Triphenylphosphine oxide is a potent and selective inhibitor of the transient receptor potential melastatin-5 ion channel

Assay and Drug Development Technologies

Volumn 8, Issue 6, 2010, Pages 703-713

  Palmer, R Kyle ^a   Atwal, Karnail ^a   Bakaj, Ivona ^a   Carlucci Derbyshire, Stacy ^a   Buber, M Tulu ^a   Cerne, Rok ^a   Cortés, Rosa Y ^a   Devantier, Heather R ^a   Jorgensen, Vincent ^a   Pawlyk, Aaron ^a   Lee, S Paul ^a   Sprous, Dennis G ^a   Zhang, Zheng ^a   Bryant, Robert ^a  

^a Redpoint Bio Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (DIPHENYLPHOSPHORYL)ANILINE; 2 (DIPHENYLPHOSPHORYL)ANISOLE; 2 (DIPHENYLPHOSPHORYL)PHENOL; 4 (DIPHENYLPHOSPHORYL)PHENOL; METHYL 2 (DIPHENYLPHOSPHORYL)BENZOATE; METHYLMETHOXY 2 (DIPHENYLPHOSPHORYL)PHENOL; OXYGEN; PROTEIN INHIBITOR; RECOMBINANT PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M4; TRANSIENT RECEPTOR POTENTIAL CHANNEL M4B; TRANSIENT RECEPTOR POTENTIAL CHANNEL M5; TRIPHENYLPHOSPHINE; TRIPHENYLPHOSPHINE OXIDE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONDUCTANCE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG POTENCY; DRUG SELECTIVITY; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IC 50; MEMBRANE POTENTIAL; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; TASTE BUD; TONGUE; TRANSGENIC MOUSE; VALIDATION STUDY;

ANIMALS; CALCIUM; HEK293 CELLS; HUMANS; ION CHANNEL GATING; LUMINESCENT MEASUREMENTS; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; ORGANOPHOSPHORUS COMPOUNDS; PATCH-CLAMP TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP; TASTE; TASTE BUDS; TRPM CATION CHANNELS;

EID: 78650438738     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2010.0334     Document Type: Article

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