Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators

Gastroenterology

Volumn 146, Issue 2, 2014, Pages

  Tahara, Tomomitsu ^a   Yamamoto, Eiichiro ^b   Madireddi, Priyanka ^a   Suzuki, Hiromu ^b   Maruyama, Reo ^b   Chung, Woonbok ^a   Garriga, Judith ^a   Jelinek, Jaroslav ^a   Yamano, Hiro O ^c   Sugai, Tamotsu ^d   Kondo, Yutaka ^e   Toyota, Minoru ^b   Issa, Jean Pierre J ^a   Estécio, Marcos R H ^f  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

^c AKITA RED CROSS HOSPITAL   (Japan)

^d IWATE MEDICAL UNIVERSITY   (Japan)

^e AICHI CANCER CENTER HOSPITAL   (Japan)

^f UNIVERSITY OF TEXAS   (United States)

Author keywords

Colon Cancer; Gene Silencing; Hypermethylation; Microsatellite Instability

Indexed keywords

ADENOSINE TRIPHOSPHATE; CPG ISLAND METHYLATOR PHENOTYPE 1; GENOMIC DNA; HELICASE; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER TISSUE; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; COHORT ANALYSIS; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; CPG ISLAND; FEMALE; GENE SEGREGATION; GENETIC RISK; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; MALE; MIDDLE AGED; PREVALENCE; PRIMARY TUMOR; PRIORITY JOURNAL; SOMATIC MUTATION; SYNDROME CHARGE; VERY ELDERLY;

CIMP; COLON CANCER; COLORECTAL CARCINOMA; CPG ISLAND METHYLATOR PHENOTYPE; CRC; GENE SILENCING; HYPERMETHYLATION; MICROSATELLITE INSTABILITY; SINGLE-NUCLEOTIDE POLYMORPHISM; SNP; TCGA; THE CANCER GENOME ATLAS;

ADENOMA; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CHROMATIN; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA HELICASES; DNA METHYLATION; DNA-BINDING PROTEINS; EXOME; FEMALE; GENE SILENCING; GENETIC MARKERS; HUMANS; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTATION; PHENOTYPE; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS;

EID: 84892735426     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.10.060     Document Type: Article

References (30)

1. A.K. Rustgi The genetics of hereditary colon cancer Genes Dev 21 2007 2525 2538
2. A. Walther, E. Johnstone, and C. Swanton et al. Genetic prognostic and predictive markers in colorectal cancer Nat Rev Cancer 9 2009 489 499
3. M. Toyota, M. Ohe-Toyota, and N. Ahuja et al. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype Proc Natl Acad Sci U S A 97 2000 710 715
4. M.R. Estecio, P.S. Yan, and A.E. Ibrahim et al. High-throughput methylation profiling by MCA coupled to CpG island microarray Genome Res 17 2007 1529 1536
5. D.J. Weisenberger, K.D. Siegmund, and M. Campan et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer Nat Genet 38 2006 787 793
6. L. Shen, M. Toyota, and Y. Kondo et al. Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer Proc Natl Acad Sci U S A 104 2007 18654 18659
7. B. Leggett, and V. Whitehall Role of the serrated pathway in colorectal cancer pathogenesis Gastroenterology 138 2010 2088 2100
8. S. Ogino, K. Nosho, and G.J. Kirkner et al. CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer Gut 58 2009 90 96
9. R. Jover, T.P. Nguyen, and L. Perez-Carbonell et al. 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer Gastroenterology 140 2011 1174 1181
10. T. Kimura, E. Yamamoto, and H.O. Yamano et al. A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma Am J Gastroenterol 107 2012 460 469
11. T. Sugai, W. Habano, and N. Uesugi et al. Three independent genetic profiles based on mucin expression in early differentiated-type gastric cancers - a new concept of genetic carcinogenesis of early differentiated-type adenocarcinomas Mod Pathol 17 2004 1223 1234
12. S.R. Lalani, A.M. Safiullah, and S.D. Fernbach et al. Spectrum of CHD7 mutations in 110 individuals with CHARGE syndrome and genotype-phenotype correlation Am J Hum Genet 78 2006 303 314
13. T. Sjoblom, S. Jones, L.D. Wood, and D.W. Parsons et al. The consensus coding sequences of human breast and colorectal cancers Science 314 2006 268 274
14. A.J. Bass, M.S. Lawrence, and L.E. Brace et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion Nat Genet 43 2011 964 968
15. The Cancer Genome Atlas Research Network Comprehensive molecular characterization of human colon and rectal cancer Nature 487 2012 330 337
16. N. Janssen, J.E. Bergman, and M.A. Swertz et al. Mutation update on the CHD7 gene involved in CHARGE syndrome Hum Mutat 33 2012 1149 1160
17. E. Engelen, U. Akinci, and J.C. Bryne et al. Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes Nat Genet 43 2011 607 611
18. T. Hinoue, D.J. Weisenberger, and C.P. Lange et al. Genome-scale analysis of aberrant DNA methylation in colorectal cancer Genome Res 22 2012 271 282
19. M.P. Schnetz, L. Handoko, and B. Akhtar-Zaidi et al. CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression PLoS Genet 6 2010 e1001023
20. S. Jones, T.L. Wang, and M. Shih Ie et al. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma Science 330 2010 228 231
21. G. van Haaften, G.L. Dalgliesh, and H. Davies et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer Nat Genet 41 2009 521 523
22. B.G. Wilson, and C.W. Roberts SWI/SNF nucleosome remodellers and cancer Nat Rev Cancer 11 2011 481 492
23. R. Bajpai, D.A. Chen, and A. Rada-Iglesias et al. CHD7 cooperates with PBAF to control multipotent neural crest formation Nature 463 2010 958 962
24. S. Srinivasan, K.M. Dorighi, and J.W. Tamkun Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II PLoS Genet 4 2008 e1000217
25. S. Huang, X. Li, and T.M. Yusufzai et al. USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier Mol Cell Biol 27 2007 7991 8002
26. K. Ishihara, M. Oshimura, and M. Nakao CTCF-dependent chromatin insulator is linked to epigenetic remodeling Mol Cell 23 2006 733 742
27. M.S. Kim, N.G. Chung, and M.R. Kang et al. Genetic and expressional alterations of CHD genes in gastric and colorectal cancers Histopathology 58 2011 660 668
28. E.D. Pleasance, P.J. Stephens, and S. O'Meara et al. A small-cell lung cancer genome with complex signatures of tobacco exposure Nature 463 2010 184 190
29. A. Bagchi, and A.A. Mills The quest for the 1p36 tumor suppressor Cancer Res 68 2008 2551 2556
30. A. Bagchi, C. Papazoglu, and Y. Wu et al. CHD5 is a tumor suppressor at human 1p36 Cell 128 2007 459 475