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Volumn 147, Issue , 2017, Pages 267-299

Matrix Metalloproteinases in Remodeling of Lower Extremity Veins and Chronic Venous Disease

Author keywords

Cell signaling; Collagen; Extracellular matrix; Protein degradation; Proteinases; Remodeling

Indexed keywords

MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; TISSUE INHIBITOR OF METALLOPROTEINASE;

EID: 85015796531     PISSN: 18771173     EISSN: 18780814     Source Type: Book Series    
DOI: 10.1016/bs.pmbts.2017.02.003     Document Type: Chapter
Times cited : (54)

References (132)
  • 1
    • 33750029602 scopus 로고    scopus 로고
    • Conception of the venous hemodynamics in the lower extremity
    • 1 Recek, C., Conception of the venous hemodynamics in the lower extremity. Angiology 57:5 (2006), 556–563.
    • (2006) Angiology , vol.57 , Issue.5 , pp. 556-563
    • Recek, C.1
  • 2
    • 70350517364 scopus 로고    scopus 로고
    • Pathogenesis of primary varicose veins
    • 2 Lim, C.S., Davies, A.H., Pathogenesis of primary varicose veins. Br J Surg 96:11 (2009), 1231–1242.
    • (2009) Br J Surg , vol.96 , Issue.11 , pp. 1231-1242
    • Lim, C.S.1    Davies, A.H.2
  • 3
    • 84966431155 scopus 로고    scopus 로고
    • Matrix metalloproteinases as regulators of vein structure and function: implications in chronic venous disease
    • 3 MacColl, E., Khalil, R.A., Matrix metalloproteinases as regulators of vein structure and function: implications in chronic venous disease. J Pharmacol Exp Ther 355:3 (2015), 410–428.
    • (2015) J Pharmacol Exp Ther , vol.355 , Issue.3 , pp. 410-428
    • MacColl, E.1    Khalil, R.A.2
  • 4
    • 33847007279 scopus 로고    scopus 로고
    • Comparison of extracellular matrix in skin and saphenous veins from patients with varicose veins: does the skin reflect venous matrix changes?
    • 4 Sansilvestri-Morel, P., Fioretti, F., Rupin, A., et al. Comparison of extracellular matrix in skin and saphenous veins from patients with varicose veins: does the skin reflect venous matrix changes?. Clin Sci (Lond) 112:4 (2007), 229–239.
    • (2007) Clin Sci (Lond) , vol.112 , Issue.4 , pp. 229-239
    • Sansilvestri-Morel, P.1    Fioretti, F.2    Rupin, A.3
  • 5
    • 19944392548 scopus 로고    scopus 로고
    • Revision of the CEAP classification for chronic venous disorders: consensus statement
    • 5 Eklof, B., Rutherford, R.B., Bergan, J.J., et al. Revision of the CEAP classification for chronic venous disorders: consensus statement. J Vasc Surg 40:6 (2004), 1248–1252.
    • (2004) J Vasc Surg , vol.40 , Issue.6 , pp. 1248-1252
    • Eklof, B.1    Rutherford, R.B.2    Bergan, J.J.3
  • 6
    • 13944251682 scopus 로고    scopus 로고
    • The epidemiology of chronic venous insufficiency and varicose veins
    • 6 Beebe-Dimmer, J.L., Pfeifer, J.R., Engle, J.S., Schottenfeld, D., The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol 15:3 (2005), 175–184.
    • (2005) Ann Epidemiol , vol.15 , Issue.3 , pp. 175-184
    • Beebe-Dimmer, J.L.1    Pfeifer, J.R.2    Engle, J.S.3    Schottenfeld, D.4
  • 7
    • 0014021308 scopus 로고
    • Venous distensibility in patients with varicose veins
    • 7 Zsoter, T., Cronin, R.F., Venous distensibility in patients with varicose veins. Can Med Assoc J 94:25 (1966), 1293–1297.
    • (1966) Can Med Assoc J , vol.94 , Issue.25 , pp. 1293-1297
    • Zsoter, T.1    Cronin, R.F.2
  • 8
    • 77949891639 scopus 로고    scopus 로고
    • Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins
    • 8 Raffetto, J.D., Qiao, X., Beauregard, K.G., Khalil, R.A., Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins. J Vasc Surg 51:4 (2010), 972–981.
    • (2010) J Vasc Surg , vol.51 , Issue.4 , pp. 972-981
    • Raffetto, J.D.1    Qiao, X.2    Beauregard, K.G.3    Khalil, R.A.4
  • 9
    • 84965270787 scopus 로고
    • Varicose veins in women cotton workers. An epidemiological study in England and Egypt
    • 9 Mekky, S., Schilling, R.S., Walford, J., Varicose veins in women cotton workers. An epidemiological study in England and Egypt. Br Med J 2:5657 (1969), 591–595.
    • (1969) Br Med J , vol.2 , Issue.5657 , pp. 591-595
    • Mekky, S.1    Schilling, R.S.2    Walford, J.3
  • 10
    • 0042667104 scopus 로고    scopus 로고
    • The influence of environmental factors in chronic venous insufficiency
    • 10 Jawien, A., The influence of environmental factors in chronic venous insufficiency. Angiology 54:suppl 1 (2003), S19–S31.
    • (2003) Angiology , vol.54 , pp. S19-S31
    • Jawien, A.1
  • 11
    • 0037929127 scopus 로고    scopus 로고
    • Epidemiology of venous insufficiency in an occupational population
    • 11 Lacroix, P., Aboyans, V., Preux, P.M., Houles, M.B., Laskar, M., Epidemiology of venous insufficiency in an occupational population. Int Angiol 22:2 (2003), 172–176.
    • (2003) Int Angiol , vol.22 , Issue.2 , pp. 172-176
    • Lacroix, P.1    Aboyans, V.2    Preux, P.M.3    Houles, M.B.4    Laskar, M.5
  • 12
    • 20144388019 scopus 로고    scopus 로고
    • Gene expression profiles in varicose veins using complementary DNA microarray
    • 12 Lee, S., Lee, W., Choe, Y., et al. Gene expression profiles in varicose veins using complementary DNA microarray. Dermatol Surg 31:4 (2005), 391–395.
    • (2005) Dermatol Surg , vol.31 , Issue.4 , pp. 391-395
    • Lee, S.1    Lee, W.2    Choe, Y.3
  • 13
    • 15044348467 scopus 로고    scopus 로고
    • Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs
    • 13 Ng, M.Y., Andrew, T., Spector, T.D., Jeffery, S., Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. J Med Genet 42:3 (2005), 235–239.
    • (2005) J Med Genet , vol.42 , Issue.3 , pp. 235-239
    • Ng, M.Y.1    Andrew, T.2    Spector, T.D.3    Jeffery, S.4
  • 14
    • 84867062052 scopus 로고    scopus 로고
    • A genetic study of chronic venous insufficiency
    • 14 Serra, R., Buffone, G., de Franciscis, A., et al. A genetic study of chronic venous insufficiency. Ann Vasc Surg 26:5 (2012), 636–642.
    • (2012) Ann Vasc Surg , vol.26 , Issue.5 , pp. 636-642
    • Serra, R.1    Buffone, G.2    de Franciscis, A.3
  • 15
    • 33847134294 scopus 로고    scopus 로고
    • Hemodynamic impairment, venous segmental disease, and clinical severity scoring in limbs with Klippel–Trenaunay syndrome
    • 15 Delis, K.T., Gloviczki, P., Wennberg, P.W., Rooke, T.W., Driscoll, D.J., Hemodynamic impairment, venous segmental disease, and clinical severity scoring in limbs with Klippel–Trenaunay syndrome. J Vasc Surg 45:3 (2007), 561–567.
