The anti-inflammatory activity of licorice, a widely used chinese herb

Pharmaceutical Biology

Volumn 55, Issue 1, 2017, Pages 5-18

  Yang, Rui ^a   Yuan, Bo Chuan ^a   Ma, Yong Sheng ^a   Zhou, Shan ^a   Liu, Ying ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Flavonoid; Glycyrrhetinic acid; Glycyrrhiza glabra L.; Glycyrrhiza inflata bat.; Glycyrrhiza uralensis fisch.; Glycyrrhizin

Indexed keywords

18ALPHA GLYCYRRHIZIN; 18BETA GLYCYRRHIZIN; DEHYDROGLYASPERIN C; DEHYDROGLYASPERIN D; ECHINATIN; FLAVONOID; FREE RADICAL; GLABRIDIN; GLYCYRRHETINIC ACID; GLYCYRRHIZA EXTRACT; GLYCYRRHIZA GLABRA EXTRACT; GLYCYRRHIZA URALENSIS EXTRACT; ISOANGUSTONE A; ISOLIQUIRITIGENIN; LICOCHALCONE A; LICOCHALCONE B; LICOCHALCONE C; LICOCHALCONE D; LICOCHALCONE E; LICORICIDIN; LICORISOFLAVAN A; MATRIX METALLOPROTEINASE; PROSTAGLANDIN E2; TRITERPENE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; AUTACOID; PLANT EXTRACT;

ACUTE LUNG INJURY; ANTIINFLAMMATORY ACTIVITY; ASTHMA; BRAIN ISCHEMIA; DEXTRAN SULFATE SODIUM-INDUCED COLITIS; DIET INDUCED OBESITY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; EAR EDEMA; GLYCYRRHIZA; HUMAN; HYPERCHOLESTEROLEMIA; INSULIN RESISTANCE; LUNG INJURY; MASTITIS; MOUTH ULCER; NONHUMAN; PAW EDEMA; REVIEW; SKIN ALLERGY; STOMACH ULCER; SYSTEMATIC REVIEW; ULCERATIVE COLITIS; ANIMAL; INFLAMMATION; ISOLATION AND PURIFICATION; MAXIMUM TOLERATED DOSE; MEDICINAL PLANT; METABOLISM; PHYTOTHERAPY; RISK ASSESSMENT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MAXIMUM TOLERATED DOSE; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; RISK ASSESSMENT;

EID: 85015348355     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880209.2016.1225775     Document Type: Review

References (93)

1. Abe K, Ikeda T, Wake K, Sato T, Sato T, Inoue H. 2008. Glycyrrhizin prevents of lipopolysaccharide/d-galactosamine-induced liver injury through down-regulation of matrix metalloproteinase-9 in mice. J Pharm Pharmacol. 60:91-97.
2. Ahn SJ, Cho EJ, Kim HJ, Park SN, Lim YK, Kook JK. 2012. The antimicrobial effects of deglycyrrhizinated licorice root extract on Streptococcus mutans UA159 in both planktonic and biofilm cultures. Anaerobe. 18:590-596.
3. Bhattacharjee S, Bhattacharjee A, Majumder S, Majumdar SB, Majumdar S. 2012. Glycyrrhizic acid suppresses Cox-2-mediated anti-inflammatory responses during Leishmania donovani infection. J Antimicrob Chemother. 67:1905-1914.
4. Bi X, Gong M, Di L. 2014. Review on prescription compatibility of shaoyaogancao decoction and reflection on pharmacokinetic compatibility mechanism of traditional Chinese medicine prescription based on in vivo drug interaction of main efficacious compounds. Evid Based Complement Alternat Med. 2014:208129.
5. Carrasco-Pozo C, Castillo RL, Beltrán C, Miranda A, Fuentes J, Gotteland M. 2016. Molecular mechanisms of gastrointestinal protection by quercetin against indomethacin-induced damage: role of NF-κB and Nrf2. J Nutr Biochem. 27:289-298.
6. Chandrasekaran CV, Deepak HB, Thiyagarajan P, Kathiresan S, Sangli GK, Deepak M, Agarwal A. 2011. Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products. Phytomedicine. 18:278-284.
