Biallelic targeting of expressed genes in mouse embryonic stem cells using the Cas9 system

Methods

Volumn 69, Issue 2, 2014, Pages 171-178

  Zhang, Yu ^a   Vanoli, Fabio ^a   LaRocque, Jeannine R ^a,b   Krawczyk, Przemek M ^a,c   Jasin, Maria ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Cas9; Double strand break (DSB); Embryonic stem cells; Gene targeting; Genome editing; Homologous recombination

Indexed keywords

CASPASE 9; ENDONUCLEASE; GUIDE RNA;

ALLELISM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DOUBLE STRANDED DNA BREAK; EMBRYO; EMBRYONIC STEM CELL; ENZYME SPECIFICITY; EXPRESSION VECTOR; GENE EXPRESSION; GENE LOCUS; GENE TARGETING; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA SEQUENCE; ALLELE; ANIMAL; BIOSYNTHESIS; BOVINE; CRISPR CAS SYSTEM; GENE EXPRESSION REGULATION; GENETICS; HUMAN; PHYSIOLOGY; PROCEDURES;

BACTERIA (MICROORGANISMS); MAMMALIA;

ALLELES; ANIMALS; CATTLE; CRISPR-CAS SYSTEMS; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION; GENE TARGETING; HUMANS; MICE; RNA, GUIDE;

EID: 84926408469     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2014.05.003     Document Type: Article

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