Intravenous administration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: Pharmacokinetics and distribution of doxorubicin in brain and other tissues

Journal of Drug Targeting

Volumn 10, Issue 4, 2002, Pages 327-335

  Zara, Gian Paolo ^a   Cavalli, Roberta ^a   Bargoni, Alessandro ^a   Fundaro, Anna ^a   Vighetto, Daniela ^a   Gasco, Maria Rosa ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Blood brain barrier; Doxorubicin; Intravenous administration; Prolonged circulation times; Solid lipid nanoparticles; Stealth solid lipid nanoparticles

Indexed keywords

DOXORUBICIN; DOXORUBICINOL; LIPID; MACROGOL 2000; NANOPARTICLE; STEARIC ACID; DRUG CARRIER; MICROSPHERE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONSCIOUSNESS; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; HEART; KIDNEY; LUNG; NONHUMAN; PRIORITY JOURNAL; RABBIT; SOLID; SPLEEN; ANIMAL; BLOOD; BRAIN; CHEMISTRY; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; METHODOLOGY; NANOTECHNOLOGY; PHYSIOLOGY; TISSUE DISTRIBUTION;

ANIMAL; BRAIN; CHEMISTRY, PHARMACEUTICAL; DOXORUBICIN; DRUG CARRIERS; INJECTIONS, INTRAVENOUS; MICROSPHERES; NANOTECHNOLOGY; RABBITS; SUPPORT, NON-U.S. GOV'T; TISSUE DISTRIBUTION; ANIMALS;

EID: 0035984818     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10611860290031868     Document Type: Article

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