-
1
-
-
0024917106
-
Electrophysiology of the pancreatic beta-cell
-
Ashcroft, F. M., and P. Rorsman . 1989. Electrophysiology of the pancreatic beta-cell. Prog. Biophys. Mol. Biol. 54:87-143.
-
(1989)
Prog. Biophys. Mol. Biol.
, vol.54
, pp. 87-143
-
-
Ashcroft, F.M.1
Rorsman, P.2
-
2
-
-
0030826078
-
Wolfram (DIDMOAD) syndrome
-
Barrett, T. G., and S. E. Bundey . 1997. Wolfram (DIDMOAD) syndrome. J. Med. Genet. 34:838-841.
-
(1997)
J. Med. Genet.
, vol.34
, pp. 838-841
-
-
Barrett, T.G.1
Bundey, S.E.2
-
3
-
-
77952889933
-
TRPM5 regulates glucose-stimulated insulin secretion
-
Brixel, L. R., M. K. Monteilh-Zoller, C. S. Ingenbrandt, A. Fleig, R. Penner, T. Enklaar, et al. 2010. TRPM5 regulates glucose-stimulated insulin secretion. Pflugers Arch. 460:69-76.
-
(2010)
Pflugers Arch.
, vol.460
, pp. 69-76
-
-
Brixel, L.R.1
Monteilh-Zoller, M.K.2
Ingenbrandt, C.S.3
Fleig, A.4
Penner, R.5
Enklaar, T.6
-
4
-
-
79953748182
-
Decreased insulin secretion and increased risk of type 2 diabetes associated with allelic variations of the WFS1 gene: the data from epidemiological study on the insulin resistance syndrome (desir) prospective study
-
Cheurfa, N., G. M. Brenner, A. F. Reis, D. Dubois-Laforgue, R. Roussel, J. Tichet, et al. 2011. Decreased insulin secretion and increased risk of type 2 diabetes associated with allelic variations of the WFS1 gene: the data from epidemiological study on the insulin resistance syndrome (desir) prospective study. Diabetologia 54:554-562.
-
(2011)
Diabetologia
, vol.54
, pp. 554-562
-
-
Cheurfa, N.1
Brenner, G.M.2
Reis, A.F.3
Dubois-Laforgue, D.4
Roussel, R.5
Tichet, J.6
-
5
-
-
77950450361
-
Loss of high-frequency glucose-induced Ca2 + oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice
-
Colsoul, B., A. Schraenen, K. Lemaire, R. Quintens, L. Van Lommel, A. Segal, et al. 2010. Loss of high-frequency glucose-induced Ca2 + oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc. Natl Acad. Sci. USA 107:5208-5213.
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 5208-5213
-
-
Colsoul, B.1
Schraenen, A.2
Lemaire, K.3
Quintens, R.4
Van Lommel, L.5
Segal, A.6
-
6
-
-
10744222064
-
Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease
-
Cryns, K., T. A. Sivakumaran, J. M. Van den Ouweland, R. J. Pennings, C. W. Cremers, K. Flothmann, et al. 2003. Mutational spectrum of the WFS1 gene in Wolfram syndrome, nonsyndromic hearing impairment, diabetes mellitus, and psychiatric disease. Hum. Mutat. 22:275-287.
-
(2003)
Hum. Mutat.
, vol.22
, pp. 275-287
-
-
Cryns, K.1
Sivakumaran, T.A.2
Van den Ouweland, J.M.3
Pennings, R.J.4
Cremers, C.W.5
Flothmann, K.6
-
7
-
-
84859254586
-
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
-
Eizirik, D. L., M. Sammeth, T. Bouckenooghe, G. Bottu, G. Sisino, M. Igoillo-Esteve, et al. 2012. The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet. 8:e1002552.
-
(2012)
PLoS Genet.
, vol.8
, pp. e1002552
-
-
Eizirik, D.L.1
Sammeth, M.2
Bouckenooghe, T.3
Bottu, G.4
Sisino, G.5
Igoillo-Esteve, M.6
-
8
-
-
39049100084
-
Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program
-
Florez, J. C., K. A. Jablonski, J. McAteer, M. S. Sandhu, N. J. Wareham, I. Barroso, et al. 2008. Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Diabetologia 51:451-457.
