-
1
-
-
0030457014
-
Ubiquitin-dependent protein degradation
-
Hochstrasser, M. (1996) Ubiquitin-dependent protein degradation Annu. Rev. Genet. 30, 405-439 10.1146/annurev.genet.30.1.405
-
(1996)
Annu. Rev. Genet.
, vol.30
, pp. 405-439
-
-
Hochstrasser, M.1
-
2
-
-
0031657807
-
The ubiquitin system
-
Hershko, A. and Ciechanover, A. (1998) The ubiquitin system Annu. Rev. Biochem. 67, 425-479 10.1146/annurev.biochem.67.1.425
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 425-479
-
-
Hershko, A.1
Ciechanover, A.2
-
3
-
-
68049084674
-
Breaking the chains: Structure and function of the deubiquitinases
-
Komander, D., Clague, M. J., and Urbe, S. (2009) Breaking the chains: structure and function of the deubiquitinases Nat. Rev. Mol. Cell Biol. 10, 550-563 10.1038/nrm2731
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 550-563
-
-
Komander, D.1
Clague, M.J.2
Urbe, S.3
-
4
-
-
55949136614
-
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry
-
Meierhofer, D., Wang, X., Huang, L., and Kaiser, P. (2008) Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry J. Proteome Res. 7, 4566-4576 10.1021/pr800468j
-
(2008)
J. Proteome Res.
, vol.7
, pp. 4566-4576
-
-
Meierhofer, D.1
Wang, X.2
Huang, L.3
Kaiser, P.4
-
5
-
-
84960324799
-
Ubiquitin chain diversity at a glance
-
Akutsu, M., Dikic, I., and Bremm, A. (2016) Ubiquitin chain diversity at a glance J. Cell Sci. 129, 875-880 10.1242/jcs.183954
-
(2016)
J. Cell Sci.
, vol.129
, pp. 875-880
-
-
Akutsu, M.1
Dikic, I.2
Bremm, A.3
-
6
-
-
0020479850
-
Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins
-
Hershko, A., Eytan, E., Ciechanover, A., and Haas, A. L. (1982) Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins J. Biol. Chem. 257, 13964-13970
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 13964-13970
-
-
Hershko, A.1
Eytan, E.2
Ciechanover, A.3
Haas, A.L.4
-
7
-
-
0024514688
-
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
-
Chau, V., Tobias, J. W., Bachmair, A., Marriott, D., Ecker, D. J., Gonda, D. K., and Varshavsky, A. (1989) A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein Science 243, 1576-1583 10.1126/science.2538923
-
(1989)
Science
, vol.243
, pp. 1576-1583
-
-
Chau, V.1
Tobias, J.W.2
Bachmair, A.3
Marriott, D.4
Ecker, D.J.5
Gonda, D.K.6
Varshavsky, A.7
-
8
-
-
0037068455
-
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
-
Hoege, C., Pfander, B., Moldovan, G. L., Pyrowolakis, G., and Jentsch, S. (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO Nature 419, 135-141 10.1038/nature00991
-
(2002)
Nature
, vol.419
, pp. 135-141
-
-
Hoege, C.1
Pfander, B.2
Moldovan, G.L.3
Pyrowolakis, G.4
Jentsch, S.5
-
9
-
-
63049125531
-
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation
-
Xu, P., Duong, D. M., Seyfried, N. T., Cheng, D., Xie, Y., Robert, J., Rush, J., Hochstrasser, M., Finley, D., and Peng, J. (2009) Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation Cell 137, 133-145 10.1016/j.cell.2009.01.041
-
(2009)
Cell
, vol.137
, pp. 133-145
-
-
Xu, P.1
Duong, D.M.2
Seyfried, N.T.3
Cheng, D.4
Xie, Y.5
Robert, J.6
Rush, J.7
Hochstrasser, M.8
Finley, D.9
Peng, J.10
-
10
-
-
43049162227
-
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex
-
Jin, L., Williamson, A., Banerjee, S., Philipp, I., and Rape, M. (2008) Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex Cell 133, 653-665 10.1016/j.cell.2008.04.012
-
(2008)
Cell
, vol.133
, pp. 653-665
-
-
Jin, L.1
Williamson, A.2
Banerjee, S.3
Philipp, I.4
Rape, M.5
-
11
-
-
33745606169
-
Putting proteomics on target: Activity-based profiling of ubiquitin and ubiquitin-like processing enzymes
-
Kessler, B. M. (2006) Putting proteomics on target: activity-based profiling of ubiquitin and ubiquitin-like processing enzymes Expert Rev. Proteomics 3, 213-221 10.1586/14789450.3.2.213
-
(2006)
Expert Rev. Proteomics
, vol.3
, pp. 213-221
-
-
Kessler, B.M.1
-
12
-
-
19344364762
-
JAMM: A metalloprotease-like zinc site in the proteasome and signalosome
-
Ambroggio, X. I., Rees, D. C., and Deshaies, R. J. (2003) JAMM: a metalloprotease-like zinc site in the proteasome and signalosome PLoS Biol. 2, 113-119 10.1371/journal.pbio.0020002
-
(2003)
PLoS Biol.
