-
1
-
-
27844445642
-
Perturbations of the AKT signaling pathway in human cancer
-
Altomare D.A., Testa J.R. Perturbations of the AKT signaling pathway in human cancer. Oncogene 2005, 24:7455-7464.
-
(2005)
Oncogene
, vol.24
, pp. 7455-7464
-
-
Altomare, D.A.1
Testa, J.R.2
-
2
-
-
78951489049
-
Feedback regulation of EGFR signalling: decision making by early and delayed loops
-
Avraham R., Yarden Y. Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nat. Rev. Mol. Cell Biol. 2011, 12:104-117.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 104-117
-
-
Avraham, R.1
Yarden, Y.2
-
4
-
-
26944490411
-
A combined approach for the localization and tandem affinity purification of protein complexes from metazoans
-
Cheeseman I.M., Desai A. A combined approach for the localization and tandem affinity purification of protein complexes from metazoans. Sci. STKE 2005, 2005:pl1.
-
(2005)
Sci. STKE
, vol.2005
-
-
Cheeseman, I.M.1
Desai, A.2
-
5
-
-
0029845891
-
Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
-
Chen R.H., Waters J.C., Salmon E.D., Murray A.W. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science 1996, 274:242-246.
-
(1996)
Science
, vol.274
, pp. 242-246
-
-
Chen, R.H.1
Waters, J.C.2
Salmon, E.D.3
Murray, A.W.4
-
6
-
-
33745828702
-
EGF-ERBB signalling: towards the systems level
-
Citri A., Yarden Y. EGF-ERBB signalling: towards the systems level. Nat. Rev. Mol. Cell Biol. 2006, 7:505-516.
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 505-516
-
-
Citri, A.1
Yarden, Y.2
-
7
-
-
84859187259
-
Systematic identification of genomic markers of drug sensitivity in cancer cells
-
Garnett M.J., Edelman E.J., Heidorn S.J., Greenman C.D., Dastur A., Lau K.W., Greninger P., Thompson I.R., Luo X., Soares J., et al. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 2012, 483:570-575.
-
(2012)
Nature
, vol.483
, pp. 570-575
-
-
Garnett, M.J.1
Edelman, E.J.2
Heidorn, S.J.3
Greenman, C.D.4
Dastur, A.5
Lau, K.W.6
Greninger, P.7
Thompson, I.R.8
Luo, X.9
Soares, J.10
-
8
-
-
22144463476
-
Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5
-
Gartner M., Sunder-Plassmann N., Seiler J., Utz M., Vernos I., Surrey T., Giannis A. Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5. ChemBioChem 2005, 6:1173-1177.
-
(2005)
ChemBioChem
, vol.6
, pp. 1173-1177
-
-
Gartner, M.1
Sunder-Plassmann, N.2
Seiler, J.3
Utz, M.4
Vernos, I.5
Surrey, T.6
Giannis, A.7
-
9
-
-
0032915392
-
Epidermal growth factor receptors: critical mediators of multiple receptor pathways
-
Hackel P.O., Zwick E., Prenzel N., Ullrich A. Epidermal growth factor receptors: critical mediators of multiple receptor pathways. Curr. Opin. Cell Biol. 1999, 11:184-189.
-
(1999)
Curr. Opin. Cell Biol.
, vol.11
, pp. 184-189
-
-
Hackel, P.O.1
Zwick, E.2
Prenzel, N.3
Ullrich, A.4
-
10
-
-
77956339402
-
CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging
-
Held M., Schmitz M.H., Fischer B., Walter T., Neumann B., Olma M.H., Peter M., Ellenberg J., Gerlich D.W. CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging. Nat. Methods 2010, 7:747-754.
-
(2010)
Nat. Methods
, vol.7
, pp. 747-754
-
-
Held, M.1
Schmitz, M.H.2
Fischer, B.3
Walter, T.4
Neumann, B.5
Olma, M.H.6
Peter, M.7
Ellenberg, J.8
Gerlich, D.W.9
-
11
-
-
63749086305
-
ErbB receptors and signaling pathways in cancer
-
Hynes N.E., MacDonald G. ErbB receptors and signaling pathways in cancer. Curr. Opin. Cell Biol. 2009, 21:177-184.
