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Volumn 5, Issue 4, 2012, Pages 460-466

A review of familial, genetic, and congenital aspects of primary varicose vein disease

Author keywords

Congenital; Familial; Genetics; Hereditary; Varicose veins; Venous ulcers

Indexed keywords

BLOOD CLOTTING FACTOR 13; FIBROBLAST GROWTH FACTOR RECEPTOR 2; MACROPHAGE ELASTASE; MESSENGER RNA; NOTCH3 RECEPTOR; THROMBOMODULIN; TRANSCRIPTION FACTOR FOXC2;

EID: 84868612528     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.112.963439     Document Type: Review
Times cited : (42)

References (72)
  • 1
    • 70350517364 scopus 로고    scopus 로고
    • Pathogenesis of primary varicose veins
    • Lim CS, Davies AH. Pathogenesis of primary varicose veins. Br J Surg. 2009;96:1231-1242.
    • (2009) Br J Surg. , vol.96 , pp. 1231-1242
    • Lim, C.S.1    Davies, A.H.2
  • 2
    • 0001153981 scopus 로고    scopus 로고
    • What are the symptoms of varicose veins? Edinburgh vein study cross sectional population survey
    • Bradbury A, Evans C, Allan P, Lee A, Ruckley C V, Flowkes FG. What are the symptoms of varicose veins? Edinburgh vein study cross sectional population survey. BMJ. 1999;318:353-356. (Pubitemid 29192081)
    • (1999) British Medical Journal , vol.318 , Issue.7180 , pp. 353-356
    • Bradbury, A.1    Evans, C.2    Allan, P.3    Lee, A.4    Ruckley, C.V.5    Fowkes, F.G.R.6
  • 3
    • 49849101359 scopus 로고    scopus 로고
    • Epidemiology of chronic venous disease
    • Robertson L, Evans C, Flowkes FG. Epidemiology of chronic venous disease. Phlebology. 2008;23:103-111.
    • (2008) Phlebology , vol.23 , pp. 103-111
    • Robertson, L.1    Evans, C.2    Flowkes, F.G.3
  • 4
    • 13944251682 scopus 로고    scopus 로고
    • The epidemiology of chronic venous insufficiency and varicose veins
    • DOI 10.1016/j.annepidem.2004.05.015
    • Beebe-Dimmer JL, Pfeifer JR, Engle JS, Schottenfibro D. The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol. 2005;15:175-184. (Pubitemid 40269465)
    • (2005) Annals of Epidemiology , vol.15 , Issue.3 , pp. 175-184
    • Beebe-Dimmer, J.L.1    Pfeifer, J.R.2    Engle, J.S.3    Schottenfeld, D.4
  • 5
    • 0015909753 scopus 로고
    • Venous thromboembolism and other venous disease in the Tecumseh community health study
    • Coon WW, Willis PW III, Keller JB. Venous thromboembolism and other venous disease in the Tecumseh community health study. Circulation. 1973;48:839-846.
    • (1973) Circulation , vol.48 , pp. 839-846
    • Coon, W.W.1    Willis III, P.W.2    Keller, J.B.3
  • 6
    • 0029147378 scopus 로고
    • Prevalence and risk factors of varicose veins in lower extremities: Mini-Finland health survey
    • Sisto T, Reunanen A, Laurikka J, Impivaara O, Heliovaara M, Knekt P, et al. Prevalence and risk factors of varicose veins in lower extremities: mini-Finland health survey. Eur J Surg. 1995;161:405-414.