-
(2008)
Diabetologia
, vol.51
, pp. 451-457
-
-
Florez, J.C.1
Jablonski, K.A.2
McAteer, J.3
Sandhu, M.S.4
Wareham, N.J.5
Barroso, I.6
-
9
-
-
28244435870
-
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells
-
Fonseca, S. G., M. Fukuma, K. L. Lipson, L. X. Nguyen, J. R. Allen, Y. Oka, et al. 2005. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J. Biol. Chem. 280:39609-39615.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 39609-39615
-
-
Fonseca, S.G.1
Fukuma, M.2
Lipson, K.L.3
Nguyen, L.X.4
Allen, J.R.5
Oka, Y.6
-
10
-
-
77949751415
-
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
-
Fonseca, S. G., S. Ishigaki, C. M. Oslowski, S. Lu, K. L. Lipson, R. Ghosh, et al. 2010. Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J. Clin. Invest. 120:744-755.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 744-755
-
-
Fonseca, S.G.1
Ishigaki, S.2
Oslowski, C.M.3
Lu, S.4
Lipson, K.L.5
Ghosh, R.6
-
11
-
-
39049146958
-
Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations
-
Franks, P. W., O. Rolandsson, S. L. Debenham, K. A. Fawcett, F. Payne, C. Dina, et al. 2008. Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. Diabetologia 51:458-463.
-
(2008)
Diabetologia
, vol.51
, pp. 458-463
-
-
Franks, P.W.1
Rolandsson, O.2
Debenham, S.L.3
Fawcett, K.A.4
Payne, F.5
Dina, C.6
-
12
-
-
79952586301
-
Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells
-
Hatanaka, M., K. Tanabe, A. Yanai, Y. Ohta, M. Kondo, M. Akiyama, et al. 2011. Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells. Hum. Mol. Genet. 20:1274-1284.
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 1274-1284
-
-
Hatanaka, M.1
Tanabe, K.2
Yanai, A.3
Ohta, Y.4
Kondo, M.5
Akiyama, M.6
-
13
-
-
70350331458
-
Shortcomings of current models of glucose-induced insulin secretion
-
Henquin, J. C., M. Nenquin, M. A. Ravier, and A. Szollosi . 2009. Shortcomings of current models of glucose-induced insulin secretion. Diabetes Obes. Metab. 11(Suppl 4):168-179.
-
(2009)
Diabetes Obes. Metab.
, vol.11
, pp. 168-179
-
-
Henquin, J.C.1
Nenquin, M.2
Ravier, M.A.3
Szollosi, A.4
-
14
-
-
58149333712
-
Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
-
van Hoek, M., A. Dehghan, J. C. Witteman, C. M. van Duijn, A. G. Uitterlinden, B. A. Oostra, et al. 2008. Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes 57:3122-3128.
-
(2008)
Diabetes
, vol.57
, pp. 3122-3128
-
-
van Hoek, M.1
Dehghan, A.2
Witteman, J.C.3
van Duijn, C.M.4
Uitterlinden, A.G.5
Oostra, B.A.6
-
15
-
-
0041919371
-
Wolfram syndrome: structural and functional analyses of mutant and wild-type wolframin, the WFS1 gene product
-
Hofmann, S., C. Philbrook, K. D. Gerbitz, and M. F. Bauer . 2003. Wolfram syndrome: structural and functional analyses of mutant and wild-type wolframin, the WFS1 gene product. Hum. Mol. Genet. 12:2003-2012.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 2003-2012
-
-
Hofmann, S.1
Philbrook, C.2
Gerbitz, K.D.3
Bauer, M.F.4
-
16
-
-
17344362695
-
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)
-
Inoue, H., Y. Tanizawa, J. Wasson, P. Behn, K. Kalidas, E. Bernal-Mizrachi, et al. 1998. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat. Genet. 20:143-148.