, vol.2
, pp. 113-119
-
-
Ambroggio, X.I.1
Rees, D.C.2
Deshaies, R.J.3
-
13
-
-
80052265841
-
Mechanism, specificity and structure of the deubiquitinases
-
Komander, D. (2010) Mechanism, specificity and structure of the deubiquitinases Subcell. Biochem. 54, 69-87 10.1007/978-1-4419-6676-6-6
-
(2010)
Subcell. Biochem.
, vol.54
, pp. 69-87
-
-
Komander, D.1
-
14
-
-
50249154326
-
DUBs and disease: Activity assays for inhibitor development
-
Shanmugham, A. and Ovaa, H. (2008) DUBs and disease: activity assays for inhibitor development Curr. Opin Drug Discovery Dev. 11, 688-696
-
(2008)
Curr. Opin Drug Discovery Dev.
, vol.11
, pp. 688-696
-
-
Shanmugham, A.1
Ovaa, H.2
-
15
-
-
84880966633
-
Deubiquitinating enzymes as therapeutic targets in cancer
-
Lim, K. H. and Baek, K. H. (2013) Deubiquitinating enzymes as therapeutic targets in cancer Curr. Pharm. Des. 19, 4039-4052 10.2174/1381612811319220013
-
(2013)
Curr. Pharm. Des.
, vol.19
, pp. 4039-4052
-
-
Lim, K.H.1
Baek, K.H.2
-
16
-
-
84873055344
-
MDM2, MDMX and p53 in oncogenesis and cancer therapy
-
Wade, M., Li, Y. C., and Wahl, G. M. (2013) MDM2, MDMX and p53 in oncogenesis and cancer therapy Nat. Rev. Cancer 13, 83-96 10.1038/nrc3430
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 83-96
-
-
Wade, M.1
Li, Y.C.2
Wahl, G.M.3
-
17
-
-
84860112066
-
Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme
-
Reverdy, C., Conrath, S., Lopez, R., Planquette, C., Atmanene, C., Collura, V., Harpon, J., Battaglia, V., Vivat, V., and Sippl, W. et al. 2012, Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme Chem. Biol. 19, 467-477 10.1016/j.chembiol.2012.02.007
-
(2012)
Chem. Biol.
, vol.19
, pp. 467-477
-
-
Reverdy, C.1
Conrath, S.2
Lopez, R.3
Planquette, C.4
Atmanene, C.5
Collura, V.6
Harpon, J.7
Battaglia, V.8
Vivat, V.9
Sippl, W.10
-
18
-
-
33749346301
-
Modification of proteins by ubiquitin and ubiquitin-like proteins
-
Kerscher, O., Felberbaum, R., and Hochstrasser, M. (2006) Modification of proteins by ubiquitin and ubiquitin-like proteins Annu. Rev. Cell Dev. Biol. 22, 159-180 10.1146/annurev.cellbio.22.010605.093503
-
(2006)
Annu. Rev. Cell Dev. Biol.
, vol.22
, pp. 159-180
-
-
Kerscher, O.1
Felberbaum, R.2
Hochstrasser, M.3
-
19
-
-
0032539582
-
Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes
-
Dang, L. C., Melandri, F. D., and Stein, R. L. (1998) Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes Biochemistry 37, 1868-1879 10.1021/bi9723360
-
(1998)
Biochemistry
, vol.37
, pp. 1868-1879
-
-
Dang, L.C.1
Melandri, F.D.2
Stein, R.L.3
-
20
-
-
84965002376
-
Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets
-
Flierman, D., van der Heden van Noort, G. J., Ekkebus, R., Geurink, P. P., Mevissen, T. E. T., Hospenthal, M. K., Komander, D., and Ovaa, H. (2016) Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets, Cell Chem. Biol., DOI: 10.1016/j.chembiol.2016.03.009.
-
(2016)
Cell Chem. Biol.
-
-
Flierman, D.1
Van Der Heden Van Noort, G.J.2
Ekkebus, R.3
Geurink, P.P.4
Mevissen, T.E.T.5
Hospenthal, M.K.6
Komander, D.7
Ovaa, H.8
-
21
-
-
80054794059
-
Morpholinecarbonyl-Rhodamine 110 based substrates for the determination of protease activity with accurate kinetic parameters
-
Terentyeva, T. G., Van Rossom, W., Van der Auweraer, M., Blank, K., and Hofkens, J. (2011) Morpholinecarbonyl-Rhodamine 110 based substrates for the determination of protease activity with accurate kinetic parameters Bioconjugate Chem. 22, 1932-1938 10.1021/bc2001038
-
(2011)
Bioconjugate Chem.