    • (1995) Eur J Surg. , vol.161 , pp. 405-414
    • Sisto, T.1    Reunanen, A.2    Laurikka, J.3    Impivaara, O.4    Heliovaara, M.5    Knekt, P.6
  • 9
    • 0036617897 scopus 로고    scopus 로고
    • Risk indicators for varicose veins in forty- to sixty-year-olds in the tampere varicose vein study
    • DOI 10.1007/s00268-001-0283-1
    • Laurikka JO, Sisto T, Tarkka MR, Auvinen O, Hakama M. Risk indicators for varicose veins in forty-to sixty-year-olds in the Tampere varicose vein study. World J Surg. 2002;26:648-651. (Pubitemid 36920336)
    • (2002) World Journal of Surgery , vol.26 , Issue.6 , pp. 648-651
    • Laurikka, J.O.1    Sisto, T.2    Tarkka, M.R.3    Auvinen, O.4    Hakama, M.5
  • 10
    • 0032977870 scopus 로고    scopus 로고
    • Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study
    • Evans CJ, Flowkes FG, Ruckley CV, Lee AJ. Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh vein study. J Epidemiol Community Health. 1999;53:149-153. (Pubitemid 29086297)
    • (1999) Journal of Epidemiology and Community Health , vol.53 , Issue.3 , pp. 149-153
    • Evans, C.J.1    Fowkes, F.G.R.2    Ruckley, C.V.3    Lee, A.J.4
  • 11
    • 0015537591 scopus 로고
    • Causative factors of varicose veins: Myths and facts. An epidemio-logical study of 610 women
    • Guberan E, Widmer LK, Glaus L, Muller R, Rougemont A, Da Silva A, et al. Causative factors of varicose veins: myths and facts. an epidemio-logical study of 610 women. Vasa. 1973;2:115-120.
    • (1973) Vasa. , vol.2 , pp. 115-120
    • Guberan, E.1    Widmer, L.K.2    Glaus, L.3    Muller, R.4    Rougemont, A.5    Da Silva, A.6
  • 13
    • 68549101842 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration
    • Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.
    • (2009) BMJ , vol.339
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3    Mulrow, C.4    Gotzsche, P.C.5    Ioannidis, J.P.6
  • 14
    • 0025257066 scopus 로고
    • Prevalence and risk factors of varicose veins in Japanese women
    • Hirai M, Naiki K, Nakayama R. Prevalence and risk factors of varicose veins in Japanese women. Angiology. 1990;41:228-232. (Pubitemid 20095400)
    • (1990) Angiology , vol.41 , Issue.3 , pp. 228-232
    • Hirai, M.1    Naiki, K.2    Nakayama, R.3
  • 15
    • 0028864146 scopus 로고
    • Risk factors for chronic venous insufficiency: A dual case-control study
    • Scott TE, La Morte WW, Gorin DR, Menzoian JO. Risk factors for chronic venous insufficiency: a dual case-control study. J Vasc Surg. 1995;22:622-628.
    • (1995) J Vasc Surg. , vol.22 , pp. 622-628
    • Scott, T.E.1    La Morte, W.W.2    Gorin, D.R.3    Menzoian, J.O.4
  • 16
    • 77956621170 scopus 로고    scopus 로고
    • Effect of family history on the risk of varicose veins is affected by differential misclassification
    • Ahti TM, Makivaara LA, Luukkaala T, Hakama M, Laurikka JO. Effect of family history on the risk of varicose veins is affected by differential misclassification. J Clin Epidemiol. 2010;63:686-690.
    • (2010) J Clin Epidemiol. , vol.63 , pp. 686-690
    • Ahti, T.M.1    Makivaara, L.A.2    Luukkaala, T.3    Hakama, M.4    Laurikka, J.O.5
  • 19
    • 47249144255 scopus 로고    scopus 로고
    • Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veins
    • Raffetto JD, Qiao X, Koledova VV, Khalil RA. Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: potential implications in varicose veins. J Vasc Surg. 2008;48:447-456.
    • (2008) J Vasc Surg. , vol.48 , pp. 447-456
    • Raffetto, J.D.1    Qiao, X.2    Koledova, V.V.3    Khalil, R.A.4
  • 21
    • 0042611650 scopus 로고    scopus 로고
    • Genomic organization and single-nucleotide polymorphism map of desmuslin, a novel intermediate filament protein on chromosome 15q26.3
    • Mizuno Y, Puca AA, O'Brien KF, Beggs AH, Kunkel LM. Genomic organization and single-nucleotide polymorphism map of desmuslin, a novel intermediate filament protein on chromosome 15q26.3. BMC Genet. 2001;2:8.