-
(1998)
Nat. Genet.
, vol.20
, pp. 143-148
-
-
Inoue, H.1
Tanizawa, Y.2
Wasson, J.3
Behn, P.4
Kalidas, K.5
Bernal-Mizrachi, E.6
-
17
-
-
2942731683
-
Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion
-
Ishihara, H., S. Takeda, A. Tamura, R. Takahashi, S. Yamaguchi, D. Takei, et al. 2004. Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion. Hum. Mol. Genet. 13:1159-1170.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 1159-1170
-
-
Ishihara, H.1
Takeda, S.2
Tamura, A.3
Takahashi, R.4
Yamaguchi, S.5
Takei, D.6
-
18
-
-
0024599929
-
Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram's syndrome
-
Karasik, A., C. O'Hara, S. Srikanta, M. Swift, J. S. Soeldner, C. R. Kahn, et al. 1989. Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram's syndrome. Diabetes Care 12:135-138.
-
(1989)
Diabetes Care
, vol.12
, pp. 135-138
-
-
Karasik, A.1
O'Hara, C.2
Srikanta, S.3
Swift, M.4
Soeldner, J.S.5
Kahn, C.R.6
-
19
-
-
66349110615
-
Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway
-
Koks, S., U. Soomets, J. L. Paya-Cano, C. Fernandes, H. Luuk, M. Plaas, et al. 2009. Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway. Physiol. Genomics 37:249-259.
-
(2009)
Physiol. Genomics
, vol.37
, pp. 249-259
-
-
Koks, S.1
Soomets, U.2
Paya-Cano, J.L.3
Fernandes, C.4
Luuk, H.5
Plaas, M.6
-
20
-
-
84866977211
-
Research resource: RNA-Seq reveals unique features of the pancreatic beta-cell transcriptome
-
Ku, G. M., H. Kim, I. W. Vaughn, M. J. Hangauer, Oh C Myung, M. S. German, et al. 2012. Research resource: RNA-Seq reveals unique features of the pancreatic beta-cell transcriptome. Mol. Endocrinol. 26:1783-1792.
-
(2012)
Mol. Endocrinol.
, vol.26
, pp. 1783-1792
-
-
Ku, G.M.1
Kim, H.2
Vaughn, I.W.3
Hangauer, M.J.4
Myung, O.C.5
German, M.S.6
-
21
-
-
48249095615
-
Distribution of Wfs1 protein in the central nervous system of the mouse and its relation to clinical symptoms of the Wolfram syndrome
-
Luuk, H., S. Koks, M. Plaas, J. Hannibal, J. F. Rehfeld, and E. Vasar . 2008. Distribution of Wfs1 protein in the central nervous system of the mouse and its relation to clinical symptoms of the Wolfram syndrome. J. Comp. Neurol. 509:642-660.
-
(2008)
J. Comp. Neurol.
, vol.509
, pp. 642-660
-
-
Luuk, H.1
Koks, S.2
Plaas, M.3
Hannibal, J.4
Rehfeld, J.F.5
Vasar, E.6
-
22
-
-
59649127277
-
Wfs1-deficient mice display impaired behavioural adaptation in stressful environment
-
Luuk, H., M. Plaas, S. Raud, J. Innos, S. Sutt, H. Lasner, et al. 2009. Wfs1-deficient mice display impaired behavioural adaptation in stressful environment. Behav. Brain Res. 198:334-345.
-
(2009)
Behav. Brain Res.
, vol.198
, pp. 334-345
-
-
Luuk, H.1
Plaas, M.2
Raud, S.3
Innos, J.4
Sutt, S.5
Lasner, H.6
-
23
-
-
0036227462
-
Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations
-
Minton, J. A., A. T. Hattersley, K. Owen, M. I. McCarthy, M. Walker, F. Latif, et al. 2002. Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Diabetes 51:1287-1290.
