Magnesium isoglycyrrhizinate protects hepatic L02 cells from ischemia/reperfusion induced injury

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 8, 2014, Pages 4755-4764

  Huang, Xinli ^a   Qin, Jianjie ^a   Lu, Sen ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Ischemia reperfusion injury; L02 cells; Liver; Magnesium isoglycyrrhizinate

Indexed keywords

18ALPHA,20BETA-HYDROXY-11-OXO-NOROLEAN-12-EN-3BETA-YL-2-O-BETA-D-GLUCOPYRANUROSYL-ALPHA-D-GLUCOPYRANOSIDURONATE MAGNESIUM TETRAHYDRATE; PROTECTIVE AGENT; SAPONIN; TRITERPENE;

APOPTOSIS; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; FLOW CYTOMETRY; HUMAN; LIVER CELL; OXIDATIVE STRESS; REPERFUSION INJURY; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; FLOW CYTOMETRY; HEPATOCYTES; HUMANS; OXIDATIVE STRESS; PROTECTIVE AGENTS; REPERFUSION INJURY; SAPONINS; TRITERPENES;

EID: 84907938315     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Teoh NC. Hepatic ischemia reperfusion injury: Contemporary perspectives on pathogenic mechanisms and basis for hepatoprotection-the good, bad and deadly. J Gastroenterol Hepatol 2011; 26 Suppl 1: 180-187.
2. Fernández V, Tapia G and Videla LA. Recent advances in liver preconditioning: Thyroid hormone, n-3 long-chain polyunsaturated fatty acids and iron. World J Hepatol 2012; 4: 119-128.
3. Zaouali MA, Abdennebi H, Padrissa-Altés S, Mahfoudh-Boussaid A, Roselló-Catafau J. Pha-rmacological strategies against cold ischemia reperfusion injury. Expert Opin Pharmacother 2010; 11: 537-555.
4. Papadopoulos D, Siempis T, Theodorakou E, Tsoulfas G. Hepatic ischemia and reperfusion injury and trauma: current concepts. Arch Trauma Res 2013; 2: 63-70.
5. Jaeschke H and Mitchell JR. Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury. Biochem Biophys Res Commun 1989; 160: 140-147.
6. Glantzounis GK, Salacinski HJ, Yang W, Davidson BR, Seifalian AM. The contemporary role of antioxidant therapy in attenuating liver ischemia-reperfusion injury: a review. Liver Transpl 2005; 11: 1031-1047.
7. Song X, Zhang N, Xu H, Cao L, Zhang H. Combined preconditioning and postconditioning provides synergistic protection against liver ischemic reperfusion injury. Int J Biol Sci 2012; 8: 707-718.
8. Jaeschke H and Lemasters JJ. Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology 2003; 125: 1246-1257.
9. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 1995; 81: 801-809.
10. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med 2003; 7: 249-257.
11. Abu-Amara M, Yang SY, Tapuria N, Fuller B, Davidson B, Seifalian A. Liver ischemia/reperfusion injury: processes in inflammatory networks--a review. Liver Transpl 2010; 16: 1016-1032.
12. Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C. PI3K/Akt and apoptosis: size matters. Oncogene 2003; 22: 8983-8998.
13. Akao M, O'Rourke B, Kusuoka H, Teshima Y, Jones SP, Marbán E. Differential actions of cardioprotective agents on the mitochondrial death pathway. Circ Res 2003; 92: 195-202.
14. Akao M, Ohler A, O'Rourke B and Marbán E. Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circ Res 2001; 88: 1267-1275.
15. Ardehali H and O'Rourke B. Mitochondrial K (ATP) channels in cell survival and death. J Mol Cell Cardiol 2005; 39: 7-16.
16. Gross GJ and Auchampach JA. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 1992; 70: 223-233.
17. Saidi RF, Chang J, Verb S, Brooks S, Nalbantoglu I, Adsay V, Jacobs MJ. The effect of methylprednisolone on warm ischaemia-reperfusion injury in the liver. Am J Surg 2007; 193: 345-347.
18. Soltys K, Dikdan G and Koneru B. Oxidative stress in fatty livers of obese Zucker rats: rapid amelioration and improved tolerance to warm ischaemia with tocopherol. Hepatology 2001; 34: 13-18.
19. Kullmann R, Breull WR, Reinsberg J, Wassermann K, Konopatzki A. Dopamine produces vasodilatation in specific regions and layers of the rabbit gastrointestinal tract. Life Sci 1983; 32: 2115-2122.
