CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 14, 2017, Pages 3696-3701

  Vanoli, Fabio ^a   Tomishima, Mark ^a   Feng, Weiran ^a   Lamribet, Khadija ^b   Babin, Loelia ^b   Brunet, Erika ^b   Jasin, Maria ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b IMAGINE INSTITUTE   (France)

Author keywords

Chromosomal translocation; CRISPR Cas9; DSRCT; EWSR1 WT1; Homology directed repair

Indexed keywords

CRE RECOMBINASE; EWSR1 WT1 PROTEIN; HYBRID PROTEIN; UNCLASSIFIED DRUG; EWSR1 PROTEIN, HUMAN; ONCOPROTEIN; RNA BINDING PROTEIN EWS; WT1 PROTEIN; WT1 PROTEIN, HUMAN;

ARTICLE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; CYTOLOGY; DOUBLE STRANDED DNA BREAK; GENE EDITING; GENE TRANSLOCATION; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; PROCEDURES;

CRISPR-CAS SYSTEMS; DNA BREAKS, DOUBLE-STRANDED; GENE EDITING; HUMANS; MESENCHYMAL STROMAL CELLS; ONCOGENE PROTEINS, FUSION; PROMOTER REGIONS, GENETIC; RNA-BINDING PROTEIN EWS; TRANSLOCATION, GENETIC; WT1 PROTEINS;

EID: 85016997705     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1700622114     Document Type: Article

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