-
(2002)
Diabetes
, vol.51
, pp. 1287-1290
-
-
Minton, J.A.1
Hattersley, A.T.2
Owen, K.3
McCarthy, M.I.4
Walker, M.5
Latif, F.6
-
24
-
-
84867070330
-
Human beta cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
-
Moran, I., I. Akerman, M. van de Bunt, R. Xie, M. Benazra, T. Nammo, et al. 2012. Human beta cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab. 16:435-448.
-
(2012)
Cell Metab.
, vol.16
, pp. 435-448
-
-
Moran, I.1
Akerman, I.2
van de Bunt, M.3
Xie, R.4
Benazra, M.5
Nammo, T.6
-
25
-
-
46249106990
-
Mapping and quantifying mammalian transcriptomes by RNA-Seq
-
Mortazavi, A., B. A. Williams, K. McCue, L. Schaeffer, and B. Wold . 2008. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat. Methods 5:621-628.
-
(2008)
Nat. Methods
, vol.5
, pp. 621-628
-
-
Mortazavi, A.1
Williams, B.A.2
McCue, K.3
Schaeffer, L.4
Wold, B.5
-
26
-
-
0030781055
-
The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects
-
Mykkanen, L., S. M. Haffner, C. N. Hales, T. Ronnemaa, and M. Laakso . 1997. The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects. Diabetes 46:1990-1995.
-
(1997)
Diabetes
, vol.46
, pp. 1990-1995
-
-
Mykkanen, L.1
Haffner, S.M.2
Hales, C.N.3
Ronnemaa, T.4
Laakso, M.5
-
27
-
-
79955916984
-
Sex differences in the development of diabetes in mice with deleted wolframin (Wfs1) gene
-
Noormets, K., S. Koks, M. Muldmaa, L. Mauring, E. Vasar, and V. Tillmann . 2011. Sex differences in the development of diabetes in mice with deleted wolframin (Wfs1) gene. Exp. Clin. Endocrinol. Diabetes 119:271-275.
-
(2011)
Exp. Clin. Endocrinol. Diabetes
, vol.119
, pp. 271-275
-
-
Noormets, K.1
Koks, S.2
Muldmaa, M.3
Mauring, L.4
Vasar, E.5
Tillmann, V.6
-
28
-
-
0347362797
-
Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium
-
Osman, A. A., M. Saito, C. Makepeace, M. A. Permutt, P. Schlesinger, and M. Mueckler . 2003. Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium. J. Biol. Chem. 278:52755-52762.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52755-52762
-
-
Osman, A.A.1
Saito, M.2
Makepeace, C.3
Permutt, M.A.4
Schlesinger, P.5
Mueckler, M.6
-
29
-
-
24644480656
-
Expressional and functional studies of Wolframin, the gene function deficient in Wolfram syndrome, in mice and patient cells
-
Philbrook, C., E. Fritz, and H. Weiher . 2005. Expressional and functional studies of Wolframin, the gene function deficient in Wolfram syndrome, in mice and patient cells. Exp. Gerontol. 40:671-678.
-
(2005)
Exp. Gerontol.
, vol.40
, pp. 671-678
-
-
Philbrook, C.1
Fritz, E.2
Weiher, H.3
-
30
-
-
0344581060
-
TRPM5 is a transient Ca2 + -activated cation channel responding to rapid changes in [Ca2 + ]i
-
Prawitt, D., M. K. Monteilh-Zoller, L. Brixel, C. Spangenberg, B. Zabel, A. Fleig, et al. 2003. TRPM5 is a transient Ca2 + -activated cation channel responding to rapid changes in [Ca2 + ]i. Proc. Natl Acad. Sci. USA 100:15166-15171.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 15166-15171
-
-
Prawitt, D.1
Monteilh-Zoller, M.K.2
Brixel, L.3
Spangenberg, C.4
Zabel, B.5
Fleig, A.6
-
31
-
-
27744523525
-
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis
-
Riggs, A. C., E. Bernal-Mizrachi, M. Ohsugi, J. Wasson, S. Fatrai, C. Welling, et al. 2005. Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis. Diabetologia 48:2313-2321.