, vol.22
, pp. 1932-1938
-
-
Terentyeva, T.G.1
Van Rossom, W.2
Van Der Auweraer, M.3
Blank, K.4
Hofkens, J.5
-
22
-
-
35548991428
-
A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate
-
Hassiepen, U., Eidhoff, U., Meder, G., Bulber, J. F., Hein, A., Bodendorf, U., Lorthiois, E., and Martoglio, B. (2007) A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate Anal. Biochem. 371, 201-207 10.1016/j.ab.2007.07.034
-
(2007)
Anal. Biochem.
, vol.371
, pp. 201-207
-
-
Hassiepen, U.1
Eidhoff, U.2
Meder, G.3
Bulber, J.F.4
Hein, A.5
Bodendorf, U.6
Lorthiois, E.7
Martoglio, B.8
-
23
-
-
23044497379
-
Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2
-
Tirat, A., Schilb, A., Riou, V., Leder, L., Gerhartz, B., Zimmermann, J., Worpenberg, S., Eidhoff, U., Freuler, F., and Stettler, T. et al. 2005, Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2 Anal. Biochem. 343, 244-255 10.1016/j.ab.2005.04.023
-
(2005)
Anal. Biochem.
, vol.343
, pp. 244-255
-
-
Tirat, A.1
Schilb, A.2
Riou, V.3
Leder, L.4
Gerhartz, B.5
Zimmermann, J.6
Worpenberg, S.7
Eidhoff, U.8
Freuler, F.9
Stettler, T.10
-
24
-
-
84855873408
-
A general chemical ligation approach towards isopeptide-linked ubiquitin and ubiquitin-like assay reagents
-
Geurink, P. P., El Oualid, F., Jonker, A., Hameed, D. S., and Ovaa, H. (2012) A general chemical ligation approach towards isopeptide-linked ubiquitin and ubiquitin-like assay reagents ChemBioChem 13, 293-297 10.1002/cbic.201100706
-
(2012)
ChemBioChem
, vol.13
, pp. 293-297
-
-
Geurink, P.P.1
El Oualid, F.2
Jonker, A.3
Hameed, D.S.4
Ovaa, H.5
-
25
-
-
84867017916
-
Bioluminescence assay platform for selective and sensitive detection of Ub/Ubl proteases
-
Orcutt, S. J., Wu, J., Eddins, M. J., Leach, C. A., and Strickler, J. E. (2012) Bioluminescence assay platform for selective and sensitive detection of Ub/Ubl proteases Biochim. Biophys. Acta, Mol. Cell Res. 1823, 2079-2086 10.1016/j.bbamcr.2012.06.004
-
(2012)
Biochim. Biophys. Acta, Mol. Cell Res.
, vol.1823
, pp. 2079-2086
-
-
Orcutt, S.J.1
Wu, J.2
Eddins, M.J.3
Leach, C.A.4
Strickler, J.E.5
-
26
-
-
84856846038
-
Targeting deubiquitinases enabled by chemical synthesis of proteins
-
Ohayon, S., Spasser, L., Aharoni, A., and Brik, A. (2012) Targeting deubiquitinases enabled by chemical synthesis of proteins J. Am. Chem. Soc. 134, 3281-3289 10.1021/ja2116712
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 3281-3289
-
-
Ohayon, S.1
Spasser, L.2
Aharoni, A.3
Brik, A.4
-
27
-
-
84871031152
-
Ubiquitin chain conformation regulates recognition and activity of interacting proteins
-
Ye, Y., Blaser, G., Horrocks, M. H., Ruedas-Rama, M. J., Ibrahim, S., Zhukov, A. A., Orte, A., Klenerman, D., Jackson, S. E., and Komander, D. (2012) Ubiquitin chain conformation regulates recognition and activity of interacting proteins Nature 492, 266-270 10.1038/nature11722
-
(2012)
Nature
, vol.492
, pp. 266-270
-
-
Ye, Y.1
Blaser, G.2
Horrocks, M.H.3
Ruedas-Rama, M.J.4
Ibrahim, S.5
Zhukov, A.A.6
Orte, A.7
Klenerman, D.8
Jackson, S.E.9
Komander, D.10
-
28
-
-
84879820535
-
High-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity
-
Arnst, J. L., Davies, C. W., Raja, S. M., Das, C., and Natarajan, A. (2013) High-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity Anal. Biochem. 440, 71-77 10.1016/j.ab.2013.05.017
-
(2013)
Anal. Biochem.
