Pharmacogenomic characterization and isobologram analysis of the combination of ascorbic acid and curcumin-two main metabolites of Curcuma longa-in cancer cells

Frontiers in Pharmacology

Volumn 8, Issue FEB, 2017, Pages

  Ooko, Edna ^a   Kadioglu, Onat ^a   Greten, Henry J ^b,c   Efferth, Thomas ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Heidelberg School of Chinese Medicine   (Germany)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Drug interaction; Isobologram analysis; Pharmacogenomics; Phytotherapy; Synergism

Indexed keywords

ASCORBIC ACID; CURCUMIN; MESSENGER RNA;

ABCA1 GENE; ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; ARTICLE; C11ORF31 GENE; CANCER CELL; CD81 GENE; CDK19 GENE; CDK7 GENE; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; CRADD GENE; CURCUMA LONGA; CYTOTOXICITY; DE4ND4B GENE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GLIOBLASTOMA; HMGN1 GENE; HNRNPR GENE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; ISOBOLOGRAM ANALYSIS; LOEWE ADDITIVITY DRUG INTERACTION MODEL; MATHEMATICAL MODEL; MICROARRAY ANALYSIS; NEUROTRANSMISSION; NONHUMAN; NR1D2 GENE; NR2F2 GENE; ONCOGENE; PDK1 GENE; PHARMACOGENOMICS; PHYTOCHEMISTRY; RBBP4 GENE; RGS13 GENE; RNA METABOLISM; RPA2 GENE; SRSF4 GENE; TCERG1 GENE; TFAM GENE; TGM2 GENE; TOM1 GENE; TOPBP1 GENE; TRANSCRIPTION REGULATION; TRIM27 GENE;

EID: 85014192974     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2017.00038     Document Type: Article

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