24
    • 0034602599 scopus 로고    scopus 로고
    • Protein encapsulation into bio-degradable microspheres by a novel S/O/W emulsion method using poly(ethylene gly-col) as a protein micronization adjuvant
    • Morita T, Sakamura Y, Horikiri Y, Sukuki T, Yoshino H. Protein encapsulation into bio-degradable microspheres by a novel S/O/W emulsion method using poly(ethylene gly-col) as a protein micronization adjuvant. J Control Release. 2000; 69: 435-444.
    • (2000) J Control Release. , vol.69 , pp. 435-444
    • Morita, T.1    Sakamura, Y.2    Horikiri, Y.3    Sukuki, T.4    Yoshino, H.5
  • 25
    • 0037436016 scopus 로고    scopus 로고
    • Poly(ethylene glycol) as stabilizer and emulsi-fying agent: A novel stabilization approach preventing aggregation and inactivation of proteins upon encapsulation in bioerodible polyester microsphere
    • Castellanos IJ, Crespo R, Griebenow K. Poly(ethylene glycol) as stabilizer and emulsi-fying agent: A novel stabilization approach preventing aggregation and inactivation of proteins upon encapsulation in bioerodible polyester microsphere. J Control Release. 2003; 88: 135-145.
    • (2003) J Control Release. , vol.88 , pp. 135-145
    • Castellanos, I.J.1    Crespo, R.2    Griebenow, K.3
  • 26
    • 33750706545 scopus 로고    scopus 로고
    • In vitro study of lysozyme in poly(lactide-co-glycolide) microspheres with sucrose acetate isobutyrate
    • Lee ES, Kwon MJ, Lee H, Na K, Kim JJ. In vitro study of lysozyme in poly(lactide-co-glycolide) microspheres with sucrose acetate isobutyrate. Eur J Pharm Sci. 2006; 29: 435-441.
    • (2006) Eur J Pharm Sci. , vol.29 , pp. 435-441
    • Lee, E.S.1    Kwon, M.J.2    Lee, H.3    Na, K.4    Kim, J.J.5
  • 27
    • 0034610166 scopus 로고    scopus 로고
    • Lysozyme microencapsulation within biode-gradable PLGA microspheres: Urea effect on protein release and stability
    • Nam YS, Song SH, Choi JY, Park TG. Lysozyme microencapsulation within biode-gradable PLGA microspheres: Urea effect on protein release and stability. Biotechnol Bioeng. 2000; 70: 270-277.
    • (2000) Biotechnol Bioeng. , vol.70 , pp. 270-277
    • Nam, Y.S.1    Song, S.H.2    Choi, J.Y.3    Park, T.G.4
  • 28
    • 0030795050 scopus 로고    scopus 로고
    • A novel biodegradable system based on gelatin nanoparticles and poly(lactic-co-glycolic acid) microspheres for protein and peptide drug delivery
    • Li JK, Wang N, Wu XS. A novel biodegradable system based on gelatin nanoparticles and poly(lactic-co-glycolic acid) microspheres for protein and peptide drug delivery. J Pharm Sci. 1997; 86: 891-895.
    • (1997) J Pharm Sci. , vol.86 , pp. 891-895
    • Li, J.K.1    Wang, N.2    Wu, X.S.3
  • 29
    • 33745335884 scopus 로고    scopus 로고
    • In vitro characteristics of poly (lactic-co-glycolic acid) microspheres incorporating gelatin particles loading basic fibroblast growth factor
    • Li, SH, Cai SX, Liu B, Ma KW, Wang ZP, Li XK. In vitro characteristics of poly (lactic-co-glycolic acid) microspheres incorporating gelatin particles loading basic fibroblast growth factor. Acta Pharmacol Sin. 2006; 27: 754-759.
    • (2006) Acta Pharmacol Sin. , vol.27 , pp. 754-759
    • Li, S.H.1    Cai, S.X.2    Liu, B.3    Ma, K.W.4    Wang, Z.P.5    Li, X.K.6
  • 30
    • 0036732080 scopus 로고    scopus 로고
    • Study on biodegradable microspheres containing recombinant interferon-f-2α
    • Zhou S, Deng X, He S, Li X, Jia W, Wei D, Zhang Z, Ma J. Study on biodegradable microspheres containing recombinant interferon-f-2α. J Pharm Pharmacol. 2002; 54: 1287-1292.
    • (2002) J Pharm Pharmacol. , vol.54 , pp. 1287-1292
    • Zhou, S.1    Deng, X.2    He, S.3    Li, X.4    Jia, W.5    Wei, D.6    Zhang, Z.7    Ma, J.8
  • 31
    • 0032834111 scopus 로고    scopus 로고
    • A heterogeneously structured composite based on poly (lactic-co-glycolic acid) microspheres and poly (vinyl alcohol) hydrogel nanospheres for long-term protein drug delivery
    • Wang N, Wu XS, Li JK. A heterogeneously structured composite based on poly (lactic-co-glycolic acid) microspheres and poly (vinyl alcohol) hydrogel nanospheres for long-term protein drug delivery. Pharm Res. 1999; 16: 1430-1435.
    • (1999) Pharm Res. , vol.16 , pp. 1430-1435
    • Wang, N.1    Wu, X.S.2    Li, J.K.3
  • 32
    • 74749107861 scopus 로고    scopus 로고
    • Microencapsulation of protein-loaded polysaccharide particles within poly(D, L-lactic-co-glycolic acid) microspheres using S/O/W: Characterization and release studies
    • Yuan W, Wu F, Jin T. Microencapsulation of protein-loaded polysaccharide particles within poly(D, L-lactic-co-glycolic acid) microspheres using S/O/W: Characterization and release studies. Polym Adv Technol. 2009; 20: 834-842.