, vol.440
, pp. 71-77
-
-
Arnst, J.L.1
Davies, C.W.2
Raja, S.M.3
Das, C.4
Natarajan, A.5
-
29
-
-
84962623766
-
Development of Diubiquitin-Based FRET Probes to Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes
-
Geurink, P. P., van Tol, B. D., van Dalen, D., Brundel, P. J., Mevissen, T. E., Pruneda, J. N., Elliott, P. R., van Tilburg, G. B., Komander, D., and Ovaa, H. (2016) Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes ChemBioChem n/a 10.1002/cbic.201600017
-
(2016)
ChemBioChem
, pp. n/a
-
-
Geurink, P.P.1
Van Tol, B.D.2
Van Dalen, D.3
Brundel, P.J.4
Mevissen, T.E.5
Pruneda, J.N.6
Elliott, P.R.7
Van Tilburg, G.B.8
Komander, D.9
Ovaa, H.10
-
30
-
-
84856266666
-
TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors
-
Madiraju, C., Welsh, K., Cuddy, M. P., Godoi, P. H., Pass, I., Ngo, T., Vasile, S., Sergienko, E. A., Diaz, P., and Matsuzawa, S. et al. 2012, TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors J. Biomol. Screening 17, 163-176 10.1177/1087057111423417
-
(2012)
J. Biomol. Screening
, vol.17
, pp. 163-176
-
-
Madiraju, C.1
Welsh, K.2
Cuddy, M.P.3
Godoi, P.H.4
Pass, I.5
Ngo, T.6
Vasile, S.7
Sergienko, E.A.8
Diaz, P.9
Matsuzawa, S.10
-
31
-
-
0035903538
-
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
-
Borodovsky, A., Kessler, B. M., Casagrande, R., Overkleeft, H. S., Wilkinson, K. D., and Ploegh, H. L. (2001) A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14 EMBO J. 20, 5187-5196 10.1093/emboj/20.18.5187
-
(2001)
EMBO J.
, vol.20
, pp. 5187-5196
-
-
Borodovsky, A.1
Kessler, B.M.2
Casagrande, R.3
Overkleeft, H.S.4
Wilkinson, K.D.5
Ploegh, H.L.6
-
32
-
-
0036775490
-
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family
-
Borodovsky, A., Ovaa, H., Kolli, N., Gan-Erdene, T., Wilkinson, K. D., Ploegh, H. L., and Kessler, B. M. (2002) Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family Chem. Biol. 9, 1149-1159 10.1016/S1074-5521(02)00248-X
-
(2002)
Chem. Biol.
, vol.9
, pp. 1149-1159
-
-
Borodovsky, A.1
Ovaa, H.2
Kolli, N.3
Gan-Erdene, T.4
Wilkinson, K.D.5
Ploegh, H.L.6
Kessler, B.M.7
-
33
-
-
84867193114
-
Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes
-
de Jong, A., Merkx, R., Berlin, I., Rodenko, B., Wijdeven, R. H., El Atmioui, D., Yalcin, Z., Robson, C. N., Neefjes, J. J., and Ovaa, H. (2012) Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes ChemBioChem 13, 2251-2258 10.1002/cbic.201200497
-
(2012)
ChemBioChem
, vol.13
, pp. 2251-2258
-
-
De Jong, A.1
Merkx, R.2
Berlin, I.3
Rodenko, B.4
Wijdeven, R.H.5
El Atmioui, D.6
Yalcin, Z.7
Robson, C.N.8
Neefjes, J.J.9
Ovaa, H.10
-
34
-
-
84874612259
-
On terminal alkynes that can react with active-site cysteine nucleophiles in proteases
-
Ekkebus, R., van Kasteren, S. I., Kulathu, Y., Scholten, A., Berlin, I., Geurink, P. P., de Jong, A., Goerdayal, S., Neefjes, J., and Heck, A. J. et al. 2013, On terminal alkynes that can react with active-site cysteine nucleophiles in proteases J. Am. Chem. Soc. 135, 2867-2870 10.1021/ja309802n
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 2867-2870
-
-
Ekkebus, R.1
Van Kasteren, S.I.2
Kulathu, Y.3
Scholten, A.4
Berlin, I.5
Geurink, P.P.6
De Jong, A.7
Goerdayal, S.8
Neefjes, J.9
Heck, A.J.10
-
35
-
-
84863449135
-
Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes
-
Iphofer, A., Kummer, A., Nimtz, M., Ritter, A., Arnold, T., Frank, R., van den Heuvel, J., Kessler, B. M., Jansch, L., and Franke, R. (2012) Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes ChemBioChem 13, 1416-1420 10.1002/cbic.201200261
-
(2012)
ChemBioChem
, vol.13
, pp. 1416-1420
-
-
Iphofer, A.1
Kummer, A.2
Nimtz, M.3
Ritter, A.4
Arnold, T.5
Frank, R.6
Van Den Heuvel, J.7
Kessler, B.M.8
Jansch, L.9
Franke, R.10
-
36
-
-
84890859198
-
Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes
-
McGouran, J. F., Gaertner, S. R., Altun, M., Kramer, H. B., and Kessler, B. M. (2013) Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes Chem. Biol. 20, 1447-1455 10.1016/j.chembiol.2013.10.012
-
(2013)
Chem. Biol.