7. Cheel J, Tůmová L, Areche C, Antwerpen PV, Neve J, Zouaoui-boudjeltia K, Martin AS, Vokral I, Wsol V, Neugebauerova J. 2013. Variations in the chemical profile and biological activities of licorice (Glycyrrhiza glabra L.), as influenced by harvest times. Acta Physiol Plant. 35:1337-1349.
8. Cho HJ, Lim SS, Lee YS, Kim JS, Lee CH, Kwon DY, Park JHY. 2010. Hexane/ethanol extract of Glycyrrhiza uralensis licorice exerts potent anti-inflammatory effects in murine macrophages and in mouse skin. Food Chem. 121:959-966.
9. Cho YC, Lee SH, Yoon G, Kim HS, Na JY, Choi HJ, Cho CW, Cheon SH, Kang BY. 2010. Licochalcone E reduces chronic allergic contact dermatitis and inhibits IL-12p40 production through down-regulation of NF-kappa B. Int Immunopharmacol. 10:1119-1126.
10. Chu X, Jiang L, Wei M, Yang X, Guan M, Xie X, Wei J, Liu D, Wang D. 2013. Attenuation of allergic airway inflammation in a murine model of asthma by licochalcone A. Immunopharmacol Immunotoxicol. 35:653-661.
11. Cui Y, Ao M, Li W, Hu J, Yu L. 2008. Anti-inflammatory activity of licochalcone A isolated from Glycyrrhiza inflata. Z Naturforsch C J Biosci. 63:361-365.
12. Farhad SZ, Aminzadeh A, Mafi M, Barekatain M, Naghney M, Ghafari MR. 2013. The effect of adjunctive low-dose doxycycline and licorice therapy on gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis. Dent Res J. 10:624-629.
13. Feng YC, Wang KC, Chiang LC, Shieh DE, Yen MH, San CJ. 2013. Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. J Ethnopharmacol. 148:466-473.
14. Ferreira SH. 1972. Prostaglandins, aspirin-like drugs and analgesia. Nature New Biol. 240:200-203.
15. Fernández-Moriano C, Gómez-Serranillos MP, Crespo A. 2016. Antioxidant potential of lichen species and their secondary metabolites. A systematic review. Pharm Biol. 54:1-17.
16. Forslund T, Fyhrquist F, Frøseth B, Tikkanen I. 1989. Effects of licorice on plasma atrial natriuretic peptide in healthy volunteers. J Intern Med. 225:95-99.
17. Fu Y, Chen J, Li YJ, Zheng YF, Li P. 2013. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice. Food Chem. 141:1063-1071.
18. Fu Y, Zhou E, Wei Z, Liang D, Wang W, Wang T, Guo M, Zhang N, Yang Z. 2014. Glycyrrhizin inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model. FEBS J. 281:2543-2557.
19. Fullerton JN, Gilroy DW. 2016. Resolution of inflammation: a new therapeutic frontier. Nat Rev Drug Discov. 15:551-567.
20. Funakoshi-Tago M, Nakamura K, Tsuruya R, Hatanaka M, Mashino T, Sonoda Y, Kasahara T. 2010. The fixed structure of licochalcone A by alpha, beta-unsaturated ketone is necessary for anti-inflammatory activity through the inhibition of NF-kappaB activation. Int Immunopharmacol. 10:562-571.
21. Funakoshi-Tago M, Tanabe S, Tago K, Itoh H, Mashino T, Sonoda Y, Kasahara T. 2009. Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation. Mol Pharmacol. 76:745-753.
22. Funk CD. 2001. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science. 294:1871-1875.
23. Furusawa J, Funakoshi-Tago M, Mashino T, Tago K, Inoue H, Sonoda Y, Kasahara T. 2009. Glycyrrhiza inflata-derived chalcones, licochalcone A, licochalcone B and licochalcone D, inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Int Immuno Pharmacol. 9:499-507.
24. Furusawa J, Funakoshi-Tago M, Tago K, Mashino T, Inoue H, Sonoda Y, Kasahara T. 2009. Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276. Cell Signal. 21:778-785.