    • (2009) Polym Adv Technol. , vol.20 , pp. 834-842
    • Yuan, W.1    Wu, F.2    Jin, T.3
  • 33
    • 33745919229 scopus 로고    scopus 로고
    • BSA degradation under acidic condi-tions: A model for protein instability during release from PLGA delivery systems
    • Estey T, Kang J, Schwendeman SP, Carpenter JF. BSA degradation under acidic condi-tions: A model for protein instability during release from PLGA delivery systems. J Pharm Sci. 2006; 95: 1626-1639.
    • (2006) J Pharm Sci. , vol.95 , pp. 1626-1639
    • Estey, T.1    Kang, J.2    Schwendeman, S.P.3    Carpenter, J.F.4
  • 34
    • 0037240295 scopus 로고    scopus 로고
    • Acylation of peptides by lactic acid solutions
    • Lucke A, Göpferich A. Acylation of peptides by lactic acid solutions. Eur J Pharm Biopharm. 2003; 55: 27-33.
    • (2003) Eur J Pharm Biopharm. , vol.55 , pp. 27-33
    • Lucke, A.1    Göpferich, A.2
  • 36
    • 38549156628 scopus 로고    scopus 로고
    • How to achieve sus-tained and complete protein release from PLGA-based microparticles?
    • Giteau A, Venier-Julienne MC, Aubert-Pouëssel A, Benoit JP. How to achieve sus-tained and complete protein release from PLGA-based microparticles? Int J Pharm. 2008; 350: 14-26.
    • (2008) Int J Pharm. , vol.350 , pp. 14-26
    • Giteau, A.1    Venier-Julienne, M.C.2    Aubert-Pouëssel, A.3    Benoit, J.P.4
  • 37
    • 0001719160 scopus 로고    scopus 로고
    • Microencapsulation of human growth hormone within biodegrad-able polyester microspheres: Protein aggregation stability and incomplete release mech-anism
    • Kim HK, Park TG. Microencapsulation of human growth hormone within biodegrad-able polyester microspheres: Protein aggregation stability and incomplete release mech-anism. Biotechnol Bioeng. 1999; 65: 659-667.
    • (1999) Biotechnol Bioeng. , vol.65 , pp. 659-667
    • Kim, H.K.1    Park, T.G.2
  • 38
    • 33645762767 scopus 로고    scopus 로고
    • Deamination, acylation and proteolysis of a model peptide in PLGA films
    • Houchin ML, Heppert K, Topp EM. Deamination, acylation and proteolysis of a model peptide in PLGA films. J Control Release. 2006; 112: 111-119.
    • (2006) J Control Release. , vol.112 , pp. 111-119
    • Houchin, M.L.1    Heppert, K.2    Topp, E.M.3
  • 39
    • 0032096180 scopus 로고    scopus 로고
    • Biodegradable comb polyesters: Part I. Synthesis, characteriza-tion and structural analysis of poly(lactide) and poly(lactide-co-glycolide) grafted onto water-soluble poly(vinyl alcohol) as backbone
    • Breitenbach A, Kissel T. Biodegradable comb polyesters: Part I. Synthesis, characteriza-tion and structural analysis of poly(lactide) and poly(lactide-co-glycolide) grafted onto water-soluble poly(vinyl alcohol) as backbone. Polymer. 1998; 39: 3261-3271.
    • (1998) Polymer. , vol.39 , pp. 3261-3271
    • Breitenbach, A.1    Kissel, T.2
  • 40
    • 0342700189 scopus 로고    scopus 로고
    • Biodegradable comb polyesters: Part II. Erosion and release properties of poly(vinyl alcohol)-g-poly(lactic-co-glycolic acid
    • Breitenbach A, Pistel KF, Kissel T. Biodegradable comb polyesters: Part II. Erosion and release properties of poly(vinyl alcohol)-g-poly(lactic-co-glycolic acid. Polymer. 2000; 41: 4781-4792.
    • (2000) Polymer. , vol.41 , pp. 4781-4792
    • Breitenbach, A.1    Pistel, K.F.2    Kissel, T.3
  • 41
    • 0035907172 scopus 로고    scopus 로고
    • Brush-like branched biodegradable polyesters: Part III. Protein release from microspheres of poly (vinyl alcohol)-grafted-poly(D, L-lactic-co-glycolic acid)
    • Pistel KF, Breitenbach A, Regina Z-V, Kissel T. Brush-like branched biodegradable polyesters: Part III. Protein release from microspheres of poly (vinyl alcohol)-grafted-poly(D, L-lactic-co-glycolic acid). J Control Release. 2001; 73: 7-20.
    • (2001) J Control Release. , vol.73 , pp. 7-20
    • Pistel, K.F.1    Breitenbach, A.2    Regina, Z.-V.3    Kissel, T.4
  • 42
    • 0034738791 scopus 로고    scopus 로고
    • Influence of process param-eters on the protein stability encapsulated in poly-DL-lactide-poly(ethylene glycol) microspheres
    • Li X, Zhang Y, Yan R, Jia W, Yuan M, Deng X, Huang Z. Influence of process param-eters on the protein stability encapsulated in poly-DL-lactide-poly(ethylene glycol) microspheres. J Control Release. 2000; 68: 41-52.
    • (2000) J Control Release. , vol.68 , pp. 41-52
    • Li, X.1    Zhang, Y.2    Yan, R.3    Jia, W.4    Yuan, M.5    Deng, X.6    Huang, Z.7
  • 43
    • 0033996360 scopus 로고    scopus 로고
    • Stabilization of proteins encapsulated in cylindrical poly(lactide-co-glycolide) implants: Mechanism of stabilization by basic additives
    • Zhu G, Schwendeman SP. Stabilization of proteins encapsulated in cylindrical poly(lactide-co-glycolide) implants: Mechanism of stabilization by basic additives. Pharm Res. 2000; 17: 351-357.