20. Abu-Amara M, Gurusamy K, Hori S, Glantzounis G, Fuller B, Davidson BR. Systematic review of randomized controlled trials of pharmacological interventions to reduce ischaemia-reperfusion injury in elective liver resection with vascular occlusion. HPB (Oxford) 2010; 12: 4-14.
21. Bao QD, Yang LL, Wang L, Cui DL. Protective effects of magnesium isoglycyrrhizinate against carbon tetrachloride-induced acute liver injury in mice. World Chinese J Digestology 2008; 16: 1004-1007.
22. Dong LP, Yu F, Liu J, Mu XM. Protective effect of magnesium isoglycyrrhizinate on acute hepatic injury in mice. China Pharmacy 2006; 17: 902-904.
23. Zhang ZL, Li ZJ, Liu SK, Zhou YL. [Effect of notoginseng radix on expression quantity of TGF-beta1/Smads and CTGF mRNA in rats with alcoholic liver disease]. Zhongguo Zhong Yao Za Zhi 2013; 38: 2859-2862.
24. Xiao ZW, Zhang W, Ma L, Qiu ZW. Therapeutic effect of magnesium isoglycyrrhizinate in rats on lung injury induced by paraquat poisoning. Eur Rev Med Pharmacol Sci 2014; 18: 311-320.
25. Chen KJ, Chen WY and Chen X. Increased elimination of paclitaxel by magnesium isoglycyrrhizinate in epithelial ovarian cancer patients treated with paclitaxel plus cisplatin: a pilot clinical study. Euro J Drug Metabo Pharmacokinet 2014; 39: 25-31.
26. Zhang JC, Zheng GF, Wu MX, Wu JW, Ouyang LY, Liu XQ. [Effect of magnesium isoglycyrrhizinate on PLA2 during liver tissue injury following limb ischemia/reperfusion in rats]. Zhonghua Gan Zang Bing Za Zhi 2012; 20: 537-541.
27. Cleary ML, Smith SD and Sklar J. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 1986; 47: 19-28.
28. Oltvai ZN, Milliman CL and Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-619.
29. Salvesen GS. Caspases: opening the boxes and interpreting the arrows. Cell Death Differ 2002; 9: 3-5.
30. Bao QD, Yang LL, Wang L, Cui DL. Protective effects of magnesium isoglycyrrhizinate again-st carbon tetrachloride-induced acute liver injury in mice. World Chinese J Digestology 2008; 16: 1004-1007.
31. Wang P and Wu XM. Therapeutic effects of magnesium isoglycyrrhizinate on chronic liver injury induced by CCl4 in rats. Chin J New Drugs Clin Rem 2004; 23: 833-836.
32. Casillas-Ramírez A, Mosbah IB, Ramalho F, Roselló-Catafau J, Peralta C. Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation. Life Sci 2006; 79: 1881-1894.
33. Hardwick JM and Soane L. Multiple functions of BCL-2 family proteins. Cold Spring Harb Perspect Bio 2013; 5: a008722.
34. Rui L. Energy metabolism in the liver. Compr Physiol 2014; 4: 177-197.
35. Zeng Z, Huang HF, He F, Wu LX, Lin J, Chen MQ. Diazoxide attenuates ischemia/reperfusion injury via upregulation of heme oxygenase-1 after liver transplantation in rats. World J Gastroenterol 2012; 18: 1765-1772.
36. Griffiths JE. Mitochondria-potential role in cell life and death. Cardiovasc Res 2000; 46: 24-27.
37. Ockaili R, Emani VR, Okubo S, Brown M, Krottapalli K, Kukreja RC. Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide. Am J Physiol Heart Circ Physiol 1999; 277: H2425-H2434.
38. Wang Y, Wang S, Harvat T, Kinzer K, Zhang L, Feng F, Qi M, Oberholzer J. Diazoxide, a KATP Channel Opener, Prevents Ischemia? Reperfusion Injury in Rodent Pancreatic Islets. Cell Transplant 2013; [Epub ahead of print].
39. Csonka C, Kupai K, Bencsik P, Görbe A, Pálóczi J, Zvara A, Puskás LG, Csont T, Ferdinandy P. Cholesterol-enriched diet inhibits cardioprotection by ATP-sensitive K+ channel activators cromakalim and diazoxide. Am J Physiol Heart Circ Physiol 2014; 306: H405-413.
40. Liu RG, Song N, Li JM, Cui X, Chen YQ. [Akt involved in diazoxide preconditioning against rat hippocampal neuronal apoptosis induced by anoxia-reoxygenation injury]. Zhonghua Yi Xue Za Zhi 2010; 90: 492-495.