    • (2007) J Vasc Surg , vol.45 , Issue.3 , pp. 561-567
    • Delis, K.T.1    Gloviczki, P.2    Wennberg, P.W.3    Rooke, T.W.4    Driscoll, D.J.5
  • 16
    • 0014975693 scopus 로고
    • Lower limb venous dynamics in normal persons and children of patients with varicose veins
    • 16 Reagan, B., Folse, R., Lower limb venous dynamics in normal persons and children of patients with varicose veins. Surg Gynecol Obstet 132:1 (1971), 15–18.
    • (1971) Surg Gynecol Obstet , vol.132 , Issue.1 , pp. 15-18
    • Reagan, B.1    Folse, R.2
  • 17
    • 33747067434 scopus 로고    scopus 로고
    • Varicose veins associated with CADASIL result from a novel mutation in the Notch3 gene
    • 17 Saiki, S., Sakai, K., Saiki, M., et al. Varicose veins associated with CADASIL result from a novel mutation in the Notch3 gene. Neurology 67:2 (2006), 337–339.
    • (2006) Neurology , vol.67 , Issue.2 , pp. 337-339
    • Saiki, S.1    Sakai, K.2    Saiki, M.3
  • 18
    • 34547677926 scopus 로고    scopus 로고
    • Ehlers-Danlos syndrome (EDS) type IV: review of the literature
    • 18 Badauy, C.M., Gomes, S.S., Sant'Ana Filho, M., Chies, J.A., Ehlers-Danlos syndrome (EDS) type IV: review of the literature. Clin Oral Investig 11:3 (2007), 183–187.
    • (2007) Clin Oral Investig , vol.11 , Issue.3 , pp. 183-187
    • Badauy, C.M.1    Gomes, S.S.2    Sant'Ana Filho, M.3    Chies, J.A.4
  • 19
    • 79955635216 scopus 로고    scopus 로고
    • Polymorphisms in MMP-9 and TIMP-2 in Chinese patients with varicose veins
    • 19 Xu, H.M., Zhao, Y., Zhang, X.M., Zhu, T., Fu, W.G., Polymorphisms in MMP-9 and TIMP-2 in Chinese patients with varicose veins. J Surg Res 168:1 (2011), e143–e148.
    • (2011) J Surg Res , vol.168 , Issue.1 , pp. e143-e148
    • Xu, H.M.1    Zhao, Y.2    Zhang, X.M.3    Zhu, T.4    Fu, W.G.5
  • 21
    • 34447277603 scopus 로고    scopus 로고
    • Current advances in the pathogenesis of varicose veins
    • 21 Naoum, J.J., Hunter, G.C., Woodside, K.J., Chen, C., Current advances in the pathogenesis of varicose veins. J Surg Res 141:2 (2007), 311–316.
    • (2007) J Surg Res , vol.141 , Issue.2 , pp. 311-316
    • Naoum, J.J.1    Hunter, G.C.2    Woodside, K.J.3    Chen, C.4
  • 22
    • 84878632582 scopus 로고    scopus 로고
    • Glycosaminoglycan sulodexide inhibition of MMP-9 gelatinase secretion and activity: possible pharmacological role against collagen degradation in vascular chronic diseases
    • 22 Mannello, F., Medda, V., Ligi, D., Raffetto, J.D., Glycosaminoglycan sulodexide inhibition of MMP-9 gelatinase secretion and activity: possible pharmacological role against collagen degradation in vascular chronic diseases. Curr Vasc Pharmacol 11:3 (2013), 354–365.
    • (2013) Curr Vasc Pharmacol , vol.11 , Issue.3 , pp. 354-365
    • Mannello, F.1    Medda, V.2    Ligi, D.3    Raffetto, J.D.4
  • 23
    • 84961799059 scopus 로고    scopus 로고
    • Clinico-histopathological study of varicose vein and role of matrix metalloproteinases-1, matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinase-1 in varicose vein formation
    • 23 Naik, B., Kumar, M., Khanna, A.K., Suman, P.K., Clinico-histopathological study of varicose vein and role of matrix metalloproteinases-1, matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinase-1 in varicose vein formation. Indian J Pathol Microbiol 59:1 (2016), 25–30.
    • (2016) Indian J Pathol Microbiol , vol.59 , Issue.1 , pp. 25-30
    • Naik, B.1    Kumar, M.2    Khanna, A.K.3    Suman, P.K.4
  • 24
    • 0027525221 scopus 로고
    • Analysis of the connective tissue matrix and proteolytic activity of primary varicose veins
    • 24 Gandhi, R.H., Irizarry, E., Nackman, G.B., Halpern, V.J., Mulcare, R.J., Tilson, M.D., Analysis of the connective tissue matrix and proteolytic activity of primary varicose veins. J Vasc Surg 18:5 (1993), 814–820.
    • (1993) J Vasc Surg , vol.18 , Issue.5 , pp. 814-820
    • Gandhi, R.H.1    Irizarry, E.2    Nackman, G.B.3    Halpern, V.J.4    Mulcare, R.J.5    Tilson, M.D.6
  • 25
    • 0033257006 scopus 로고    scopus 로고
    • The determination of the collagen and elastin amount in the human varicose vein by the computer morphometric method
    • 25 Haviarova, Z., Weismann, P., Stvrtinova, V., Benuska, J., The determination of the collagen and elastin amount in the human varicose vein by the computer morphometric method. Gen Physiol Biophys 18:suppl 1 (1999), 30–33.
    • (1999) Gen Physiol Biophys , vol.18 , pp. 30-33
    • Haviarova, Z.1    Weismann, P.2    Stvrtinova, V.3    Benuska, J.4
  • 27
    • 0030060046 scopus 로고    scopus 로고
    • Biochemical assay of collagen and elastin in the normal and varicose vein wall
    • 27 Venturi, M., Bonavina, L., Annoni, F., et al. Biochemical assay of collagen and elastin in the normal and varicose vein wall. J Surg Res 60:1 (1996), 245–248.
    • (1996) J Surg Res , vol.60 , Issue.1 , pp. 245-248
    • Venturi, M.1    Bonavina, L.2    Annoni, F.3
  • 28
    • 0034093466 scopus 로고    scopus 로고
    • Proximal long saphenous vein valves in primary venous insufficiency
    • 28 Corcos, L., De Anna, D., Dini, M., Macchi, C., Ferrari, P.A., Dini, S., Proximal long saphenous vein valves in primary venous insufficiency. J Mal Vasc 25:1 (2000), 27–36.
    • (2000) J Mal Vasc , vol.25 , Issue.1 , pp. 27-36
    • Corcos, L.1    De Anna, D.2    Dini, M.3    Macchi, C.4    Ferrari, P.A.5    Dini, S.6
  • 29
    • 0024570045 scopus 로고
    • Viscoelastic properties and collagen content of the long saphenous vein in normal and varicose veins
    • 29 Psaila, J.V., Melhuish, J., Viscoelastic properties and collagen content of the long saphenous vein in normal and varicose veins. Br J Surg 76:1 (1989), 37–40.
    • (1989) Br J Surg , vol.76 , Issue.1 , pp. 37-40
    • Psaila, J.V.1    Melhuish, J.2
  • 31
    • 44949120819 scopus 로고    scopus 로고
    • Mechanisms of varicose vein formation: valve dysfunction and wall dilation
    • 31 Raffetto, J.D., Khalil, R.A., Mechanisms of varicose vein formation: valve dysfunction and wall dilation. Phlebology 23:2 (2008), 85–98.
    • (2008) Phlebology , vol.23 , Issue.2 , pp. 85-98
    • Raffetto, J.D.1    Khalil, R.A.2
  • 32
    • 84940835045 scopus 로고    scopus 로고
    • Increased levels of metalloproteinase 10 and hemostatic markers in patients with noncomplicated primary varicose veins
    • 32 Dzieciuchowicz, L., Espinosa, G., Paramo, J.A., Increased levels of metalloproteinase 10 and hemostatic markers in patients with noncomplicated primary varicose veins. Clin Appl Thromb Hemost 21:7 (2015), 684–687.