25. Guo J, Shang E, Zhao J, Fan X, Duan J, Qian D, Tao W, Tang Y. 2014. Data mining and frequency analysis for licorice as a “on Chinese Formulae Database” herb in Chinese Formulae based on Chinese Formulae. Phytomedicine. 21:1281-1286.
26. Haraguchi H, Ishikawa H, Mizutani K, Tamura Y, Kinoshita T. 1998. Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata. Bioorg Med Chem. 6:339-347.
27. Harahap IS, Sasaki N, Gunadi Yusoff S, Lee MJ, Morikawa S, Nishimura N, Sasaki T, Usuki S, Hirai M, et al. 2011. Herbal medicine containing licorice may be contraindicated for a patient with an HSD11B2 mutation. Evid Based Complement Alternat Med. doi: 10.1093/ecam/nep211.
28. Haworth C, Brennan FM, Chantry D, Turner M, Maini RN, Feldmann M. 1991. Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha. Eur J Immunol. 21:2575-2579.
29. Hong YK, Wu HT, Ma T, Liu WJ, He XJ. 2009. Effects of Glycyrrhiza glabra polysaccharides on immune and antioxidant activities in high-fat mice. Int J Biol Macromol. 45:61-64.
30. Honda H, Nagai Y, Matsunaga T, Okamoto N, Watanabe Y, Tsuneyama K, Hayashi H, Fujii I, Ikutani M, Hirai Y, et al. 2014. Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. J Leukoc Biol. 96:1087-1100.
31. Huang X, Qin J, Lu S. 2014. Magnesium isoglycyrrhizinate protects hepatic L02 cells from ischemia/reperfusion induced injury. Int J Clin Exp Pathol. 7:4755-4764.
32. Huo HZ, Wang B, Liang YK, Bao YY, Gu Y. 2011. Hepatoprotective and antioxidant effects of licorice extract against CCl4-induced oxidative damage in rats. Int J Mol Sci. 12:6529-6543.
33. Ishida T, Miki I, Tanahashi T, Yagi S, Kondo Y, Inoue J, Kawauchi S, Nishiumia S, Yoshida M, Maeda H, et al. 2013. Effect of 18β-glycyrrhetinic acid and hydroxypropyl γcyclodextrin complex on indomethacin-induced small intestinal injury in mice. Eur J Pharmacol. 714:125-131.
34. Jayaraman A, Lent-Schochet D, Pike CJ. 2014. Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function. J Neuroinflammation. 11:162
35. Jeong SJ, Lim HS, Seo CS, Kim JH, Jin SE, Yoo SR, Shin HK. 2015. Traditional herbal formula Jakyakgamcho-tang (Paeonia lactiflora and Glycyrrhiza uralensis) impairs inflammatory chemokine production by inhibiting activation of STAT1 and NF-κB in HaCa T cells. Phytomedicine. 22:326-332.
36. Kageyama K, Takayasu S, Moriyama T, Sakihara S, Suda T. 2004. A case of pseudoaldosteronism, accompanied with hypocalcemia and exaggerated ACTH response. Endocr J. 51:83-87.
37. Kang SW, Choi JS, Choi YJ, Bae JY, Li J, Kim DS, Kim JL, Shin SY, Lee YJ, Kwun IS, et al. 2010. Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases. J Nutr Biochem. 21:55-65.
38. Karthikeyan C, Moorthy NS, Ramasamy S, Vanam U, Manivannan E, Karunagaran D, Trivedi P. 2015. Advances in chalcones with anticancer activities. Recent Pat Anticancer Drug Discov. 10:97-115.
39. Kim HJ, Lim SS, Park IS, Lim JS, Seo JY, Kim JS. 2012a. Neuroprotective effects of dehydroglyasperin C through activation of heme oxygenase-1 in mouse hippocampal cells. J Agric Food Chem. 60:5583-5589.
40. Kim HJ, Seo JY, Suh HJ, Lim SS, Kim JS. 2012b. Antioxidant activities of licorice-derived prenylflavonoids. Nutr Res Pract. 6:491-498.