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 177-184
-
-
Hynes, N.E.1
MacDonald, G.2
-
12
-
-
35548995475
-
Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle
-
Indjeian V.B., Murray A.W. Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle. Curr. Biol. 2007, 17:1837-1846.
-
(2007)
Curr. Biol.
, vol.17
, pp. 1837-1846
-
-
Indjeian, V.B.1
Murray, A.W.2
-
13
-
-
0034605123
-
Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5
-
Kapoor T.M., Mayer T.U., Coughlin M.L., Mitchison T.J. Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J.Cell Biol. 2000, 150:975-988.
-
(2000)
J.Cell Biol.
, vol.150
, pp. 975-988
-
-
Kapoor, T.M.1
Mayer, T.U.2
Coughlin, M.L.3
Mitchison, T.J.4
-
14
-
-
84964618041
-
Dual pathway spindle assembly increases both the speed and the fidelity of mitosis
-
Kaseda K., McAinsh A.D., Cross R.A. Dual pathway spindle assembly increases both the speed and the fidelity of mitosis. Biol. Open 2012, 1:12-18.
-
(2012)
Biol. Open
, vol.1
, pp. 12-18
-
-
Kaseda, K.1
McAinsh, A.D.2
Cross, R.A.3
-
15
-
-
63749101351
-
Targeting the EGFR and the PKB pathway in cancer
-
Klein S., Levitzki A. Targeting the EGFR and the PKB pathway in cancer. Curr. Opin. Cell Biol. 2009, 21:185-193.
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 185-193
-
-
Klein, S.1
Levitzki, A.2
-
16
-
-
4344595410
-
Differential effects of monastrol in two human cell lines
-
Leizerman I., Avunie-Masala R., Elkabets M., Fich A., Gheber L. Differential effects of monastrol in two human cell lines. Cell. Mol. Life Sci. 2004, 61:2060-2070.
-
(2004)
Cell. Mol. Life Sci.
, vol.61
, pp. 2060-2070
-
-
Leizerman, I.1
Avunie-Masala, R.2
Elkabets, M.3
Fich, A.4
Gheber, L.5
-
17
-
-
0031004175
-
Genetic instability in colorectal cancers
-
Lengauer C., Kinzler K.W., Vogelstein B. Genetic instability in colorectal cancers. Nature 1997, 386:623-627.
-
(1997)
Nature
, vol.386
, pp. 623-627
-
-
Lengauer, C.1
Kinzler, K.W.2
Vogelstein, B.3
-
18
-
-
80051985198
-
The spatial arrangement of chromosomes during prometaphase facilitates spindle assembly
-
Magidson V., O'Connell C.B., Lončarek J., Paul R., Mogilner A., Khodjakov A. The spatial arrangement of chromosomes during prometaphase facilitates spindle assembly. Cell 2011, 146:555-567.
-
(2011)
Cell
, vol.146
, pp. 555-567
-
-
Magidson, V.1
O'Connell, C.B.2
Lončarek, J.3
Paul, R.4
Mogilner, A.5
Khodjakov, A.6
-
19
-
-
84869139686
-
Mitotic lamin disassembly is triggered by lipid-mediated signaling
-
Mall M., Walter T., Gorjánácz M., Davidson I.F., Nga Ly-Hartig T.B., Ellenberg J., Mattaj I.W. Mitotic lamin disassembly is triggered by lipid-mediated signaling. J.Cell Biol. 2012, 198:981-990.
-
(2012)
J.Cell Biol.
, vol.198
, pp. 981-990
-
-
Mall, M.1
Walter, T.2
Gorjánácz, M.3
Davidson, I.F.4
Nga Ly-Hartig, T.B.5
Ellenberg, J.6
Mattaj, I.W.7
-
20
-
-
84860272984
-
Breaking the ties that bind: new advances in centrosome biology
-
Mardin B.R., Schiebel E. Breaking the ties that bind: new advances in centrosome biology. J.Cell Biol. 2012, 197:11-18.
-
(2012)
J.Cell Biol.
