MEG3 noncoding RNA: A tumor suppressor

Journal of Molecular Endocrinology

Volumn 48, Issue 3, 2012, Pages

  Zhou, Yunli ^a   Zhang, Xun ^a   Klibanski, Anne ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATERNALLY EXPRESSED GENE 3 PROTEIN; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ANGIOGENESIS; APOPTOSIS; CELL PROLIFERATION; CHROMOSOME 12; CHROMOSOME 14Q; COLONY FORMATION; DNA METHYLATION; GENE DELETION; GENE EXPRESSION; GENE LOCUS; HUMAN; IN VIVO STUDY; NONFUNCTIONING PITUITARY ADENOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; TUMOR CELL;

ANIMALS; CELL PROLIFERATION; DNA METHYLATION; GENE DELETION; GENE EXPRESSION; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC; PITUITARY NEOPLASMS; RNA, UNTRANSLATED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84861156701     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-12-0008     Document Type: Review

References (54)

1. Alexander JM, Biller BM, Bikkal H, Zervas NT, Arnold A & Klibanski A 1990 Clinically nonfunctioning pituitary tumors are monoclonal in origin. Journal of Clinical Investigation 86 336-340. (doi:10.1172/JCI114705)
2. Astuti D, Latif F, Wagner K, Gentle D, Cooper WN, Catchpoole D, Grundy R, Ferguson-Smith AC & Maher ER 2005 Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour. British Journal of Cancer 92 1574-1580. (doi:10.1038/sj.bjc.6602478)
3. Bando T, Kato Y, Ihara Y, Yamagishi F, Tsukada K & Isobe M 1999 Loss of heterozygosity of 14q32 in colorectal carcinoma. Cancer Genetics and Cytogenetics 111 161-165. (doi:10.1016/S0165-4608(98)00242-8)
4. Biller BM, Alexander JM, Zervas NT, Hedley-Whyte ET, Arnold A & Klibanski A 1992 Clonal origins of adrenocorticotropin-secreting pituitary tissue in Cushing's disease. Journal of Clinical Endocrinology and Metabolism 75 1303-1309. (doi:10.1210/jc.75.5.1303)
5. Braconi C, Kogure T, Valeri N, Huang N, Nuovo G, Costinean S, Negrini M, Miotto E, Croce CM & Patel T 2011 MicroRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Oncogene 30 4750-4756. (doi:10.1038/onc.2011.193)
6. Brooks CL & Gu W 2011 P53 regulation by ubiquitin. FEBS Letters 585 2803-2809. (doi:10.1016/j.febslet.2011.05.022)
7. Chaidarun SS & Klibanski A 2002 Gonadotropinomas. Seminars in Reproductive Medicine 20 339-348. (doi:10.1055/s-2002-36708)
8. Cheunsuchon P, Zhou Y, Zhang X, Lee H, Chen W, Nakayama Y, Rice KA, Tessa Hedley-Whyte E, Swearingen B & Klibanski A 2011 Silencing of the imprinted DLK1-MEG3 locus in human clinically nonfunctioning pituitary adenomas. American Journal of Pathology 179 2120-2130. (doi:10.1016/j.ajpath.2011.07.002)
9. Clarke AR, Maandag ER, van Roon M, van der Lugt NM, van der Valk M, Hooper ML, Berns A & te Riele H 1992 Requirement for a functional Rb-1 gene in murine development. Nature 359 328-330. (doi:10.1038/359328a0)
10. Danila DC, Zhang X, Zhou Y, Dickersin GR, Fletcher JA, Hedley-Whyte ET, Selig MK, Johnson SR & Klibanski A 2000 A human pituitary tumorderived folliculostellate cell line. Journal of Clinical Endocrinology and Metabolism 85 1180-1187. (doi:10.1210/jc.85.3.1180)
11. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW & Vogelstein B 1993 WAF1, a potential mediator of p53 tumor suppression. Cell 75 817-825. (doi:10.1016/0092-8674(93)90500-P)
12. Folkman J 2002 Role of angiogenesis in tumor growth and metastasis. Seminars in Oncology 29 15-18. (doi:10.1053/sonc.2002.37263)
13. Gejman R, Batista DL, Zhong Y, Zhou Y, Zhang X, Swearingen B, Stratakis CA, Hedley-Whyte ET & Klibanski A 2008 Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas. Journal of Clinical Endocrinology and Metabolism 93 4119-4125. (doi:10.1210/jc.2007-2633)
14. Gibb EA, Brown CJ & Lam WL 2011 The functional role of long non-coding RNA in human carcinomas. Molecular Cancer 10 38. (doi:10.1186/1476-4598-10-38)
