Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response

Nature Communications

Volumn 5, Issue , 2014, Pages

  Houthuijzen, Julia M ^a   Daenen, Laura G M ^b   Roodhart, Jeanine M L ^a   Oosterom, Ilse ^d   Van Jaarsveld, Marijn T M ^b   Govaert, Klaas M ^e   Smith, Michelle E ^c   Sadatmand, Sahar J ^a   Rosing, Hilde ^a   Kruse, Fabian ^b   Helms, Bernd J ^a   Van Rooijen, Nico ^b   Beijnen, Jos H ^a   Haribabu, Bodduluri ^a   Van De Lest, Chris H A ^a   Voest, Emile E ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c University of Louisville School of Medicine   (United States)

^d UTRECHT UNIVERSITY   (Netherlands)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

12 S KETO 5,8,10 HEPTADECATRIENOIC ACID; 4,7,10,13 HEXADECATETRAENOIC; CISPLATIN; CLODRONIC ACID; FATTY ACID; HISTONE H2AX; LEUKOTRIENE B4 RECEPTOR; LYSOPHOSPHATIDYLCHOLINE; LYSOPHOSPHOLIPID; PLATINUM DERIVATIVE; UNCLASSIFIED DRUG; 12-KETO-5,8,10-HEPTADECATRIENOIC ACID; ANTINEOPLASTIC AGENT; HEXADECA-4,7,10,13-TETRAENOIC ACID; LTB4R2 PROTEIN, MOUSE; UNSATURATED FATTY ACID;

BLOOD; CHEMICAL COMPOUND; CHEMOTHERAPY; DNA; DRUG RESISTANCE; FATTY ACID; PHOSPHOLIPID; PLATINUM; RODENT; SIGNALING; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RESISTANCE; CELL FUNCTION; CHEMOTHERAPY; DNA DAMAGE; IN VIVO STUDY; MACROPHAGE; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; SPLEEN CELL; SPLENECTOMY; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CYTOLOGY; DRUG RESISTANCE; NEOPLASMS, EXPERIMENTAL; PHYSIOLOGY; SECRETION (PROCESS); SPLEEN;

ANIMALS; ANTINEOPLASTIC AGENTS; CISPLATIN; DNA DAMAGE; DRUG RESISTANCE, NEOPLASM; FATTY ACIDS, UNSATURATED; LYSOPHOSPHOLIPIDS; MACROPHAGES; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; RECEPTORS, LEUKOTRIENE B4; SPLEEN; SPLENECTOMY;

EID: 84923366363     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6275     Document Type: Article

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