    • (2000) Pharm Res. , vol.17 , pp. 351-357
    • Zhu, G.1    Schwendeman, S.P.2
  • 44
    • 0033986610 scopus 로고    scopus 로고
    • Stabilization of proteins encapsulated in inject-able poly(lactide-co-glycolide)
    • Zhu G, Mallery SR, Schwendeman SP. Stabilization of proteins encapsulated in inject-able poly(lactide-co-glycolide). Nat Biotechnol. 2000; 18: 52-57.
    • (2000) Nat Biotechnol. , vol.18 , pp. 52-57
    • Zhu, G.1    Mallery, S.R.2    Schwendeman, S.P.3
  • 45
    • 33845502714 scopus 로고    scopus 로고
    • Conjugates of poly(DL-lactide-co-glycolide) on amino cyclodextrins and their nanoparticles as protein delivery system
    • Gao H, Wang YN, Fan YG, Ma JB. Conjugates of poly(DL-lactide-co-glycolide) on amino cyclodextrins and their nanoparticles as protein delivery system. J Biomed Mater Res A. 2006; 80: 111-122. doi: 10.1002.
    • (2006) J Biomed Mater Res A , vol.80 , pp. 111-122
    • Gao, H.1    Wang, Y.N.2    Fan, Y.G.3    Ma, J.B.4
  • 46
    • 39449113296 scopus 로고    scopus 로고
    • Novel controlled-release Lemna-derived IFN-alpha2b (Locteron): Pharmacokinetics, pharmacodynamics, and tolerability in phase I clinical trial
    • De Leede LG, Humphries JE, Bechet AC, Van Hoogdalem EJ, Verrijk R, Spencer DG. Novel controlled-release Lemna-derived IFN-alpha2b (Locteron): Pharmacokinetics, pharmacodynamics, and tolerability in phase I clinical trial. J Interferon Cytokine Res 2008; 28: 113-122.
    • (2008) J Interferon Cytokine Res , vol.28 , pp. 113-122
    • De Leede, L.G.1    Humphries, J.E.2    Bechet, A.C.3    Van Hoogdalem, E.J.4    Verrijk, R.5    Spencer, D.G.6
  • 47
    • 34548715930 scopus 로고    scopus 로고
    • Bioresorbable drug-eluting stent coating formulations based on SynBioysys biodegradable multi-block copolymers
    • Steendam R, van der Laan A, Hissink D. Bioresorbable drug-eluting stent coating formulations based on SynBioysys biodegradable multi-block copolymers. J Control Release. 2006; 116: e94-e95.
    • (2006) J Control Release , vol.116 , pp. 94-95
    • Steendam, R.1    van der Laan, A.2    Hissink, D.3
  • 49
    • 0036279839 scopus 로고    scopus 로고
    • Semisolid, self-catalyzed poly(ortho ester) as controlled-release systems: Protein release and protein stability issues
    • van de Weert M, van Steenbergen MJ, Cleland JL, Heller J, Hennink WE, Crommelin DJA. Semisolid, self-catalyzed poly(ortho ester) as controlled-release systems: Protein release and protein stability issues. J Pharm Sci. 2002; 91: 1065-1074.
    • (2002) J Pharm Sci. , vol.91 , pp. 1065-1074
    • van de Weert, M.1    van Steenbergen, M.J.2    Cleland, J.L.3    Heller, J.4    Hennink, W.E.5    Crommelin, D.J.A.6
  • 50
    • 5044235051 scopus 로고    scopus 로고
    • Poly(ortho esters)-from concept to reality
    • Heller J, Barr J. Poly(ortho esters)-from concept to reality. Biomacromolecules. 2004; 5: 1625-1632.
    • (2004) Biomacromolecules. , vol.5 , pp. 1625-1632
    • Heller, J.1    Barr, J.2
  • 53
    • 72149093216 scopus 로고    scopus 로고
    • Silk nanospheres and microspheres from silk/pva blend films for drug delivery
    • Wang X, Yucel T, Lu Q, Hu X, Kaplan DL. Silk nanospheres and microspheres from silk/pva blend films for drug delivery. Biomaterials. 2010; 31: 1025-1035.
    • (2010) Biomaterials. , vol.31 , pp. 1025-1035
    • Wang, X.1    Yucel, T.2    Lu, Q.3    Hu, X.4    Kaplan, D.L.5
  • 55
    • 54949157213 scopus 로고    scopus 로고
    • Silk fibroin spheres as a platform for con-trolled drug delivery
    • Wenk E, Wandrey AJ, Merkle HP, Meinel L. Silk fibroin spheres as a platform for con-trolled drug delivery. J Control Release. 2008; 132: 26-34.
    • (2008) J Control Release. , vol.132 , pp. 26-34
    • Wenk, E.1    Wandrey, A.J.2    Merkle, H.P.3    Meinel, L.4
  • 56
    • 55049124030 scopus 로고    scopus 로고
    • Thermo-responsive systems for controlled drug delivery
    • Bikram M, West JL. Thermo-responsive systems for controlled drug delivery. Expert Opin Drug Deliv. 2008; 5: 1077-1091.
    • (2008) Expert Opin Drug Deliv. , vol.5 , pp. 1077-1091
    • Bikram, M.1    West, J.L.2
  • 58
    • 67149123505 scopus 로고    scopus 로고
    • In situ gelling polymers in ocular drug delivery systems: A review
    • Mundada AS, Avari, JG. In situ gelling polymers in ocular drug delivery systems: A review. Crit Rev Ther Drug Carrier Syst. 2008; 26: 85-118.
    • (2008) Crit Rev Ther Drug Carrier Syst. , vol.26 , pp. 85-118
    • Mundada, A.S.1    Avari, J.G.2
  • 60
    • 16344387352 scopus 로고    scopus 로고
    • PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release
    • Bhattarai N, Ramay HR, Gunn J, Matsen FA, Zhang M. PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release. J Control Release. 2005; 103: 609-624.