    • (2001) BMC Genet. , vol.2 , pp. 8
    • Mizuno, Y.1    Puca, A.A.2    O'Brien, K.F.3    Beggs, A.H.4    Kunkel, L.M.5
  • 22
    • 32344436569 scopus 로고    scopus 로고
    • Downregulation of desmuslin in primary vein incompetence
    • DOI 10.1016/j.jvs.2005.10.018, PII S0741521405017271
    • Yin H, Zhang X, Wang J, Yin W, Zhang G, Wang S, et al. Downregulation of desmuslin in primary vein incompetence. J Vasc Surg. 2006;43:372-378. (Pubitemid 43221936)
    • (2006) Journal of Vascular Surgery , vol.43 , Issue.2 , pp. 372-378
    • Yin, H.1    Zhang, X.2    Wang, J.3    Yin, W.4    Zhang, G.5    Wang, S.6    Liu, Q.7
  • 23
    • 0035736333 scopus 로고    scopus 로고
    • Smooth muscle changes in varicose veins: An ultrastructural study
    • DOI 10.1540/jsmr.37.123
    • Wali MA, Eid RA. Smooth muscle changes in varicose veins: an ultra-structural study. J Smooth Muscle Res. 2001;37:123-135. (Pubitemid 34456771)
    • (2001) Journal of Smooth Muscle Research , vol.37 , Issue.5-6 , pp. 123-135
    • Wali, M.A.1    Eid, R.A.2
  • 25
    • 70350565362 scopus 로고    scopus 로고
    • In vitro differences between smooth muscle cells derived from varicose veins and normal veins
    • Xiao Y, Huang Z, Yin H, Lin Y, Wang S. In vitro differences between smooth muscle cells derived from varicose veins and normal veins. J Vasc Surg. 2009;50:1149-1154.
    • (2009) J Vasc Surg. , vol.50 , pp. 1149-1154
    • Xiao, Y.1    Huang, Z.2    Yin, H.3    Lin, Y.4    Wang, S.5
  • 26
    • 77956392303 scopus 로고    scopus 로고
    • Desmuslin gene knockdown causes altered expression of phenotype markers and differentiation of saphenous vein smooth muscle cells
    • Xiao Y, Huang Z, Yin H, Zhang H, Wang S. Desmuslin gene knockdown causes altered expression of phenotype markers and differentiation of saphenous vein smooth muscle cells. J Vasc Surg. 2010;52:684-690.
    • (2010) J Vasc Surg. , vol.52 , pp. 684-690
    • Xiao, Y.1    Huang, Z.2    Yin, H.3    Zhang, H.4    Wang, S.5
  • 29
    • 0000813821 scopus 로고
    • Angioma formation in connection with hypertrophy of limbs and hemi-hypertrophy
    • Parkes-Weber F. Angioma formation in connection with hypertrophy of limbs and hemi-hypertrophy. Br J Dermatol Syph. 1907;19:231-235.
    • (1907) Br J Dermatol Syph. , vol.19 , pp. 231-235
    • Parkes-Weber, F.1
  • 30
    • 33746605224 scopus 로고    scopus 로고
    • Klippel-Trenaunay syndrome: A multisystem disorder possibly resulting from a pathogenic gene for vascular and tissue overgrowth
    • DOI 10.1111/j.1365-4632.2006.02940.x
    • Kihiczak GG, Meine JG, Schwartz RA, Janniger CK. Klippel-Trenaunay syndrome: a multisystem disorder possibly resulting from a pathogenic gene for vascular and tissue overgrowth. Int J Dermatol. 2006;45:883-890. (Pubitemid 44145020)
