Roasted licorice extracts dampen high glucose-induced mesangial hyperplasia and matrix deposition through blocking Akt activation and TGF-β signaling

Phytomedicine

Volumn 17, Issue 10, 2010, Pages 800-810

  Li, J ^a   Lee, Y S ^a   Choi, J S ^a   Sung, H Y ^a   Kim, J K ^a   Lim, S S ^a   Kang, Y H ^a  

^a Hallym University   (South Korea)

Author keywords

Akt activation; Connective tissue growth factor; Glycyrrhiza inflate; High glucose; Licorice; Mesangial matrix deposition; TGF signaling

Indexed keywords

ALCOHOL; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; GELATINASE A; GLUCOSE; GLYCYRRHETINIC ACID; LICORICE EXTRACT; MANNITOL; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PLANT EXTRACT; PROTEIN KINASE B; SMAD PROTEIN; TRANSCRIPTION FACTOR YAP1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WATER;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; DEGRADATION; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG EXPOSURE; ENZYME ACTIVATION; GLOMERULOSCLEROSIS; GLYCYRRHIZA; HUMAN; HUMAN CELL; KIDNEY FIBROSIS; KIDNEY HYPERTROPHY; MESANGIUM CELL; NONHUMAN; OSMOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SOLUBILITY;

GLYCYRRHIZA;

EID: 79151485354     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.02.004     Document Type: Article

References (31)

