Peony-glycyrrhiza decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome p450s, but not flavin-containing monooxygenase in in vitro models

Drug Metabolism and Disposition

Volumn 43, Issue 7, 2015, Pages 1147-1153

  Wang, Wei ^a   Tian, Dan Dan ^a   Zheng, Bin ^b   Wang, Di ^b   Tan, Qing Rong ^c   Wang, Chuan Yue ^d   Zhang, Zhang Jin ^a  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b JILIN UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; CLOZAPINE N OXIDE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; DIMETHYLANILINE MONOOXYGENASE; GLYCYRRHIZA RADIX PLUS PAEONIA RADIX; HERBACEOUS AGENT; NORCLOZAPINE; PEONY GLYCYRRHIZA; UNCLASSIFIED DRUG; CYTOCHROME P450 INHIBITOR; ENZYME INHIBITOR; FLAVINE MONONUCLEOTIDE REDUCTASE; NEUROLEPTIC AGENT; PLANT MEDICINAL PRODUCT; RECOMBINANT PROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; HERB DRUG INTERACTION; HUMAN; IN VITRO STUDY; LIVER MICROSOME; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GLYCYRRHIZA; MALE; METABOLISM; PAEONIA; PHARMACOKINETICS;

ANIMALIA; GLYCYRRHIZA; PAEONIA;

ANTIPSYCHOTIC AGENTS; CLOZAPINE; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FEMALE; FMN REDUCTASE; GLYCYRRHIZA; HUMANS; IN VITRO TECHNIQUES; MALE; MICROSOMES, LIVER; PAEONIA; PHARMACOKINETICS; PLANT PREPARATIONS; RECOMBINANT PROTEINS;

EID: 84940372057     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.062653     Document Type: Article

References (37)