41. Kim J, Kim J, Shim J, Lee S, Kim J, Lim SS, Lee KW, Lee HJ. 2013. Licorice-derived dehydroglyasperin C increases MKP-1 expression and suppresses inflammation-mediated neurodegeneration. Neurochem Int. 63:732-740.
42. Kim SJ, Jun JG. 2013. First total synthesis of highly anti-inflammatory active licochalcone D through water-accelerated [3, 3]-sigmatropicre arrangement. Bull Korean Chem Soc. 34:54-58.
43. Kim SW, Jin Y, Shin JH, Kim ID, Lee HK, Park S, Han PL, Lee JK. 2012. Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion. Neurobiol Dis. 46:147-156.
44. Kwon HJ, Kim HH, Ryu YB, Kim JH, Jeong HJ, Lee SW, Chang JS, Cho KO, Rho MC, Park SJ, et al. 2010. In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. Bioorg Med Chem. 18:7668-7674.
45. Kwon HS, Oh SM, Kim JK. 2008. Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis. Clin Exp Immunol. 151:165-173.
46. La VD, Tanabe S, Bergeron C, Gafner S, Grenier D. 2011. Modulation of matrix metalloproteinase and cytokine production by licorice isolates licoricidin and licorisoflavan A: potential therapeutic approach for periodontitis. J Periodontol. 82:122-128.
47. Lee HN, Cho HJ, Lim DY, Kang YH, Lee KW, Park JHY. 2013. Mechanisms by which licochalcone E exhibits potent anti-inflammatory properties: studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages. Int J Mol Sci. 14:10926-10943.
48. Li J, Lee YS, Choi JS, Sung HY, Kim JK, Lim SS, Kang YH. 2010. Roasted licorice extracts dampen high glucose-induced mesangial hyperplasia and matrix deposition through blocking Akt activation and TGF-beta signaling. Phytomedicine. 17:800-810.
49. Li S, Zhu JH, Cao LP, Sun Q, Liu HD, Li WD, Li JS, Hang CH. 2014. Growth inhibitory in vitro effects of glycyrrhizic acid in U251 glioblastoma cell line. Neurol Sci. 35:1115-1120.
50. Li XB, He XJ, Liu B, Xu L, Lu C, Zhao HY, Niu XY, Chen SL, Lu AP. 2012. Maturation of murine bone marrow-derived dendritic cells induced by Radix Glycyrrhizae polysaccharide. Molecules. 17:6557-6568.
51. Li YJ, Chen J, Li Y, Li Q, Zheng YF, Fu Y, Li P. 2011. Screening and characterization of natural antioxidants in four Glycyrrhiza species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. J Chromatogr A. 1218:8181-8191.
52. Liu H, Wang J, Zhou W, Wang Y, Yang L. 2013. Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licorice. J Ethnopharmacol. 146:773-793.
53. Liu HL, Peng NH, Chen LW, Shu CC, Hwu YJ. 2011. Effectiveness of licorice on aphthous ulcers in children: a systematic review. JBI Database Syst Rev Implement Rep. 9:S198-S214.
54. Liu J, Peter K, Shi D, Zhang L, Dong G, Zhang D, Breiteneder H, Bauer R, Jakowitsch J, Ma Y. 2014. Anti-inflammatory effects of the Chinese herbal formula sini tang in myocardial infarction rats. Evid Based Complement Alternat Med. 2014:309378.
55. Long DR, Mead J, Hendricks JM, Hardy ME, Voyich JM. 2013. 18β-Glycyrrhetinic acid inhibits methicillin-resistant Staphylococcus aureus survival and attenuates virulence gene expression. Antimicrob Agents Chemother.57:241-247.
56. Luo L, Jin Y, Kim ID, Lee JK. 2013. Glycyrrhizin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. Exp Neurobiol. 22:107-115.
57. Ma X, Lian QQ, Dong Q, Ge RS. 2011. Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2. Toxicology. 285:83-89.
58. Mae T, Kishida H, Nishiyama T, Tsukagawa M, Konishi E, Kuroda M, Mimaki Y, Sashida Y, Takahashi K, Kawada T, et al. 2003. A licorice ethanolic extract with peroxisome proliferators activated receptor gamma ligand binding activity affects diabetes in KKAy mice, abdominal obesity in diet induced obese C57BL mice and hypertension in spontaneously hypertensive rats. J Nutr. 133:3369-3377.