1. Aida, K., Tawata, M., Shindo, H., Onaya, T., Sasaki, H., et al., 1990. Isoliquiritigenin: a new aldose reductase inhibitor from Glycyrrhizae radix. Planta Med. 56, 254-258.
2. Asano, T., Ishihara, K., Morota, T., Takeda, S., Aburada, M., 2003. Permeability of the flavonoids liquiritigenin and its glycosides in licorice roots and davidigenin, a hydrogenated metabolite of liquiritigenin, using human intestinal cell line Caco-2. J. Ethnopharmacol. 89, 285-299.
3. Baltina, L.A., 2003. Chemical modification of glycyrrhizic acid as a route to new bioactive components for medicine. Curr. Med. Chem. 10, 155-171.
4. Ban, C.R., Twigg, S.M., 2008. Fibrosis in diabetes complications: pathogenic mechanisms and circulating and urinary markers. Vasc. Health Risk Manage. 4, 575-596.
5. Berrou, J., Tostivint, I., Verrecchia, F., Berthier, C., Boulanger, E., et al., 2009. Advanced glycation end products regulate extracellular matrix protein and protease expression by human glomerular mesangial cells. Int. J. Mol. Med. 23, 513-520.
6. Bielory, L., 2004. Complementary and alternative interventions in asthma, allergy, and immunology. Ann. Allergy Asthma Immunol. 93, S45-S54.
7. Carbonell-Barrachina, A.A., Aracil, P., Garcia, E., Burlo, F., Martinez-Sanchez, F., 2003. Source of arsenic in licorice confectionery products. J. Agric. Food Chem. 51, 1749-1752.
8. Catania, J.M., Chen, G., Parrish, A.R., 2007. Role of matrix metalloproteinases in renal pathophysiologies. Am. J. Physiol. Renal Physiol. 292, F905-F911.
9. Choi, Y.J., Lim, S.S., Jung, J.Y., Choi, J.S., Kim, J.K., et al., 2008. Blockade of nitroxidative stress by roasted licorice extracts in high glucose-exposed endothelial cells. J. Cardiovasc. Pharmacol. 52, 344-354.
10. Fu, Y., Hsieh, T.C., Guo, J, Kunicki, J., Lee, M.Y., et al., 2004. Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells. Biochem. Biophys. Res. Commun. 322, 263-270.
11. Hayashida, T., Schnaper, H.W., 2004. High ambient glucose enhances sensitivity to TGF-β1 via extracellular signal-regulated kinase and protein kinase Cδ activities in human mesangial cells. J. Am. Soc. Nephrol. 15, 2032-2041.
12. Jeong, S.I., Kwak, D.H., Lee, S., Choo, Y.K., Woo, W.H., et al., 2005. Inhibitory effects of Cnidium officinale Makino and Tabanus fulvus Meigan on the high glucose-induced proliferation of glomerular mesangial cells. Phytomedicine 12, 648-655.
13. Ji, L., Yin, X.X., Wu, Z.M., Wang, J.Y., Lu, Q., Gao, Y.Y., 2009. Ginkgo biloba extract prevents glucose-induced accumulation of ECM in rat mesangial cells. Phytother. Res. 23, 477-485.
14. Kamalakkannan, N., Stanely, Mainzen, Prince, P., 2006. The influence of rutin on the extracellular matrix in streptozotocin-induced diabetic rat kidney. J. Pharm. Pharmacol. 58, 1091-1098. (Pubitemid 44213642)
15. Kang, S.W., Choi, J.S., Choi, Y.J., Bae, J.Y., Li, J., et al., 2010. Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases. J. Nutr. Biochem. 21, 55-65.
16. Kang, J.S., Yoon, Y.D., Cho, I.J., Han, M.H., Lee, C W., et al., 2005. Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock. J. Pharmacol. Exp. Ther. 312, 1187-1194.
17. Kanwar, Y.S., Wada, J., Sun, L., Xie, P., Wallner, E.I., et al., 2008. Diabetic nephropathy: mechanisms of renal disease progression. Exp. Biol. Med. (Maywood) 233, 4-11.
18. Kwon, H.M., Choi, Y.J., Choi, J.S., Kang, S.W., Bae, J.Y., et al., 2007. Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-κB signal disruption. Exp. Biol. Med. (Maywood) 232, 235-245.
19. Li, J.H., Huang, X.R., Zhu, H.J., Oldfield, M., Cooper, M., et al., 2004. Advanced glycation end products activate Smad signaling via TGF-β-dependent and independent mechanisms: implications for diabetic renal and vascular disease. FASEB J. 18, 176-178.
20. Li, J.J., Lee, S.H., Kim, D.K., Jin, R., Jung, D.S., et al., 2009. Colchicine attenuates inflammatory cell infiltration and extracellular matrix accumulation in diabetic nephropathy. Am. J. Physiol. Renal Physiol. 297, F200-F209.
21. Luo, P., Tan, Z., Zhang, Z., Li, H., Mo, Z., 2008. Inhibitory effects of salvianolic acid B on the high glucose-induced mesangial proliferation via NF-κB-dependent pathway. Biol. Pharm. Bull. 31, 1381-1386.
22. Miyazono, K., ten Dijke, P., Heldin, C.H., 2000. TGF-β signaling by Smad proteins. Adv. Immunol. 75, 115-157.
23. Presti, R.L., Carollo, C., Caimi, G., 2007. Wine consumption and renal diseases: new perspectives. Nutrition 23, 598-602.
24. Qi, W., Chen, X., Poronnik, P., Pollock, C.A., 2008. Transforming growth factor-β/connective tissue growth factor axis in the kidney. Int. J. Biochem. Cell Biol. 40, 9-13.
25. Schena, F.P., Gesualdo, L., 2005. Pathogenetic mechanisms of diabetic nephropathy. J. Am. Soc. Nephrol. 16, S30-S33.
26. Shin, Y.W., Bae, E.A., Lee, B., Lee, S.H., Kim, J.A., et al., 2007. In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components. Planta Med. 73, 257-261.
27. Wang, W., Koka, V., Lan, H.Y., 2005. Transforming growth factor-β and Smad signalling in kidney diseases. Nephrology (Carlton) 10, 48-56.
28. Wu, D., Peng, F., Zhang, B., Ingram, A.J., Kelly, D.J., et al., 2009. PKC-β1 mediates glucose-induced Akt activation and TGF-β1 upregulation in mesangial cells. J. Am. Soc. Nephrol. 20, 554-566.
29. Yamabe, N., Yokozawa, T., Oya, T., Kim, M., 2006. Therapeutic potential of (-)-epigallocatechin 3-O-gallate on renal damage in diabetic nephropathy model rats. J. Pharmacol. Exp. Ther. 319, 228-236.
30. Zhou, G., Li, C., Cai, L., 2004. Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor β-independent pathway. Am. J. Pathol. 165, 2033-2043.
31. Ziyadeh, F.N., 2004. Mediators of diabetic renal disease: the case for TGFβ as the major mediator. J. Am. Soc. Nephrol. 15, S55-S57.