    • (2015) Clin Appl Thromb Hemost , vol.21 , Issue.7 , pp. 684-687
    • Dzieciuchowicz, L.1    Espinosa, G.2    Paramo, J.A.3
  • 33
    • 0036389631 scopus 로고    scopus 로고
    • Varicose veins possess greater quantities of MMP-1 than normal veins and demonstrate regional variation in MMP-1 and MMP-13
    • 33 Gillespie, D.L., Patel, A., Fileta, B., et al. Varicose veins possess greater quantities of MMP-1 than normal veins and demonstrate regional variation in MMP-1 and MMP-13. J Surg Res 106:2 (2002), 233–238.
    • (2002) J Surg Res , vol.106 , Issue.2 , pp. 233-238
    • Gillespie, D.L.1    Patel, A.2    Fileta, B.3
  • 34
    • 0037771303 scopus 로고    scopus 로고
    • Morphologic characteristics of varicose veins: possible role of metalloproteinases
    • 34 Woodside, K.J., Hu, M., Burke, A., et al. Morphologic characteristics of varicose veins: possible role of metalloproteinases. J Vasc Surg 38:1 (2003), 162–169.
    • (2003) J Vasc Surg , vol.38 , Issue.1 , pp. 162-169
    • Woodside, K.J.1    Hu, M.2    Burke, A.3
  • 35
    • 84895524336 scopus 로고    scopus 로고
    • Decreased PGE(2) content reduces MMP-1 activity and consequently increases collagen density in human varicose vein
    • 35 Gomez, I., Benyahia, C., Louedec, L., et al. Decreased PGE(2) content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. PLoS One, 9(2), 2014, e88021.
    • (2014) PLoS One , vol.9 , Issue.2
    • Gomez, I.1    Benyahia, C.2    Louedec, L.3
  • 36
    • 84962618161 scopus 로고    scopus 로고
    • From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases
    • 36 Serra, R., Gallelli, L., Butrico, L., et al. From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases. Int Wound J 14:1 (2017), 233–240.
    • (2017) Int Wound J , vol.14 , Issue.1 , pp. 233-240
    • Serra, R.1    Gallelli, L.2    Butrico, L.3
  • 37
    • 84886181903 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in non-healing venous ulcers
    • 37 Amato, B., Coretti, G., Compagna, R., et al. Role of matrix metalloproteinases in non-healing venous ulcers. Int Wound J 12:6 (2015), 641–645.
    • (2015) Int Wound J , vol.12 , Issue.6 , pp. 641-645
    • Amato, B.1    Coretti, G.2    Compagna, R.3
  • 38
    • 84955640552 scopus 로고    scopus 로고
    • Extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines
    • 38 Serra, R., Grande, R., Buffone, G., et al. Extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines. Int Wound J 13:1 (2016), 53–58.
    • (2016) Int Wound J , vol.13 , Issue.1 , pp. 53-58
    • Serra, R.1    Grande, R.2    Buffone, G.3
  • 39
    • 0344837735 scopus 로고    scopus 로고
    • Uniaxial strain upregulates matrix-degrading enzymes produced by human vascular smooth muscle cells
    • 39 Asanuma, K., Magid, R., Johnson, C., Nerem, R.M., Galis, Z.S., Uniaxial strain upregulates matrix-degrading enzymes produced by human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 284:5 (2003), H1778–H1784.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284 , Issue.5 , pp. H1778-H1784
    • Asanuma, K.1    Magid, R.2    Johnson, C.3    Nerem, R.M.4    Galis, Z.S.5
  • 40
    • 47249144255 scopus 로고    scopus 로고
    • Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: potential implications in varicose veins
    • 40 Raffetto, J.D., Qiao, X., Koledova, V.V., Khalil, R.A., Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: potential implications in varicose veins. J Vasc Surg 48:2 (2008), 447–456.
    • (2008) J Vasc Surg , vol.48 , Issue.2 , pp. 447-456
    • Raffetto, J.D.1    Qiao, X.2    Koledova, V.V.3    Khalil, R.A.4
  • 41
    • 79951851894 scopus 로고    scopus 로고
    • Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava
    • 41 Lim, C.S., Qiao, X., Reslan, O.M., et al. Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava. J Vasc Surg 53:3 (2011), 764–773.
    • (2011) J Vasc Surg , vol.53 , Issue.3 , pp. 764-773
    • Lim, C.S.1    Qiao, X.2    Reslan, O.M.3
  • 42
    • 0034882846 scopus 로고    scopus 로고
    • New advances in the understanding of the pathophysiology of chronic venous insufficiency
    • 42 Schmid-Schonbein, G.W., Takase, S., Bergan, J.J., New advances in the understanding of the pathophysiology of chronic venous insufficiency. Angiology 52:suppl 1 (2001), S27–S34.
    • (2001) Angiology , vol.52 , pp. S27-S34
    • Schmid-Schonbein, G.W.1    Takase, S.2    Bergan, J.J.3
  • 44
    • 0035511667 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases 1, 2, and 9 and tissue inhibitor of matrix metalloproteinase-1 in chronic venous insufficiency
    • 44 Saito, S., Trovato, M.J., You, R., et al. Role of matrix metalloproteinases 1, 2, and 9 and tissue inhibitor of matrix metalloproteinase-1 in chronic venous insufficiency. J Vasc Surg 34:5 (2001), 930–938.
    • (2001) J Vasc Surg , vol.34 , Issue.5 , pp. 930-938
    • Saito, S.1    Trovato, M.J.2    You, R.3
  • 45
    • 84876732671 scopus 로고    scopus 로고
    • Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins
    • 45 Kucukguven, A., Khalil, R.A., Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins. Curr Drug Targets 14:3 (2013), 287–324.
    • (2013) Curr Drug Targets , vol.14 , Issue.3 , pp. 287-324
    • Kucukguven, A.1    Khalil, R.A.2
  • 46
    • 4744355701 scopus 로고    scopus 로고
    • Immunocytochemical characterisation of the inflammatory cell infiltrate of varicose veins
    • 46 Sayer, G.L., Smith, P.D., Immunocytochemical characterisation of the inflammatory cell infiltrate of varicose veins. Eur J Vasc Endovasc Surg 28:5 (2004), 479–483.
    • (2004) Eur J Vasc Endovasc Surg , vol.28 , Issue.5 , pp. 479-483
    • Sayer, G.L.1    Smith, P.D.2
  • 47
    • 24344450341 scopus 로고    scopus 로고
    • Histopathological changes and expression of adhesion molecules and laminin in varicose veins
    • 47 Aunapuu, M., Arend, A., Histopathological changes and expression of adhesion molecules and laminin in varicose veins. Vasa 34:3 (2005), 170–175.
    • (2005) Vasa , vol.34 , Issue.3 , pp. 170-175
    • Aunapuu, M.1    Arend, A.2
  • 48
    • 0037199422 scopus 로고    scopus 로고
    • Plasma matrix metalloproteinase-9 as a marker of blood stasis in varicose veins
    • 48 Jacob, M.P., Cazaubon, M., Scemama, A., et al. Plasma matrix metalloproteinase-9 as a marker of blood stasis in varicose veins. Circulation 106:5 (2002), 535–538.
    • (2002) Circulation , vol.106 , Issue.5 , pp. 535-538
    • Jacob, M.P.1    Cazaubon, M.2    Scemama, A.3
  • 49
    • 0027438302 scopus 로고
    • v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines
    • 49 Sato, H., Kita, M., Seiki, M., v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines. J Biol Chem 268:31 (1993), 23460–23468.
