Smooth muscle cell modulation and cytokine overproduction in varicose veins. An in situ study

Journal of Pathology

Volumn 193, Issue 3, 2001, Pages 398-407

  Badier Commander, Cécile ^a,b   Couvelard, Anne ^a   Henin, Dominique ^a   Verbeuren, Tony ^b   Michel, Jean Baptiste ^b   Jacob, Marie Paule ^b  

^a INSERM   (France)

^b BICHAT HOSPITAL   (France)

Author keywords

Growth factors; Human; Immunohistochemistry; Smooth muscle cells; Varicose veins

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CYTOKINE; DNA; PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; ATROPHY; BIOCHEMISTRY; CELL COMPOSITION; CELL HETEROGENEITY; CELL METABOLISM; CELL STRUCTURE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FEMALE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; MALE; MODULATION; MORPHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RISK ASSESSMENT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; TISSUE SECTION; VARICOSIS; VASA VASORUM; VASCULAR SMOOTH MUSCLE; VEIN ANEURYSM; VEIN DILATATION; VEIN RECONSTRUCTION; VEIN WALL;

ADULT; CYTOKINES; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GROWTH SUBSTANCES; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; MUSCLE, SMOOTH; SAPHENOUS VEIN; VARICOSE VEINS;

EID: 0035094867     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.819     Document Type: Article

References (39)

1. Increase of the TIMP/MMP ratio in varicose veins: A possible explanation for extracellular matrix accumulation
2. Connective tissue in varicose veins
3. Viscoelastic properties and collagen content of the long saphenous vein in normal and varicose veins
4. Content of collagen, elastin and hexosamine in primary varicose veins
5. Some thoughts on the aetiology of varicose veins
6. Assessment of wall structure and composition of varicose veins with reference to collagen, elastin and smooth muscle content
7. Analysis of the connective tissue matrix and proteolytic activity of primary varicose veins
8. Connective tissue accumulation in the muscle layer in normal and varicose saphenous veins
9. Biochemical assay of collagen and elastin in the normal and varicose vein wall
10. Vascularremodelinginvaricoseveins
11. A review of the proliferative behaviour, morphology and phenotypes of vascular smooth muscle
12. Regulation of differentiation of vascular smooth muscle cells
13. Control of growth and differentiation of vascular cells by extracellular matrix proteins
14. Composition and organization of the extracellular matrix of vein walls: Collagen networks
15. Immunolabeling of type IV collagen, laminin, and α-smooth muscle actin cells in the intima of normal and varicose saphenous veins
16. Ultrastructural evidence for collagen degradation in the walls of varicose veins
17. Nature of species differences in the medial distribution of aortic vasa vasorum in mammals
18. Increased mast cell infiltration in varicose veins of the lower limbs: A possible role in the development of varices
19. Comparative cytokine gene expression: Regulation and release by human mast cells
20. Human mast cells stimulate vascular tube formation: Tryptase is a novel, potent angiogenic factor
21. Immunohistochemical and ultrastructural examination of smooth muscle cells in aortocoronary saphenous vein grafts
22. Relevance of smooth muscle replication and development to vascular disease
23. Stranger in a strange land: The pathogenesis of saphenous vein graft stenosis with emphasis on structural and functional differences between veins and arteries
24. Proliferation migration, matrix turnover and death of smooth muscle cells in native coronary and vein graft atherosclerosis
25. Histomorphological and pathobiochemical changes of varicose veins a possible explanation of the development of varicosis
26. The scanning electron microscope in the pathology of varicose veins
27. Primary venous aneurysms: Case reports
28. True venous aneurysms and arterial 'steal' secondary to arteriovenous fistule for dialysis
29. Growth factors and vascular wall
30. Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-β1 in human fibroblasts
31. Proliferation of smooth muscle cells after vascular injury is inhibited, by an antibody against basic fibroblast growth factor
32. Histopathological changes in the venous grafts and in varicose and non-varicose veins
33. Biological roles of fibroblast growth factor-2
34. Basic fibroblast growth factor stimulates endothelial regrowth and proliferation in denuded arteries
35. Regulation of arterial smooth muscle growth
36. Hypoxia stimulates human endothelial cells to release smooth muscle cell mitogens: Role of prostaglandins and bFGF
37. Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth
38. Basic fibroblast growth factor induces angiogenesis in vitro
39. The role of angiogenic cytokines in cardiovascular diseases