Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 9, 2013, Pages 2511-2517

  Sommer, Stefanie ^a   Weikart, Nadine D ^a   Linne, Uwe ^b   Mootz, Henning D ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Catalytic triad; Cysteine peptidase; Electrophile; Posttranslational modification; Suicide inhibitor

Indexed keywords

ALKYNE; CYSTEINE PROTEINASE; SUMO PROTEIN; THIOL; UBIQUITIN PROTEIN LIGASE;

ADDITION REACTION; AMINOLYSIS; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CROSS REACTION; ELECTROPHILICITY; ESCHERICHIA COLI; MASS SPECTROMETRY; MOUSE; NONHUMAN; PLASMID; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PURIFICATION; REACTION TIME;

ALKYNES; ANIMALS; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; MICE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 84876105929     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.02.039     Document Type: Article

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