    • (1993) J Biol Chem , vol.268 , Issue.31 , pp. 23460-23468
    • Sato, H.1    Kita, M.2    Seiki, M.3
  • 50
    • 77958074931 scopus 로고    scopus 로고
    • Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation
    • 50 Reddy, V.S., Prabhu, S.D., Mummidi, S., et al. Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation. Am J Physiol Heart Circ Physiol 299:4 (2010), H1242–H1254.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , Issue.4 , pp. H1242-H1254
    • Reddy, V.S.1    Prabhu, S.D.2    Mummidi, S.3
  • 51
    • 0037154250 scopus 로고    scopus 로고
    • Reactive oxygen generated by Nox1 triggers the angiogenic switch
    • 51 Arbiser, J.L., Petros, J., Klafter, R., et al. Reactive oxygen generated by Nox1 triggers the angiogenic switch. Proc Natl Acad Sci U S A 99:2 (2002), 715–720.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.2 , pp. 715-720
    • Arbiser, J.L.1    Petros, J.2    Klafter, R.3
  • 52
    • 84904287079 scopus 로고    scopus 로고
    • Urokinase stimulates production of matrix metalloproteinase-9 in fibroblasts with involvement of reactive oxygen species
    • 52 Zubkova, E.S., Men'shikov, M.Y., Plekhanova, O.S., Beloglazova, I.B., Ratner, E.I., Parfenova, E.V., Urokinase stimulates production of matrix metalloproteinase-9 in fibroblasts with involvement of reactive oxygen species. Bull Exp Biol Med 157:1 (2014), 18–21.
    • (2014) Bull Exp Biol Med , vol.157 , Issue.1 , pp. 18-21
    • Zubkova, E.S.1    Men'shikov, M.Y.2    Plekhanova, O.S.3    Beloglazova, I.B.4    Ratner, E.I.5    Parfenova, E.V.6
  • 53
    • 1342346608 scopus 로고    scopus 로고
    • Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation
    • 53 Fu, X., Kao, J.L., Bergt, C., et al. Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation. J Biol Chem 279:8 (2004), 6209–6212.
    • (2004) J Biol Chem , vol.279 , Issue.8 , pp. 6209-6212
    • Fu, X.1    Kao, J.L.2    Bergt, C.3
  • 54
    • 34548364176 scopus 로고    scopus 로고
    • HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle
    • 54 Milkiewicz, M., Doyle, J.L., Fudalewski, T., Ispanovic, E., Aghasi, M., Haas, T.L., HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. J Physiol 583:pt 2 (2007), 753–766.
    • (2007) J Physiol , vol.583 , pp. 753-766
    • Milkiewicz, M.1    Doyle, J.L.2    Fudalewski, T.3    Ispanovic, E.4    Aghasi, M.5    Haas, T.L.6
  • 55
    • 0013199207 scopus 로고    scopus 로고
    • Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway
    • 55 Kim, C.H., Cho, Y.S., Chun, Y.S., Park, J.W., Kim, M.S., Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway. Circ Res 90:2 (2002), E25–E33.
    • (2002) Circ Res , vol.90 , Issue.2 , pp. E25-E33
    • Kim, C.H.1    Cho, Y.S.2    Chun, Y.S.3    Park, J.W.4    Kim, M.S.5
  • 56
    • 66149088448 scopus 로고    scopus 로고
    • TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling
    • 56 Thodeti, C.K., Matthews, B., Ravi, A., et al. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res 104:9 (2009), 1123–1130.
    • (2009) Circ Res , vol.104 , Issue.9 , pp. 1123-1130
    • Thodeti, C.K.1    Matthews, B.2    Ravi, A.3
  • 57
    • 84860357030 scopus 로고    scopus 로고
    • Increased activation of the hypoxia-inducible factor pathway in varicose veins
    • 57 Lim, C.S., Kiriakidis, S., Paleolog, E.M., Davies, A.H., Increased activation of the hypoxia-inducible factor pathway in varicose veins. J Vasc Surg 55:5 (2012), 1427–1439.
    • (2012) J Vasc Surg , vol.55 , Issue.5 , pp. 1427-1439
    • Lim, C.S.1    Kiriakidis, S.2    Paleolog, E.M.3    Davies, A.H.4
  • 58
    • 38349170116 scopus 로고    scopus 로고
    • Expression of hypoxia inducible factor-1 alpha, macrophage migration inhibition factor, matrix metalloproteinase-2 and -9, and their inhibitors in hemodialysis grafts and arteriovenous fistulas
    • 58 Misra, S., Fu, A.A., Rajan, D.K., et al. Expression of hypoxia inducible factor-1 alpha, macrophage migration inhibition factor, matrix metalloproteinase-2 and -9, and their inhibitors in hemodialysis grafts and arteriovenous fistulas. J Vasc Interv Radiol 19:2 pt 1 (2008), 252–259.
    • (2008) J Vasc Interv Radiol , vol.19 , Issue.2 pt 1 , pp. 252-259
    • Misra, S.1    Fu, A.A.2    Rajan, D.K.3
  • 59
    • 0035198816 scopus 로고    scopus 로고
    • Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340)
    • 59 Foda, H.D., Rollo, E.E., Drews, M., et al. Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340). Am J Respir Cell Mol Biol 25:6 (2001), 717–724.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , Issue.6 , pp. 717-724
    • Foda, H.D.1    Rollo, E.E.2    Drews, M.3
  • 60
    • 0036885949 scopus 로고    scopus 로고
    • Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers
    • 60 Norgauer, J., Hildenbrand, T., Idzko, M., et al. Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers. Br J Dermatol 147:6 (2002), 1180–1186.
    • (2002) Br J Dermatol , vol.147 , Issue.6 , pp. 1180-1186
    • Norgauer, J.1    Hildenbrand, T.2    Idzko, M.3
  • 61
    • 84930479281 scopus 로고    scopus 로고
    • Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn
    • 61 Majed, B.H., Khalil, R.A., Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Pharmacol Rev 64:3 (2012), 540–582.
    • (2012) Pharmacol Rev , vol.64 , Issue.3 , pp. 540-582
    • Majed, B.H.1    Khalil, R.A.2
  • 62
    • 78650520313 scopus 로고    scopus 로고
    • Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases
    • 62 Lee, J., Banu, S.K., Subbarao, T., Starzinski-Powitz, A., Arosh, J.A., Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases. Mol Cell Endocrinol 332:1–2 (2011), 306–313.
    • (2011) Mol Cell Endocrinol , vol.332 , Issue.1-2 , pp. 306-313
    • Lee, J.1    Banu, S.K.2    Subbarao, T.3    Starzinski-Powitz, A.4    Arosh, J.A.5
  • 63
    • 84904036451 scopus 로고    scopus 로고
    • Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats
    • 63 Takai, S., Jin, D., Chen, H., et al. Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats. J Hypertens 32:8 (2014), 1637–1649.
    • (2014) J Hypertens , vol.32 , Issue.8 , pp. 1637-1649
    • Takai, S.1    Jin, D.2    Chen, H.3
  • 64
    • 84863646236 scopus 로고    scopus 로고
    • Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones
    • 64 Yin, Z., Sada, A.A., Reslan, O.M., Narula, N., Khalil, R.A., Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab 303:1 (2012), E55–E70.
    • (2012) Am J Physiol Endocrinol Metab , vol.303 , Issue.1 , pp. E55-E70
    • Yin, Z.1    Sada, A.A.2    Reslan, O.M.3    Narula, N.4    Khalil, R.A.5
  • 65
    • 84885184327 scopus 로고    scopus 로고
    • EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone
    • 65 Dang, Y., Li, W., Tran, V., Khalil, R.A., EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone. Biochem Pharmacol 86:6 (2013), 734–747.
    • (2013) Biochem Pharmacol , vol.86 , Issue.6 , pp. 734-747
    • Dang, Y.1    Li, W.2    Tran, V.3    Khalil, R.A.4
  • 66
    • 84900822786 scopus 로고    scopus 로고
    • The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs
    • 66 Serra, R., Gallelli, L., Conti, A., et al. The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs. Drug Des Devel Ther 8 (2014), 519–527.
    • (2014) Drug Des Devel Ther , vol.8 , pp. 519-527
    • Serra, R.1    Gallelli, L.2    Conti, A.3
  • 67
    • 0033828464 scopus 로고    scopus 로고
    • Increased TIMP/MMP ratio in varicose veins: a possible explanation for extracellular matrix accumulation
    • 67 Badier-Commander, C., Verbeuren, T., Lebard, C., Michel, J.B., Jacob, M.P., Increased TIMP/MMP ratio in varicose veins: a possible explanation for extracellular matrix accumulation. J Pathol 192:1 (2000), 105–112.