, vol.197
, pp. 11-18
-
-
Mardin, B.R.1
Schiebel, E.2
-
21
-
-
78649870675
-
Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction
-
Mardin B.R., Lange C., Baxter J.E., Hardy T., Scholz S.R., Fry A.M., Schiebel E. Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. Nat. Cell Biol. 2010, 12:1166-1176.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 1166-1176
-
-
Mardin, B.R.1
Lange, C.2
Baxter, J.E.3
Hardy, T.4
Scholz, S.R.5
Fry, A.M.6
Schiebel, E.7
-
22
-
-
79960161183
-
Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction
-
Mardin B.R., Agircan F.G., Lange C., Schiebel E. Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction. Curr. Biol. 2011, 21:1145-1151.
-
(2011)
Curr. Biol.
, vol.21
, pp. 1145-1151
-
-
Mardin, B.R.1
Agircan, F.G.2
Lange, C.3
Schiebel, E.4
-
23
-
-
0033615357
-
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
-
Mayer T.U., Kapoor T.M., Haggarty S.J., King R.W., Schreiber S.L., Mitchison T.J. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 1999, 286:971-974.
-
(1999)
Science
, vol.286
, pp. 971-974
-
-
Mayer, T.U.1
Kapoor, T.M.2
Haggarty, S.J.3
King, R.W.4
Schreiber, S.L.5
Mitchison, T.J.6
-
24
-
-
84855551873
-
Kinetochores accelerate centrosome separation to ensure faithful chromosome segregation
-
McHedlishvili N., Wieser S., Holtackers R., Mouysset J., Belwal M., Amaro A.C., Meraldi P. Kinetochores accelerate centrosome separation to ensure faithful chromosome segregation. J.Cell Sci. 2012, 125:906-918.
-
(2012)
J.Cell Sci.
, vol.125
, pp. 906-918
-
-
McHedlishvili, N.1
Wieser, S.2
Holtackers, R.3
Mouysset, J.4
Belwal, M.5
Amaro, A.C.6
Meraldi, P.7
-
25
-
-
77950387346
-
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes
-
Neumann B., Walter T., Hériché J.K., Bulkescher J., Erfle H., Conrad C., Rogers P., Poser I., Held M., Liebel U., et al. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature 2010, 464:721-727.
-
(2010)
Nature
, vol.464
, pp. 721-727
-
-
Neumann, B.1
Walter, T.2
Hériché, J.K.3
Bulkescher, J.4
Erfle, H.5
Conrad, C.6
Rogers, P.7
Poser, I.8
Held, M.9
Liebel, U.10
-
26
-
-
32044464123
-
Epidermal growth factor receptor (EGFR) signaling in cancer
-
Normanno N., De Luca A., Bianco C., Strizzi L., Mancino M., Maiello M.R., Carotenuto A., De Feo G., Caponigro F., Salomon D.S. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 2006, 366:2-16.
-
(2006)
Gene
, vol.366
, pp. 2-16
-
-
Normanno, N.1
De Luca, A.2
Bianco, C.3
Strizzi, L.4
Mancino, M.5
Maiello, M.R.6
Carotenuto, A.7
De Feo, G.8
Caponigro, F.9
Salomon, D.S.10
-
27
-
-
79955934629
-
Gitools: analysis and visualisation of genomic data using interactive heat-maps
-
Perez-Llamas C., Lopez-Bigas N. Gitools: analysis and visualisation of genomic data using interactive heat-maps. PLoS ONE 2011, 6:e19541.
-
(2011)
PLoS ONE
, vol.6
-
-
Perez-Llamas, C.1
Lopez-Bigas, N.2
-
28
-
-
42949095911
-
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals
-
Poser I., Sarov M., Hutchins J.R., Hériché J.K., Toyoda Y., Pozniakovsky A., Weigl D., Nitzsche A., Hegemann B., Bird A.W., et al. BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat. Methods 2008, 5:409-415.
-
(2008)
Nat. Methods
, vol.5
, pp. 409-415
-
-
Poser, I.1
Sarov, M.2
Hutchins, J.R.3
Hériché, J.K.4
Toyoda, Y.5
Pozniakovsky, A.6
Weigl, D.7
Nitzsche, A.8
Hegemann, B.9
Bird, A.W.10
-
29
-
-
84868537751
-
Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation
-
Raaijmakers J.A., van Heesbeen R.G., Meaders J.L., Geers E.F., Fernandez-Garcia B., Medema R.H., Tanenbaum M.E. Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation. EMBO J. 2012, 31:4179-4190.