-
(2005)
Diabetologia
, vol.48
, pp. 2313-2321
-
-
Riggs, A.C.1
Bernal-Mizrachi, E.2
Ohsugi, M.3
Wasson, J.4
Fatrai, S.5
Welling, C.6
-
32
-
-
34547536393
-
Common variants in WFS1 confer risk of type 2 diabetes
-
Sandhu, M. S., M. N. Weedon, K. A. Fawcett, J. Wasson, S. L. Debenham, A. Daly, et al. 2007. Common variants in WFS1 confer risk of type 2 diabetes. Nat. Genet. 39:951-953.
-
(2007)
Nat. Genet.
, vol.39
, pp. 951-953
-
-
Sandhu, M.S.1
Weedon, M.N.2
Fawcett, K.A.3
Wasson, J.4
Debenham, S.L.5
Daly, A.6
-
33
-
-
65449119577
-
Insulin secretion from beta-cells is affected by deletion of nicotinamide nucleotide transhydrogenase
-
Shimomura, K., J. Galvanovskis, M. Goldsworthy, A. Hugill, S. Kaizak, A. Lee, et al. 2009. Insulin secretion from beta-cells is affected by deletion of nicotinamide nucleotide transhydrogenase. Methods Enzymol. 457:451-480.
-
(2009)
Methods Enzymol.
, vol.457
, pp. 451-480
-
-
Shimomura, K.1
Galvanovskis, J.2
Goldsworthy, M.3
Hugill, A.4
Kaizak, S.5
Lee, A.6
-
34
-
-
0031761895
-
Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein
-
Strom, T. M., K. Hortnagel, S. Hofmann, F. Gekeler, C. Scharfe, W. Rabl, et al. 1998. Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein. Hum. Mol. Genet. 7:2021-2028.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 2021-2028
-
-
Strom, T.M.1
Hortnagel, K.2
Hofmann, S.3
Gekeler, F.4
Scharfe, C.5
Rabl, W.6
-
35
-
-
0035283066
-
WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain
-
Takeda, K., H. Inoue, Y. Tanizawa, Y. Matsuzaki, J. Oba, Y. Watanabe, et al. 2001. WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain. Hum. Mol. Genet. 10:477-484.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 477-484
-
-
Takeda, K.1
Inoue, H.2
Tanizawa, Y.3
Matsuzaki, Y.4
Oba, J.5
Watanabe, Y.6
-
36
-
-
33749342602
-
WFS1 protein modulates the free Ca(2 + ) concentration in the endoplasmic reticulum
-
Takei, D., H. Ishihara, S. Yamaguchi, T. Yamada, A. Tamura, H. Katagiri, et al. 2006. WFS1 protein modulates the free Ca(2 + ) concentration in the endoplasmic reticulum. FEBS Lett. 580:5635-5640.
-
(2006)
FEBS Lett.
, vol.580
, pp. 5635-5640
-
-
Takei, D.1
Ishihara, H.2
Yamaguchi, S.3
Yamada, T.4
Tamura, A.5
Katagiri, H.6
-
37
-
-
84856399700
-
Wfs1 mutation makes mice sensitive to insulin-like effect of acute valproic acid and resistant to streptozocin
-
Terasmaa, A., U. Soomets, J. Oflijan, M. Punapart, M. Hansen, V. Matto, et al. 2011. Wfs1 mutation makes mice sensitive to insulin-like effect of acute valproic acid and resistant to streptozocin. J. Physiol. Biochem. 67:381-390.
-
(2011)
J. Physiol. Biochem.
, vol.67
, pp. 381-390
-
-
Terasmaa, A.1
Soomets, U.2
Oflijan, J.3
Punapart, M.4
Hansen, M.5
Matto, V.6
-
38
-
-
33745202552
-
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells
-
Yamada, T., H. Ishihara, A. Tamura, R. Takahashi, S. Yamaguchi, D. Takei, et al. 2006. WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells. Hum. Mol. Genet. 15:1600-1609.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 1600-1609
-
-
Yamada, T.1
Ishihara, H.2
Tamura, A.3
Takahashi, R.4
Yamaguchi, S.5
Takei, D.6
|