    • (2000) J Pathol , vol.192 , Issue.1 , pp. 105-112
    • Badier-Commander, C.1    Verbeuren, T.2    Lebard, C.3    Michel, J.B.4    Jacob, M.P.5
  • 68
    • 0033818123 scopus 로고    scopus 로고
    • Changes in the extracellular matrix of the vein wall—the cause of primary varicosis?
    • 68 Kirsch, D., Dienes, H.P., Kuchle, R., et al. Changes in the extracellular matrix of the vein wall—the cause of primary varicosis?. Vasa 29:3 (2000), 173–177.
    • (2000) Vasa , vol.29 , Issue.3 , pp. 173-177
    • Kirsch, D.1    Dienes, H.P.2    Kuchle, R.3
  • 69
    • 0035217825 scopus 로고    scopus 로고
    • Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veins
    • 69 Sansilvestri-Morel, P., Rupin, A., Badier-Commander, C., et al. Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veins. J Vasc Res 38:6 (2001), 560–568.
    • (2001) J Vasc Res , vol.38 , Issue.6 , pp. 560-568
    • Sansilvestri-Morel, P.1    Rupin, A.2    Badier-Commander, C.3
  • 70
    • 25444526347 scopus 로고    scopus 로고
    • Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3
    • 70 Sansilvestri-Morel, P., Rupin, A., Jullien, N.D., et al. Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3. J Vasc Res 42:5 (2005), 388–398.
    • (2005) J Vasc Res , vol.42 , Issue.5 , pp. 388-398
    • Sansilvestri-Morel, P.1    Rupin, A.2    Jullien, N.D.3
  • 71
    • 70350565362 scopus 로고    scopus 로고
    • In vitro differences between smooth muscle cells derived from varicose veins and normal veins
    • 71 Xiao, Y., Huang, Z., Yin, H., Lin, Y., Wang, S., In vitro differences between smooth muscle cells derived from varicose veins and normal veins. J Vasc Surg 50:5 (2009), 1149–1154.
    • (2009) J Vasc Surg , vol.50 , Issue.5 , pp. 1149-1154
    • Xiao, Y.1    Huang, Z.2    Yin, H.3    Lin, Y.4    Wang, S.5
  • 72
    • 73549087821 scopus 로고    scopus 로고
    • Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism
    • 72 Shi, Z.D., Ji, X.Y., Berardi, D.E., Qazi, H., Tarbell, J.M., Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism. Am J Physiol Heart Circ Physiol 298:1 (2010), H127–H135.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , Issue.1 , pp. H127-H135
    • Shi, Z.D.1    Ji, X.Y.2    Berardi, D.E.3    Qazi, H.4    Tarbell, J.M.5
  • 73
    • 46449089508 scopus 로고    scopus 로고
    • Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway
    • 73 Jin, U.H., Suh, S.J., Chang, H.W., et al. Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J Cell Biochem 104:1 (2008), 15–26.
    • (2008) J Cell Biochem , vol.104 , Issue.1 , pp. 15-26
    • Jin, U.H.1    Suh, S.J.2    Chang, H.W.3
  • 74
    • 0034720452 scopus 로고    scopus 로고
    • Control of smooth muscle cell proliferation and phenotype by integrin signaling through focal adhesion kinase
    • 74 Morla, A.O., Mogford, J.E., Control of smooth muscle cell proliferation and phenotype by integrin signaling through focal adhesion kinase. Biochem Biophys Res Commun 272:1 (2000), 298–302.
    • (2000) Biochem Biophys Res Commun , vol.272 , Issue.1 , pp. 298-302
    • Morla, A.O.1    Mogford, J.E.2
  • 75
    • 0037114003 scopus 로고    scopus 로고
    • Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis
    • 75 Karsdal, M.A., Larsen, L., Engsig, M.T., et al. Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. J Biol Chem 277:46 (2002), 44061–44067.
    • (2002) J Biol Chem , vol.277 , Issue.46 , pp. 44061-44067
    • Karsdal, M.A.1    Larsen, L.2    Engsig, M.T.3
  • 76
    • 84922391846 scopus 로고    scopus 로고
    • Molecular basis underlying inhibition of metastasis of gastric cancer by anti-VEGFa treatment
    • 76 Mao, D., Zhang, Y., Lu, H., Zhang, H., Molecular basis underlying inhibition of metastasis of gastric cancer by anti-VEGFa treatment. Tumour Biol 35:8 (2014), 8217–8223.
    • (2014) Tumour Biol , vol.35 , Issue.8 , pp. 8217-8223
    • Mao, D.1    Zhang, Y.2    Lu, H.3    Zhang, H.4
  • 77
    • 8844228835 scopus 로고    scopus 로고
    • Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle
    • 77 Zhang, H., Chalothorn, D., Jackson, L.F., Lee, D.C., Faber, J.E., Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. Circ Res 95:10 (2004), 989–997.
    • (2004) Circ Res , vol.95 , Issue.10 , pp. 989-997
    • Zhang, H.1    Chalothorn, D.2    Jackson, L.F.3    Lee, D.C.4    Faber, J.E.5
  • 79
    • 84903464616 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB induces matrix metalloproteinase-2 expression and rat vascular smooth muscle cell migration via ROCK and ERK/p38 MAPK pathways
    • 79 Cui, Y., Sun, Y.W., Lin, H.S., et al. Platelet-derived growth factor-BB induces matrix metalloproteinase-2 expression and rat vascular smooth muscle cell migration via ROCK and ERK/p38 MAPK pathways. Mol Cell Biochem 393:1–2 (2014), 255–263.
    • (2014) Mol Cell Biochem , vol.393 , Issue.1-2 , pp. 255-263
    • Cui, Y.1    Sun, Y.W.2    Lin, H.S.3
  • 80
    • 84920279385 scopus 로고    scopus 로고
    • MMP-1 and MMP-9 regulate epidermal growth factor-dependent collagen loss in human carotid plaque smooth muscle cells
    • 80 Rao, V.H., Kansal, V., Stoupa, S., Agrawal, D.K., MMP-1 and MMP-9 regulate epidermal growth factor-dependent collagen loss in human carotid plaque smooth muscle cells. Physiol Rep, 2(2), 2014, e00224.
    • (2014) Physiol Rep , vol.2 , Issue.2
    • Rao, V.H.1    Kansal, V.2    Stoupa, S.3    Agrawal, D.K.4
  • 81
    • 8844258082 scopus 로고    scopus 로고
    • Matrix metalloproteinase-specific inhibition of Ca2 + entry mechanisms of vascular contraction
    • 81 Chew, D.K., Conte, M.S., Khalil, R.A., Matrix metalloproteinase-specific inhibition of Ca2 + entry mechanisms of vascular contraction. J Vasc Surg 40:5 (2004), 1001–1010.
    • (2004) J Vasc Surg , vol.40 , Issue.5 , pp. 1001-1010
    • Chew, D.K.1    Conte, M.S.2    Khalil, R.A.3
  • 82
    • 77949486220 scopus 로고    scopus 로고
    • MMP-2 induced vein relaxation via inhibition of [Ca2 +]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides
    • 82 Raffetto, J.D., Barros, Y.V., Wells, A.K., Khalil, R.A., MMP-2 induced vein relaxation via inhibition of [Ca2 +]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides. J Surg Res 159:2 (2010), 755–764.
    • (2010) J Surg Res , vol.159 , Issue.2 , pp. 755-764
    • Raffetto, J.D.1    Barros, Y.V.2    Wells, A.K.3    Khalil, R.A.4
  • 83
    • 0037040825 scopus 로고    scopus 로고
    • alpha(4)beta(1) Integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction
    • 83 Waitkus-Edwards, K.R., Martinez-Lemus, L.A., Wu, X., et al. alpha(4)beta(1) Integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction. Circ Res 90:4 (2002), 473–480.
