Generation of conditional oncogenic chromosomal translocations using CRISPR–Cas9 genomic editing and homology-directed repair

Journal of Pathology

Volumn 242, Issue 1, 2017, Pages 102-112

  Spraggon, Lee ^a   Martelotto, Luciano G ^a   Hmeljak, Julija ^a   Hitchman, Tyler D ^a   Wang, Jiang ^a   Wang, Lu ^a   Slotkin, Emily K ^a   Fan, Pang Dian ^a   Reis Filho, Jorge S ^a   Ladanyi, Marc ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

chromosomal translocations; CRISPR Cas9; desmoplastic small round cell tumour (DSRCT); Ewing sarcoma; genomic editing; homology directed repair; oncogene

Indexed keywords

CRE RECOMBINASE; ENDONUCLEASE; GENOMIC DNA; DNA; ONCOPROTEIN;

ALLELE; ARTICLE; CELL POPULATION; CHROMOSOME 11; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CRISPR CAS SYSTEM; DESMOPLASTIC SMALL ROUND CELL TUMOR; EWING SARCOMA; GENE EDITING; GENE EXPRESSION; GENE FUSION; HUMAN; HUMAN CELL; HYBRID; NONHUMAN; PRIORITY JOURNAL; CHROMOSOME 22; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETICS; PROCEDURES; RECOMBINATION REPAIR; TUMOR CELL CULTURE;

ARTIFICIAL GENE FUSION; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 22; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DESMOPLASTIC SMALL ROUND CELL TUMOR; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ONCOGENE PROTEINS, FUSION; RECOMBINATIONAL DNA REPAIR; SARCOMA, EWING; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 85016967426     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4883     Document Type: Article

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