CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells

Molecular Autism

Volumn 8, Issue 1, 2017, Pages

  Wang, Ping ^a   Mokhtari, Ryan ^b   Pedrosa, Erika ^b   Kirschenbaum, Michael ^b   Bayrak, Can ^c   Zheng, Deyou ^a   Lachman, Herbert M ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b ERCIYES UNIVERSITY MEDICAL FACULTY   (Turkey)

^c ERCIYES UNIVERSITY   (Turkey)

Author keywords

Autism; Beta catenin; Bipolar disorder; Cancer; Distal less homeobox; DLX6 AS1; Gabaergic; HMGA2; Schizophrenia; TCF4; Wnt; ZNF132

Indexed keywords

BETA CATENIN; TRANSCRIPTOME; CHD8 PROTEIN, HUMAN; DNA BINDING PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; AUTISM; AXONAL GUIDANCE; BIOLOGICAL MODEL; BRAIN; BRAIN DEVELOPMENT; CELL STRUCTURE; CEREBRAL ORGANOID; CHD8 GENE; COMPARATIVE STUDY; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; DLX1 GENE; DLX6 AS1 GENE; FOREBRAIN; GABAERGIC SYSTEM; GENE; GENE EDITING; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE REGULATORY NETWORK; GENETIC ASSOCIATION; GENETIC VARIABILITY; HETEROZYGOSITY; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; INTRACELLULAR SIGNALING; MONOLAYER CULTURE; NERVE CELL CHARACTERISTICS AND FUNCTIONS; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; RNA SEQUENCE; TCF4 GENE; TELENCEPHALON; TRANSCRIPTIONAL NETWORK; TRANSCRIPTOMICS; UPREGULATION; WNT SIGNALING PATHWAY; BIPOLAR DISORDER; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; CYTOPLASM; GENE EXPRESSION PROFILING; GENETICS; MENTAL DISEASE; MUTATION; PROCEDURES; SCHIZOPHRENIA; SEQUENCE ANALYSIS;

AUTISM SPECTRUM DISORDER; BIPOLAR DISORDER; CELL DIFFERENTIATION; CELLS, CULTURED; CRISPR-CAS SYSTEMS; DNA-BINDING PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; GENE REGULATORY NETWORKS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MENTAL DISORDERS; MUTATION; ORGANOIDS; SCHIZOPHRENIA; SEQUENCE ANALYSIS, RNA; TELENCEPHALON; TRANSCRIPTION FACTORS;

EID: 85015368721     PISSN: None     EISSN: 20402392     Source Type: Journal    
DOI: 10.1186/s13229-017-0124-1     Document Type: Article

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