    • (2006) International Journal of Dermatology , vol.45 , Issue.8 , pp. 883-890
    • Kihiczak, G.G.1    Meine, J.G.2    Schwartz, R.A.3    Janniger, C.K.4
  • 31
    • 0031712860 scopus 로고    scopus 로고
    • Increased parental age and number of pregnancies in Klippel-Trenaunay- Weber syndrome
    • DOI 10.1017/S0003480098006903
    • Lorda-Sanchez I, Prieto L, Rodriguez-Pinilla E, Martinez-Frias ML. Increased parental age and number of pregnancies in Klippel-Trenaunay-Weber syndrome. Ann Hum Genet. 1998;62:235-239. (Pubitemid 28468154)
    • (1998) Annals of Human Genetics , vol.62 , Issue.3 , pp. 235-239
    • Lorda-Sanchez, I.1    Prieto, L.2    Rodriguez-Pinilla, E.3    Martinez-Frias, M.L.4
  • 32
    • 0036282546 scopus 로고    scopus 로고
    • Identification and molecular characterization of de novo translocation t(8;14)(q22.3;q13) associated with a vascular and tissue overgrowth syndrome
    • Wang Q, Timur AA, Szafranski P, Sadgephour A, Jurecic V, Cowell J, et al. Identification and molecular characterization of de novo translocation t (8;14) (q22.3;q13) associated with a vascular and tissue overgrowth syndrome. Cytogenet Cell Genet. 2001;95:183-188. (Pubitemid 34638956)
    • (2002) Cytogenetics and Cell Genetics , vol.95 , Issue.3-4 , pp. 183-188
    • Wang, Q.1    Timur, A.A.2    Szafranski, P.3    Sadgephour, A.4    Jurecic, V.5    Cowell, J.6    Baldini, A.7    Driscoll, D.J.8
  • 34
  • 35
    • 0021893313 scopus 로고
    • Klippel and Trenaunay's syndrome. 768 operated cases
    • Servelle M. Klippel and Trenaunay's syndrome. 768 operated cases. Ann Surg. 1985;201:365-373. (Pubitemid 15010467)
    • (1985) Annals of Surgery , vol.201 , Issue.3 , pp. 365-373
    • Servelle, M.1
  • 36
    • 0028484673 scopus 로고
    • The use of ultrasound in the venous assessment of lower limb Klippel-Trenaunay syndrome
    • DOI 10.1016/0720-048X(94)90340-9
    • Howlett DC, Roebuck DJ, Frazer CK, Ayers B. The use of ultrasound in the venous assessment of lower limb Klippel-Trenaunay syndrome. Eur J Radiol. 1994;18:224-226. (Pubitemid 24287200)
    • (1994) European Journal of Radiology , vol.18 , Issue.3 , pp. 224-226
    • Howlett, D.C.1    Roebuck, D.J.2    Frazer, C.K.3    Ayers, B.4
  • 37
    • 0028217099 scopus 로고
    • Distichiasis-lymphoedema syndrome: A family report
    • Temple IK, Collin JR. Distichiasis-lymphoedema syndrome: a family report. Clin Dysmorphol. 1994;3:139-142. (Pubitemid 24138132)
    • (1994) Clinical Dysmorphology , vol.3 , Issue.2 , pp. 139-142
    • Temple, I.K.1    Collin, J.R.O.2
  • 38
    • 0033646615 scopus 로고    scopus 로고
    • Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome
    • Fang J, Dagenais SL, Erickson RP, Arlt MF, Glynn MW, Gorski JL, et al. Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome. Am J Hum Genet. 2000;67:1382-1388.
