Intraocular pharmacokinetics and safety of a humanized monoclonal antibody in rabbits after intravitreal administration of a solution or a PLGA microsphere formulation

Toxicological Sciences

Volumn 52, Issue 1, 1999, Pages 101-106

  Mordenti, Joyce ^a,b   Thomsen, Karen ^a   Licko, Vojtech ^a   Berleau, Lea ^a   Kahn, Jeanne W ^a   Cuthbertson, R Andrew ^a   Duenas, Eileen T ^a   Ryan, Anne M ^a   Schofield, Cheryl ^a   Berger, Terrence W ^a   Meng, Y Gloria ^a   Cleland, Jeffrey ^a  

^a GENENTECH INC   (United States)

^b Axys Pharmaceuticals Inc   (United States)

Author keywords

Formulation; Immunogenicity; Intraocular; Intravitreal; Kinetics; Monoclonal antibody; Pharmacokinetics; Poly(lactic co glycolic) acid (PLGA) bioresorbable microspheres; Recombinant protein; Safety

Indexed keywords

HUMAN MONOCLONAL ANTIBODY; MICROSPHERE; POLYGLACTIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG SAFETY; DRUG SCREENING; HISTOLOGY; IMMUNOGENICITY; MALE; NONHUMAN; OPHTHALMOSCOPY; PLASMA; VITREOUS BODY;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0032699973     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/52.1.101     Document Type: Article

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