Parenteral ascorbate as a cancer therapeutic: A reassessment based on pharmacokinetics

Antioxidants and Redox Signaling

Volumn 19, Issue 17, 2013, Pages 2141-2156

  Parrow, Nermi L ^a   Leshin, Jonathan A ^a   Levine, Mark ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; ACETYLCYSTEINE; AMINO ACID TRANSFER RNA LIGASE; APOPTOSIS INDUCING FACTOR; ASCORBIC ACID; BECLIN 1; BORTEZOMIB; CASPASE 3; CISPLATIN; CYCLOOXYGENASE 2; DEFEROXAMINE MESYLATE; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; FOLINIC ACID; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GEMCITABINE; HYDROGEN PEROXIDE; IRINOTECAN; MENADIONE; MITOGEN ACTIVATED PROTEIN KINASE P38; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROTEIN P53; RADIOSENSITIZING AGENT; RAF PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UNINDEXED DRUG;

ALTERNATIVE MEDICINE; ANGIOGENESIS; APOPTOSIS; AUTOPHAGY; BREAST CANCER; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SIZE; CANCER SURVIVAL; CANCER THERAPY; CELL CYCLE ARREST; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; COLORECTAL CANCER; CONTINUOUS INFUSION; CYTOTOXICITY; DNA DAMAGE; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; ENZYME DEFICIENCY; ESOPHAGUS CANCER; GLIOBLASTOMA; GLUCOSE 6 DEHYDROGENASE DEFICIENCY; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; KIDNEY FAILURE; LEWIS CARCINOMA; LUNG METASTASIS; NONHODGKIN LYMPHOMA; NONHUMAN; PANCREAS CANCER; PARENTERAL DRUG ADMINISTRATION; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PHARMACOKINETICS; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECEPTOR DOWN REGULATION; REVIEW; TREATMENT DURATION; TREATMENT RESPONSE; TUMOR XENOGRAFT; URINARY EXCRETION;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; ASCORBIC ACID; BIOLOGICAL AVAILABILITY; CELL DEATH; DRUG INTERACTIONS; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84890463822     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2013.5372     Document Type: Review

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