    • (2000) Am J Hum Genet. , vol.67 , pp. 1382-1388
    • Fang, J.1    Dagenais, S.L.2    Erickson, R.P.3    Arlt, M.F.4    Glynn, M.W.5    Gorski, J.L.6
  • 40
    • 4744342993 scopus 로고    scopus 로고
    • Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome
    • DOI 10.1016/j.modgep.2004.07.004, PII S1567133X04001085
    • Dagenais SL, Hartsough RL, Erickson RP, Witte MH, Butler MG, Glover TW. FOXC2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome. Gene Expr Patterns. 2004;4:611-619. (Pubitemid 39307524)
    • (2004) Gene Expression Patterns , vol.4 , Issue.6 , pp. 611-619
    • Dagenais, S.L.1    Hartsough, R.L.2    Erickson, R.P.3    Witte, M.H.4    Butler, M.G.5    Glover, T.W.6
  • 44
    • 15044348467 scopus 로고    scopus 로고
    • Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected siblings pairs
    • DOI 10.1136/jmg.2004.024075
    • Ng MY, Andrew T, Spector TD, Jeffery S. Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. J Med Genet. 2005;42:235-239. (Pubitemid 40380304)
    • (2005) Journal of Medical Genetics , vol.42 , Issue.3 , pp. 235-239
    • Ng, M.Y.M.1    Andrew, T.2    Spector, T.D.3    Jeffery, S.4
  • 46
    • 33747067434 scopus 로고    scopus 로고
    • Varicose veins associated with CADASIL result from a novel mutation in the Notch3 gene
    • DOI 10.1212/01.wnl.0000224758.52970.19, PII 0000611420060725000040
    • Saiki S, Sakai K, Saiki M, Kitagawa Y, Umemori T, Murata K, et al. Varicose veins associated with CADASIL result from a novel mutation in the Notch3 gene. Neurology. 2006;67:337-339. (Pubitemid 44305431)
    • (2006) Neurology , vol.67 , Issue.2 , pp. 337-339
    • Saiki, S.1    Sakai, K.2    Saiki, M.3    Kitagawa, Y.4    Umemori, T.5    Murata, K.6    Matsui, M.7    Hirose, G.8
  • 47
    • 0004200641 scopus 로고
    • Moscow, Russia: Scientific Research Institute of Hematology and Blood Transfusion
    • Polyyakova LA. Familial-hereditary erythrocytosis. 1977; Moscow, Russia: Scientific Research Institute of Hematology and Blood Transfusion.
    • (1977) Familial-hereditary Erythrocytosis
    • Polyyakova, L.A.1
  • 49
    • 0035029319 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Control of oxygen homeostasis in health and disease
    • Semenza GL. Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease. Pediatr Res. 2001;49:614-617. (Pubitemid 32390848)
    • (2001) Pediatric Research , vol.49 , Issue.5 , pp. 614-617
    • Semenza, G.L.1
  • 50
    • 2342631195 scopus 로고    scopus 로고
    • Congenital disorder of oxygen sensing: Association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors
    • DOI 10.1182/blood-2003-07-2535
    • Gordeuk VR, Sergueeva AI, Miasnikova GY, Okhotin D, Voloshin Y, Choyke PL, et al. Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors. Blood. 2004;103:3924-3932. (Pubitemid 38596314)
    • (2004) Blood , vol.103 , Issue.10 , pp. 3924-3932
    • Gordeuk, V.R.1    Sergueeva, A.I.2    Miasnikova, G.Y.3    Okhotin, D.4    Voloshin, Y.5    Choyke, P.L.6    Butman, J.A.7    Jedlickova, K.8    Prchal, J.T.9    Polyakova, L.A.10
  • 51
    • 85028120628 scopus 로고    scopus 로고
    • Further delineation of the phenotype of severe congenital neu-tropenia type 4 due to mutations in G6PC3
    • Banka S, Chervinsky E, Newman WG, Crow YJ, Yeganeh S, Yacobovich J, et al. Further delineation of the phenotype of severe congenital neu-tropenia type 4 due to mutations in G6PC3. Eur J Hum Genet. 2011;19:18-22.