    • (2005) J Control Release. , vol.103 , pp. 609-624
    • Bhattarai, N.1    Ramay, H.R.2    Gunn, J.3    Matsen, F.A.4    Zhang, M.5
  • 61
    • 0031575549 scopus 로고    scopus 로고
    • A novel in situ-forming ophthalmic drug deliv-ery system from alginate undergoing gelation in the eye
    • Cohen S, Lobel E, Trevgoda A, Peled Y. A novel in situ-forming ophthalmic drug deliv-ery system from alginate undergoing gelation in the eye. J Control Release. 1997; 44: 201-208.
    • (1997) J Control Release. , vol.44 , pp. 201-208
    • Cohen, S.1    Lobel, E.2    Trevgoda, A.3    Peled, Y.4
  • 64
    • 28244465502 scopus 로고    scopus 로고
    • Mobility of model proteins in hydrogels composed of oppositely charged dextran microspheres studied by protein release and fluorescence recovery after photobleaching
    • Van Tomme SR, De Geest BG, Braeckmans K, De Smedt SC, Siepmann F, Siepmann J, van Nostrum CF, Hennink WE. Mobility of model proteins in hydrogels composed of oppositely charged dextran microspheres studied by protein release and fluorescence recovery after photobleaching. J Control Release 2005; 110: 67-78.
    • (2005) J Control Release , vol.110 , pp. 67-78
    • Van Tomme, S.R.1    De Geest, B.G.2    Braeckmans, K.3    De Smedt, S.C.4    Siepmann, F.5    Siepmann, J.6    van Nostrum, C.F.7    Hennink, W.E.8
  • 65
    • 68149115172 scopus 로고    scopus 로고
    • Nanoparticles and microparticles: Particle engineering, cell uptake, in vivo disposition & efficacy
    • Amrite AC, Kompella UB. Nanoparticles and microparticles: Particle engineering, cell uptake, in vivo disposition & efficacy. Drug Deliv Technol. 2007; 7: 52-56.
    • (2007) Drug Deliv Technol. , vol.7 , pp. 52-56
    • Amrite, A.C.1    Kompella, U.B.2
  • 66
    • 67349084376 scopus 로고    scopus 로고
    • Polymeric nanoparticulate system: A potential approach for ocular drug delivery
    • Nagarwal RC, Kant S, Singh PN, Maiti P, Pandit JK. Polymeric nanoparticulate system: A potential approach for ocular drug delivery. J Control Release. 2009; 136: 2-13.
    • (2009) J Control Release. , vol.136 , pp. 2-13
    • Nagarwal, R.C.1    Kant, S.2    Singh, P.N.3    Maiti, P.4    Pandit, J.K.5
  • 70
    • 33644625226 scopus 로고    scopus 로고
    • G-CSF loaded biodegradable PLGA nanoparticles prepared by a single oil-in-water emulsion method
    • Choi SH, Park TG. G-CSF loaded biodegradable PLGA nanoparticles prepared by a single oil-in-water emulsion method. Int J Pharm. 2006; 311: 223-228.
    • (2006) Int J Pharm. , vol.311 , pp. 223-228
    • Choi, S.H.1    Park, T.G.2
  • 72
    • 0346735299 scopus 로고    scopus 로고
    • Effective protein release from PEG/PLA nano-particles produced by compressed gas anti-solvent precipitation techniques
    • Caliceti P, Salmaso S, Elvassore N, Bertucco A. Effective protein release from PEG/PLA nano-particles produced by compressed gas anti-solvent precipitation techniques. J Control Release 2004; 94: 195-205.
    • (2004) J Control Release , vol.94 , pp. 195-205
    • Caliceti, P.1    Salmaso, S.2    Elvassore, N.3    Bertucco, A.4
  • 73
    • 34347324085 scopus 로고    scopus 로고
    • Chitosan nanoparticle as protein delivery carrier-Systemic examination of fabrication conditions for efficient loading and release
    • Gan Q, Wang T. Chitosan nanoparticle as protein delivery carrier-Systemic examination of fabrication conditions for efficient loading and release. Colloids Surf B Biointerfaces. 2007; 59: 24-34.
    • (2007) Colloids Surf B Biointerfaces. , vol.59 , pp. 24-34
    • Gan, Q.1    Wang, T.2
  • 74
    • 0037027876 scopus 로고    scopus 로고
    • Bioadhesive polysaccharide in protein delivery system: Chitosan nanoparticles improve the intestinal absorption of insulin in vivo
    • Pan Y, Li Y, Zhao H, Zheng J, Xu H, Wei G, Hao J, Cui F. Bioadhesive polysaccharide in protein delivery system: Chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm 2002; 249: 139-147.
    • (2002) Int J Pharm , vol.249 , pp. 139-147
    • Pan, Y.1    Li, Y.2    Zhao, H.3    Zheng, J.4    Xu, H.5    Wei, G.6    Hao, J.7    Cui, F.8
  • 75
    • 34547899919 scopus 로고    scopus 로고
    • Solid lipid nanoparticles as a drug delivery system for peptides and proteins
    • Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv Drug Deliv Rev. 2007; 59: 478-490.
    • (2007) Adv Drug Deliv Rev. , vol.59 , pp. 478-490
    • Almeida, A.J.1    Souto, E.2
  • 76
    • 0033800767 scopus 로고    scopus 로고
    • Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: Pharmacokinetics and tis-sue distribution after i.v. administration to rats
    • Fundarò A, Cavalla R, Bargoni A, Vighetto D, Zara GP, Gasco MR. Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: Pharmacokinetics and tis-sue distribution after i.v. administration to rats. Pharm Res. 2000; 42: 337-343.
