Doxycycline speeds up healing of chronic venous ulcers

International Wound Journal

Volumn 12, Issue 2, 2015, Pages 179-184

  Serra, Raffaele ^a   Gallelli, Luca ^a   Buffone, Gianluca ^a   Molinari, Vincenzo ^a   Stillitano, Domenico M ^a   Palmieri, Camillo ^a   De Franciscis, Stefano ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Chronic venous leg ulcers; Doxycycline; Metalloproteinase 9; Neutrophil gelatinase associated lipocalin; Wound healing

Indexed keywords

DOXYCYCLINE; GELATINASE B; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; VASCULOTROPIN;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL CLASSIFICATION; COMPARATIVE EFFECTIVENESS; COMPRESSION STOCKING; CONTROLLED STUDY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOMODULATION; LEG COMPRESSION; LEG ULCER; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; PARALLEL DESIGN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; ULCER HEALING; VEIN SURGERY; VENOUS REFLUX; WESTERN BLOTTING; WOUND FLUID;

EID: 84959852399     PISSN: 17424801     EISSN: 1742481X     Source Type: Journal    
DOI: 10.1111/iwj.12077     Document Type: Article

References (32)

1. Callam MJ, Ruckley CV, Harper DR, Dale JJ. Chronic ulceration of the leg: extent of the problem and provision of care. Br Med J (Clin Res Ed) 1985;290:1855-6.
2. Margolis DJ, Bilker W, Santanna J, Baumgarten M. Venous leg ulcer: incidence and prevalence in the elderly. J Am Acad Dermatol 2002;46:381-6.
3. Reichenberg J, Davis M. Venous ulcers. Semin Cutan Med Surg 2005;24:216-26.
4. Serra R, Buffone G, de Franciscis A, Mastrangelo D, Molinari V, Montemurro R, de Franciscis S. A genetic study of chronic venous insufficiency. Ann Vasc Surg 2012;26:636-42.
5. Serra R, Buffone G, Costanzo G, Montemurro R, Perri P, Damiano R, de Franciscis S. Varicocele in younger as risk factor for inguinal hernia and for chronic venous disease in older: preliminary results of a prospective cohort study. Ann Vasc Surg 2013;27:329-31. DOI: 10.1016/j.avsg.2012.03.016.
6. Serra R, Buffone G, Falcone D, Molinari V, Scaramuzzino M, Gallelli L, de Franciscis S. Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase associated lipocalin. Wound Repair Regen 2013; in press. DOI: 10.1111/wrr12035.
7. Tan JH, Price P, Gut I, Stacey MC, Warrington NM, Wallace HJ. Characterization of tumor necrosis factor-α block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients. Hum Immunol 2010;71:1214-9.
8. Rayment EA, Upton Z, Shooter GK. Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer. Br J Dermatol 2008;158:951-61.
9. Barresi V, Reggiani-Bonetti L, Di Gregorio C, Vitarelli E, Ponz De Leon M, Barresi G. Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic value in stage I colorectal carcinoma. Pathol Res Pract 2011;207:479-86.
10. Longo C, Serra R, Mastrangelo D, de Franciscis S. VEGF as a biological marker of the venous disease-associated ulcers natural history in the elderly: preliminary data. BMC Geriatr 2010;10(Suppl 1):A64.
11. Sapadin AN, Fleischmajer R. Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol 2006;54:258-65.
12. Tauber SC, Nau R. Immunomodulatory properties of antibiotics. Curr Mol Pharmacol 2008;1:68-79.
13. Zarogoulidis P, Papanas N, Kioumis I, Chatzaki E, Maltezos E, Zarogoulidis K. Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases. Eur J Clin Pharmacol 2012;68:479-503.
14. Lee HM, Ciancio SG, Tüter G, Ryan ME, Komaroff E, Golub LM. Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steroidal anti-inflammatory drug. J Periodontol 2004;75:453-63.
15. Castro MM, Tanus-Santos JE, Gerlach RF. Matrix metalloproteinases: targets for doxycycline to prevent the vascular alterations of hypertension. Pharmacol Res 2011;64:567-72.
16. Lee H, Park JW, Kim SP, Lo EH, Lee SR. Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia. Neurobiol Dis 2009;34:189-9.
17. Gu Y, Lee HM, Sorsa T, Salminen A, Ryan ME, Slepian MJ, Golub LM. Non-antibacterial tetracyclines modulate mediators of periodontitis and atherosclerotic cardiovascular disease: a mechanistic link between local and systemic inflammation. Pharmacol Res 2011;64:573-9.