-
(2012)
EMBO J.
, vol.31
, pp. 4179-4190
-
-
Raaijmakers, J.A.1
van Heesbeen, R.G.2
Meaders, J.L.3
Geers, E.F.4
Fernandez-Garcia, B.5
Medema, R.H.6
Tanenbaum, M.E.7
-
31
-
-
76249097011
-
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt
-
Romano D., Matallanas D., Weitsman G., Preisinger C., Ng T., Kolch W. Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. Cancer Res. 2010, 70:1195-1203.
-
(2010)
Cancer Res.
, vol.70
, pp. 1195-1203
-
-
Romano, D.1
Matallanas, D.2
Weitsman, G.3
Preisinger, C.4
Ng, T.5
Kolch, W.6
-
32
-
-
0029011952
-
Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle
-
Sawin K.E., Mitchison T.J. Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle. Proc. Natl. Acad. Sci. USA 1995, 92:4289-4293.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 4289-4293
-
-
Sawin, K.E.1
Mitchison, T.J.2
-
33
-
-
0026739078
-
Mitotic spindle organization by a plus-end-directed microtubule motor
-
Sawin K.E., LeGuellec K., Philippe M., Mitchison T.J. Mitotic spindle organization by a plus-end-directed microtubule motor. Nature 1992, 359:540-543.
-
(1992)
Nature
, vol.359
, pp. 540-543
-
-
Sawin, K.E.1
LeGuellec, K.2
Philippe, M.3
Mitchison, T.J.4
-
34
-
-
0020313101
-
Epidermal growth factor induces rapid centrosomal separation in HeLa and 3T3 cells
-
Sherline P., Mascardo R.N. Epidermal growth factor induces rapid centrosomal separation in HeLa and 3T3 cells. J.Cell Biol. 1982, 93:507-512.
-
(1982)
J.Cell Biol.
, vol.93
, pp. 507-512
-
-
Sherline, P.1
Mascardo, R.N.2
-
35
-
-
84856426337
-
Timing of centrosome separation is important for accurate chromosome segregation
-
Silkworth W.T., Nardi I.K., Paul R., Mogilner A., Cimini D. Timing of centrosome separation is important for accurate chromosome segregation. Mol. Biol. Cell 2012, 23:401-411.
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 401-411
-
-
Silkworth, W.T.1
Nardi, I.K.2
Paul, R.3
Mogilner, A.4
Cimini, D.5
-
36
-
-
33745867225
-
S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression
-
Skoufias D.A., DeBonis S., Saoudi Y., Lebeau L., Crevel I., Cross R., Wade R.H., Hackney D.D., Kozielski F. S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression. J.Biol. Chem. 2006, 281:17559-17569.
-
(2006)
J.Biol. Chem.
, vol.281
, pp. 17559-17569
-
-
Skoufias, D.A.1
DeBonis, S.2
Saoudi, Y.3
Lebeau, L.4
Crevel, I.5
Cross, R.6
Wade, R.H.7
Hackney, D.D.8
Kozielski, F.9
-
37
-
-
78649957196
-
Mechanisms of centrosome separation and bipolar spindle assembly
-
Tanenbaum M.E., Medema R.H. Mechanisms of centrosome separation and bipolar spindle assembly. Dev. Cell 2010, 19:797-806.
-
(2010)
Dev. Cell
, vol.19
, pp. 797-806
-
-
Tanenbaum, M.E.1
Medema, R.H.2
-
38
-
-
70350575316
-
Kif15 cooperates with eg5 to promote bipolar spindle assembly
-
Tanenbaum M.E., Macůrek L., Janssen A., Geers E.F., Alvarez-Fernández M., Medema R.H. Kif15 cooperates with eg5 to promote bipolar spindle assembly. Curr. Biol. 2009, 19:1703-1711.
-
(2009)
Curr. Biol.
, vol.19
, pp. 1703-1711
-
-
Tanenbaum, M.E.1
Macůrek, L.2
Janssen, A.3
Geers, E.F.4
Alvarez-Fernández, M.5
Medema, R.H.6
-
39
-
-
27844432603
-
AKT signaling in normal and malignant cells
-
Testa J.R., Tsichlis P.N. AKT signaling in normal and malignant cells. Oncogene 2005, 24:7391-7393.