, vol.20
, pp. 1447-1455
-
-
McGouran, J.F.1
Gaertner, S.R.2
Altun, M.3
Kramer, H.B.4
Kessler, B.M.5
-
37
-
-
84889020913
-
Activity-based diubiquitin probes for elucidating the linkage specificity of deubiquitinating enzymes
-
Li, G., Liang, Q., Gong, P., Tencer, A. H., and Zhuang, Z. (2014) Activity-based diubiquitin probes for elucidating the linkage specificity of deubiquitinating enzymes Chem. Commun. (Cambridge, U. K.) 50, 216-218 10.1039/C3CC47382A
-
(2014)
Chem. Commun. (Cambridge, U. K.)
, vol.50
, pp. 216-218
-
-
Li, G.1
Liang, Q.2
Gong, P.3
Tencer, A.H.4
Zhuang, Z.5
-
38
-
-
84896760735
-
Dehydroalanine-based diubiquitin activity probes
-
Haj-Yahya, N., Hemantha, H. P., Meledin, R., Bondalapati, S., Seenaiah, M., and Brik, A. (2014) Dehydroalanine-based diubiquitin activity probes Org. Lett. 16, 540-543 10.1021/ol403416w
-
(2014)
Org. Lett.
, vol.16
, pp. 540-543
-
-
Haj-Yahya, N.1
Hemantha, H.P.2
Meledin, R.3
Bondalapati, S.4
Seenaiah, M.5
Brik, A.6
-
39
-
-
84899659989
-
A native chemical ligation handle that enables the synthesis of advanced activity-based probes: Diubiquitin as a case study
-
Mulder, M. P., El Oualid, F., ter Beek, J., and Ovaa, H. (2014) A native chemical ligation handle that enables the synthesis of advanced activity-based probes: diubiquitin as a case study ChemBioChem 15, 946-949 10.1002/cbic.201402012
-
(2014)
ChemBioChem
, vol.15
, pp. 946-949
-
-
Mulder, M.P.1
El Oualid, F.2
Ter Beek, J.3
Ovaa, H.4
-
40
-
-
77249098370
-
Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes
-
Lu, X., Olsen, S. K., Capili, A. D., Cisar, J. S., Lima, C. D., and Tan, D. S. (2010) Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes J. Am. Chem. Soc. 132, 1748-1749 10.1021/ja9088549
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 1748-1749
-
-
Lu, X.1
Olsen, S.K.2
Capili, A.D.3
Cisar, J.S.4
Lima, C.D.5
Tan, D.S.6
-
41
-
-
84887639752
-
Development of activity-based probes for ubiquitin and ubiquitin-like protein signaling pathways
-
An, H. and Statsyuk, A. V. (2013) Development of activity-based probes for ubiquitin and ubiquitin-like protein signaling pathways J. Am. Chem. Soc. 135, 16948-16962 10.1021/ja4099643
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 16948-16962
-
-
An, H.1
Statsyuk, A.V.2
-
42
-
-
84957573418
-
Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis
-
An, H. and Statsyuk, A. V. (2016) Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis Chem. Commun. (Cambridge, U. K.) 52, 2477-2480 10.1039/C5CC08592F
-
(2016)
Chem. Commun. (Cambridge, U. K.)
, vol.52
, pp. 2477-2480
-
-
An, H.1
Statsyuk, A.V.2
-
43
-
-
84959192267
-
Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation
-
Pao, K. C., Stanley, M., Han, C., Lai, Y. C., Murphy, P., Balk, K., Wood, N. T., Corti, O., Corvol, J. C., and Muqit, M. M. et al. 2016, Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation Nat. Chem. Biol. 10.1038/nchembio.2045
-
(2016)
Nat. Chem. Biol.
-
-
Pao, K.C.1
Stanley, M.2
Han, C.3
Lai, Y.C.4
Murphy, P.5
Balk, K.6
Wood, N.T.7
Corti, O.8
Corvol, J.C.9
Muqit, M.M.10
-
44
-
-
0034664080
-
Nonhydrolyzable diubiquitin analogues are inhibitors of ubiquitin conjugation and deconjugation
-
Yin, L., Krantz, B., Russell, N. S., Deshpande, S., and Wilkinson, K. D. (2000) Nonhydrolyzable diubiquitin analogues are inhibitors of ubiquitin conjugation and deconjugation Biochemistry 39, 10001-10010 10.1021/bi0007019
-
(2000)
Biochemistry
, vol.39
, pp. 10001-10010
-
-
Yin, L.1
Krantz, B.2
Russell, N.S.3
Deshpande, S.4
Wilkinson, K.D.5
-
45
-
-
84966320591
-
Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on alpha-Synuclein Aggregation and Toxicity
-
Lewis, Y. E., Abeywardana, T., Lin, Y. H., Galesic, A., and Pratt, M. R. (2016) Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on alpha-Synuclein Aggregation and Toxicity ACS Chem. Biol. 11, 931 10.1021/acschembio.5b01042
-
(2016)
ACS Chem. Biol.