    • (2002) Circ Res , vol.90 , Issue.4 , pp. 473-480
    • Waitkus-Edwards, K.R.1    Martinez-Lemus, L.A.2    Wu, X.3
  • 84
    • 33846438987 scopus 로고    scopus 로고
    • Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K + channels: relevance to varicose vein formation
    • 84 Raffetto, J.D., Ross, R.L., Khalil, R.A., Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K + channels: relevance to varicose vein formation. J Vasc Surg 45:2 (2007), 373–380.
    • (2007) J Vasc Surg , vol.45 , Issue.2 , pp. 373-380
    • Raffetto, J.D.1    Ross, R.L.2    Khalil, R.A.3
  • 85
    • 33745023668 scopus 로고    scopus 로고
    • Endothelium-derived hyperpolarizing factor: where are we now?
    • 85 Feletou, M., Vanhoutte, P.M., Endothelium-derived hyperpolarizing factor: where are we now?. Arterioscler Thromb Vasc Biol 26:6 (2006), 1215–1225.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , Issue.6 , pp. 1215-1225
    • Feletou, M.1    Vanhoutte, P.M.2
  • 86
    • 13544255506 scopus 로고    scopus 로고
    • PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
    • 86 Boire, A., Covic, L., Agarwal, A., Jacques, S., Sherifi, S., Kuliopulos, A., PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120:3 (2005), 303–313.
    • (2005) Cell , vol.120 , Issue.3 , pp. 303-313
    • Boire, A.1    Covic, L.2    Agarwal, A.3    Jacques, S.4    Sherifi, S.5    Kuliopulos, A.6
  • 87
    • 0027492461 scopus 로고
    • Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor
    • 87 McNamara, C.A., Sarembock, I.J., Gimple, L.W., Fenton, J.W. 2nd, Coughlin, S.R., Owens, G.K., Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest 91:1 (1993), 94–98.
    • (1993) J Clin Invest , vol.91 , Issue.1 , pp. 94-98
    • McNamara, C.A.1    Sarembock, I.J.2    Gimple, L.W.3    Fenton, J.W.4    Coughlin, S.R.5    Owens, G.K.6
  • 88
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • 88 Coughlin, S.R., Thrombin signalling and protease-activated receptors. Nature 407:6801 (2000), 258–264.
    • (2000) Nature , vol.407 , Issue.6801 , pp. 258-264
    • Coughlin, S.R.1
  • 89
    • 0027275314 scopus 로고
    • Thrombin receptor activating peptides induce Ca2 + mobilization, barrier dysfunction, prostaglandin synthesis, and platelet-derived growth factor mRNA expression in cultured endothelium
    • 89 Garcia, J.G., Patterson, C., Bahler, C., Aschner, J., Hart, C.M., English, D., Thrombin receptor activating peptides induce Ca2 + mobilization, barrier dysfunction, prostaglandin synthesis, and platelet-derived growth factor mRNA expression in cultured endothelium. J Cell Physiol 156:3 (1993), 541–549.
    • (1993) J Cell Physiol , vol.156 , Issue.3 , pp. 541-549
    • Garcia, J.G.1    Patterson, C.2    Bahler, C.3    Aschner, J.4    Hart, C.M.5    English, D.6
  • 90
    • 38549083858 scopus 로고    scopus 로고
    • Forkhead factor, FOXO3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases
    • 90 Lee, H.Y., You, H.J., Won, J.Y., et al. Forkhead factor, FOXO3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases. Arterioscler Thromb Vasc Biol 28:2 (2008), 302–308.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.2 , pp. 302-308
    • Lee, H.Y.1    You, H.J.2    Won, J.Y.3
  • 91
    • 84891933924 scopus 로고    scopus 로고
    • Quantifying the degree graduated elastic compression stockings enhance venous emptying
    • 91 Lattimer, C.R., Kalodiki, E., Kafeza, M., Azzam, M., Geroulakos, G., Quantifying the degree graduated elastic compression stockings enhance venous emptying. Eur J Vasc Endovasc Surg 47:1 (2014), 75–80.
    • (2014) Eur J Vasc Endovasc Surg , vol.47 , Issue.1 , pp. 75-80
    • Lattimer, C.R.1    Kalodiki, E.2    Kafeza, M.3    Azzam, M.4    Geroulakos, G.5
  • 92
    • 84879410980 scopus 로고    scopus 로고
    • Compression stockings significantly improve hemodynamic performance in post-thrombotic syndrome irrespective of class or length
    • 92 Lattimer, C.R., Azzam, M., Kalodiki, E., Makris, G.C., Geroulakos, G., Compression stockings significantly improve hemodynamic performance in post-thrombotic syndrome irrespective of class or length. J Vasc Surg 58:1 (2013), 158–165.
    • (2013) J Vasc Surg , vol.58 , Issue.1 , pp. 158-165
    • Lattimer, C.R.1    Azzam, M.2    Kalodiki, E.3    Makris, G.C.4    Geroulakos, G.5
  • 93
    • 37349082926 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease
    • 93 Raffetto, J.D., Khalil, R.A., Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. Biochem Pharmacol 75:2 (2008), 346–359.
    • (2008) Biochem Pharmacol , vol.75 , Issue.2 , pp. 346-359
    • Raffetto, J.D.1    Khalil, R.A.2
  • 94
    • 0031300139 scopus 로고    scopus 로고
    • Evaluation of haemorheological and microcirculatory disturbances in chronic venous insufficiency: activity of Daflon 500 mg
    • 94 Le Devehat, C., Khodabandehlou, T., Vimeux, M., Kempf, C., Evaluation of haemorheological and microcirculatory disturbances in chronic venous insufficiency: activity of Daflon 500 mg. Int J Microcirc Clin Exp 17:suppl 1 (1997), 27–33.
    • (1997) Int J Microcirc Clin Exp , vol.17 , pp. 27-33
    • Le Devehat, C.1    Khodabandehlou, T.2    Vimeux, M.3    Kempf, C.4
  • 95
    • 33645740058 scopus 로고    scopus 로고
    • Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency
    • 95 Cesarone, M.R., Belcaro, G., Pellegrini, L., et al. Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency. Angiology 57:2 (2006), 131–138.
    • (2006) Angiology , vol.57 , Issue.2 , pp. 131-138
    • Cesarone, M.R.1    Belcaro, G.2    Pellegrini, L.3
  • 96
    • 79961165994 scopus 로고    scopus 로고
    • Ca(2 +)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins
    • 96 Raffetto, J.D., Khalil, R.A., Ca(2 +)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins. J Vasc Surg 54:2 (2011), 489–496.
    • (2011) J Vasc Surg , vol.54 , Issue.2 , pp. 489-496
    • Raffetto, J.D.1    Khalil, R.A.2
  • 98
    • 79961100353 scopus 로고    scopus 로고
    • Sclerotherapy: it is back and better
    • vii
    • 98 Mann, M.W., Sclerotherapy: it is back and better. Clin Plast Surg 38:3 (2011), 475–487 vii.
    • (2011) Clin Plast Surg , vol.38 , Issue.3 , pp. 475-487
    • Mann, M.W.1
  • 99
    • 84941792201 scopus 로고    scopus 로고
    • Treatment of truncal incompetence and varicose veins with a single administration of a new polidocanol endovenous microfoam preparation improves symptoms and appearance
    • 99 King, J.T., O'Byrne, M., Vasquez, M., Wright, D., Treatment of truncal incompetence and varicose veins with a single administration of a new polidocanol endovenous microfoam preparation improves symptoms and appearance. Eur J Vasc Endovasc Surg 50:6 (2015), 784–793.