59. Matsuzaki K, Murata M, Yoshida K, Sekimoto G, Uemura Y, Sakaida N, Kaibori M, Kamiyama Y, Nishizawa M, Fujisawa J, et al. 2007. Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma. Hepatology. 46:48-57.
60. Michel HE, Tadros MG, Abdel-Naim AB, Khalifa AE. 2013. Prepulse inhibition (PPI) disrupting effects of Glycyrrhiza glabra extract in mice: a possible role of monoamines. Neurosci Lett. 544:110-114.
61. Nagy G, Clark JM, Buzas E, Gorman C, Pasztoi M, Koncz A, Falus A, Cope AP. 2008. Nitric oxide production of T lymphocytes is increased in rheumatoid arthritis. Immunol Lett. 118:55-58.
62. Ni YF, Kuai JK, Lu ZF, Yang GD, Fu HY, Wang J, Tian F, Yan XL, Zhao YC, Wang YJ, et al. 2011. Glycyrrhizin treatment is associated with attenuation of lipopolysaccharide-induced acute lung injury by inhibiting cyclooxygenase-2 and inducible nitric oxide synthase expression. J Surg Res. 165:e29-e35.
63. Oztanir MN, Ciftci O, Cetin A, Durak MA, Basak N, Akyuva Y. 2014. The beneficial effects of 18β-glycyrrhetinic acid following oxidative and neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model. Neurol Sci. 35:1221-1228.
64. Parikh A, Scadding GK. 2014. Topical nasal lysine aspirin in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis with nasal polyposis. Expert Rev Clin Immunol. 10:657-665.
65. Poli G. 2000. Pathogenesis of liver fibrosis: role of oxidative stress. Mol Aspects Med. 21:49-98.
66. Raikkonen K, Seckl JR, Heinonen K, Pyhala R, Feldt K, Jones A, Pesonen AK, Phillips DI, Lahti J, Javenpaa AL, et al. 2010. Maternal prenatal licorice consumption alters hypothalamic-pituitary-adrenocortical axis function in children. Psychoneuroendocrinology. 35:1587-1593.
67. Ruiz-Granados ES, Shouls G, Sainsbury C, Antonios T. 2012. A salty cause of severe hypertension. BMJ Case Rep. doi: 10.1136/bcr.12.2011.5336.
68. Samadnejad AZ, Mehrvarz S, Naeini SA, Tanideh N. 2012. Healing effect of licorice extract in acetic acid-induced ulcerative colitis in rat. Res PharmSci. 7:S837-S845.
69. Seki H, Sawai S, Ohyama K, Mizutani M, Ohnishi T, Sudo H, Fukushima EO, Akashi T, Aoki T, Saito K, et al. 2011. Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. Plant Cell Online. 23:4112-4123.
70. Sharifzadeh M, Shamsa F, Shiran S, Karimfar MH, Miri AH, Jalalizadeh H, Gholizadeh S, Salar F, Tabrizian K. 2008. A time course analysis of systemic administration of aqueous licorice extract on spatial memory retention in rats. Planta Med. 74:485-490.
71. Sorsa T, Tjäderhane L, Konttinen YT, Lauhio A, Salo T, Lee HM, Golub LM, Brown DL, Mäntylä P. 2006. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med. 38:306-321.
72. Sostres C, Gargallo CJ, Arroyo MT, Lanas A. 2010. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, and coxibs) on upper gastrointestinal tract. Best Pract Res Cl Ga. 24:121-132.
73. Suzuki M, Tetsuka T, Yoshida S, Watanabe N, Kobayashi M, Matsui N, Okamoto T. 2000. The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha- or IL-1beta-stimulated rheumatoid synovial fibroblasts. FEBS Lett. 465:23-27.
74. Takhshid MA, Mehrabani D, Ai J. 2012. The healing effect of licorice extract in acetic acid-induced ulcerative colitis in rat model. Comp Clin Pathol. 21:1139-1144.