, vol.11
, pp. 931
-
-
Lewis, Y.E.1
Abeywardana, T.2
Lin, Y.H.3
Galesic, A.4
Pratt, M.R.5
-
46
-
-
78649265501
-
Synthesis of defined ubiquitin dimers
-
Eger, S., Scheffner, M., Marx, A., and Rubini, M. (2010) Synthesis of defined ubiquitin dimers J. Am. Chem. Soc. 132, 16337-16339 10.1021/ja1072838
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 16337-16339
-
-
Eger, S.1
Scheffner, M.2
Marx, A.3
Rubini, M.4
-
47
-
-
77950671571
-
Generation of site-specific and enzymatically stable conjugates of recombinant proteins with ubiquitin-like modifiers by the Cu(I)-catalyzed azide-alkyne cycloaddition
-
Weikart, N. D. and Mootz, H. D. (2010) Generation of site-specific and enzymatically stable conjugates of recombinant proteins with ubiquitin-like modifiers by the Cu(I)-catalyzed azide-alkyne cycloaddition ChemBioChem 11, 774-777 10.1002/cbic.200900738
-
(2010)
ChemBioChem
, vol.11
, pp. 774-777
-
-
Weikart, N.D.1
Mootz, H.D.2
-
48
-
-
67649211954
-
Functional ubiquitin conjugates with lysine-epsilon-amino-specific linkage by thioether ligation of cysteinyl-ubiquitin peptide building blocks
-
Jung, J. E., Wollscheid, H. P., Marquardt, A., Manea, M., Scheffner, M., and Przybylski, M. (2009) Functional ubiquitin conjugates with lysine-epsilon-amino-specific linkage by thioether ligation of cysteinyl-ubiquitin peptide building blocks Bioconjugate Chem. 20, 1152-1162 10.1021/bc800539p
-
(2009)
Bioconjugate Chem.
, vol.20
, pp. 1152-1162
-
-
Jung, J.E.1
Wollscheid, H.P.2
Marquardt, A.3
Manea, M.4
Scheffner, M.5
Przybylski, M.6
-
49
-
-
77954285146
-
Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes
-
Shanmugham, A., Fish, A., Luna-Vargas, M. P., Faesen, A. C., El Oualid, F., Sixma, T. K., and Ovaa, H. (2010) Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes J. Am. Chem. Soc. 132, 8834-8835 10.1021/ja101803s
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 8834-8835
-
-
Shanmugham, A.1
Fish, A.2
Luna-Vargas, M.P.3
Faesen, A.C.4
El Oualid, F.5
Sixma, T.K.6
Ovaa, H.7
-
50
-
-
0024755696
-
Total chemical synthesis of ubiquitin using BOP reagent: Biochemical and immunochemical properties of the purified synthetic product
-
Briand, J. P., Van Dorsselaer, A., Raboy, B., and Muller, S. (1989) Total chemical synthesis of ubiquitin using BOP reagent: biochemical and immunochemical properties of the purified synthetic product Pept. Res. 2, 381-388
-
(1989)
Pept. Res.
, vol.2
, pp. 381-388
-
-
Briand, J.P.1
Van Dorsselaer, A.2
Raboy, B.3
Muller, S.4
-
51
-
-
0038421068
-
Solid phase peptide synthesis of ubiquitin
-
Ramage, R., Green, J., and Ogunjobi, O. M. (1989) Solid phase peptide synthesis of ubiquitin Tetrahedron Lett. 30, 2149-2152 10.1016/S0040-4039(01)93735-9
-
(1989)
Tetrahedron Lett.
, vol.30
, pp. 2149-2152
-
-
Ramage, R.1
Green, J.2
Ogunjobi, O.M.3
-
52
-
-
78650446183
-
Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin
-
El Oualid, F., Merkx, R., Ekkebus, R., Hameed, D. S., Smit, J. J., de Jong, A., Hilkmann, H., Sixma, T. K., and Ovaa, H. (2010) Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin Angew. Chem., Int. Ed. 49, 10149-10153 10.1002/anie.201005995
-
(2010)
Angew. Chem., Int. Ed.