    • (2000) Pharm Res. , vol.42 , pp. 337-343
    • Fundarò, A.1    Cavalla, R.2    Bargoni, A.3    Vighetto, D.4    Zara, G.P.5    Gasco, M.R.6
  • 77
    • 0035984818 scopus 로고    scopus 로고
    • Intravenous adminis-tration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: Pharmacokinetics and distribution of doxo-rubicin in brain and other tissues
    • Zara GP, Cavalli R, Bargoni A, Fundarò A, Vighetto D, Gasco MR. Intravenous adminis-tration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: Pharmacokinetics and distribution of doxo-rubicin in brain and other tissues. J Drug Target 2007; 10: 327-335.
    • (2007) J Drug Target , vol.10 , pp. 327-335
    • Zara, G.P.1    Cavalli, R.2    Bargoni, A.3    Fundarò, A.4    Vighetto, D.5    Gasco, M.R.6
  • 78
    • 0035850227 scopus 로고    scopus 로고
    • Lipid microparticles as a parental controlled release device for peptides
    • Reithmeier H, Herrmann J, Göpferich A. Lipid microparticles as a parental controlled release device for peptides. J Control Release. 2001; 73: 339-350.
    • (2001) J Control Release. , vol.73 , pp. 339-350
    • Reithmeier, H.1    Herrmann, J.2    Göpferich, A.3
  • 79
    • 0035821356 scopus 로고    scopus 로고
    • Development and characterization of lipid microparticles as a drug carrier for somatostatin
    • Reithmeier H, Herrmann J, Göpferich A. Development and characterization of lipid microparticles as a drug carrier for somatostatin. Int J Pharm. 2001; 218: 133-143.
    • (2001) Int J Pharm. , vol.218 , pp. 133-143
    • Reithmeier, H.1    Herrmann, J.2    Göpferich, A.3
  • 80
    • 34547908177 scopus 로고    scopus 로고
    • Review on Medusa®: A polymer-based sustained release technology for protein and peptide drugs
    • Chan YP, Meyrueix R, Kravtzoff R, Nicolas F, Lundstrom K. Review on Medusa®: A polymer-based sustained release technology for protein and peptide drugs. Expert Opin Drug Deliv. 2007; 4: 441-451.
    • (2007) Expert Opin Drug Deliv. , vol.4 , pp. 441-451
    • Chan, Y.P.1    Meyrueix, R.2    Kravtzoff, R.3    Nicolas, F.4    Lundstrom, K.5
  • 83
    • 0026692103 scopus 로고
    • Stealth liposomes: An improved sus-tained release system for 1-beta-D-arabinofuranosylcytosine
    • Allen TM, Mehra T, Hansen C, Chin YC. Stealth liposomes: An improved sus-tained release system for 1-beta-D-arabinofuranosylcytosine. Cancer Res. 1992; 52: 2431-2439.
    • (1992) Cancer Res. , vol.52 , pp. 2431-2439
    • Allen, T.M.1    Mehra, T.2    Hansen, C.3    Chin, Y.C.4
  • 84
    • 0032237799 scopus 로고    scopus 로고
    • Retinal toxicity of liposome-incorporated and free ofloxacin after intravitreal injection in rabbit eyes
    • Wiechens B, Neumann D, Grammer JB, Pleyer U, Hedderich J, Duncker GIW. Retinal toxicity of liposome-incorporated and free ofloxacin after intravitreal injection in rabbit eyes. Int Ophthalmol. 1999; 22: 133-143.
    • (1999) Int Ophthalmol. , vol.22 , pp. 133-143
    • Wiechens, B.1    Neumann, D.2    Grammer, J.B.3    Pleyer, U.4    Hedderich, J.5    Duncker, G.I.W.6
  • 85
    • 77955537470 scopus 로고    scopus 로고
    • Treatment of experimental autoim-mune uveoretinitis with intravitreal injection of Tacrolimus (FK506) encapsulated in liposomes
    • Zhang R, He R, Qian J, Guo J, Xue K, Yuan Y. Treatment of experimental autoim-mune uveoretinitis with intravitreal injection of Tacrolimus (FK506) encapsulated in liposomes. Invest Ophthalmol Vis Sci. 2010; 51: 3575-3582.
    • (2010) Invest Ophthalmol Vis Sci. , vol.51 , pp. 3575-3582
    • Zhang, R.1    He, R.2    Qian, J.3    Guo, J.4    Xue, K.5    Yuan, Y.6
  • 87
    • 0036018133 scopus 로고    scopus 로고
    • A lipid based Depot (DepoFoam® technology) for sustained release drug delivery
    • Mantripragada S. A lipid based Depot (DepoFoam® technology) for sustained release drug delivery. Prog Lipid Res. 2002; 41: 392-406.
    • (2002) Prog Lipid Res. , vol.41 , pp. 392-406
    • Mantripragada, S.1
  • 88
    • 76149134362 scopus 로고    scopus 로고
    • Enhancement of the efficacy of therapeutic proteins by formulation with PEGylated liposomes: A case of FVIII, FVIIa and G-CSF
    • Yatuv R, Robinson M, Dayan I, Baru M. Enhancement of the efficacy of therapeutic proteins by formulation with PEGylated liposomes: A case of FVIII, FVIIa and G-CSF. Expert Opin Drug Deliv. 2010; 7: 187-201.
    • (2010) Expert Opin Drug Deliv. , vol.7 , pp. 187-201
    • Yatuv, R.1    Robinson, M.2    Dayan, I.3    Baru, M.4
  • 89
    • 34250805948 scopus 로고    scopus 로고
    • Polymeric protein delivery systems
    • Lee KY, Yuk SH. Polymeric protein delivery systems. Prog Polym Sci. 2007; 32: 669-697.
    • (2007) Prog Polym Sci. , vol.32 , pp. 669-697
    • Lee, K.Y.1    Yuk, S.H.2
  • 92
    • 34848928410 scopus 로고    scopus 로고
    • Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glau-coma
    • Jiang C, Moore MJ, Zhang X, Klassen H, Langer R, Young M. Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glau-coma. Mol Vis. 2007; 13: 1783-1792.