75. Tanifuji S, Aizu-Yokota E, Funakoshi-Tago M, Sonoda Y, Inoue H, Kasahara T. 2010. Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells. Int Immunopharmacol. 10:769-776.
76. Thiyagarajan P, Chandrasekaran CV, Deepak HB, Agarwal A. 2011. Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. Inflammopharmacology. 19:235-241.
77. Wananukul S, Chatproedprai S, Chunharas A, Limpongsanuruk W, Singalavanija S, Nitiyarom R, Wisuthsarewong W. 2013. Randomized, double-blind, split-side, comparison study of moisturizer containing licochalcone A and 1% hydrocortisone in the treatment of childhood atopic dermatitis. J Med Assoc Thailand. 96:1135-1142.
78. Wang CY, Kao TC, Lo WH, Yen GC. 2011. Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. J Agr Food Chem. 59:7726-7733.
79. Wang KL, Hsia SM, Chan CJ, Chang FY, Huang CY, Bau DT, Wang PS. 2013. Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells. Expert Opin Ther Targets. 17:337-349.
80. Wang W, Tian DD, Zheng B, Wang D, Tan QR, Wang CY, Zhang ZJ. 2015. Peony-Glycyrrhiza decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome P450s, but not flavin-containing monooxygenase in vitro models. Drug Metab Dispos. 43:1147-1153.
81. Wang Z, Cao Y, Paudel S, Yoon G, Cheon SH. 2013. Concise synthesis of licochalcone C and its regioisomer, licochalcone H. Arch Pharm Res. 36:1432-1436.
82. Wang ZY, Nixon DW. 2001. Licorice and cancer. Nutr Cancer. 39:1-11.
83. Whorwood CB, Sheppard MC, Stewart PM. 1993. Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action. Endocrinology. 132:2287-2292.
84. Wu TY, Khor TO, Saw CL, Loh SC, Chen AI, Lim SS, Park JH, Cai L, Kong AN. 2011. Anti-inflammatory/anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis. AAPS J. 13:1-13.
85. Xiao ZW, Zhang W, Ma L, Qiu ZW. 2014. Therapeutic effect of magnesium isoglycyrrhizinate in rats on lung injury induced by paraquat poisoning. Eur Rev Med Pharmacol Sci. 18:311-320.
86. Xie C, Li X, Wu J, Liang Z, Deng F, Xie W, Zhu M, Zhu J, Zhu W, Geng S, et al. 2015. Anti-inflammatory activity of magnesium isoglycyrrhizinate through inhibition of phospholipase A2/Arachidonic acid pathway. Inflammation. 38:1639-1648.
87. Xu R, Xiao Q, Cao Y, Yang J. 2013. Comparison of the exposure of glycyrrhizin and its metabolites and the pseudoaldosteronism after intravenous administration of alpha- and beta-glycyrrhizin in rat. Drug Res (Stuttg). 63:620-624.
88. Yang CLH, Or TCT, Ho MHK, Lau ASY. 2013. Scientific basis of botanical medicine as alternative remedies for rheumatoid arthritis. Clin Rev Allerg Immu. 44:284-300.
89. Yang H, Ko HJ, Yang JY, Kim JJ, Seo SU, Park SG, Choi SS, Seong JK, Kweon MN. 2013. Interleukin-1 promotes coagulation, which is necessary for protective immunity in the lung against Streptococcus pneumoniae infection. J Infect Dis. 207:50-60.
90. Yehuda I, Madar Z, Leikin-Frenkel A, Tamir S. 2015. Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation. Mol Nutr Food Res. 59:1041-1052.
91. Zeng CX, Yang Q, Hu Q. 2006. A comparison of the distribution of two glycyrrhizic acid epimers in rat tissues. Eur J Drug Metab Pharmacokinet. 31:253-258.
92. Zhao Z, Wang W, Guo H, Zhou D. 2008. Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. Behav Brain Res. 194:108-113.
93. Zhu ZH, Tao WW, Li JP, Guo S, Qian DW, Shang EX, Su SL, Duan JA. 2016. Rapid determination of flavonoids in licorice and comparison of three licorice species. J Sep Sci. 39:473-482.