, vol.49
, pp. 10149-10153
-
-
El Oualid, F.1
Merkx, R.2
Ekkebus, R.3
Hameed, D.S.4
Smit, J.J.5
De Jong, A.6
Hilkmann, H.7
Sixma, T.K.8
Ovaa, H.9
-
53
-
-
0027944205
-
Synthesis of proteins by native chemical ligation
-
Dawson, P. E., Muir, T. W., Clark-Lewis, I., and Kent, S. B. (1994) Synthesis of proteins by native chemical ligation Science 266, 776-779 10.1126/science.7973629
-
(1994)
Science
, vol.266
, pp. 776-779
-
-
Dawson, P.E.1
Muir, T.W.2
Clark-Lewis, I.3
Kent, S.B.4
-
54
-
-
78649575597
-
Total chemical synthesis of di-ubiquitin chains
-
Kumar, K. S., Spasser, L., Erlich, L. A., Bavikar, S. N., and Brik, A. (2010) Total chemical synthesis of di-ubiquitin chains Angew. Chem., Int. Ed. 49, 9126-9131 10.1002/anie.201003763
-
(2010)
Angew. Chem., Int. Ed.
, vol.49
, pp. 9126-9131
-
-
Kumar, K.S.1
Spasser, L.2
Erlich, L.A.3
Bavikar, S.N.4
Brik, A.5
-
55
-
-
84878225960
-
Non-enzymatic synthesis of ubiquitin chains: Where chemistry makes a difference
-
Hemantha, H. P. and Brik, A. (2013) Non-enzymatic synthesis of ubiquitin chains: where chemistry makes a difference Bioorg. Med. Chem. 21, 3411-3420 10.1016/j.bmc.2013.02.004
-
(2013)
Bioorg. Med. Chem.
, vol.21
, pp. 3411-3420
-
-
Hemantha, H.P.1
Brik, A.2
-
56
-
-
84959084059
-
Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins
-
Meledin, R., Mali, S. M., and Brik, A. (2016) Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins Chem. Rec. 16, 509-519 10.1002/tcr.201500209
-
(2016)
Chem. Rec.
, vol.16
, pp. 509-519
-
-
Meledin, R.1
Mali, S.M.2
Brik, A.3
-
57
-
-
84934954174
-
Peeling away the layers of ubiquitin signaling complexities with synthetic ubiquitin-protein conjugates
-
Pham, G. H. and Strieter, E. R. (2015) Peeling away the layers of ubiquitin signaling complexities with synthetic ubiquitin-protein conjugates Curr. Opin. Chem. Biol. 28, 57-65 10.1016/j.cbpa.2015.06.001
-
(2015)
Curr. Opin. Chem. Biol.
, vol.28
, pp. 57-65
-
-
Pham, G.H.1
Strieter, E.R.2
-
58
-
-
84555218153
-
The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
-
Faesen, A. C., Luna-Vargas, M. P., Geurink, P. P., Clerici, M., Merkx, R., van Dijk, W. J., Hameed, D. S., El Oualid, F., Ovaa, H., and Sixma, T. K. (2011) The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types Chem. Biol. 18, 1550-1561 10.1016/j.chembiol.2011.10.017
-
(2011)
Chem. Biol.
, vol.18
, pp. 1550-1561
-
-
Faesen, A.C.1
Luna-Vargas, M.P.2
Geurink, P.P.3
Clerici, M.4
Merkx, R.5
Van Dijk, W.J.6
Hameed, D.S.7
El Oualid, F.8
Ovaa, H.9
Sixma, T.K.10
-
59
-
-
84855465067
-
An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains
-
Licchesi, J. D., Mieszczanek, J., Mevissen, T. E., Rutherford, T. J., Akutsu, M., Virdee, S., El Oualid, F., Chin, J. W., Ovaa, H., and Bienz, M. et al. 2011, An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains Nat. Struct. Mol. Biol. 19, 62-71 10.1038/nsmb.2169
-
(2011)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 62-71
-
-
Licchesi, J.D.1
Mieszczanek, J.2
Mevissen, T.E.3
Rutherford, T.J.4
Akutsu, M.5
Virdee, S.6
El Oualid, F.7
Chin, J.W.8
Ovaa, H.9
Bienz, M.10
-
60
-
-
84907358982
-
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry
-
Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., and Gray, N. S. et al. 2014, Screening of DUB activity and specificity by MALDI-TOF mass spectrometry Nat. Commun. 5, 4763 10.1038/ncomms5763
-
(2014)
Nat. Commun.
, vol.5
, pp. 4763
-
-
Ritorto, M.S.1
Ewan, R.2
Perez-Oliva, A.B.3
Knebel, A.4
Buhrlage, S.J.5
Wightman, M.6
Kelly, S.M.7
Wood, N.T.8
Virdee, S.9
Gray, N.S.10
-
61
-
-
84942543892
-
Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation
-
Rosner, D., Schneider, T., Schneider, D., Scheffner, M., and Marx, A. (2015) Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation Nat. Protoc. 10, 1594-1611 10.1038/nprot.2015.106
-
(2015)
Nat. Protoc.