    • (2011) Eur J Hum Genet. , vol.19 , pp. 18-22
    • Banka, S.1    Chervinsky, E.2    Newman, W.G.3    Crow, Y.J.4    Yeganeh, S.5    Yacobovich, J.6
  • 53
    • 34447503707 scopus 로고    scopus 로고
    • Clinical implications of gene polymorphisms in venous leg ulcer: A model in tissue injury and reparative process
    • DOI 10.1160/TH06-11-0625
    • Zamboni P, Gemmati D. Clinical implications of gene polymorphisms in venous leg ulcer: a model in tissue injury and reparative process. Thromb Haemost. 2007;98:131-137. (Pubitemid 47074189)
    • (2007) Thrombosis and Haemostasis , vol.98 , Issue.1 , pp. 131-137
    • Zamboni, P.1    Gemmati, D.2
  • 55
    • 3843090635 scopus 로고    scopus 로고
    • Protective role of heme oxygenase in the blood vessel wall during atherogenesis
    • DOI 10.1139/o04-006
    • Hoekstra KA, Godin DV, Cheng KM. Protective role of heme oxyge-nase in the blood vessel wall during atherogenesis. Biochem Cell Biol. 2004;82:351-359. (Pubitemid 39037114)
    • (2004) Biochemistry and Cell Biology , vol.82 , Issue.3 , pp. 351-359
    • Hoekstra, K.A.1    Godin, D.V.2    Cheng, K.M.3
  • 57
    • 0242408365 scopus 로고    scopus 로고
    • The prevalence of hyperhomocysteinemia, methylene tetrahydrofolate reductase C677T mutation, and vitamin B12 and folate deficiency in patients with chronic venous insufficiency
    • DOI 10.1016/S0741-5214(03)00923-6
    • Sam RC, Burns PJ, Hobbs SD, Marshall T, Wilmink AB, Silverman SH, et al. The prevalence of hyperhomocysteinemia, methylene tetrahydrofo-late reductase C677T mutation, and vitamin B12 and folate deficiency in patients with chronic venous insufficiency. J Vasc Surg. 2003;38:904-908. (Pubitemid 37409620)
    • (2003) Journal of Vascular Surgery , vol.38 , Issue.5 , pp. 904-908
    • Sam, R.C.1    Burns, P.J.2    Hobbs, S.D.3    Marshall, T.4    Wilmink, A.B.M.5    Silverman, S.H.6    Bradbury, A.W.7
  • 60
    • 18244393168 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of the fibroblast growth factor receptor 2 gene in patients with chronic venous insufficiency with leg ulcer [8]
    • DOI 10.1111/j.0022-202X.2005.23689.x
    • Nagy N, Szolnoky G, Szabad G, Bata-Csorgo Z, Dobozy A, Kemeny L, et al. Single nucleotide polymorphisms of the fibroblast growth factor receptor 2 gene in patients with chronic venous insufficiency with leg ulcer. J Invest Dermatol. 2005;124:1085-1088. (Pubitemid 40629118)
    • (2005) Journal of Investigative Dermatology , vol.124 , Issue.5 , pp. 1085-1088
    • Nagy, N.1    Szolnoky, Gy.2    Szabad, G.3    Bata-Csorgo, Zs.4    Dobozy, A.5    Kemeny, L.6    Szell, M.7
  • 65
    • 26444519775 scopus 로고    scopus 로고
    • Incomplete saphenopopliteal ligation after short saphenous vein surgery: A summation analysis
    • DOI 10.1258/0268355054985848
    • Tsang FJ, Davies AH. Incomplete saphenopopliteal ligation after short sa-phenous vein surgery: a summation analysis. Phlebology. 2005;20:106-109. (Pubitemid 41433822)
    • (2005) Phlebology , vol.20 , Issue.3 , pp. 106-109
    • Tsang, F.J.1    Davis, M.2    Davies, A.H.3
  • 69
    • 0036463681 scopus 로고    scopus 로고
    • Metabonomics: A platform for studying drug toxicity and gene function
    • DOI 10.1038/nrd728
    • Nicholson JK, Connelly J, Lindon JC, Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov. 2002;1:153-161. (Pubitemid 41646523)
    • (2002) Nature Reviews Drug Discovery , vol.1 , Issue.2 , pp. 153-161
    • Nicholson, J.K.1    Connelly, J.2    Lindon, J.C.3    Holmes, E.4
  • 72
    • 84863011283 scopus 로고    scopus 로고
    • Untargeted metabolome quantitative trait locus mapping associates variation in urine glycerate to mutant glycerate kinase
    • Cazier JB, Kaisaki PJ, Argoud K, Blaise BJ, Veselkov K, Ebbels TM, et al. Untargeted metabolome quantitative trait locus mapping associates variation in urine glycerate to mutant glycerate kinase. J Proteome Res. 2012;11:631-642.
    • (2012) J Proteome Res. , vol.11 , pp. 631-642
    • Cazier, J.B.1    Kaisaki, P.J.2    Argoud, K.3    Blaise, B.J.4    Veselkov, K.5    Ebbels, T.M.6


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