Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

Nature Communications

Volumn 8, Issue , 2017, Pages

  Philippaert, Koenraad ^a,b   Pironet, Andy ^a,b   Mesuere, Margot ^a,b   Sones, William ^c   Vermeiren, Laura ^a,b   Kerselaers, Sara ^a,b   Pinto, Sílvia ^a,b   Segal, Andrei ^a,b   Antoine, Nancy ^d   Gysemans, Conny ^b   Laureys, Jos ^b   Lemaire, Katleen ^b   Gilon, Patrick ^d   Cuypers, Eva ^b   Tytgat, Jan ^b   Mathieu, Chantal ^b   Schuit, Frans ^b   Rorsman, Patrik ^c   Talavera, Karel ^a,b   Voets, Thomas ^a,b   Vennekens, Rudi ^a,b   more..

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c CHURCHILL HOSPITAL   (United Kingdom)

^d UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INCRETIN; INSULIN; REBAUDIOSIDE A; STEVIOL; STEVIOSIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M5; UNCLASSIFIED DRUG; GLUCOSIDE; KAURANE DERIVATIVE; SWEETENING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM4 PROTEIN, HUMAN; TRPM5 PROTEIN, HUMAN; TRPM5 PROTEIN, MOUSE;

CELLS AND CELL COMPONENTS; DIABETES; MOLECULAR ANALYSIS; PERCEPTION; RODENT; SCRUB; SECRETION; TASTE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BITTER TASTE; CALCIUM SIGNALING; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INFUSION; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INSIDE OUT PATCH CLAMP; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; KIDNEY CAPSULE; LIPID DIET; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; STEVIA REBAUDIANA; SWEETNESS; TASTE BUD; TASTE PREFERENCE; UMAMI; WHOLE CELL PATCH CLAMP; ANIMAL; DRUG EFFECT; KNOCKOUT MOUSE; METABOLISM; PATCH CLAMP TECHNIQUE; SECRETION (PROCESS); TASTE;

MUS; STEVIA REBAUDIANA;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DITERPENES, KAURANE; FEMALE; GLUCOSIDES; HEK293 CELLS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, KNOCKOUT; PATCH-CLAMP TECHNIQUES; SWEETENING AGENTS; TASTE; TRPM CATION CHANNELS;

EID: 85016619279     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms14733     Document Type: Article

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