Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents

Cell Reports

Volumn 19, Issue 1, 2017, Pages 101-113

  Olson, Oakley C ^a   Kim, Hyunjung ^a   Quail, Daniela F ^a   Foley, Emily A ^a   Joyce, Johanna A ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

antimitotic; breast cancer; chemoresistance; chemotherapy; macrophage; microenvironment; mitotic arrest; mitotic slippage; Taxol; tetraploid

Indexed keywords

BLZ 945; CYTOKINE RECEPTOR ANTAGONIST; HISTONE H2AX; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; PACLITAXEL; PROTEIN P53; UNCLASSIFIED DRUG; 4-(2-(2-HYDROXYCYCLOHEXYLAMINO)BENZOTHIAZOL-6-YLOXY)PYRIDINE-2-CARBOXYLIC ACID METHYLAMIDE; ANTIMITOTIC AGENT; BENZOTHIAZOLE DERIVATIVE; H2AFX PROTEIN, HUMAN; HISTONE; PICOLINIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW DERIVED MACROPHAGE; BREAST CANCER; BREAST CANCER CELL LINE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG RESPONSE; DRUG TARGETING; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INTERPHASE; MITOSIS INHIBITION; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TUMOR ASSOCIATED LEUKOCYTE; ANIMAL; BREAST TUMOR; CELL SURVIVAL; DRUG EFFECTS; ENDOTHELIUM CELL; HUMAN; IMMUNOLOGY; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; METABOLISM; MITOSIS; TRANSGENIC MOUSE; TUMOR CELL CULTURE;

ANIMALS; ANTIMITOTIC AGENTS; APOPTOSIS; BENZOTHIAZOLES; BREAST NEOPLASMS; CELL SURVIVAL; DNA DAMAGE; ENDOTHELIAL CELLS; FEMALE; HISTONES; HUMANS; MACROPHAGES; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOSIS; PACLITAXEL; PICOLINIC ACIDS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85017032227     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.03.038     Document Type: Article

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