Injectable thermosensitive PLGA-PEG-PLGA triblock copolymers-based hydrogels as carriers for interleukin-2

Pharmazie

Volumn 63, Issue 1, 2008, Pages 27-30

  Qiao, Mingxi ^a   Chen, Dawei ^a   Hao, Tangna ^a   Zhao, Xiuli ^a   Hu, Haiyang ^a   Ma, Xichen ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b DALIAN POLYTECHNIC UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

POLYGLACTIN; RECOMBINANT INTERLEUKIN 2; REGEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SYNTHESIS; HEAT SENSITIVITY; HUMAN; HUMAN CELL; HYDROGEL; MALE; NONHUMAN; POLYMERIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CHEMISTRY, PHYSICAL; DRUG CARRIERS; EXCIPIENTS; GELS; HYDROGELS; INJECTIONS; INTERLEUKIN-2; MALE; MICE; MOLECULAR WEIGHT; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PHARMACEUTICAL SOLUTIONS; POLYETHYLENE GLYCOLS; POLYGLACTIN 910; RECOMBINANT PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 38549114777     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2008.7115     Document Type: Article

References (16)

1. Cadée JA, Groot CJ, Jiskoot W, Otter WD, Hennink WE (2002) Release of recombinant of interleukin-2 from dextran-based hydrogels. J Control Release 78: 1-13.
2. Egilmez N, Jong YS, Iwanuma Y, Jacob JS, Santos CA, Chen F, Mathiowitz E, Bankert RB (1998) Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse References model, Cancer Immunol Immunother 46: 21-24.
3. Higuchi T (1963) Mechanisms of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 52: 1145-1149.
4. Hora MS, Rana RK, Nunberg JH, Tice TR, Gilley RM, Hudson ME (1990) Controlled release of interleukin-2 from biodegradable microspheres. Biotechnology 8: 755-758.
5. Jeong B, Choi YK, Bae YH, Zentner G, Kim SW (1999) New biodegradable polymers for injectable drug delivery systems. J Control Release 62: 109-114.
6. Johnston TP, Punjabi MA, Froelich CJ (1992) Sustained delivery of interleukin-2 from a poloxamer 407 gel matrix following intraperitoneal injection in mice. Pharm Res 9: 425-434.
7. Kim YJ, Choi S, Koh JJ, Lee M, Ko KS, Kim SW (2001) Controlled release of insulin from injectable biodegradable triblock copolymer. Pharm Res 18: 548-550.
8. Liu LS, Liu SQ, Ng SY, Froix M, Ohno T, Heller J (1997) Controlled release of interleukin-2 for tumor immunotherapy using alginate/chitosan porous microspheres. J Control Release 43: 65-74.
9. Lotze MT, Frana LW, Sharrow SO, Robb RJ, Rosenberg SA (1985) In vivo admimistration of purified human interleukin-2. Half life and immunologic effects of Jurkat cell-line derived interleukin-2. J Immunol 134: 110-119.
10. Pardoll DM (1995) Paracrine cytokine adjuvants in cancer immunotherapy. Annu Rev Immunol 13: 399-415.
11. Qiao MX, Chen, DW, Ma XC, Liu YJ (2005) Injectable biodegradable temperature-responsive PLGA-PEG-PLGA copolymers: synthesis and effect of copolymer composition on the drug release from the copolymer-based hydrogels. Int J Pharm 294: 103-112.
12. Qiao MX, Chen DW, Ma XC, Hu HY (2006) Sustained release of bee venom peptide from biodegradable thermosensitive PLGA-PEG-PLGA triblock copolymer-based hydrogels in vitro. Pharmazie 61: 199-202.
13. Rosenberg SA, Spiess P, Lafreniere R (1986) A new approach to the adaptive immunotherapy of cancer with tumor-infiltrating lymphocyts. Science 233: 1318-1321.
14. Rosenberg SA, Lotze MT, Muul LM, Leitman S, Chang AE, Ettinghausen SE, Matory YL, Skibber JM, Shiloni E, Vetto JT, Seipp CA, Simpson C, Reichert CM (1985) Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer N Enge J Med 313: 1485-1492.
15. Yong CS, Choi JS, Quan QZ, Rhee JD, Kim CK, Lim SJ, Kim KM, Oh PS, Choi HG (2001) Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium. Int J Pharm 226: 195-205.
16. Zentner G, Rathi R, Shih C, Mcrea JC, Seo MH, Oh H, Rhee BG, Mestechy J, Moldoveanu Z, Morgan M, Weitman S (2001) Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. J Control Release 72: 203-215.