Licorice-derived dehydroglyasperin C increases MKP-1 expression and suppresses inflammation-mediated neurodegeneration

Neurochemistry International

Volumn 63, Issue 8, 2013, Pages 732-740

  Kim, Jaekyoon ^a   Kim, Jiyoung ^a,b,c   Shim, Jaesung ^a   Lee, Siyoung ^a   Kim, Jisung ^a   Lim, Soon Sung ^d   Lee, Ki Won ^a,b,c   Lee, Hyong Joo ^a,b,c  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

^d Hallym University   (South Korea)

Author keywords

Dehydroglyasperin C; Microglia; Mitogen activated protein kinase phosphatase 1 (MKP 1); Neurodegeneration; Neuron; Tumor necrosis factor (TNF )

Indexed keywords

DEHYDROGLYASPERIN C; FLAVONOID; I KAPPA B; I KAPPA B ALPHA; LIPOPOLYSACCHARIDE; MICROTUBULE ASSOCIATED PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; NEUROPROTECTIVE AGENT; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DNA BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; GLYCYRRHIZA; MICROGLIA; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEURITE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

GLYCYRRHIZA;

CM; CONDITIONED MEDIA; DEHYDROGLYASPERIN C; DGC; ERK; EXTRACELLULAR SIGNAL-REGULATED KINASE; INHIBITOR OF KAPPA B-Α; IΚB-Α; LIPOPOLYSACCHARIDE; LPS; MAP2; MAPK; MICROGLIA; MICROTUBULE-ASSOCIATED PROTEIN 2; MITOGEN-ACTIVATED PROTEIN KINASE; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASE; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASE-1 (MKP-1); MKP; NEURODEGENERATION; NEURON; NF-ΚB; NUCLEAR FACTOR-KAPPA B; SFN; SULFORAPHANE; TNF-Α; TUMOR NECROSIS FACTOR-Α; TUMOR NECROSIS FACTOR-Α (TNF-Α);

ANIMALS; BASE SEQUENCE; BENZOPYRANS; CELL LINE; DNA PRIMERS; DUAL SPECIFICITY PHOSPHATASE 1; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GLYCYRRHIZA; INFLAMMATION; MICE; MICROGLIA; NERVOUS SYSTEM DISEASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84887100912     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.09.013     Document Type: Article

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