    • (2015) Eur J Vasc Endovasc Surg , vol.50 , Issue.6 , pp. 784-793
    • King, J.T.1    O'Byrne, M.2    Vasquez, M.3    Wright, D.4
  • 100
    • 0036546892 scopus 로고    scopus 로고
    • Endovenous treatment of the greater saphenous vein with a 940-nm diode laser: thrombotic occlusion after endoluminal thermal damage by laser-generated steam bubbles
    • 100 Proebstle, T.M., Lehr, H.A., Kargl, A., et al. Endovenous treatment of the greater saphenous vein with a 940-nm diode laser: thrombotic occlusion after endoluminal thermal damage by laser-generated steam bubbles. J Vasc Surg 35:4 (2002), 729–736.
    • (2002) J Vasc Surg , vol.35 , Issue.4 , pp. 729-736
    • Proebstle, T.M.1    Lehr, H.A.2    Kargl, A.3
  • 101
    • 15044341487 scopus 로고    scopus 로고
    • Four-year follow-up on endovascular radiofrequency obliteration of great saphenous reflux
    • 101 Merchant, R.F., Pichot, O., Myers, K.A., Four-year follow-up on endovascular radiofrequency obliteration of great saphenous reflux. Dermatol Surg 31:2 (2005), 129–134.
    • (2005) Dermatol Surg , vol.31 , Issue.2 , pp. 129-134
    • Merchant, R.F.1    Pichot, O.2    Myers, K.A.3
  • 102
    • 0042068171 scopus 로고    scopus 로고
    • Endovenous laser treatment of saphenous vein reflux: long-term results
    • 102 Min, R.J., Khilnani, N., Zimmet, S.E., Endovenous laser treatment of saphenous vein reflux: long-term results. J Vasc Interv Radiol 14:8 (2003), 991–996.
    • (2003) J Vasc Interv Radiol , vol.14 , Issue.8 , pp. 991-996
    • Min, R.J.1    Khilnani, N.2    Zimmet, S.E.3
  • 103
    • 9144249634 scopus 로고    scopus 로고
    • Prospective randomized controlled trial: conventional versus powered phlebectomy
    • 103 Aremu, M.A., Mahendran, B., Butcher, W., et al. Prospective randomized controlled trial: conventional versus powered phlebectomy. J Vasc Surg 39:1 (2004), 88–94.
    • (2004) J Vasc Surg , vol.39 , Issue.1 , pp. 88-94
    • Aremu, M.A.1    Mahendran, B.2    Butcher, W.3
  • 104
    • 84954498588 scopus 로고    scopus 로고
    • The advent of non-thermal, non-tumescent techniques for treatment of varicose veins
    • 104 Bootun, R., Lane, T.R., Davies, A.H., The advent of non-thermal, non-tumescent techniques for treatment of varicose veins. Phlebology 31:1 (2016), 5–14.
    • (2016) Phlebology , vol.31 , Issue.1 , pp. 5-14
    • Bootun, R.1    Lane, T.R.2    Davies, A.H.3
  • 105
    • 84992736575 scopus 로고    scopus 로고
    • Nonthermal, nontumescent endovenous treatment of varicose veins
    • 105 Tekin, A.I., Tuncer, O.N., Memetoglu, M.E., et al. Nonthermal, nontumescent endovenous treatment of varicose veins. Ann Vasc Surg 36 (2016), 231–235.
    • (2016) Ann Vasc Surg , vol.36 , pp. 231-235
    • Tekin, A.I.1    Tuncer, O.N.2    Memetoglu, M.E.3
  • 107
    • 31344458952 scopus 로고    scopus 로고
    • Structure and function of matrix metalloproteinases and TIMPs
    • 107 Nagase, H., Visse, R., Murphy, G., Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 69:3 (2006), 562–573.
    • (2006) Cardiovasc Res , vol.69 , Issue.3 , pp. 562-573
    • Nagase, H.1    Visse, R.2    Murphy, G.3
  • 108
    • 0036800192 scopus 로고    scopus 로고
    • Metalloproteinase inhibitors: biological actions and therapeutic opportunities
    • 108 Baker, A.H., Edwards, D.R., Murphy, G., Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 115:pt 19 (2002), 3719–3727.
    • (2002) J Cell Sci , vol.115 , pp. 3719-3727
    • Baker, A.H.1    Edwards, D.R.2    Murphy, G.3
  • 109
    • 84860868139 scopus 로고    scopus 로고
    • Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure
    • 109 Batra, J., Robinson, J., Soares, A.S., Fields, A.P., Radisky, D.C., Radisky, E.S., Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. J Biol Chem 287:19 (2012), 15935–15946.
    • (2012) J Biol Chem , vol.287 , Issue.19 , pp. 15935-15946
    • Batra, J.1    Robinson, J.2    Soares, A.S.3    Fields, A.P.4    Radisky, D.C.5    Radisky, E.S.6
  • 110
    • 0033538059 scopus 로고    scopus 로고
    • Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1′ residue of substrate
    • 110 Meng, Q., Malinovskii, V., Huang, W., et al. Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1′ residue of substrate. J Biol Chem 274:15 (1999), 10184–10189.
    • (1999) J Biol Chem , vol.274 , Issue.15 , pp. 10184-10189
    • Meng, Q.1    Malinovskii, V.2    Huang, W.3
  • 111
    • 78649629120 scopus 로고    scopus 로고
    • Inhibitory effect of TIMP influences the morphology of varicose veins
    • 111 Aravind, B., Saunders, B., Navin, T., et al. Inhibitory effect of TIMP influences the morphology of varicose veins. Eur J Vasc Endovasc Surg 40:6 (2010), 754–765.
    • (2010) Eur J Vasc Endovasc Surg , vol.40 , Issue.6 , pp. 754-765
    • Aravind, B.1    Saunders, B.2    Navin, T.3
  • 112
    • 0035094867 scopus 로고    scopus 로고
    • Smooth muscle cell modulation and cytokine overproduction in varicose veins. An in situ study
    • 112 Badier-Commander, C., Couvelard, A., Henin, D., Verbeuren, T., Michel, J.B., Jacob, M.P., Smooth muscle cell modulation and cytokine overproduction in varicose veins. An in situ study. J Pathol 193:3 (2001), 398–407.
    • (2001) J Pathol , vol.193 , Issue.3 , pp. 398-407
    • Badier-Commander, C.1    Couvelard, A.2    Henin, D.3    Verbeuren, T.4    Michel, J.B.5    Jacob, M.P.6
  • 113
    • 84938571456 scopus 로고    scopus 로고
    • Behaviour of the plasma concentration of gelatinases and their tissue inhibitors in subjects with venous leg ulcers
    • 113 Caimi, G., Ferrara, F., Montana, M., et al. Behaviour of the plasma concentration of gelatinases and their tissue inhibitors in subjects with venous leg ulcers. Clin Hemorheol Microcirc 60:3 (2015), 309–316.
    • (2015) Clin Hemorheol Microcirc , vol.60 , Issue.3 , pp. 309-316
    • Caimi, G.1    Ferrara, F.2    Montana, M.3
  • 114
    • 84901281082 scopus 로고    scopus 로고
    • Deep sea water prevents balloon angioplasty-induced hyperplasia through MMP-2: an in vitro and in vivo study
    • 114 Li, P.C., Pan, C.H., Sheu, M.J., Wu, C.C., Ma, W.F., Wu, C.H., Deep sea water prevents balloon angioplasty-induced hyperplasia through MMP-2: an in vitro and in vivo study. PLoS One, 9(5), 2014, e96927.
    • (2014) PLoS One , vol.9 , Issue.5
    • Li, P.C.1    Pan, C.H.2    Sheu, M.J.3    Wu, C.C.4    Ma, W.F.5    Wu, C.H.6
  • 115
    • 84861816728 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease
    • 115 Benjamin, M.M., Khalil, R.A., Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease. EXS 103 (2012), 209–279.