, vol.10
, pp. 1594-1611
-
-
Rosner, D.1
Schneider, T.2
Schneider, D.3
Scheffner, M.4
Marx, A.5
-
62
-
-
0023039206
-
Synthesis and characterization of ubiquitin ethyl ester, a new substrate for ubiquitin carboxyl-terminal hydrolase
-
Wilkinson, K. D., Cox, M. J., Mayer, A. N., and Frey, T. (1986) Synthesis and characterization of ubiquitin ethyl ester, a new substrate for ubiquitin carboxyl-terminal hydrolase Biochemistry 25, 6644-6649 10.1021/bi00369a047
-
(1986)
Biochemistry
, vol.25
, pp. 6644-6649
-
-
Wilkinson, K.D.1
Cox, M.J.2
Mayer, A.N.3
Frey, T.4
-
63
-
-
84910068147
-
Catching a DUB in the act: Novel ubiquitin-based active site directed probes
-
Ekkebus, R., Flierman, D., Geurink, P. P., and Ovaa, H. (2014) Catching a DUB in the act: novel ubiquitin-based active site directed probes Curr. Opin. Chem. Biol. 23, 63-70 10.1016/j.cbpa.2014.10.005
-
(2014)
Curr. Opin. Chem. Biol.
, vol.23
, pp. 63-70
-
-
Ekkebus, R.1
Flierman, D.2
Geurink, P.P.3
Ovaa, H.4
-
64
-
-
10744227299
-
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins
-
Hemelaar, J., Borodovsky, A., Kessler, B. M., Reverter, D., Cook, J., Kolli, N., Gan-Erdene, T., Wilkinson, K. D., Gill, G., and Lima, C. D. et al. 2004, Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins Mol. Cell. Biol. 24, 84-95 10.1128/MCB.24.1.84-95.2004
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 84-95
-
-
Hemelaar, J.1
Borodovsky, A.2
Kessler, B.M.3
Reverter, D.4
Cook, J.5
Kolli, N.6
Gan-Erdene, T.7
Wilkinson, K.D.8
Gill, G.9
Lima, C.D.10
-
65
-
-
84876105929
-
Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition
-
Sommer, S., Weikart, N. D., Linne, U., and Mootz, H. D. (2013) Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition Bioorg. Med. Chem. 21, 2511-2517 10.1016/j.bmc.2013.02.039
-
(2013)
Bioorg. Med. Chem.
, vol.21
, pp. 2511-2517
-
-
Sommer, S.1
Weikart, N.D.2
Linne, U.3
Mootz, H.D.4
-
66
-
-
84878832998
-
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
-
Mevissen, T. E., Hospenthal, M. K., Geurink, P. P., Elliott, P. R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., and El Oualid, F. et al. 2013, OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis Cell 154, 169-184 10.1016/j.cell.2013.05.046
-
(2013)
Cell
, vol.154
, pp. 169-184
-
-
Mevissen, T.E.1
Hospenthal, M.K.2
Geurink, P.P.3
Elliott, P.R.4
Akutsu, M.5
Arnaudo, N.6
Ekkebus, R.7
Kulathu, Y.8
Wauer, T.9
El Oualid, F.10
-
67
-
-
84873085753
-
A strategy for modulation of enzymes in the ubiquitin system
-
Ernst, A., Avvakumov, G., Tong, J., Fan, Y., Zhao, Y., Alberts, P., Persaud, A., Walker, J. R., Neculai, A. M., and Neculai, D. et al. 2013, A strategy for modulation of enzymes in the ubiquitin system Science 339, 590-595 10.1126/science.1230161
-
(2013)
Science
, vol.339
, pp. 590-595
-
-
Ernst, A.1
Avvakumov, G.2
Tong, J.3
Fan, Y.4
Zhao, Y.5
Alberts, P.6
Persaud, A.7
Walker, J.R.8
Neculai, A.M.9
Neculai, D.10
-
68
-
-
84871298878
-
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7
-
Zhang, Y., Zhou, L., Rouge, L., Phillips, A. H., Lam, C., Liu, P., Sandoval, W., Helgason, E., Murray, J. M., and Wertz, I. E. et al. 2013, Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7 Nat. Chem. Biol. 9, 51-58 10.1038/nchembio.1134
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 51-58
-
-
Zhang, Y.1
Zhou, L.2
Rouge, L.3
Phillips, A.H.4
Lam, C.5
Liu, P.6
Sandoval, W.7
Helgason, E.8
Murray, J.M.9
Wertz, I.E.10
-
69
-
-
84922235969
-
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
-
Wauer, T., Swatek, K. N., Wagstaff, J. L., Gladkova, C., Pruneda, J. N., Michel, M. A., Gersch, M., Johnson, C. M., Freund, S. M., and Komander, D. (2015) Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis EMBO J. 34, 307-325 10.15252/embj.201489847
-
(2015)
EMBO J.
, vol.34
, pp. 307-325
-
-
Wauer, T.1
Swatek, K.N.2
Wagstaff, J.L.3
Gladkova, C.4
Pruneda, J.N.5
Michel, M.A.6
Gersch, M.7
Johnson, C.M.8
Freund, S.M.9
Komander, D.10
|