1. Cashman JR and Zhang J (2006) Human flavin-containing monooxygenases. Annu Rev Pharmacol Toxicol 46:65-100.
2. Chen LC, Chen YF, Chou MH, Lin MF, Yang LL, and Yen KY (2002) Pharmacokinetic interactions between carbamazepine and the traditional Chinese medicine Paeoniae Radix. Biol Pharm Bull 25:532-535.
3. Chetty M and Murray M (2007) CYP-mediated clozapine interactions: how predictable are they? Curr Drug Metab 8:307-313.
4. Chinese Pharmacopoeia Commission (2010) Pharmacopoeia of the People's. Republic of China, 2010 ed, Chemical Industry Press, Beijing.
5. Costa AM, Lima MS, and Mari JdeJ (2006) A systematic review on clinical management of antipsychotic-induced sexual dysfunction in schizophrenia. Sao Paulo Med J 124: 291-297.
6. Fang J (2000) Metabolism of clozapine by rat brain: The role of flavin-containing monooxygenase (FMO) and cytochrome P450 enzymes. Eur J Drug Metab Pharmacokinet 25: 109-114.
7. Fang J, Coutts RT, McKenna KF, and Baker GB (1998) Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine. Naunyn Schmiedebergs Arch Pharmacol 358:592-599.
8. Fang S, Zhu W, Zhang Y, Shu Y, and Liu P (2012) Paeoniflorin modulates multidrug resistance of a human gastric cancer cell line via the inhibition of NF-kB activation. Mol Med Rep 5: 351-356.
9. Kane JM and Correll CU (2010) Past and present progress in the pharmacologic treatment of schizophrenia. J Clin Psychiatry 71:1115-1124.
10. Krueger SK and Williams DE (2005) Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacol Ther 106:357-387.
11. Pandit S, Ponnusankar S, Bandyopadhyay A, Ota S, and Mukherjee PK (2011) Exploring the possible metabolism mediated interaction of Glycyrrhiza glabra extract with CYP3A4 and CYP2D6. Phytother Res 25:1429-1434.
12. Pei L, Bao Y, Liu S, Zheng J, and Chen X (2013) Material basis of Chinese herbal formulas explored by combining pharmacokinetics with network pharmacology. PLoS ONE 8: e57414.
13. Peterson E, Stoebner A, Weatherill J, and Kutscher E (2008) Case of acute psychosis from herbal supplements. S D Med 61:173-177.
14. Przekop P and Lee T (2009) Persistent psychosis associated with salvia divinorum use. Am J Psychiatry 166:832.
15. Shen L, Cong WJ, Lin X, Hong YL, Hu RW, Feng Y, Xu DS, and Ruan KF (2012) Characterization using LC/MS of the absorption compounds and metabolites in rat plasma after oral administration of a single or mixed decoction of Shaoyao and Gancao. Chem Pharm Bull (Tokyo) 60:712-721.
16. Tang YL, Mao PX, Jiang F, Chen Q, Wang CY, Cai ZJ, and Mitchell PB (2008) Clozapine in China. Pharmacopsychiatry 41:1-9.
17. Tsukamoto S, Aburatani M, Yoshida T, Yamashita Y, El-Beih AA, and Ohta T (2005) CYP3A4 inhibitors isolated from Licorice. Biol Pharm Bull 28:2000-2002.
18. Tugnait M, Hawes EM, McKay G, Rettie AE, Haining RL, and Midha KK (1997) Noxygenation of clozapine by flavin-containing monooxygenase. Drug Metab Dispos 25: 524-527.
19. Wang D, Wong HK, Zhang L, McAlonan GM, Wang XM, Sze SC, Feng YB, and Zhang ZJ (2012a) Not only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia. Prog Neuropsychopharmacol Biol Psychiatry 39:332-338.
20. Wang D, Tan QR, and Zhang ZJ (2013a) Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. J Mol Neurosci 51: 581-590.
21. Wang D, Wong HK, Feng YB, and Zhang ZJ (2013b) Paeoniflorin, a natural neuroprotective agent, modulates multiple anti-apoptotic and pro-apoptotic pathways in differentiated PC12 cells. Cell Mol Neurobiol 33:521-529.
22. Wang D, Wong HK, Feng YB, and Zhang ZJ (2014a) 18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway. J Neurooncol 116: 221-230.
23. Wang D, Wong HK, Feng YB, and Zhang ZJ (2014b) Liquiritigenin exhibits antitumour action in pituitary adenoma cells via Ras/ERKs and ROS-dependent mitochondrial signalling pathways. J Pharm Pharmacol 66:408-417.
24. Wang X, Zhang H, Chen L, Shan L, Fan G, and Gao X (2013c) Liquorice, a unique "guide drug" of traditional Chinese medicine: A review of its role in drug interactions. J Ethnopharmacol 150:781-790.
25. Warnez S and Alessi-Severini S (2014) Clozapine: A review of clinical practice guidelines and prescribing trends. BMC Psychiatry 14:102.
26. Wu JJ, Ai CZ, Liu Y, Zhang YY, Jiang M, Fan XR, Lv AP, and Yang L (2012) Interactions between phytochemicals from traditional Chinese medicines and human cytochrome P450 enzymes. Curr Drug Metab 13:599-614.
27. Xu CH, Wang P, Wang Y, Yang Y, Li DH, Li HF, Sun SQ, and Wu XZ (2013) Pharmacokinetic comparisons of two different combinations of Shaoyao-Gancao Decoction in rats: competing mechanisms between paeoniflorin and glycyrrhetinic acid. J Ethnopharmacol 149:443-452.
28. Xu JX (2013) Treatment of hyperprolactinemic impotence by Jiawei Shaoyao Gancao Tang: A clinical observation of 58 cases. J New Chin Med (Xin-Zhong-Yi) 35: 21-22.
29. Yamada K, Kanba S, Murata T, Fukuzawa M, Terashi B, Yagi G, and Asai M (1996) Effectiveness of shakuyaku-kanzo-to in neuroleptic-induced hyperprolactinemia: A preliminary report. Psychiatry Clin Neurosci 50:341-342.
30. Yamada K, Kanba S, Yagi G, and Asai M (1997) Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. J Clin Psychopharmacol 17:234-235.
31. Yamada K, Kanba S, Yagi G, and Asai M (1999) Herbal medicine (Shakuyaku-kanzo-to) in the treatment of risperidone-induced amenorrhea. J Clin Psychopharmacol 19: 380-381.
32. Yuan HN, Wang CY, Sze CW, Tong Y, Tan QR, Feng XJ, Liu RM, Zhang JZ, Zhang YB, and Zhang ZJ (2008) A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. J Clin Psychopharmacol 28:264-370.
33. Zhang WV, D'Esposito F, Edwards RJ, Ramzan I, and Murray M (2008) Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes. Drug Metab Dispos 36: 2547-2555.
34. Zhang ZJ, Tan QR, Zhen XC, and Tong Y (2010) The potential benefits of herbal medicines for schizophrenia: From empirical observations to clinical trials, in Clinical Trials in Psychopharmacology (Hertzman M and Adler L eds) pp 311-335, Wiley-Blackwell, UK.
35. Zhang ZJ, Tan QR, Tong Y, Wang XY, Wang HH, Ho LM, Wong HK, Feng YB, Wang D, and Ng R, et al. (2011) An epidemiological study of concomitant use of Chinese medicine and antipsychotics in schizophrenic patients: implication for herb-drug interaction. PLoS ONE 6: e17239.
36. Zhao K, Ding M, Cao H, and Cao ZX (2012) In-vitro metabolism of glycyrrhetinic acid by human and rat liver microsomes and its interactions with six CYP substrates. J Pharm Pharmacol 64: 1445-1451.
37. Zhou S, Gao Y, Jiang W, Huang M, Xu A, and Paxton JW (2003) Interactions of herbs with cytochrome P450. Drug Metab Rev 35:35-98.