Mechanism of Ascorbate-Induced Cell Death in Human Pancreatic Cancer Cells: Role of Bcl-2, Beclin 1 and Autophagy

Planta Medica

Volumn 81, Issue 10, 2015, Pages 838-846

  Fukui, Masayuki ^a,b   Yamabe, Noriko ^a   Choi, Hye Joung ^a   Polireddy, Kishore ^a   Chen, Qi ^a   Zhu, Bao Ting ^a,c  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF THE RYUKYUS   (Japan)

^c SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

ascorbate; autophagy; cell death; pancreatic cancer

Indexed keywords

ANTINEOPLASTIC AGENT; ASCORBIC ACID; BECLIN 1; CASPASE 3; PACLITAXEL; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; MAP1LC3B PROTEIN, HUMAN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER INHIBITION; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREATIC CANCER CELL LINE; TUMOR VOLUME; ANIMAL; DRUG EFFECTS; DRUG SCREENING; GENETICS; METABOLISM; NUDE MOUSE; PANCREATIC NEOPLASMS; PATHOLOGY; TUMOR CELL LINE;

AGOUTI PACA;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; ASCORBIC ACID; AUTOPHAGY; CELL DEATH; CELL LINE, TUMOR; FEMALE; HUMANS; MEMBRANE PROTEINS; MICE, NUDE; MICROTUBULE-ASSOCIATED PROTEINS; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84936985002     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0035-1546132     Document Type: Article

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