    • (2007) Mol Vis. , vol.13 , pp. 1783-1792
    • Jiang, C.1    Moore, M.J.2    Zhang, X.3    Klassen, H.4    Langer, R.5    Young, M.6
  • 93
    • 0034121754 scopus 로고    scopus 로고
    • Concurrent downregulation of a glutamate transporter and receptor in glaucoma
    • Naskar R, Vorwerk C, Dreyer EB. Concurrent downregulation of a glutamate transporter and receptor in glaucoma. Invest Ophthalmol Vis Sci. 2000; 41: 1940-1944.
    • (2000) Invest Ophthalmol Vis Sci. , vol.41 , pp. 1940-1944
    • Naskar, R.1    Vorwerk, C.2    Dreyer, E.B.3
  • 95
    • 0029588236 scopus 로고
    • At least two mechanisms are involved in the death of retinal ganglion cells following target ablation in neonatal rats
    • Cui Q, Harvey AR. At least two mechanisms are involved in the death of retinal ganglion cells following target ablation in neonatal rats. J Neurosci. 1995; 15: 8143-8155.
    • (1995) J Neurosci. , vol.15 , pp. 8143-8155
    • Cui, Q.1    Harvey, A.R.2
  • 97
    • 0035833541 scopus 로고    scopus 로고
    • Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signaling cascade
    • Digicaylioglu M, Lipton SA. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signaling cascade. Nature. 2001; 412: 641-647.
    • (2001) Nature. , vol.412 , pp. 641-647
    • Digicaylioglu, M.1    Lipton, S.A.2
  • 100
  • 101
    • 0034223561 scopus 로고    scopus 로고
    • Topical treatment with nerve growth factor for neurotrophic keratitis
    • Bonini S, Lambiase A, Rama P, Caprioglio G, Aloe L. Topical treatment with nerve growth factor for neurotrophic keratitis. Ophthalmology 2000; 107: 1347-1351.
    • (2000) Ophthalmology , vol.107 , pp. 1347-1351
    • Bonini, S.1    Lambiase, A.2    Rama, P.3    Caprioglio, G.4    Aloe, L.5
  • 102
    • 0032560036 scopus 로고    scopus 로고
    • Topical treatment with nerve growth factor for corneal neurotrophic ulcers
    • Lambiase A, Rama P, Bonini S, Caprioglio G, Aloe L. Topical treatment with nerve growth factor for corneal neurotrophic ulcers. N Engl J Med. 1998; 338: 1174-1180.
    • (1998) N Engl J Med. , vol.338 , pp. 1174-1180
    • Lambiase, A.1    Rama, P.2    Bonini, S.3    Caprioglio, G.4    Aloe, L.5
  • 104
    • 65549162660 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration
    • Ciulla TA, Rosenfeld PJ. Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration. Curr Opin Ophthalmol 2009; 20: 158-165.
    • (2009) Curr Opin Ophthalmol , vol.20 , pp. 158-165
    • Ciulla, T.A.1    Rosenfeld, P.J.2
  • 105
    • 43749096100 scopus 로고    scopus 로고
    • Neovascular age-related macular degeneration: Potential therapies
    • Chappelow AV, Kaiser PK. Neovascular age-related macular degeneration: Potential therapies. Drugs 2008; 68: 1029-1036.
    • (2008) Drugs , vol.68 , pp. 1029-1036
    • Chappelow, A.V.1    Kaiser, P.K.2
  • 110
    • 53049090850 scopus 로고    scopus 로고
    • Targeted monoclonal antibody therapy and radioimmunotherapy for lymphoproliferative disorders of the ocular adnexa
    • Shome D, Esmaeli B. Targeted monoclonal antibody therapy and radioimmunotherapy for lymphoproliferative disorders of the ocular adnexa. Curr Opin Ophthalmol 2008; 19: 414-421.
    • (2008) Curr Opin Ophthalmol , vol.19 , pp. 414-421
    • Shome, D.1    Esmaeli, B.2
  • 112
    • 33646925637 scopus 로고    scopus 로고
    • Fluocinolone aceton-ide implant (Retisert) for noninfectious posterior uveitis: Thirty-four-week results of a multicenter randomized clinical study
    • Jaffe GJ, Martin D, Callanan D, Pearson PA, Levy B, Comstock T. Fluocinolone aceton-ide implant (Retisert) for noninfectious posterior uveitis: Thirty-four-week results of a multicenter randomized clinical study. Ophthalmology 2006; 113: 1020-1027.
    • (2006) Ophthalmology , vol.113 , pp. 1020-1027
    • Jaffe, G.J.1    Martin, D.2    Callanan, D.3    Pearson, P.A.4    Levy, B.5    Comstock, T.6
  • 113
    • 54049091605 scopus 로고    scopus 로고
    • Iluvien: A new sustained delivery technology for posterior eye disease
    • Kane FE, Burdan J, Cutino A, Green KE. Iluvien: A new sustained delivery technology for posterior eye disease. Expert Opin Drug Deliv 2008; 5: 1039-1046.
    • (2008) Expert Opin Drug Deliv , vol.5 , pp. 1039-1046
    • Kane, F.E.1    Burdan, J.2    Cutino, A.3    Green, K.E.4
  • 116
    • 0021962284 scopus 로고
    • Biodegradable polymers for the sustained release of peptides
    • Hutchinson FG, Furr BJA. Biodegradable polymers for the sustained release of peptides. Biochem Soc Trans. 1985; 13: 502-523.
    • (1985) Biochem Soc Trans. , vol.13 , pp. 502-523
    • Hutchinson, F.G.1    Furr, B.J.A.2
  • 117
    • 0026710376 scopus 로고
    • A biodegradable delivery system for peptides: Preclinical experience with the gonadotrophin-releasing hormone agonist
    • Furr BJA, Hutchinson FG. A biodegradable delivery system for peptides: Preclinical experience with the gonadotrophin-releasing hormone agonist. J Control Release 1992; 21: 117-128.