18. Lim CS, Kiriakidis S, Paleolog EM, Davies AH. The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent. J Vasc Surg 2012;56:1069-77.
19. Eklöf B, Rutherford RB, Bergan JJ, Carpentier PH, Gloviczki P, Kistner RL, Meissner MH, Moneta GL, Myers K, Padberg FT, Perrin M, Ruckley CV, Smith PC, Wakefield TW, American Venous Forum International Ad Hoc Committee for Revision of the CEAP Classification. Revision of the CEAP classification for chronic venous disorders: consensus statement. J Vasc Surg 2004;40:1248-52.
20. Fragomeni G, Merola A, Serra R, de Franciscis S, Amato F. A nonlinear lumped parameters model to analyze the dynamics of venous reflux. Conf Proc IEEE Eng Med Biol Soc 2008;2008:1407-10. DOI: 10.1109/IEMBS.2008.4649429.
21. de Franciscis S, De Sarro GB, Longo P, Buffone G, Molinari V, Stillitano DM, Gallelli L, Serra R. Hyperhomocysteinaemia and chronic venous ulcers. Int Wound J 2013. DOI: 10.1111/iwj.12042.
22. Preianò M, Pasqua L, Gallelli L, Galasso O, Gasparini G, Savino R, Terracciano R. Simultaneous extraction and rapid visualization of peptidomic & lipidomic body fluids fingerprints by using mesoporous aluminosilicate and MALDI-TOF MS. Proteomics 2012;12:3286-94. DOI: 10.1002/pmic.201200204.
23. Pelaia G, Gallelli L, D'Agostino B, Vatrella A, Cuda G, Fratto D, Renda T, Galderisi U, Piegari E, Crimi N, Rossi F, Caputi M, Costanzo FS, Vancheri C, Maselli R, Marsico SA. Effects of TGF-beta and glucocorticoids on map kinase phosphorylation, IL-6/IL-11 secretion and cell proliferation in primary cultures of human lung fibroblasts. J Cell Physiol 2007;210:489-97.
24. Gallelli L, Falcone D, Pelaia G, Renda T, Terracciano R, Malara N, Vatrella A, Sanduzzi A, D'Agostino B, Rossi F, Cancheri C, Maselli R, Marsico SA, Savino R. Interleukin-6 receptor superantagonist Sant7 inhibits TGF-induced proliferation of human lung fibroblasts. Cell Prolif 2008;41:393-407.
25. Gallelli L, Pelaia G, Fratto D, Muto V, Falcone D, Vatrella A, Curto LS, Renda T, Busceti MT, Liberto MC, Savino R, Cazzola M, Marsico SA, Maselli R. Effects of budesonide on P38 MAPK activation, apoptosis and IL-8 secretion, induced by TNF-alpha and Haemophilus influenzae in human bronchial epithelial cells. Int J Immunopathol Pharmacol 2010;23:471-9.
26. Pelaia G, Gallelli L, Renda T, Fratto D, Falcone D, Caraglia M, Busceti MT, Terracciano R, Vatrella A, Maselli R, Savino R. Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non small lung cancer cells. Cell Prolif 2012;11:25-31.
27. Malara N, Focà D, Casadonte F, Sesto MF, Macrina L, Santoro L, Scaramuzzino M, Terracciano R, Savino R. Simultaneous inhibition of the constitutively activated nuclear factor κB and of the Interleukin-6 pathways is necessary and sufficient to completely overcome apoptosis resistance of human U266 myeloma cells. Cell Cycle 2008;7:3235-45.
28. Gallelli L, Pelaia G, D'Agostino B, Cuda G, Vatrella A, Fratto D, Gioffre V, Galderisi U, De Nardo M, Mastruzzo C, Salinaro ET, Maniscalco M, Sofia M, Crimi N, Rossi F, Caputi M, Costanzo FS, Maselli R, Marsico SA, Vancheri C. Endothelin-1 induces proliferation of human lung fibroblasts and IL-11 secretion through an ET(A) receptor-dependent activation of map kinases. J Cell Biochem 2005;96:858-68.
29. Pelaia G, Cuda G, Vatrella A, Gallelli L, Fratto D, Gioffre V, D'Agostino B, Caputi M, Maselli R, Rossi F, Costanzo FS, Marsico SA. Effects of hydrogen peroxide on MAPK activation, IL-8 production and cell viability in primary cultures of human bronchial epithelial cells. J Cell Biochem 2004;93:142-52.
30. Serra R, Buffone G, de Franciscis A, Mastrangelo D, Vitagliano T, Greco M, de Franciscis S. Skin grafting followed by low-molecular-weight heparin long-term therapy in chronic venous leg ulcers. Ann Vasc Surg 2012;26:190-7.
31. Serra R, Buffone G, Molinari V, Montemurro R, Perri P, Stillitano DM, Amato B, de Franciscis S. Low molecular weight heparin seems to improve healing of chronic venous ulcers especially in the elderly. Int Wound J 2013 in press. DOI: 10.1111/iwj.12071.
32. Hobeika MJ, Thompson RW, Muhs BE, Brooks PC, Gagne PJ. Matrix metalloproteinases in peripheral vascular disease. J Vasc Surg 2007;45:849-57.