    • (2012) EXS , vol.103 , pp. 209-279
    • Benjamin, M.M.1    Khalil, R.A.2
  • 116
    • 34447520043 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
    • 116 Hu, J., Van den Steen, P.E., Sang, Q.X., Opdenakker, G., Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. Nat Rev Drug Discov 6:6 (2007), 480–498.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.6 , pp. 480-498
    • Hu, J.1    Van den Steen, P.E.2    Sang, Q.X.3    Opdenakker, G.4
  • 117
    • 77149131528 scopus 로고    scopus 로고
    • To bind zinc or not to bind zinc: an examination of innovative approaches to improved metalloproteinase inhibition
    • 117 Jacobsen, J.A., Major Jourden, J.L., Miller, M.T., Cohen, S.M., To bind zinc or not to bind zinc: an examination of innovative approaches to improved metalloproteinase inhibition. Biochim Biophys Acta 1803:1 (2010), 72–94.
    • (2010) Biochim Biophys Acta , vol.1803 , Issue.1 , pp. 72-94
    • Jacobsen, J.A.1    Major Jourden, J.L.2    Miller, M.T.3    Cohen, S.M.4
  • 118
    • 0034609778 scopus 로고    scopus 로고
    • Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes
    • 118 Scozzafava, A., Supuran, C.T., Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J Med Chem 43:20 (2000), 3677–3687.
    • (2000) J Med Chem , vol.43 , Issue.20 , pp. 3677-3687
    • Scozzafava, A.1    Supuran, C.T.2
  • 119
    • 32344433663 scopus 로고    scopus 로고
    • Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates
    • 119 Pochetti, G., Gavuzzo, E., Campestre, C., et al. Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. J Med Chem 49:3 (2006), 923–931.
    • (2006) J Med Chem , vol.49 , Issue.3 , pp. 923-931
    • Pochetti, G.1    Gavuzzo, E.2    Campestre, C.3
  • 121
    • 0035030734 scopus 로고    scopus 로고
    • The design, structure, and therapeutic application of matrix metalloproteinase inhibitors
    • 121 Skiles, J.W., Gonnella, N.C., Jeng, A.Y., The design, structure, and therapeutic application of matrix metalloproteinase inhibitors. Curr Med Chem 8:4 (2001), 425–474.
    • (2001) Curr Med Chem , vol.8 , Issue.4 , pp. 425-474
    • Skiles, J.W.1    Gonnella, N.C.2    Jeng, A.Y.3
  • 122
    • 3142738143 scopus 로고    scopus 로고
    • New beginnings for matrix metalloproteinase inhibitors: identification of high-affinity zinc-binding groups
    • 122 Puerta, D.T., Lewis, J.A., Cohen, S.M., New beginnings for matrix metalloproteinase inhibitors: identification of high-affinity zinc-binding groups. J Am Chem Soc 126:27 (2004), 8388–8389.
    • (2004) J Am Chem Soc , vol.126 , Issue.27 , pp. 8388-8389
    • Puerta, D.T.1    Lewis, J.A.2    Cohen, S.M.3
  • 123
    • 0037192860 scopus 로고    scopus 로고
    • Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases
    • 123 Bernardo, M.M., Brown, S., Li, Z.H., Fridman, R., Mobashery, S., Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases. J Biol Chem 277:13 (2002), 11201–11207.
    • (2002) J Biol Chem , vol.277 , Issue.13 , pp. 11201-11207
    • Bernardo, M.M.1    Brown, S.2    Li, Z.H.3    Fridman, R.4    Mobashery, S.5
  • 124
    • 34948864524 scopus 로고    scopus 로고
    • Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects
    • 124 Johnson, A.R., Pavlovsky, A.G., Ortwine, D.F., et al. Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. J Biol Chem 282:38 (2007), 27781–27791.
    • (2007) J Biol Chem , vol.282 , Issue.38 , pp. 27781-27791
    • Johnson, A.R.1    Pavlovsky, A.G.2    Ortwine, D.F.3
  • 125
    • 33749569829 scopus 로고    scopus 로고
    • Adenovirus-mediated small interfering RNA against matrix metalloproteinase-2 suppresses tumor growth and lung metastasis in mice
    • 125 Chetty, C., Bhoopathi, P., Joseph, P., Chittivelu, S., Rao, J.S., Lakka, S., Adenovirus-mediated small interfering RNA against matrix metalloproteinase-2 suppresses tumor growth and lung metastasis in mice. Mol Cancer Ther 5:9 (2006), 2289–2299.
    • (2006) Mol Cancer Ther , vol.5 , Issue.9 , pp. 2289-2299
    • Chetty, C.1    Bhoopathi, P.2    Joseph, P.3    Chittivelu, S.4    Rao, J.S.5    Lakka, S.6
  • 126
    • 84903842041 scopus 로고    scopus 로고
    • The influence of elastin degradation products, glucose and atorvastatin on metalloproteinase-1, -2, -9 and tissue inhibitor of metalloproteinases-1, -2, -3 expression in human retinal pigment epithelial cells
    • 126 Dorecka, M., Francuz, T., Garczorz, W., Siemianowicz, K., Romaniuk, W., The influence of elastin degradation products, glucose and atorvastatin on metalloproteinase-1, -2, -9 and tissue inhibitor of metalloproteinases-1, -2, -3 expression in human retinal pigment epithelial cells. Acta Biochim Pol 61:2 (2014), 265–270.
    • (2014) Acta Biochim Pol , vol.61 , Issue.2 , pp. 265-270
    • Dorecka, M.1    Francuz, T.2    Garczorz, W.3    Siemianowicz, K.4    Romaniuk, W.5
  • 127
    • 0037625637 scopus 로고    scopus 로고
    • Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages
    • 127 Luan, Z., Chase, A.J., Newby, A.C., Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol 23:5 (2003), 769–775.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , Issue.5 , pp. 769-775
    • Luan, Z.1    Chase, A.J.2    Newby, A.C.3
  • 128
    • 31344455023 scopus 로고    scopus 로고
    • Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure
    • 128 Ichihara, S., Noda, A., Nagata, K., et al. Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure. Cardiovasc Res 69:3 (2006), 726–735.
    • (2006) Cardiovasc Res , vol.69 , Issue.3 , pp. 726-735
    • Ichihara, S.1    Noda, A.2    Nagata, K.3
  • 129
    • 84880174251 scopus 로고    scopus 로고
    • Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling
    • 129 Chen, Q., Jin, M., Yang, F., Zhu, J., Xiao, Q., Zhang, L., Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators Inflamm, 2013, 2013, 928315.
    • (2013) Mediators Inflamm , vol.2013 , pp. 928315
    • Chen, Q.1    Jin, M.2    Yang, F.3    Zhu, J.4    Xiao, Q.5    Zhang, L.6
  • 130
    • 84959852399 scopus 로고    scopus 로고
    • Doxycycline speeds up healing of chronic venous ulcers
    • 130 Serra, R., Gallelli, L., Buffone, G., et al. Doxycycline speeds up healing of chronic venous ulcers. Int Wound J 12:2 (2015), 179–184.
    • (2015) Int Wound J , vol.12 , Issue.2 , pp. 179-184
    • Serra, R.1    Gallelli, L.2    Buffone, G.3
  • 131
    • 0037975559 scopus 로고    scopus 로고
    • Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats
    • 131 Renkiewicz, R., Qiu, L., Lesch, C., et al. Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats. Arthritis Rheum 48:6 (2003), 1742–1749.
    • (2003) Arthritis Rheum , vol.48 , Issue.6 , pp. 1742-1749
    • Renkiewicz, R.1    Qiu, L.2    Lesch, C.3
  • 132
    • 25844469594 scopus 로고    scopus 로고
    • Synthesis and SAR of highly selective MMP-13 inhibitors
    • 132 Li, J., Rush, T.S. 3rd, Li, W., et al. Synthesis and SAR of highly selective MMP-13 inhibitors. Bioorg Med Chem Lett 15:22 (2005), 4961–4966.
    • (2005) Bioorg Med Chem Lett , vol.15 , Issue.22 , pp. 4961-4966
    • Li, J.1    Rush, T.S.2    Li, W.3


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