    • (1992) J Control Release , vol.21 , pp. 117-128
    • Furr, B.J.A.1    Hutchinson, F.G.2
  • 118
    • 67650101251 scopus 로고    scopus 로고
    • Preparation and characterization of protein loaded microspheres based on a hydroxylated aliphatic polyester, poly(lactic-co-hydroxymethyl glycolic acid)
    • Ghassemi AH, Steenbergen MJV, Talsma H, van Nostrum CF, Jiskoot W, Crommelin DJA, Hennink WE. Preparation and characterization of protein loaded microspheres based on a hydroxylated aliphatic polyester, poly(lactic-co-hydroxymethyl glycolic acid). J Control Release 2009; 138: 57-63.
    • (2009) J Control Release , vol.138 , pp. 57-63
    • Ghassemi, A.H.1    Steenbergen, M.J.V.2    Talsma, H.3    van Nostrum, C.F.4    Jiskoot, W.5    Crommelin, D.J.A.6    Hennink, W.E.7
  • 119
    • 70349482672 scopus 로고    scopus 로고
    • Preparation and characterization of protein-loaded polyanhydrides microspheres
    • Sun L, Zhou S, Wang W, Su Q, Li X, Weng J. Preparation and characterization of protein-loaded polyanhydrides microspheres. J Mater Sci Mater Med 2009; 20: 2035-2042.
    • (2009) J Mater Sci Mater Med , vol.20 , pp. 2035-2042
    • Sun, L.1    Zhou, S.2    Wang, W.3    Su, Q.4    Li, X.5    Weng, J.6
  • 121
    • 65449172441 scopus 로고    scopus 로고
    • Functional protein delivery into neurons using polymeric nanoparticles
    • Hasadsri L, Kreuter J, Hattori H, Iwasaki T, George JM. Functional protein delivery into neurons using polymeric nanoparticles. J Biol Chem 2009; 284: 6972-6981.
    • (2009) J Biol Chem , vol.284 , pp. 6972-6981
    • Hasadsri, L.1    Kreuter, J.2    Hattori, H.3    Iwasaki, T.4    George, J.M.5
  • 122
    • 0022643996 scopus 로고
    • Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity
    • Leong KW, D’Amore PD, Marletta M, Langer R. Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity. J Biomed Mater Res. 1986; 20: 51-64.
    • (1986) J Biomed Mater Res. , vol.20 , pp. 51-64
    • Leong, K.W.1    D’Amore, P.D.2    Marletta, M.3    Langer, R.4
  • 123
    • 85055778555 scopus 로고    scopus 로고
    • Modified-Release Drug Delivery Technology
    • 2nd ed, New York: Informa Healthcare
    • Rathbone MJ. Modified-Release Drug Delivery Technology, 2nd ed., vol. 2, Drugs and the Pharmaceutical Sciences. New York: Informa Healthcare, 2008, 155.
    • (2008) Drugs and the Pharmaceutical Sciences , vol.2 , pp. 155
    • Rathbone, M.J.1
  • 125
    • 38549114777 scopus 로고    scopus 로고
    • Injectable thermosensitive PLGA-PEG-PLGA triblock copolymers-based hydrogels as carriers for interleukin-2
    • Qiao M, Chen D, Hao T, Zhao X, Hu H, Ma X. Injectable thermosensitive PLGA-PEG-PLGA triblock copolymers-based hydrogels as carriers for interleukin-2. Pharmazie. 2008; 63: 27-30.
    • (2008) Pharmazie. , vol.63 , pp. 27-30
    • Qiao, M.1    Chen, D.2    Hao, T.3    Zhao, X.4    Hu, H.5    Ma, X.6
  • 126
    • 0034948794 scopus 로고    scopus 로고
    • Controlled release of insulin from injectable biodegradable triblock copolymer
    • Kim, YJ, Choi S, Koh JJ, Lee M, Ko, KS, Kim SW. Controlled release of insulin from injectable biodegradable triblock copolymer. Pharm Res. 2001; 18: 548-550.
    • (2001) Pharm Res. , vol.18 , pp. 548-550
    • Kim, Y.J.1    Choi, S.2    Koh, J.J.3    Lee, M.4    Ko, K.S.5    Kim, S.W.6
  • 128
    • 34848910216 scopus 로고    scopus 로고
    • Smart polymer based delivery systems for peptides and proteins
    • Al-Tahami K, Singh J. Smart polymer based delivery systems for peptides and proteins. Recent Pat Drug Deliv Formul. 2007; 1: 65-71.
    • (2007) Recent Pat Drug Deliv Formul. , vol.1 , pp. 65-71
    • Al-Tahami, K.1    Singh, J.2
  • 129
    • 34447639976 scopus 로고    scopus 로고
    • Thermosensitive polymers: Synthesis, characterization, and delivery of proteins
    • Singh S, Webster DC, Singh J. Thermosensitive polymers: Synthesis, characterization, and delivery of proteins. Int J Pharm 2007; 341: 68-77.
    • (2007) Int J Pharm , vol.341 , pp. 68-77
    • Singh, S.1    Webster, D.C.2    Singh, J.3
  • 130
    • 0035864327 scopus 로고    scopus 로고
    • Protein release from physically cross-linked hydrogels of the PLA/PEO/PLA triblock copolymer-type
    • Molina I, Li SM, Martinez MB, Vert M. Protein release from physically cross-linked hydrogels of the PLA/PEO/PLA triblock copolymer-type. Biomaterials. 2001; 22: 363-369.