15. Gordon FE, Nutt CL, Cheunsuchon P, Nakayama Y, Provencher KA, Rice KA, Zhou Y, Zhang X & Klibanski A 2010 Increased expression of angiogenic genes in the brains of mouse meg3-null embryos. Endocrinology 151 2443-2452. (doi:10.1210/en.2009-1151)
16. Hakem R & Mak TW 2001 Animal models of tumor-suppressor genes. Annual Review of Genetics 35 209-241. (doi:10.1146/annurev.genet.35.102401.090432)
17. Harris SL & Levine AJ 2005 The p53 pathway: positive and negative feedback loops. Oncogene 24 2899-2908. (doi:10.1038/sj.onc.1208615)
18. Haupt Y, Maya R, Kazaz A & Oren M 1997 Mdm2 promotes the rapid degradation of p53. Nature 387 296-299. (doi:10.1038/387296a0)
19. Herman V, Fagin J, Gonsky R, Kovacs K & Melmed S 1990 Clonal origin of pituitary adenomas. Journal of Clinical Endocrinology andMetabolism 71 1427-1433. (doi:10.1210/jcem-71-6-1427)
20. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA & Weinberg RA 1992 Effects of an Rb mutation in the mouse. Nature 359 295-300. (doi:10.1038/359295a0)
21. Kagami M, O'Sullivan MJ, Green AJ, Watabe Y, Arisaka O, Masawa N, Matsuoka K, Fukami M, Matsubara K, Kato F et al. 2010 The IG-DMR and the MEG3-DMR at human chromosome 14q32.2: hierarchical interaction and distinct functional properties as imprinting control centers. PLoS Genetics 6 e1000992. (doi:10.1371/journal.pgen.1000992)
22. Kubbutat MH, Jones SN & Vousden KH 1997 Regulation of p53 stability by Mdm2. Nature 387 299-303. (doi:10.1038/387299a0)
23. Lin SP, Youngson N, Takada S, Seitz H, Reik W, Paulsen M, Cavaille J & Ferguson-Smith AC 2003 Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nature Genetics 35 97-102. (doi:10.1038/ng1233)
24. Lin SP, Coan P, da Rocha ST, Seitz H, Cavaille J, Teng PW, Takada S & Ferguson-Smith AC 2007 Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region. Development 134 417-426. (doi:10.1242/dev.02726)
25. Mathews DH, Sabina J, Zuker M & Turner DH 1999 Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. Journal of Molecular Biology 288 911-940. (doi:10.1006/jmbi.1999.2700)
26. Mayo LD & Donner DB 2002 The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends in Biochemical Sciences 27 462-467. (doi:10.1016/S0968-0004(02)02166-7)
27. Mezzomo LC, Gonzales PH, Pesce FG, Kretzmann Filho N, Ferreira NP, Oliveira MC & Kohek MB 2012 Expression of cell growth negative regulators MEG3 and GADD45gamma is lost in most sporadic human pituitary adenomas. Pituitary In press. (doi:10.1007/s11102-011-0340-1)
28. Miyoshi N, Wagatsuma H, Wakana S, Shiroishi T, Nomura M, Aisaka K, Kohda T, Surani MA, Kaneko-Ishino T & Ishino F 2000 Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. Genes to Cells: Devoted to Molecular & Cellular Mechanisms 5 211-220. (doi:10.1046/j.1365-2443.2000.00320.x)
29. Mutirangura A, Pornthanakasem W, Sriuranpong V, Supiyaphun P & Voravud N 1998 Loss of heterozygosity on chromosome 14 in nasopharyngeal carcinoma. International Journal of Cancer 78 153-156. (doi:10.1002/(SICI)1097-0215(19981005)78:2!153::AID-IJC5O3.0.CO;2-Y)
30. Olivier M, Hollstein M & Hainaut P 2010 TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harbor Perspectives in Biology 2 a001008. (doi:10.1101/cshperspect.a001008)
31. Ouchi T, Monteiro AN, August A, Aaronson SA & Hanafusa H 1998 BRCA1 regulates p53-dependent gene expression. PNAS 95 2302-2306. (doi:10.1073/pnas.95.5.2302)
32. Paulsen M, Takada S, Youngson NA, Benchaib M, Charlier C, Segers K, Georges M & Ferguson-Smith AC 2001 Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region. Genome Research 11 2085-2094. (doi:10.1101/gr.206901)
33. da Rocha ST, Edwards CA, Ito M, Ogata T & Ferguson-Smith AC 2008 Genomic imprinting at the mammalian Dlk1-Dio3 domain. Trends in Genetics 24 306-316. (doi:10.1016/j.tig.2008.03.011)
