Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 1, 2010, Pages

  Shi, Zhong Dong ^a   Ji, Xin Ying ^a   Berardi, Danielle E ^a   Qazi, Henry ^a   Tarbell, John M ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Activator protein 1; Extracellular signal regulated kinase; Matrix metalloproteinase; Mitogen activated protein kinase; Neointima formation; Shear stress; Smooth muscle cell

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; COLLAGEN TYPE 1; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; BLOOD FLOW; BLOOD VESSEL INJURY; CELL MIGRATION; FIBROBLAST; INTIMA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR ENDOTHELIUM; VASCULAR LESION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL SEPARATION; COLLAGEN TYPE I; DNA PRIMERS; ENZYME ACTIVATION; EXTRACELLULAR FLUID; GELS; GENE SILENCING; GENES, FOS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; MALE; MATRIX METALLOPROTEINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCYTES, SMOOTH MUSCLE; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY; RNA; RNA INTERFERENCE; TRANSCRIPTION FACTOR AP-1;

EID: 73549087821     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00732.2009     Document Type: Article

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