    • (2001) Biomaterials. , vol.22 , pp. 363-369
    • Molina, I.1    Li, S.M.2    Martinez, M.B.3    Vert, M.4
  • 131
    • 33646120544 scopus 로고    scopus 로고
    • Synthesis of a chemically cross-linked thermo-sensitive hydrogel film and in situ encapsulation of model protein drugs
    • Wang B, Zhu W, Zhang Y, Yang ZG, Ding JD. Synthesis of a chemically cross-linked thermo-sensitive hydrogel film and in situ encapsulation of model protein drugs. React Funct Polym. 2006; 66: 509-518.
    • (2006) React Funct Polym. , vol.66 , pp. 509-518
    • Wang, B.1    Zhu, W.2    Zhang, Y.3    Yang, Z.G.4    Ding, J.D.5
  • 132
    • 44949238722 scopus 로고    scopus 로고
    • Injectable and sustained delivery of human growth hormone using chemically modified Pluronic copolymer hydrogels
    • Park SY, Chung HJ, Lee Y, Park TG. Injectable and sustained delivery of human growth hormone using chemically modified Pluronic copolymer hydrogels. Biotechnol J 2008; 3: 1-7.
    • (2008) Biotechnol J , vol.3 , pp. 1-7
    • Park, S.Y.1    Chung, H.J.2    Lee, Y.3    Park, T.G.4
  • 133
    • 40649101153 scopus 로고    scopus 로고
    • Thermo-sensitive and biodegradable hydrogels based on stereocomplexed pluronic multi-block copolymers for controlled protein delivery
    • Chung HJ, Lee Y, Park TG. Thermo-sensitive and biodegradable hydrogels based on stereocomplexed pluronic multi-block copolymers for controlled protein delivery. J Control Release. 2008; 127: 22-30.
    • (2008) J Control Release. , vol.127 , pp. 22-30
    • Chung, H.J.1    Lee, Y.2    Park, T.G.3
  • 134
    • 34247618686 scopus 로고    scopus 로고
    • In vitro and in vivo release of albumin using a biodegradable MPEG-PCL diblock copolymer as an in situ gel-forming carrier
    • Hyun H, Kim YH, Song IB, Lee JW, Kim MS, Khang G, Park K, Lee HB. In vitro and in vivo release of albumin using a biodegradable MPEG-PCL diblock copolymer as an in situ gel-forming carrier. Biomacromolecules. 2007; 8: 1093-1100.
    • (2007) Biomacromolecules. , vol.8 , pp. 1093-1100
    • Hyun, H.1    Kim, Y.H.2    Song, I.B.3    Lee, J.W.4    Kim, M.S.5    Khang, G.6    Park, K.7    Lee, H.B.8
  • 135
    • 77953626607 scopus 로고    scopus 로고
    • Injectable biodegradable hydrogels
    • Nguyen MK, Lee DS. Injectable biodegradable hydrogels. Macromol Biosci. 2010; 10: 563-579.
    • (2010) Macromol Biosci. , vol.10 , pp. 563-579
    • Nguyen, M.K.1    Lee, D.S.2
  • 136
    • 33646105618 scopus 로고    scopus 로고
    • Synthesis and characterization of bio-compatible poly(organophosphazenes) aiming for local delivery of protein drugs
    • Seong JY, Jun YJ, Kim BM, Park YM, Sohn YS. Synthesis and characterization of bio-compatible poly(organophosphazenes) aiming for local delivery of protein drugs. Int J Pharm. 2006; 314: 90-96.
    • (2006) Int J Pharm. , vol.314 , pp. 90-96
    • Seong, J.Y.1    Jun, Y.J.2    Kim, B.M.3    Park, Y.M.4    Sohn, Y.S.5
  • 137
    • 37349035782 scopus 로고    scopus 로고
    • Effect of chitosan on the release of protein from thermosensitive poly(organophosphazene) hydrogels
    • Kang GD, Song SC. Effect of chitosan on the release of protein from thermosensitive poly(organophosphazene) hydrogels. Int J Pharm. 2008; 349: 188-195.
    • (2008) Int J Pharm. , vol.349 , pp. 188-195
    • Kang, G.D.1    Song, S.C.2
  • 138
    • 63049131601 scopus 로고    scopus 로고
    • Thermosensitive hydrogels as a new ocular drug deliv-ery platform to the posterior segment of the eye
    • Kang Derwent JJ, Mieler WF. Thermosensitive hydrogels as a new ocular drug deliv-ery platform to the posterior segment of the eye. Tans Am Ophthalmol Soc. 2008; 106: 206-213.
    • (2008) Tans Am Ophthalmol Soc. , vol.106 , pp. 206-213
    • Kang Derwent, J.J.1    Mieler, W.F.2
  • 139
    • 34447309294 scopus 로고    scopus 로고
    • Poly(N-isopropylacrylamide)-chitosan as thermosensitive in situ gel-forming system for ocular drug delivery
    • Cao Y, Zhang C, Shen W, Cheng Z, Yu L, Ping Q. Poly(N-isopropylacrylamide)-chitosan as thermosensitive in situ gel-forming system for ocular drug delivery. J Control Release. 2007; 120: 186-194.
    • (2007) J Control Release. , vol.120 , pp. 186-194
    • Cao, Y.1    Zhang, C.2    Shen, W.3    Cheng, Z.4    Yu, L.5    Ping, Q.6
  • 140
    • 34447292845 scopus 로고    scopus 로고
    • Hydrolytic degradation and protein release studies of thermogel-ling polyurethane copolymers consisting of poly[(R)-3-hydroxybutyrate], poly(ethylene glycol), and poly(propylene glycol)
    • Loh XJ, Goh SH, Li J. Hydrolytic degradation and protein release studies of thermogel-ling polyurethane copolymers consisting of poly[(R)-3-hydroxybutyrate], poly(ethylene glycol), and poly(propylene glycol). Biomaterials. 2007; 28: 4113-4123.
    • (2007) Biomaterials. , vol.28 , pp. 4113-4123
    • Loh, X.J.1    Goh, S.H.2    Li, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.