34. Schuster-Gossler K, Bilinski P, Sado T, Ferguson-Smith A & Gossler A 1998 The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA. Developmental Dynamics 212 214-228. (doi:10.1002/(SICI)1097-0177(199806)212:2!214::AIDAJA6O3.0.CO;2-K)
35. Sherr CJ & Weber JD 2000 The ARF/p53 pathway. Current Opinion in Genetics & Development 10 94-99. (doi:10.1016/S0959-437X(99)00038-6)
36. Smas CM & Sul HS 1993 Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 73 725-734. (doi:10.1016/0092-8674(93)90252-L)
37. Soussi T 2011 TP53 mutations in human cancer: database reassessment and prospects for the next decade. Advances in Cancer Research 110 107-139. (doi:10.1016/B978-0-12-386469-7.00005-0)
38. Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W et al. 1998 High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Current Biology 8 1169-1178. (doi:10.1016/S0960-9822(07)00488-5)
39. Takada S, Paulsen M, Tevendale M, Tsai CE, Kelsey G, Cattanach BM & Ferguson-Smith AC 2002 Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19. Human Molecular Genetics 11 77-86. (doi:10.1093/hmg/11.1.77)
40. Takahashi N, Okamoto A, Kobayashi R, Shirai M, Obata Y, Ogawa H, Sotomaru Y & Kono T 2009 Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice. Human Molecular Genetics 18 1879-1888. (doi:10.1093/hmg/ddp108)
41. Veikkola T & Alitalo K 1999 VEGFs, receptors and angiogenesis. Seminars in Cancer Biology 9 211-220. (doi:10.1006/scbi.1998.0091)
42. Vousden KH & Prives C 2009 Blinded by the light: the growing complexity of p53. Cell 137 413-431. (doi:10.1016/j.cell.2009.04.037)
43. Wang PJ, Ren ZQ & Sun PY 2012 Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation. Journal of Cellular Biochemistry In press. (doi:10.1002/jcb.24055)
44. Weinberg RA 1991 Tumor suppressor genes. Science 254 1138-1146. (doi:10.1126/science.1659741)
45. Weinberg R 1993 Tumor suppressor genes. Neuron 11 191-196. (doi:10.1016/0896-6273(93)90177-S)
46. Zhang X, Sun H, Danila DC, Johnson SR, Zhou Y, Swearingen B & Klibanski A 2002 Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis. Journal of Clinical Endocrinology and Metabolism 87 1262-1267. (doi:10.1210/jc.87.3.1262)
47. Zhang X, Zhou Y, Mehta KR, Danila DC, Scolavino S, Johnson SR & Klibanski A 2003 A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. Journal of Clinical Endocrinology and Metabolism 88 5119-5126. (doi:10.1210/jc.2003-030222)
48. Zhang X, Gejman R, Mahta A, Zhong Y, Rice KA, Zhou Y, Cheunsuchon P, Louis DN & Klibanski A 2010a Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. Cancer Research 70 2350-2358. (doi:10.1158/0008-5472.CAN-09-3885)
49. Zhang X, Rice K, Wang Y, Chen W, Zhong Y, Nakayama Y, Zhou Y & Klibanski A 2010b Maternally expressed gene 3 (MEG3) noncoding ribonucleic acid: isoform structure, expression, and functions. Endocrinology 151 939-947. (doi:10.1210/en.2009-0657)
50. Zhao J, Dahle D, Zhou Y, Zhang X & Klibanski A 2005 Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. Journal of Clinical Endocrinology and Metabolism 90 2179-2186. (doi:10.1210/jc.2004-1848)
51. Zhao J, Zhang X, Zhou Y, Ansell PJ & Klibanski A 2006 Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP-response element (CRE) in the MEG3 proximal promoter region. International Journal of Biochemistry & Cell Biology 38 1808-1820. (doi:10.1016/j.biocel.2006.05.004)
52. Zhou Y, Zhong Y, Wang Y, Zhang X, Batista DL, Gejman R, Ansell PJ, Zhao J, Weng C & Klibanski A 2007 Activation of p53 by MEG3 non-coding RNA. Journal of Biological Chemistry 282 24731-24742. (doi:10.1074/jbc.M702029200)
53. Zhou Y, Cheunsuchon P, Nakayama Y, Lawlor MW, Zhong Y, Rice KA, Zhang L, Zhang X, Gordon FE, Lidov HG et al. 2010 Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. Development 137 2643-2652. (doi:10.1242/dev.045724)
54. Zuker M 2003 Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Research 31 3406-3415. (doi:10.1093/nar/gkg595)