-
(2005)
Oncogene
, vol.24
, pp. 7391-7393
-
-
Testa, J.R.1
Tsichlis, P.N.2
-
40
-
-
62849098748
-
Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly
-
Toso A., Winter J.R., Garrod A.J., Amaro A.C., Meraldi P., McAinsh A.D. Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly. J.Cell Biol. 2009, 184:365-372.
-
(2009)
J.Cell Biol.
, vol.184
, pp. 365-372
-
-
Toso, A.1
Winter, J.R.2
Garrod, A.J.3
Amaro, A.C.4
Meraldi, P.5
McAinsh, A.D.6
-
41
-
-
70350575315
-
The role of Hklp2 in the stabilization and maintenance of spindle bipolarity
-
Vanneste D., Takagi M., Imamoto N., Vernos I. The role of Hklp2 in the stabilization and maintenance of spindle bipolarity. Curr. Biol. 2009, 19:1712-1717.
-
(2009)
Curr. Biol.
, vol.19
, pp. 1712-1717
-
-
Vanneste, D.1
Takagi, M.2
Imamoto, N.3
Vernos, I.4
-
42
-
-
38949132114
-
Mechanisms of mitotic spindle assembly and function
-
Walczak C.E., Heald R. Mechanisms of mitotic spindle assembly and function. Int. Rev. Cytol. 2008, 265:111-158.
-
(2008)
Int. Rev. Cytol.
, vol.265
, pp. 111-158
-
-
Walczak, C.E.1
Heald, R.2
-
43
-
-
77950525573
-
Automatic identification and clustering of chromosome phenotypes in a genome wide RNAi screen by time-lapse imaging
-
Walter T., Held M., Neumann B., Hériché J.K., Conrad C., Pepperkok R., Ellenberg J. Automatic identification and clustering of chromosome phenotypes in a genome wide RNAi screen by time-lapse imaging. J.Struct. Biol. 2010, 170:1-9.
-
(2010)
J.Struct. Biol.
, vol.170
, pp. 1-9
-
-
Walter, T.1
Held, M.2
Neumann, B.3
Hériché, J.K.4
Conrad, C.5
Pepperkok, R.6
Ellenberg, J.7
-
44
-
-
0032101688
-
Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
-
Waters J.C., Chen R.H., Murray A.W., Salmon E.D. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J.Cell Biol. 1998, 141:1181-1191.
-
(1998)
J.Cell Biol.
, vol.141
, pp. 1181-1191
-
-
Waters, J.C.1
Chen, R.H.2
Murray, A.W.3
Salmon, E.D.4
-
45
-
-
0031696367
-
Expanding the role of HsEg5 within the mitotic and post-mitotic phases of the cell cycle
-
Whitehead C.M., Rattner J.B. Expanding the role of HsEg5 within the mitotic and post-mitotic phases of the cell cycle. J.Cell Sci. 1998, 111:2551-2561.
-
(1998)
J.Cell Sci.
, vol.111
, pp. 2551-2561
-
-
Whitehead, C.M.1
Rattner, J.B.2
-
46
-
-
63049100044
-
Functional selectivity of EGF family peptide growth factors: implications for cancer
-
Wilson K.J., Gilmore J.L., Foley J., Lemmon M.A., Riese D.J. Functional selectivity of EGF family peptide growth factors: implications for cancer. Pharmacol. Ther. 2009, 122:1-8.
-
(2009)
Pharmacol. Ther.
, vol.122
, pp. 1-8
-
-
Wilson, K.J.1
Gilmore, J.L.2
Foley, J.3
Lemmon, M.A.4
Riese, D.J.5
-
47
-
-
0033214444
-
The EGF receptor as central transducer of heterologous signalling systems
-
Zwick E., Hackel P.O., Prenzel N., Ullrich A. The EGF receptor as central transducer of heterologous signalling systems. Trends Pharmacol. Sci. 1999, 20:408-412.
-
(1999)
Trends Pharmacol. Sci.
, vol.20
, pp. 408-412
-
-
Zwick, E.1
Hackel, P.O.2
Prenzel, N.3
Ullrich, A.4
|